Question 1

The need for an increasingly larger dose of a drug to obtain the same effects as the original dose is

Accepted Answer

A) drug dependency. 
B) insufficiency. 
C) drug tolerance. 
D) craving. 
A) drug dependency. 
B) insufficiency. 
C) drug tolerance. 
D) craving. C

Question 2

Administering a drug of greater potency is better because drugs of greater potency do not require as high a dose.

Accepted Answer

A) Both parts of the statement are true. 
B) Both parts of the statement are false. 
C) The first part of the statement is true;the second part is false. 
D) The first part of the statement is false;the second part is true. 
A) Both parts of the statement are true. 
B) Both parts of the statement are false. 
C) The first part of the statement is true;the second part is false. 
D) The first part of the statement is false;the second part is true. D

Question 3

Which of the following routes of drug administration produces the most rapid drug response?

Accepted Answer

A) Intravenous 
B) Intramuscular 
C) Subcutaneous 
D) Intradermal 
A) Intravenous 
B) Intramuscular 
C) Subcutaneous 
D) Intradermal A

Question 4

A noncompetitive antagonist

Accepted Answer

A) binds to the same receptor site as the binding site for the agonist. 
B) causes a shift to the right in the dose-response curve. 
C) enhances the maximal response of the agonist. 
D) reduces the maximal response of the agonist. 
A) binds to the same receptor site as the binding site for the agonist. 
B) causes a shift to the right in the dose-response curve. 
C) enhances the maximal response of the agonist. 
D) reduces the maximal response of the agonist.

Question 5

Which of the following processes in the kidney can result in retention of a drug in the body?

Accepted Answer

A) Glomerular filtration 
B) Active tubular secretion 
C) Passive tubular diffusion 
D) All of the above 
A) Glomerular filtration 
B) Active tubular secretion 
C) Passive tubular diffusion 
D) All of the above

Question 6

What route is used to administer the tuberculosis skin test?

Accepted Answer

A) Intramuscular 
B) Intradermal 
C) Intravenous 
D) Subcutaneous 
A) Intramuscular 
B) Intradermal 
C) Intravenous 
D) Subcutaneous

Question 7

In comparing two drugs,the dose-response curve for the drug that is more efficacious would

Accepted Answer

A) be closer to the y-axis. 
B) be farther from the y-axis. 
C) have a greater curve height. 
D) have a higher median effective dose (ED50). 
A) be closer to the y-axis. 
B) be farther from the y-axis. 
C) have a greater curve height. 
D) have a higher median effective dose (ED50).

Question 8

A drug is defined as a biologically active substance that can modify

Accepted Answer

A) the environment. 
B) the pH of tissue. 
C) cellular function. 
D) immune response. 
A) the environment. 
B) the pH of tissue. 
C) cellular function. 
D) immune response.

Question 9

How many half-lives of repeated dosing does it take to reach a steady state in the body?

Accepted Answer

A) One 
B) Two or three 
C) Four or five 
D) Six or seven 
E) Eight or nine 
A) One 
B) Two or three 
C) Four or five 
D) Six or seven 
E) Eight or nine

Question 10

Which of the following statements is (are)true concerning passage across body membranes?

Accepted Answer

A) The membrane lipids make the membrane relatively permeable to ions and polar molecules. 
B) The lipid molecules orient themselves so that they form a fluid bimolecular leaflet structure with the hydrophobic ends of the molecules shielded from the surrounding aqueous environment. 
C) Membrane carbohydrates make up the structural components of the membrane and help move the molecules across the membrane during the transport process. 
D) Both A and B are true. 
E) Both B and C are true. 
A) The membrane lipids make the membrane relatively permeable to ions and polar molecules. 
B) The lipid molecules orient themselves so that they form a fluid bimolecular leaflet structure with the hydrophobic ends of the molecules shielded from the surrounding aqueous environment. 
C) Membrane carbohydrates make up the structural components of the membrane and help move the molecules across the membrane during the transport process. 
D) Both A and B are true. 
E) Both B and C are true.

Question 11

Which of the following statements are true regarding drug-receptor interactions? (Select all that apply. )

Accepted Answer

A) Drug receptors appear to consist of many large molecules that exist either on the cell membrane or within the cell itself. 
B) A specific drug will usually bind with a specific receptor in a lock-and-key fashion. 
C) Only a single receptor type is found at the site of action. 
D) The energy formed by a drug-receptor interaction is very strong and the bond is difficult to break. 
A) Drug receptors appear to consist of many large molecules that exist either on the cell membrane or within the cell itself. 
B) A specific drug will usually bind with a specific receptor in a lock-and-key fashion. 
C) Only a single receptor type is found at the site of action. 
D) The energy formed by a drug-receptor interaction is very strong and the bond is difficult to break.

Question 12

An enteral route of administration would be

Accepted Answer

A) intravenous. 
B) oral. 
C) sublingual. 
D) transdermal. 
A) intravenous. 
B) oral. 
C) sublingual. 
D) transdermal.

Question 13

The metabolite formed during metabolism (biotransformation)is usually _____ polar and _____ lipid soluble than its parent compound.

Accepted Answer

A) more;more 
B) more;less 
C) less;more 
D) less;less 
A) more;more 
B) more;less 
C) less;more 
D) less;less

Question 14

If a drug displays zero-order elimination kinetics

Accepted Answer

A) elimination increases as the dose of the drug is increased. 
B) a constant amount is eliminated per unit time. 
C) the drug is not eliminated and is retained in the body. 
D) the elimination of the drug cannot be predicted mathematically. 
A) elimination increases as the dose of the drug is increased. 
B) a constant amount is eliminated per unit time. 
C) the drug is not eliminated and is retained in the body. 
D) the elimination of the drug cannot be predicted mathematically.

