Question 1

For which reason is clavulanate included in some formulations of β-lactam drugs?

Accepted Answer

A)  blocks formation of cell wall precursors 
B)  prevents cross-linking of cell wall peptides 
C)  inhibits renal tubular secretion of β-lactam drugs 
D)  inhibits bacterial degradation of β-lactam drugs 
E)  inhibits renal degradation of β-lactam drugs 
A)  blocks formation of cell wall precursors 
B)  prevents cross-linking of cell wall peptides 
C)  inhibits renal tubular secretion of β-lactam drugs 
D)  inhibits bacterial degradation of β-lactam drugs 
E)  inhibits renal degradation of β-lactam drugs D

Question 2

Which attribute is associated with a third-generation cephalosporin that is excreted primarily in the bile?

Accepted Answer

A)  well absorbed from the gut 
B)  long plasma half-life 
C)  used to treat Pseudomonas infections 
D)  may cause platelet dysfunction and bleeding 
E)  prolongs the QT interval of the electrocardiogram 
A)  well absorbed from the gut 
B)  long plasma half-life 
C)  used to treat Pseudomonas infections 
D)  may cause platelet dysfunction and bleeding 
E)  prolongs the QT interval of the electrocardiogram B

Question 3

A woman is dispensed a single dose of a drug for a urinary tract infection. Which step in bacterial cell wall synthesis is inhibited by this drug?

Accepted Answer

A)  transpeptidase 
B)  addition of phosphoenolpyruvate 
C)  formation of N-acetylglucosamine 
D)  incorporation of D-alanine residues 
E)  formation of pentaglycine bridge 
A)  transpeptidase 
B)  addition of phosphoenolpyruvate 
C)  formation of N-acetylglucosamine 
D)  incorporation of D-alanine residues 
E)  formation of pentaglycine bridge B

Question 4

After receiving a rapid intravenous infusion of an antibiotic, a man develops hypotension and an erythematous rash.
Which drug is most likely responsible for this adverse effect?

Accepted Answer

A)  ceftriaxone 
B)  ertapenem 
C)  aztreonam 
D)  piperacillin 
E)  vancomycin 
A)  ceftriaxone 
B)  ertapenem 
C)  aztreonam 
D)  piperacillin 
E)  vancomycin

Exam 38: Inhibitors of Bacterial Cell Wall Synthesis

For which reason is clavulanate included in some formulations of β-lactam drugs?

Which attribute is associated with a third-generation cephalosporin that is excreted primarily in the bile?

A woman is dispensed a single dose of a drug for a urinary tract infection. Which step in bacterial cell wall synthesis is inhibited by this drug?

After receiving a rapid intravenous infusion of an antibiotic, a man develops hypotension and an erythematous rash. Which drug is most likely responsible for this adverse effect?

Introduction to Pharmacology

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Drug Development and Safety

Introduction to Autonomic and Neuromuscular Pharmacology

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Introduction to Central Nervous System Pharmacology

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Principles of Antimicrobial Chemotherapy

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