Question 1

Leflunomide prevents leukocyte proliferation by inhibiting which step in this process?

Accepted Answer

A)  formation of active folate 
B)  pyrimidine biosynthesis 
C)  purine biosynthesis 
D)  ribonucleotide reductase 
E)  DNA polymerase 
A)  formation of active folate 
B)  pyrimidine biosynthesis 
C)  purine biosynthesis 
D)  ribonucleotide reductase 
E)  DNA polymerase B

Question 2

Abatacept exerts its antirheumatic effects by binding to which molecular target?

Accepted Answer

A)  interleukin-1 type I receptor 
B)  tumor necrosis factor-α 
C)  cell surface proteins of T lymphocytes 
D)  immunoglobulin G rheumatoid factor 
E)  interleukin-2 transcription factors 
A)  interleukin-1 type I receptor 
B)  tumor necrosis factor-α 
C)  cell surface proteins of T lymphocytes 
D)  immunoglobulin G rheumatoid factor 
E)  interleukin-2 transcription factors C

Question 3

The use of ketorolac is limited to the short-term management of postsurgical pain because long-term use is associated with a risk of which adverse effect?

Accepted Answer

A)  lactic acidosis 
B)  heart failure 
C)  drug dependence 
D)  hepatitis 
E)  gastrointestinal bleeding 
A)  lactic acidosis 
B)  heart failure 
C)  drug dependence 
D)  hepatitis 
E)  gastrointestinal bleeding E

Question 4

Administration of allopurinol produces which effect on serum and urinary levels of uric acid in a patient with gout?

Accepted Answer

A)  increased serum and urinary levels 
B)  increased serum and decreased urinary levels 
C)  decreased serum levels and no change in urinary levels 
D)  decreased serum and urinary levels 
E)  decreased serum and increased urinary levels 
A)  increased serum and urinary levels 
B)  increased serum and decreased urinary levels 
C)  decreased serum levels and no change in urinary levels 
D)  decreased serum and urinary levels 
E)  decreased serum and increased urinary levels

Exam 30: Drugs for Pain, Inflammation, and Arthritic Disorders

Leflunomide prevents leukocyte proliferation by inhibiting which step in this process?

Abatacept exerts its antirheumatic effects by binding to which molecular target?

The use of ketorolac is limited to the short-term management of postsurgical pain because long-term use is associated with a risk of which adverse effect?

Administration of allopurinol produces which effect on serum and urinary levels of uric acid in a patient with gout?

Introduction to Pharmacology

Pharmacokinetics

Pharmacodynamics

Drug Development and Safety

Introduction to Autonomic and Neuromuscular Pharmacology

Acetylcholine Receptor Agonists

Acetylcholine Receptor Antagonists

Adrenoceptor Agonists

Adrenoceptor Antagonists

Antihypertensive Drugs

Antianginal Drugs

Drugs for Heart Failure

Diuretics

Antiarrhythmic Drugs

Drugs for Hyperlipidemia

Anticoagulant, Antiplatelet, and Fibrinolytic Drugs

Hematopoietic Drugs

Introduction to Central Nervous System Pharmacology

Sedative-Hypnotic and Anxiolytic Drugs

Antiepileptic Drugs

Local and General Anesthetics

Psychotherapeutic Drugs

Opioid Analgesics and Antagonists

Drugs for Neurodegenerative Diseases

Drugs of Abuse

Autacoid Drugs

Drugs for Respiratory Tract Disorders

Drugs for Gastrointestinal Tract Disorders

Drugs for Headache Disorders

Hypothalamic and Pituitary Drugs

Thyroid Drugs

Adrenal Steroids and Related Drugs

Drugs Affecting Fertility and Reproduction

Drugs for Diabetes Mellitus

Drugs Affecting Calcium and Bone

Principles of Antimicrobial Chemotherapy

Inhibitors of Bacterial Cell Wall Synthesis

Inhibitors of Bacterial Protein Synthesis

Quinolones, Antifolate Drugs, and Other Antimicrobial Agents

Antimycobacterial Drugs

Antifungal Drugs

Antiviral Drugs

Antiparasitic Drugs

Antineoplastic and Immunomodulating Drugs

Filters