Question 1

A patient with decompensated heart failure is given an intravenous infusion of a peptide drug. Which effect is produced by this treatment?

Accepted Answer

A)  decreased synthesis of angiotensin II 
B)  blockade of angiotensin II receptors 
C)  increased levels of cyclic AMP 
D)  increased levels of cyclic GMP 
E)  increased influx of calcium 
A)  decreased synthesis of angiotensin II 
B)  blockade of angiotensin II receptors 
C)  increased levels of cyclic AMP 
D)  increased levels of cyclic GMP 
E)  increased influx of calcium D

Question 2

Several weeks after beginning treatment for severe heart failure, a man develops hyperkalemia requiring hospitalization.
Which agent is most likely responsible for this adverse effect?

Accepted Answer

A)  eplerenone 
B)  digoxin 
C)  furosemide 
D)  dobutamine 
E)  milrinone 
A)  eplerenone 
B)  digoxin 
C)  furosemide 
D)  dobutamine 
E)  milrinone A

Question 3

The beneficial effects of carvedilol in persons with heart failure are obtained with the use of which drug administration regimen?

Accepted Answer

A)  intravenous infusion for 3 to 7 days 
B)  low doses that are gradually increased over time 
C)  loading doses followed by maintenance doses 
D)  high doses that are gradually tapered over time 
E)  titration to obtain the desired increase in cardiac output 
A)  intravenous infusion for 3 to 7 days 
B)  low doses that are gradually increased over time 
C)  loading doses followed by maintenance doses 
D)  high doses that are gradually tapered over time 
E)  titration to obtain the desired increase in cardiac output B

Exam 12: Drugs for Heart Failure

A patient with decompensated heart failure is given an intravenous infusion of a peptide drug. Which effect is produced by this treatment?

Several weeks after beginning treatment for severe heart failure, a man develops hyperkalemia requiring hospitalization. Which agent is most likely responsible for this adverse effect?

The beneficial effects of carvedilol in persons with heart failure are obtained with the use of which drug administration regimen?

Introduction to Pharmacology

Pharmacokinetics

Pharmacodynamics

Drug Development and Safety

Introduction to Autonomic and Neuromuscular Pharmacology

Acetylcholine Receptor Agonists

Acetylcholine Receptor Antagonists

Adrenoceptor Agonists

Adrenoceptor Antagonists

Antihypertensive Drugs

Antianginal Drugs

Diuretics

Antiarrhythmic Drugs

Drugs for Hyperlipidemia

Anticoagulant, Antiplatelet, and Fibrinolytic Drugs

Hematopoietic Drugs

Introduction to Central Nervous System Pharmacology

Sedative-Hypnotic and Anxiolytic Drugs

Antiepileptic Drugs

Local and General Anesthetics

Psychotherapeutic Drugs

Opioid Analgesics and Antagonists

Drugs for Neurodegenerative Diseases

Drugs of Abuse

Autacoid Drugs

Drugs for Respiratory Tract Disorders

Drugs for Gastrointestinal Tract Disorders

Drugs for Headache Disorders

Drugs for Pain, Inflammation, and Arthritic Disorders

Hypothalamic and Pituitary Drugs

Thyroid Drugs

Adrenal Steroids and Related Drugs

Drugs Affecting Fertility and Reproduction

Drugs for Diabetes Mellitus

Drugs Affecting Calcium and Bone

Principles of Antimicrobial Chemotherapy

Inhibitors of Bacterial Cell Wall Synthesis

Inhibitors of Bacterial Protein Synthesis

Quinolones, Antifolate Drugs, and Other Antimicrobial Agents

Antimycobacterial Drugs

Antifungal Drugs

Antiviral Drugs

Antiparasitic Drugs

Antineoplastic and Immunomodulating Drugs

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