Question 1

Proteins are targeted to the endoplasmic reticulum by a _______ that binds to a(n) _______.

Accepted Answer

signal sequence; SRP

Question 2

The ribosomes of the rough endoplasmic reticulum are targeted to the cytoplasmic side of the membrane via

Accepted Answer

A)  a signal sequence within the 28S ribosomal RNA. 
B)  a sequence within the protein being synthesized. 
C)  the S6 ribosomal protein. 
D)  the cap sequence at the 5′ end of the mRNA being translated. 
A)  a signal sequence within the 28S ribosomal RNA. 
B)  a sequence within the protein being synthesized. 
C)  the S6 ribosomal protein. 
D)  the cap sequence at the 5′ end of the mRNA being translated.

Question 3

What roles do SNAREs play in the specific binding and fusion of vesicles to a target membrane?

Accepted Answer

SNAREs are pairs of proteins,

Question 4

During cargo protein transport through the Golgi apparatus, N-linked oligosaccharide side chains are processed from high-_______ to _______ acid-rich.

Accepted Answer

The answer of During cargo protein transport through the Golgi...

Question 5

A signal sequence in a polypeptide chain targets all but _______ proteins to the rough ER surface.

Accepted Answer

A)  secreted 
B)  plasma membrane 
C)  mitochondrial 
D)  lysosomal 
A)  secreted 
B)  plasma membrane 
C)  mitochondrial 
D)  lysosomal

Question 6

What is the function of the trans-Golgi network?

Accepted Answer

The trans-Golgi network is the

Question 7

N-linked glycosylation at an Asn-X-Ser/Thr consensus sequence adds _______ sugar(s) to the protein in a single step.

Accepted Answer

A)  1 
B)  14 
C)  30 
D)  100 
A)  1 
B)  14 
C)  30 
D)  100

Question 8

Vesicles that carry proteins from the rough ER to the Golgi apparatus bud off as _______ vesicles.

Accepted Answer

A)  uncoated 
B)  clathrin-coated 
C)  COPI-coated 
D)  COPII-coated 
A)  uncoated 
B)  clathrin-coated 
C)  COPI-coated 
D)  COPII-coated

Question 9

In yeasts, posttranslational translocation of proteins targeting the ER is

Accepted Answer

A)  a process affecting many newly synthesized proteins. 
B)  much less common than in mammalian cells. 
C)  rare. 
D)  impossible because translocation into the ER requires the energy of protein synthesis. 
A)  a process affecting many newly synthesized proteins. 
B)  much less common than in mammalian cells. 
C)  rare. 
D)  impossible because translocation into the ER requires the energy of protein synthesis.

Question 10

Proteins attached to the outer half of the plasma membrane bilayer are usually attached by a

Accepted Answer

A)  farnesyl tail. 
B)  prenyl tail. 
C)  geranyl tail. 
D)  glycosylphosphatidylinositol (GPI) anchor. 
A)  farnesyl tail. 
B)  prenyl tail. 
C)  geranyl tail. 
D)  glycosylphosphatidylinositol (GPI) anchor.

Question 11

Which of the following vesicle types does not bud directly from the trans-Golgi network?

Accepted Answer

A)  Vesicles transporting plasma membrane receptors 
B)  Vesicles that form regulated secretory vesicles 
C)  Vesicles carrying lysosomal enzymes 
D)  Lysosomes 
A)  Vesicles transporting plasma membrane receptors 
B)  Vesicles that form regulated secretory vesicles 
C)  Vesicles carrying lysosomal enzymes 
D)  Lysosomes

Question 12

Lysosomal proteins are initially incorporated into _______ vesicles.

Accepted Answer

A)  uncoated 
B)  clathrin-coated 
C)  COPI-coated 
D)  COPII-coated 
A)  uncoated 
B)  clathrin-coated 
C)  COPI-coated 
D)  COPII-coated

Question 13

Cotranslational transport of proteins across the endoplasmic reticulum membrane occurs through a protein channel called the _______.

Accepted Answer

The answer of Cotranslational transport of proteins across the endoplasmic...

Question 14

Membrane lipid biosynthesis occurs in the _______ endoplasmic reticulum.

Accepted Answer

The answer of Membrane lipid biosynthesis occurs in the _______...

Question 15

Which of the following is not a contiguous membrane domain?

Accepted Answer

A)  Rough ER 
B)  Secretory granules 
C)  Smooth ER 
D)  ER exit site (ERES) 
A)  Rough ER 
B)  Secretory granules 
C)  Smooth ER 
D)  ER exit site (ERES)

Question 16

A newly synthesized polypeptide chain enters the ER through a translocon.

Accepted Answer

A) True 
 B)False

Question 17

Describe the roles of clathrin and associated adaptor proteins in the sorting and transport of proteins to lysosomes.

Accepted Answer

Proteins destined for lysosomes are reco

Question 18

The major site at which membrane lipids are synthesized is the

Accepted Answer

A)  cytosolic side of the ER membrane. 
B)  cytosol. 
C)  lumenal side of the ER membrane. 
D)  cytosolic side of the Golgi membrane. 
A)  cytosolic side of the ER membrane. 
B)  cytosol. 
C)  lumenal side of the ER membrane. 
D)  cytosolic side of the Golgi membrane.

