Question 1

A patient exhibits a rapid loss of responsiveness to a drug during the first several hours of drug administration. Which event is most likely responsible for this effect?

Accepted Answer

A)  up-regulation of drug metabolizing enzymes 
B)  down-regulation of drug metabolizing enzymes 
C)  internalization of cell membrane receptors 
D)  formation of receptor antibodies 
E)  phosphorylation of G protein-coupled receptors 
A)  up-regulation of drug metabolizing enzymes 
B)  down-regulation of drug metabolizing enzymes 
C)  internalization of cell membrane receptors 
D)  formation of receptor antibodies 
E)  phosphorylation of G protein-coupled receptors E

Question 2

In what way is the log-concentration effect (dose response) curve of an agonist drug modified in the presence of a competitive receptor antagonist?

Accepted Answer

A)  shifted to the right without a change in slope or maximum effect 
B)  shifted to the left without a change in slope or maximum effect 
C)  shifted to the right with a decreased slope and maximum effect 
D)  shifted to the left with a decreased slope and maximum effect 
E)  not shifted right or left but shows a decreased maximum effect 
A)  shifted to the right without a change in slope or maximum effect 
B)  shifted to the left without a change in slope or maximum effect 
C)  shifted to the right with a decreased slope and maximum effect 
D)  shifted to the left with a decreased slope and maximum effect 
E)  not shifted right or left but shows a decreased maximum effect A

Exam 3: Pharmacodynamics

A patient exhibits a rapid loss of responsiveness to a drug during the first several hours of drug administration. Which event is most likely responsible for this effect?

In what way is the log-concentration effect (dose response) curve of an agonist drug modified in the presence of a competitive receptor antagonist?

Introduction to Pharmacology

Pharmacokinetics

Drug Development and Safety

Introduction to Autonomic and Neuromuscular Pharmacology

Acetylcholine Receptor Agonists

Acetylcholine Receptor Antagonists

Adrenoceptor Agonists

Adrenoceptor Antagonists

Antihypertensive Drugs

Antianginal Drugs

Drugs for Heart Failure

Diuretics

Antiarrhythmic Drugs

Drugs for Hyperlipidemia

Anticoagulant, Antiplatelet, and Fibrinolytic Drugs

Hematopoietic Drugs

Introduction to Central Nervous System Pharmacology

Sedative-Hypnotic and Anxiolytic Drugs

Antiepileptic Drugs

Local and General Anesthetics

Psychotherapeutic Drugs

Opioid Analgesics and Antagonists

Drugs for Neurodegenerative Diseases

Drugs of Abuse

Autacoid Drugs

Drugs for Respiratory Tract Disorders

Drugs for Gastrointestinal Tract Disorders

Drugs for Headache Disorders

Drugs for Pain, Inflammation, and Arthritic Disorders

Hypothalamic and Pituitary Drugs

Thyroid Drugs

Adrenal Steroids and Related Drugs

Drugs Affecting Fertility and Reproduction

Drugs for Diabetes Mellitus

Drugs Affecting Calcium and Bone

Principles of Antimicrobial Chemotherapy

Inhibitors of Bacterial Cell Wall Synthesis

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Quinolones, Antifolate Drugs, and Other Antimicrobial Agents

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