Question 1

GPI-anchored proteins are synthesized

Accepted Answer

A)  on free ribosomes and attached to the GPI group on the outside of the ER. 
B)  as transmembrane proteins, then are cleaved and joined to the GPI group on the cytosolic surface of the ER. 
C)  as transmembrane proteins, then are cleaved and joined to the GPI group on the lumenal surface of the ER. 
D)  on free ribosomes and attached to the GPI group on the cytosolic surface of the ER. 
A)  on free ribosomes and attached to the GPI group on the outside of the ER. 
B)  as transmembrane proteins, then are cleaved and joined to the GPI group on the cytosolic surface of the ER. 
C)  as transmembrane proteins, then are cleaved and joined to the GPI group on the lumenal surface of the ER. 
D)  on free ribosomes and attached to the GPI group on the cytosolic surface of the ER.

Question 2

Binding of SRP to the signal sequence arrests the further translation of the nascent polypeptide chain. How does the arrest of translation promote the subsequent translocation of the polypeptide chain through the Sec61 translocation complex?

Accepted Answer

SRP, in binding to the nascent polypepti

Question 3

Vesicle fusion is mediated by the formation of protein complexes between vesicle and target _______.

Accepted Answer

The answer of Vesicle fusion is mediated by the formation...

Question 4

Plasma membrane proteins of intestinal epithelial cells require separate targeting to

Accepted Answer

A)  one continuous plasma membrane domain. 
B)  two plasma membrane domains: the apical and basolateral. 
C)  three plasma membrane domains: the apical, lateral, and basal. 
D)  four plasma membrane domains: one apical, two lateral, and a basal. 
A)  one continuous plasma membrane domain. 
B)  two plasma membrane domains: the apical and basolateral. 
C)  three plasma membrane domains: the apical, lateral, and basal. 
D)  four plasma membrane domains: one apical, two lateral, and a basal.

Question 5

Protein folding in the ER is assisted by a chaperone called

Accepted Answer

A)  BiP. 
B)  PiP. 
C)  Hsp60. 
D)  Hsp90. 
A)  BiP. 
B)  PiP. 
C)  Hsp60. 
D)  Hsp90.

Question 6

Most cellular lipids are synthesized in

Accepted Answer

A)  fat droplets. 
B)  mitochondria. 
C)  the endoplasmic reticulum. 
D)  the Golgi apparatus. 
A)  fat droplets. 
B)  mitochondria. 
C)  the endoplasmic reticulum. 
D)  the Golgi apparatus.

Question 7

Vesicles enter the Golgi apparatus by fusing with _______, and they exit from the _______.

Accepted Answer

A)  the cis (convex) face; trans (concave) face 
B)  the trans (concave) face; cis (convex) face 
C)  both the cis (convex) and the trans (concave) faces; sides of cisternae 
D)  the sides of the cisternae; cis (convex) face 
A)  the cis (convex) face; trans (concave) face 
B)  the trans (concave) face; cis (convex) face 
C)  both the cis (convex) and the trans (concave) faces; sides of cisternae 
D)  the sides of the cisternae; cis (convex) face

Question 8

Cargo protein transport between different organelles in the secretory pathway occurs by _______-mediated transport.

Accepted Answer

The answer of Cargo protein transport between different organelles in...

Question 9

Proteins are translocated into the ER lumen

Accepted Answer

A)  by flippases. 
B)  through an aqueous channel created by the Sec61 protein. 
C)  by being pushed by translation through the lipid bilayer of the ER membrane. 
D)  by being pulled by BiP across the lipid bilayer of the ER membrane. 
A)  by flippases. 
B)  through an aqueous channel created by the Sec61 protein. 
C)  by being pushed by translation through the lipid bilayer of the ER membrane. 
D)  by being pulled by BiP across the lipid bilayer of the ER membrane.

Question 10

The trans-Golgi network is the

Accepted Answer

A)  intermediate compartment between the ER and the Golgi. 
B)  part of the Golgi where fusion of vesicles from the ER occurs. 
C)  exit part of the Golgi where sorting of proteins to the lysosomes, plasma membrane, and cell exterior occurs. 
D)  network of vesicles that transport resident Golgi proteins between cisternae. 
A)  intermediate compartment between the ER and the Golgi. 
B)  part of the Golgi where fusion of vesicles from the ER occurs. 
C)  exit part of the Golgi where sorting of proteins to the lysosomes, plasma membrane, and cell exterior occurs. 
D)  network of vesicles that transport resident Golgi proteins between cisternae.