Question 19

Transmembrane proteins in the plasma membrane are synthesized on the rough ER.

Accepted Answer

A) True 
 B)False

Question 20

Describe the role of each of the following in targeting and processing proteins in the endoplasmic reticulum.
-A signal peptidase

Accepted Answer

A signal peptidase c

Proteins are targeted to the endoplasmic reticulum by a _ that binds to a(n) _.

The ribosomes of the rough endoplasmic reticulum are targeted to the cytoplasmic side of the membrane via

What roles do SNAREs play in the specific binding and fusion of vesicles to a target membrane?

During cargo protein transport through the Golgi apparatus, N-linked oligosaccharide side chains are processed from high-_ to _ acid-rich.

A signal sequence in a polypeptide chain targets all but _______ proteins to the rough ER surface.

What is the function of the trans-Golgi network?

N-linked glycosylation at an Asn-X-Ser/Thr consensus sequence adds _______ sugar(s) to the protein in a single step.

Vesicles that carry proteins from the rough ER to the Golgi apparatus bud off as _______ vesicles.

In yeasts, posttranslational translocation of proteins targeting the ER is

Proteins attached to the outer half of the plasma membrane bilayer are usually attached by a

Which of the following vesicle types does not bud directly from the trans-Golgi network?

Lysosomal proteins are initially incorporated into _______ vesicles.

Cotranslational transport of proteins across the endoplasmic reticulum membrane occurs through a protein channel called the _______.

Membrane lipid biosynthesis occurs in the _______ endoplasmic reticulum.

Which of the following is not a contiguous membrane domain?

A newly synthesized polypeptide chain enters the ER through a translocon.

Describe the roles of clathrin and associated adaptor proteins in the sorting and transport of proteins to lysosomes.

The major site at which membrane lipids are synthesized is the

Transmembrane proteins in the plasma membrane are synthesized on the rough ER.

Describe the role of each of the following in targeting and processing proteins in the endoplasmic reticulum. -A signal peptidase

An Overview of Cells and Cell Research

Molecules and Membranes

Bioenergetics and Metabolism

Fundamentals of Molecular Biology

Genomics, Proteomics, and Systems Biology

Genes and Genomes

Replication, Maintenance, and Rearrangements of Genomic Dna

RNA Synthesis and Processing

Transcriptional Regulation and Epigenetics

Protein Synthesis, Processing, and Regulation

The Nucleus

Mitochondria, Chloroplasts, and Peroxisomes

The Cytoskeleton and Cell Movement

The Plasma Membrane

Cell Walls, the Extracellular Matrix, and Cell Interactions

Cell Signaling

The Cell Cycle

Cell Death and Cell Renewal

Cancer

Filters

Exam 12: Protein Sorting and Transport

Proteins are targeted to the endoplasmic reticulum by a _______ that binds to a(n) _______.

The ribosomes of the rough endoplasmic reticulum are targeted to the cytoplasmic side of the membrane via

What roles do SNAREs play in the specific binding and fusion of vesicles to a target membrane?

During cargo protein transport through the Golgi apparatus, N-linked oligosaccharide side chains are processed from high-_______ to _______ acid-rich.

A signal sequence in a polypeptide chain targets all but _______ proteins to the rough ER surface.

What is the function of the trans-Golgi network?

N-linked glycosylation at an Asn-X-Ser/Thr consensus sequence adds _______ sugar(s) to the protein in a single step.

Vesicles that carry proteins from the rough ER to the Golgi apparatus bud off as _______ vesicles.

In yeasts, posttranslational translocation of proteins targeting the ER is

Proteins attached to the outer half of the plasma membrane bilayer are usually attached by a

Which of the following vesicle types does not bud directly from the trans-Golgi network?

Lysosomal proteins are initially incorporated into _______ vesicles.

Cotranslational transport of proteins across the endoplasmic reticulum membrane occurs through a protein channel called the _______.

Membrane lipid biosynthesis occurs in the _______ endoplasmic reticulum.

Which of the following is not a contiguous membrane domain?

A newly synthesized polypeptide chain enters the ER through a translocon.

Describe the roles of clathrin and associated adaptor proteins in the sorting and transport of proteins to lysosomes.

The major site at which membrane lipids are synthesized is the

Transmembrane proteins in the plasma membrane are synthesized on the rough ER.

Describe the role of each of the following in targeting and processing proteins in the endoplasmic reticulum. -A signal peptidase

An Overview of Cells and Cell Research

Molecules and Membranes

Bioenergetics and Metabolism

Fundamentals of Molecular Biology

Genomics, Proteomics, and Systems Biology

Genes and Genomes

Replication, Maintenance, and Rearrangements of Genomic Dna

RNA Synthesis and Processing

Transcriptional Regulation and Epigenetics

Protein Synthesis, Processing, and Regulation

The Nucleus

Mitochondria, Chloroplasts, and Peroxisomes

The Cytoskeleton and Cell Movement

The Plasma Membrane

Cell Walls, the Extracellular Matrix, and Cell Interactions

Cell Signaling

The Cell Cycle

Cell Death and Cell Renewal

Cancer

Filters

Proteins are targeted to the endoplasmic reticulum by a _ that binds to a(n) _.

During cargo protein transport through the Golgi apparatus, N-linked oligosaccharide side chains are processed from high-_ to _ acid-rich.