Question 1

Advantages of oral administration of a drug include all the following except

Accepted Answer

A) large surface area for drug absorption. 
B) many different dose forms that may be administered orally. 
C) more predictable response than intravenous administration. 
D) the simplest way to introduce a drug into the body. 
A) large surface area for drug absorption. 
B) many different dose forms that may be administered orally. 
C) more predictable response than intravenous administration. 
D) the simplest way to introduce a drug into the body.

Question 2

The half-life of a drug is most related to its

Accepted Answer

A) onset. 
B) duration. 
C) safety. 
D) time to peak concentration. 
A) onset. 
B) duration. 
C) safety. 
D) time to peak concentration.

Question 3

The _____ is the most common site for biotransformation.

Accepted Answer

A) kidney 
B) blood plasma 
C) liver 
D) small intestine 
A) kidney 
B) blood plasma 
C) liver 
D) small intestine

Question 4

Enterohepatic circulation of a drug involves the secretion of a metabolized drug into the intestine.If enterohepatic circulation is blocked,the level of the drug in the serum will fall.

Accepted Answer

A) Both statements are true. 
B) Both statements are false. 
C) The first statement is true,the second statement is false. 
D) The first statement is false,the second statement is true. 
A) Both statements are true. 
B) Both statements are false. 
C) The first statement is true,the second statement is false. 
D) The first statement is false,the second statement is true.

Question 5

Which organ is involved in the first-pass effect after oral administration of a drug?

Accepted Answer

A) Kidney 
B) Lungs 
C) Liver 
D) Spleen 
A) Kidney 
B) Lungs 
C) Liver 
D) Spleen

Question 6

With zero-order kinetics,the

Accepted Answer

A) same amount of drug is metabolized and eliminated from the body per unit of time regardless of dose. 
B) same percentage of drug is metabolized and eliminated from the body per unit of time. 
C) drug is irreversibly bound to receptor sites. 
D) drug is not bound to receptor sites. 
A) same amount of drug is metabolized and eliminated from the body per unit of time regardless of dose. 
B) same percentage of drug is metabolized and eliminated from the body per unit of time. 
C) drug is irreversibly bound to receptor sites. 
D) drug is not bound to receptor sites.

Question 7

Most drugs are excreted through which mechanism?

Accepted Answer

A) Gastrointestinal tract 
B) Glomerular filtration 
C) Active tubular secretion 
D) Passive tubular diffusion 
A) Gastrointestinal tract 
B) Glomerular filtration 
C) Active tubular secretion 
D) Passive tubular diffusion

Question 8

Which term refers to the time required for a drug to begin to have its effect?

Accepted Answer

A) First pass 
B) Duration 
C) Onset 
D) Efficacy 
A) First pass 
B) Duration 
C) Onset 
D) Efficacy

Question 9

Increasing the pH of a solution will cause

Accepted Answer

A) a greater percentage of a weak base in the solution to be in the ionized form. 
B) a greater percentage of a weak acid in the solution to be in the un-ionized form. 
C) the hydrogen ion concentration to increase. 
D) a greater percentage of a weak base in the solution to be in the un-ionized form. 
E) no change in the relative ionization of weak acids or weak bases. 
A) a greater percentage of a weak base in the solution to be in the ionized form. 
B) a greater percentage of a weak acid in the solution to be in the un-ionized form. 
C) the hydrogen ion concentration to increase. 
D) a greater percentage of a weak base in the solution to be in the un-ionized form. 
E) no change in the relative ionization of weak acids or weak bases.

Question 10

Which of the following choices is the process by which a substance is transported against a concentration gradient?

Accepted Answer

A) Passive transfer 
B) Active transport 
C) Facilitated diffusion 
D) Filtration 
A) Passive transfer 
B) Active transport 
C) Facilitated diffusion 
D) Filtration

Question 11

A prodrug is an inactive drug compound that becomes transformed into an active drug compound.

Accepted Answer

A) True 
 B)False

Question 12

What type of administration involves the injection of solutions into the spinal subarachnoid space?

Accepted Answer

A) Intrathecal route 
B) Intraperitoneal route 
C) Intravenous route 
D) Intradermal route 
A) Intrathecal route 
B) Intraperitoneal route 
C) Intravenous route 
D) Intradermal route

Question 13

If one dose of a drug is administered and the drug's half-life in the body is 3 hours,what percentage of the drug would be left after four half-lives?

