Question 1

Which pair of drugs produces antiepileptic effects by blocking T-type calcium channels in neuronal membranes?

Accepted Answer

A)  topiramate and vigabatrin 
B)  gabapentin and pregabalin 
C)  zonisamide and carbamazepine 
D)  lamotrigine and topiramate 
E)  ethosuximide and valproate 
A)  topiramate and vigabatrin 
B)  gabapentin and pregabalin 
C)  zonisamide and carbamazepine 
D)  lamotrigine and topiramate 
E)  ethosuximide and valproate E

Question 2

A child whose seizures have been controlled with valproate experiences breakthrough seizures and lamotrigine is being added to the regimen. Which adverse effect is more common in children receiving both drugs?

Accepted Answer

A)  aplastic anemia 
B)  hepatitis 
C)  Stevens-Johnson syndrome 
D)  megaloblastic anemia 
E)  gingival hyperplasia 
A)  aplastic anemia 
B)  hepatitis 
C)  Stevens-Johnson syndrome 
D)  megaloblastic anemia 
E)  gingival hyperplasia C

Question 3

After sustaining head trauma, a woman experiences recurrent tonic-clonic seizures without regaining consciousness.
Which pair of drugs is most often used to control this type of seizure?

Accepted Answer

A)  valproate and carbamazepine 
B)  zonisamide and gabapentin 
C)  topiramate and vigabatrin 
D)  diazepam and phenytoin 
E)  pregabalin and tiagabine 
A)  valproate and carbamazepine 
B)  zonisamide and gabapentin 
C)  topiramate and vigabatrin 
D)  diazepam and phenytoin 
E)  pregabalin and tiagabine D

Question 4

A woman with epilepsy is instructed to take larger doses of vitamin D than are usually recommended. Which drug is most likely being taken by this patient?

Accepted Answer

A)  valproate 
B)  phenytoin 
C)  phenobarbital 
D)  gabapentin 
E)  topiramate 
A)  valproate 
B)  phenytoin 
C)  phenobarbital 
D)  gabapentin 
E)  topiramate

Exam 20: Antiepileptic Drugs

Which pair of drugs produces antiepileptic effects by blocking T-type calcium channels in neuronal membranes?

A child whose seizures have been controlled with valproate experiences breakthrough seizures and lamotrigine is being added to the regimen. Which adverse effect is more common in children receiving both drugs?

After sustaining head trauma, a woman experiences recurrent tonic-clonic seizures without regaining consciousness. Which pair of drugs is most often used to control this type of seizure?

A woman with epilepsy is instructed to take larger doses of vitamin D than are usually recommended. Which drug is most likely being taken by this patient?

Introduction to Pharmacology

Pharmacokinetics

Pharmacodynamics

Drug Development and Safety

Introduction to Autonomic and Neuromuscular Pharmacology

Acetylcholine Receptor Agonists

Acetylcholine Receptor Antagonists

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Antihypertensive Drugs

Antianginal Drugs

Drugs for Heart Failure

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Introduction to Central Nervous System Pharmacology

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Opioid Analgesics and Antagonists

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Drugs Affecting Fertility and Reproduction

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Principles of Antimicrobial Chemotherapy

Inhibitors of Bacterial Cell Wall Synthesis

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