Exam 11: The Nucleus

What are the expected phenotypic consequences of a mutation in Ran GAP that reduces its affinity for cytoplasmic filaments of the nuclear pore?

In addition to the rRNAs derived from the pre-rRNA primary transcript, what other components make up the two ribosomal subunits?

The first nuclear localization signal to be mapped is the signal responsible for the transport of

Inactive, condensed chromatin is called heterochromatin.

Sites of newly replicated DNA can be detected with antibodies if the DNA is labeled with

The 5.8S rRNA associates with

The nucleolus is the site where

Which of the following factors contributes to the relative ease of determining how pre-rRNA is processed?

If you stained mammalian cells with fluorescent antibodies against the three different RNA polymerases, antibodies directed against which RNA polymerase would be expected to stain the nucleoli?

Export of RNAs from the nucleus occurs primarily by

The region of chromosomes that codes for most of the rRNAs is found in the

What are LADs and NADs?

Heterochromatin is normally associated with

What is the basis for referring to replication and transcription sites in the nucleus as "factories"?

In addition to replication factories, the nucleus contains a number of discrete structures, maintained by protein-protein and protein-RNA interactions, that are referred to as _______.

Initial steps in the assembly of functional snRNPs occur in the

Eukaryotic ribosomal RNAs are synthesized as three transcripts, with sizes of 28S, 18S, and 5.8S.

The nuclear localization signal is recognized by and binds to which protein in the process of nuclear protein import?

Polycomb bodies act on _______ regions of chromatin, silencing gene expression.

Eukaryotic ribosomes leave the nucleus as