Accepted Answer

A) 50% 
B) 6.25% 
C) 2% 
D) Insufficient information to determine 
A) 50% 
B) 6.25% 
C) 2% 
D) Insufficient information to determine

Question 14

All of the following choices are true with regard to cytochrome P-450 hepatic microsomal enzymes except that they

Accepted Answer

A) can be induced to speed up drug metabolism. 
B) can be inhibited to slow down drug metabolism. 
C) exist as numerous isoenzymes. 
D) inactivate drugs through conjugation reactions. 
A) can be induced to speed up drug metabolism. 
B) can be inhibited to slow down drug metabolism. 
C) exist as numerous isoenzymes. 
D) inactivate drugs through conjugation reactions.

Question 15

Which of the following is not a subject of pharmacokinetics?

Accepted Answer

A) Physiologic action of drugs 
B) Metabolism of drugs 
C) Elimination of drugs 
D) Absorption of drugs 
A) Physiologic action of drugs 
B) Metabolism of drugs 
C) Elimination of drugs 
D) Absorption of drugs

Question 16

Application of a transdermal patch is an example of parenteral administration because the drug is delivered in a manner that bypasses the gastrointestinal tract.

Accepted Answer

A) Both parts of the statements are true. 
B) Both parts of the statements are false. 
C) The first part of the statement is true;the second part is false. 
D) The first part of the statement is false;the second part is true. 
A) Both parts of the statements are true. 
B) Both parts of the statements are false. 
C) The first part of the statement is true;the second part is false. 
D) The first part of the statement is false;the second part is true.

Question 17

Which is true of a drug with a stronger affinity for a receptor site versus a drug with a weaker affinity for the same site?

Accepted Answer

A) A drug with stronger affinity is more potent than a drug with weaker affinity. 
B) A drug with stronger affinity will function as a competitive antagonist rather than as an agonist. 
C) A drug with stronger affinity will function as a competitive antagonist rather than as an Agonist. 
D) A drug with stronger affinity will function as an agonist. 
A) A drug with stronger affinity is more potent than a drug with weaker affinity. 
B) A drug with stronger affinity will function as a competitive antagonist rather than as an agonist. 
C) A drug with stronger affinity will function as a competitive antagonist rather than as an Agonist. 
D) A drug with stronger affinity will function as an agonist.

Question 18

The route of administration of a drug affects both the onset and duration of response.

Accepted Answer

A) True 
 B)False

Question 19

The movement of a drug from one site in the body to other sites is called

Accepted Answer

A) distribution. 
B) disruption. 
C) dispersion. 
D) active transport. 
A) distribution. 
B) disruption. 
C) dispersion. 
D) active transport.

Question 20

Which is true regarding excretion when tubular urine is more alkaline?

Accepted Answer

A) Both weak acids and weak bases are excreted more rapidly. 
B) Weak acids are excreted more rapidly,and weak bases are excreted more slowly. 
C) Weak acids are excreted more slowly,and weak bases are excreted more rapidly. 
D) Both weak acids and weak bases are excreted more slowly. 
A) Both weak acids and weak bases are excreted more rapidly. 
B) Weak acids are excreted more rapidly,and weak bases are excreted more slowly. 
C) Weak acids are excreted more slowly,and weak bases are excreted more rapidly. 
D) Both weak acids and weak bases are excreted more slowly.

Exam 2: Drug Action and Handling

Advantages of oral administration of a drug include all the following except

The half-life of a drug is most related to its

The _____ is the most common site for biotransformation.

Enterohepatic circulation of a drug involves the secretion of a metabolized drug into the intestine.If enterohepatic circulation is blocked,the level of the drug in the serum will fall.

Which organ is involved in the first-pass effect after oral administration of a drug?

With zero-order kinetics,the

Most drugs are excreted through which mechanism?

Which term refers to the time required for a drug to begin to have its effect?

Increasing the pH of a solution will cause

Which of the following choices is the process by which a substance is transported against a concentration gradient?

A prodrug is an inactive drug compound that becomes transformed into an active drug compound.

What type of administration involves the injection of solutions into the spinal subarachnoid space?

If one dose of a drug is administered and the drug's half-life in the body is 3 hours,what percentage of the drug would be left after four half-lives?

All of the following choices are true with regard to cytochrome P-450 hepatic microsomal enzymes except that they

Which of the following is not a subject of pharmacokinetics?

Application of a transdermal patch is an example of parenteral administration because the drug is delivered in a manner that bypasses the gastrointestinal tract.

Which is true of a drug with a stronger affinity for a receptor site versus a drug with a weaker affinity for the same site?

The route of administration of a drug affects both the onset and duration of response.

The movement of a drug from one site in the body to other sites is called

Which is true regarding excretion when tubular urine is more alkaline?

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