Question 15

The distribution of a drug is determined by

Accepted Answer

A) blood flow to the organ. 
B) presence of certain barriers. 
C) plasma protein-binding capacity. 
D) solubility of the drug. 
E) All of the above 
A) blood flow to the organ. 
B) presence of certain barriers. 
C) plasma protein-binding capacity. 
D) solubility of the drug. 
E) All of the above

Question 16

Tolerance is most closely associated with which category of drug?

Accepted Answer

A) Antibiotics 
B) Angiotensin receptor blockers 
C) Nonsteroidal anti-inflammatory drugs 
D) Opioids 
E) Anti-hypertensive drugs 
A) Antibiotics 
B) Angiotensin receptor blockers 
C) Nonsteroidal anti-inflammatory drugs 
D) Opioids 
E) Anti-hypertensive drugs

Question 17

A patient's perception that a pill without active ingredients is having a pharmacologic effect is termed

Accepted Answer

A) tachyphylaxis. 
B) hypersensitivity. 
C) neurosis. 
D) compliance. 
E) placebo effect. 
A) tachyphylaxis. 
B) hypersensitivity. 
C) neurosis. 
D) compliance. 
E) placebo effect.

Question 18

When the acidity of the tissue increases,as in instances of infection,the effect of a local anesthetic decreases;therefore,the local anesthetic is a weak acid.

Accepted Answer

A) Both parts of the statement are true. 
B) Both parts of the statement are false. 
C) The first part of the statement is true;the second part is false. 
D) The first part of the statement is false;the second part is true. 
A) Both parts of the statement are true. 
B) Both parts of the statement are false. 
C) The first part of the statement is true;the second part is false. 
D) The first part of the statement is false;the second part is true.

Question 19

Which of the following is true regarding basic principles of drug distribution in the bloodstream?

Accepted Answer

A) All drugs in the blood are either bound to plasma proteins or free. 
B) Only the drug that is bound to plasma proteins can exert the pharmacologic effect. 
C) Only the drug that is bound to plasma proteins can pass across cell membranes. 
D) The free drug is a reservoir for the drug. 
A) All drugs in the blood are either bound to plasma proteins or free. 
B) Only the drug that is bound to plasma proteins can exert the pharmacologic effect. 
C) Only the drug that is bound to plasma proteins can pass across cell membranes. 
D) The free drug is a reservoir for the drug.

Question 20

Drug preparations may be administered for local or systemic effects.Which is an example of a dose form used for a local effect?

Accepted Answer

A) Sublingual tablet 
B) Transdermal patch 
C) Ophthalmic ointment 
D) Subcutaneous injection 
A) Sublingual tablet 
B) Transdermal patch 
C) Ophthalmic ointment 
D) Subcutaneous injection

Exam 2: Drug Action and Handling

The need for an increasingly larger dose of a drug to obtain the same effects as the original dose is

Administering a drug of greater potency is better because drugs of greater potency do not require as high a dose.

Which of the following routes of drug administration produces the most rapid drug response?

A noncompetitive antagonist

Which of the following processes in the kidney can result in retention of a drug in the body?

What route is used to administer the tuberculosis skin test?

In comparing two drugs,the dose-response curve for the drug that is more efficacious would

A drug is defined as a biologically active substance that can modify

How many half-lives of repeated dosing does it take to reach a steady state in the body?

Which of the following statements is (are)true concerning passage across body membranes?

Which of the following statements are true regarding drug-receptor interactions? (Select all that apply. )

An enteral route of administration would be

The metabolite formed during metabolism (biotransformation)is usually _____ polar and _____ lipid soluble than its parent compound.

If a drug displays zero-order elimination kinetics

The distribution of a drug is determined by

Tolerance is most closely associated with which category of drug?

A patient's perception that a pill without active ingredients is having a pharmacologic effect is termed

When the acidity of the tissue increases,as in instances of infection,the effect of a local anesthetic decreases;therefore,the local anesthetic is a weak acid.

Which of the following is true regarding basic principles of drug distribution in the bloodstream?

Drug preparations may be administered for local or systemic effects.Which is an example of a dose form used for a local effect?

Information Sources, Regulatory Agencies, Drug Legislation, and Prescription Writing

Adverse Reactions

Autonomic Drugs

Nonopioid Non-Narcoticanalgesics

Opioid Narcoticanalgesics and Antagonists

Antiinfective Agents

Antifungal and Antiviral Agents

Local Anesthetics

General Anesthetics

Antianxiety Agents

Drugs for the Treatment of Cardiovascular Disease

Drugs for the Treatment of Gastrointestinal Diseases

Drugs for the Treatment of Seizure Disorders

Drugs for the Treatment of Central Nervous System Disorders

Adrenocorticosteroids

Drugs for the Treatment of Respiratory Disorders and Allergic Rhinitis

Drugs for the Treatment of Diabetes Mellitus

Drugs for the Treatment of Other Endocrine Disorders

Antineoplastic Drugs

Emergency Drugs

Pregnancy and Breast Feeding

Substance Use Disorders

Naturalherbal Products and Dietary Supplements

Oral Conditions and Their Treatment

Hygiene-Related Oral Disorders

Filters

The metabolite formed during metabolism (biotransformation)is usually _ polar and _ lipid soluble than its parent compound.