Question 11

Which of the following polysaccharides is synthesized in the Golgi apparatus?

Accepted Answer

A)  Pectin 
B)  Cellulose 
C)  Amylose 
D)  Glycogen 
A)  Pectin 
B)  Cellulose 
C)  Amylose 
D)  Glycogen

Question 12

Transport vesicles carrying acid hydrolases fuse with

Accepted Answer

A)  lysosomes. 
B)  endocytic vesicles. 
C)  early endosomes. 
D)  late endosomes. 
A)  lysosomes. 
B)  endocytic vesicles. 
C)  early endosomes. 
D)  late endosomes.

Question 13

What are Rab proteins?

Accepted Answer

Rab proteins are small GTP-bin

Question 14

Proteins with a C-terminal transmembrane sequence are

Accepted Answer

A)  cotranslationally brought to the ER by SRP, where they are inserted into the ER lumen. 
B)  posttranslationally brought to the ER by TRC40, where they remain in the ER membrane with their N-terminal domain facing the lumen. 
C)  posttranslationally brought to the ER by SRP, where they remain in the ER membrane with their N-terminal domain facing the lumen. 
D)  posttranslationally brought to the ER by TRC40, where they remain in the ER membrane with their C-terminal domain facing the lumen. 
A)  cotranslationally brought to the ER by SRP, where they are inserted into the ER lumen. 
B)  posttranslationally brought to the ER by TRC40, where they remain in the ER membrane with their N-terminal domain facing the lumen. 
C)  posttranslationally brought to the ER by SRP, where they remain in the ER membrane with their N-terminal domain facing the lumen. 
D)  posttranslationally brought to the ER by TRC40, where they remain in the ER membrane with their C-terminal domain facing the lumen.

Question 15

Which coat protein(s) would you expect to be recruited for vesicle formation by a KDEL receptor?

Accepted Answer

A)  COPI. 
B)  COPII. 
C)  clathrin. 
D)  COPI and clathrin. 
A)  COPI. 
B)  COPII. 
C)  clathrin. 
D)  COPI and clathrin.

Question 16

Which of the following would you expect to find at high concentrations in lysosomes?

Accepted Answer

A)  Proteins destined for secretion 
B)  Glycosylation enzymes 
C)  Degradative enzymes 
D)  Recycling endosomes 
A)  Proteins destined for secretion 
B)  Glycosylation enzymes 
C)  Degradative enzymes 
D)  Recycling endosomes

Question 17

As they emerge from the ribosome, signal sequences are recognized and bound by a(n)

Accepted Answer

A)  tRNA. 
B)  signal peptidase. 
C)  signal recognition particle (SRP). 
D)  SRP receptor. 
A)  tRNA. 
B)  signal peptidase. 
C)  signal recognition particle (SRP). 
D)  SRP receptor.

Question 18

Which coat protein directs retrograde vesicular transport from the ERGIC or Golgi to the endoplasmic reticulum?

Accepted Answer

A)  COPII 
B)  COPI 
C)  clathrin 
D)  Both COPI and COPII 
A)  COPII 
B)  COPI 
C)  clathrin 
D)  Both COPI and COPII

Question 19

Which of the following is not a destination for vesicles leaving the Golgi apparatus?

Accepted Answer

A)  The plasma membrane 
B)  The exterior of the cell 
C)  Lysosomes 
D)  Mitochondria 
A)  The plasma membrane 
B)  The exterior of the cell 
C)  Lysosomes 
D)  Mitochondria

Question 20

Gaucher disease results from the failure of macrophage lysosomes to hydrolyze

Accepted Answer

A)  proteins. 
B)  glycolipids. 
C)  DNA. 
D)  polysaccharides. 
A)  proteins. 
B)  glycolipids. 
C)  DNA. 
D)  polysaccharides.

GPI-anchored proteins are synthesized

Binding of SRP to the signal sequence arrests the further translation of the nascent polypeptide chain. How does the arrest of translation promote the subsequent translocation of the polypeptide chain through the Sec61 translocation complex?

