Exam 12: Protein Sorting and Transport

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The major function of the hydrophobic sequence at the amino terminals of proteins that are to be secreted from eukaryotic cells is to target those proteins to the rough ER.

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How many Rab proteins have been shown to play a specific role in vesicular transport?

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What is the likely transport pathway for lysosomal hydrolases in patients with I-cell disease?

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They are secreted into the extracellular space.

In some proteins, the only transmembrane sequence is located C-terminally in the protein. These proteins are recognized by

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The main method by which a cell gets rid of old, worn-out organelles is exocytosis.

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Lysosomes digest

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In cisternal maturation, the carriers for cargo protein transport through the Golgi apparatus are the Golgi _______.

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Synaptic vesicles use a special mode of fusion that is completely different from regulated secretion in a typical secretory cell.

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The lumen of the ER is equivalent topologically to the

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If secretory proteins are isolated from secretory vesicles and injected into the cytosol, they will

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The three major classes of vesicle coat proteins are _______, _______, and _______.

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Describe the role of each of the following in targeting and processing proteins in the endoplasmic reticulum. -A signal recognition particle (SRP)

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What happens to a glycoprotein in the ER lumen if it cannot be folded correctly?

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N-linked oligosaccharides are added in the _______ and modified in the _______.

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Describe the role of each of the following in targeting and processing proteins in the endoplasmic reticulum. -Protein disulfide isomerase

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As they emerge from the ribosome, signal sequences are recognized and bound by

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The signal sequence that targets a nascent polypeptide and its mRNA to the rough ER is rich in _______ amino acids.

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In polarized epithelial cells, proteins may be specifically targeted to what two membrane domains?

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Describe the role of each of the following in targeting and processing proteins in the endoplasmic reticulum. -A signal sequence

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The transcription factors that direct the unfolded protein response are _______ and _______.

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