Question 1

Which enzyme serves as the receptor for aliskiren?

Accepted Answer

A)  angiotensin-converting enzyme 
B)  renin 
C)  sodium-potassium adenosine triphosphatase 
D)  carbonic anhydrase 
E)  nitric oxide synthase 
A)  angiotensin-converting enzyme 
B)  renin 
C)  sodium-potassium adenosine triphosphatase 
D)  carbonic anhydrase 
E)  nitric oxide synthase B

Question 2

After several months of antihypertensive drug therapy, a patient develops a lupus erythematosus-like syndrome.
Which agent is most likely responsible for this adverse effect?

Accepted Answer

A)  minoxidil 
B)  hydrochlorothiazide 
C)  captopril 
D)  verapamil 
E)  hydralazine 
A)  minoxidil 
B)  hydrochlorothiazide 
C)  captopril 
D)  verapamil 
E)  hydralazine E

Question 3

A patient with a hypertensive emergency is given an intravenous infusion of a drug that dilates renal afferent and efferent arterioles and is rapidly metabolized with a half-life of 5 minutes. Which mechanism is responsible for the therapeutic effect of this drug?

Accepted Answer

A)  activation of dopamine D1 receptors 
B)  activation of dopamine D2 receptors 
C)  blockade of α 1-adrenoceptors 
D)  activation of α 2-adrenoceptors 
E)  blockade of α 1- and β
1-adrenoceptors 
A)  activation of dopamine D1 receptors 
B)  activation of dopamine D2 receptors 
C)  blockade of α 1-adrenoceptors 
D)  activation of α 2-adrenoceptors 
E)  blockade of α 1- and β
1-adrenoceptors A

Question 4

Nitroprusside administration may lead to the accumulation of which toxic compound in the body?

Accepted Answer

A)  formaldehyde 
B)  bromine 
C)  cyanide 
D)  nitrobenzene 
E)  superoxide 
A)  formaldehyde 
B)  bromine 
C)  cyanide 
D)  nitrobenzene 
E)  superoxide

Question 5

Which antihypertensive drug is most likely to reduce vascular injury by inhibiting activation of growth factors that cause smooth muscle proliferation and hypertrophy?

Accepted Answer

A)  clonidine 
B)  terazosin 
C)  atenolol 
D)  candesartan 
E)  nifedipine 
A)  clonidine 
B)  terazosin 
C)  atenolol 
D)  candesartan 
E)  nifedipine

Exam 10: Antihypertensive Drugs

Which enzyme serves as the receptor for aliskiren?

After several months of antihypertensive drug therapy, a patient develops a lupus erythematosus-like syndrome. Which agent is most likely responsible for this adverse effect?

A patient with a hypertensive emergency is given an intravenous infusion of a drug that dilates renal afferent and efferent arterioles and is rapidly metabolized with a half-life of 5 minutes. Which mechanism is responsible for the therapeutic effect of this drug?

Nitroprusside administration may lead to the accumulation of which toxic compound in the body?

Which antihypertensive drug is most likely to reduce vascular injury by inhibiting activation of growth factors that cause smooth muscle proliferation and hypertrophy?

Introduction to Pharmacology

Pharmacokinetics

Pharmacodynamics

Drug Development and Safety

Introduction to Autonomic and Neuromuscular Pharmacology

Acetylcholine Receptor Agonists

Acetylcholine Receptor Antagonists

Adrenoceptor Agonists

Adrenoceptor Antagonists

Antianginal Drugs

Drugs for Heart Failure

Diuretics

Antiarrhythmic Drugs

Drugs for Hyperlipidemia

Anticoagulant, Antiplatelet, and Fibrinolytic Drugs

Hematopoietic Drugs

Introduction to Central Nervous System Pharmacology

Sedative-Hypnotic and Anxiolytic Drugs

Antiepileptic Drugs

Local and General Anesthetics

Psychotherapeutic Drugs

Opioid Analgesics and Antagonists

Drugs for Neurodegenerative Diseases

Drugs of Abuse

Autacoid Drugs

Drugs for Respiratory Tract Disorders

Drugs for Gastrointestinal Tract Disorders

Drugs for Headache Disorders

Drugs for Pain, Inflammation, and Arthritic Disorders

Hypothalamic and Pituitary Drugs

Thyroid Drugs

Adrenal Steroids and Related Drugs

Drugs Affecting Fertility and Reproduction

Drugs for Diabetes Mellitus

Drugs Affecting Calcium and Bone

Principles of Antimicrobial Chemotherapy

Inhibitors of Bacterial Cell Wall Synthesis

Inhibitors of Bacterial Protein Synthesis

Quinolones, Antifolate Drugs, and Other Antimicrobial Agents

Antimycobacterial Drugs

Antifungal Drugs

Antiviral Drugs

Antiparasitic Drugs

Antineoplastic and Immunomodulating Drugs

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