Vesicle fusion is mediated by the formation of protein complexes between vesicle and target _______.

Plasma membrane proteins of intestinal epithelial cells require separate targeting to

Protein folding in the ER is assisted by a chaperone called

Most cellular lipids are synthesized in

Vesicles enter the Golgi apparatus by fusing with _, and they exit from the _.

Cargo protein transport between different organelles in the secretory pathway occurs by _______-mediated transport.

Proteins are translocated into the ER lumen

The trans-Golgi network is the

Which of the following polysaccharides is synthesized in the Golgi apparatus?

Transport vesicles carrying acid hydrolases fuse with

What are Rab proteins?

Proteins with a C-terminal transmembrane sequence are

Which coat protein(s) would you expect to be recruited for vesicle formation by a KDEL receptor?

Which of the following would you expect to find at high concentrations in lysosomes?

As they emerge from the ribosome, signal sequences are recognized and bound by a(n)

Which coat protein directs retrograde vesicular transport from the ERGIC or Golgi to the endoplasmic reticulum?

Which of the following is not a destination for vesicles leaving the Golgi apparatus?

Gaucher disease results from the failure of macrophage lysosomes to hydrolyze

An Overview of Cells and Cell Research

Molecules and Membranes

Bioenergetics and Metabolism

Fundamentals of Molecular Biology

Genomics, Proteomics, and Systems Biology

Genes and Genomes

Replication, Maintenance, and Rearrangements of Genomic Dna

RNA Synthesis and Processing

Transcriptional Regulation and Epigenetics

Protein Synthesis, Processing, and Regulation

The Nucleus

Mitochondria, Chloroplasts, and Peroxisomes

The Cytoskeleton and Cell Movement

The Plasma Membrane

Cell Walls, the Extracellular Matrix, and Cell Interactions

Cell Signaling

The Cell Cycle

Cell Death and Cell Renewal

Cancer

Filters

Exam 12: Protein Sorting and Transport

GPI-anchored proteins are synthesized

Binding of SRP to the signal sequence arrests the further translation of the nascent polypeptide chain. How does the arrest of translation promote the subsequent translocation of the polypeptide chain through the Sec61 translocation complex?

Vesicle fusion is mediated by the formation of protein complexes between vesicle and target _______.

Plasma membrane proteins of intestinal epithelial cells require separate targeting to

Protein folding in the ER is assisted by a chaperone called

Most cellular lipids are synthesized in

Vesicles enter the Golgi apparatus by fusing with _______, and they exit from the _______.

Cargo protein transport between different organelles in the secretory pathway occurs by _______-mediated transport.

Proteins are translocated into the ER lumen

The trans-Golgi network is the

Which of the following polysaccharides is synthesized in the Golgi apparatus?

Transport vesicles carrying acid hydrolases fuse with

What are Rab proteins?

Proteins with a C-terminal transmembrane sequence are

Which coat protein(s) would you expect to be recruited for vesicle formation by a KDEL receptor?

Which of the following would you expect to find at high concentrations in lysosomes?

As they emerge from the ribosome, signal sequences are recognized and bound by a(n)

Which coat protein directs retrograde vesicular transport from the ERGIC or Golgi to the endoplasmic reticulum?

Which of the following is not a destination for vesicles leaving the Golgi apparatus?

Gaucher disease results from the failure of macrophage lysosomes to hydrolyze

An Overview of Cells and Cell Research

Molecules and Membranes

Bioenergetics and Metabolism

Fundamentals of Molecular Biology

Genomics, Proteomics, and Systems Biology

Genes and Genomes

Replication, Maintenance, and Rearrangements of Genomic Dna

RNA Synthesis and Processing

Transcriptional Regulation and Epigenetics

Protein Synthesis, Processing, and Regulation

The Nucleus

Mitochondria, Chloroplasts, and Peroxisomes

The Cytoskeleton and Cell Movement

The Plasma Membrane

Cell Walls, the Extracellular Matrix, and Cell Interactions

Cell Signaling

The Cell Cycle

Cell Death and Cell Renewal

Cancer

Filters

Vesicles enter the Golgi apparatus by fusing with _, and they exit from the _.