Exam 15: Psychological Disorders-Part B

Use the following to answer questions Scenario II The following scenario presents fabricated data consistent with the results of the following study: Tienari,P. ,Wynne,L.C. ,Sorri,A. ,Lahti,I. ,Läksy,K. ,Moring,J. ,& ...Wahlberg,K.(2004).Genotype-environment interaction in schizophrenia-spectrum disorder: Long-term follow-up study of Finnish adoptees.The British Journal of Psychiatry,184(3),216-222.doi:10.1192/bjp.184.3.216 Schizophrenia affects approximately 1% of the general population and is characterized by the profound disruption of basic psychological processes;a distorted perception of reality;altered or blunted emotional affect;and disturbances in thought,motivation,and behavior.The symptoms of schizophrenia are varied and are typically classified as either positive or negative.Positive symptoms of schizophrenia refer to thoughts and behaviors typically not observed in those without the disease and can include things like delusions (patently false beliefs),hallucinations (false perceptual experiences),and disorganized speech.Negative symptoms of schizophrenia are deficits or disruptions in normal behaviors,such as social withdrawal.Cognitive deficits in executive functioning,attention span,and working memory may also be observed. The symptoms of schizophrenia usually begin in late adolescence and the disease has a strong genetic component.Over the years,a number of biological factors have been linked to schizophrenia,although none alone adequately accounts for the disorder.One such example is the dopamine hypothesis,which states that schizophrenia is related to an excess in dopamine activity.Another theory points to enlarged brain ventricles and progressive cortex tissue loss as predictive of schizophrenia.Although only a minority of persons with schizophrenia have enlarged ventricles,this structural anomaly can appear in those without the disease,and dopamine antagonists may also produce this effect. Although research into the environmental determinants of schizophrenia has focused largely on the prenatal environment,psychological and social factors also contribute.Tienari and colleagues (2004)compared the risk of developing schizophrenia in children adopted into healthy versus disturbed families,the latter characterized by extreme conflict,volatile relationships,and communication deficits.Some of these children under investigation were identified as at-risk genetically for schizophrenia because their biological mothers were schizophrenic.The remainder were classified at low risk.The investigators utilized a longitudinal design and obtained the diagnostic status of the children with respect to schizophrenia when they reached young adulthood.Fabricated results consistent with this study are shown in Figure 15.2 Figure 15.2 -(Scenario II)Numerous studies have demonstrated enlarged ventricles in patients with schizophrenia,particularly those exhibiting the negative symptoms of the disease.Why would interpretation of this finding NOT be complicated?

Use the following to answer questions Scenario II The following scenario presents fabricated data consistent with the results of the following study: Tienari,P. ,Wynne,L.C. ,Sorri,A. ,Lahti,I. ,Läksy,K. ,Moring,J. ,& ...Wahlberg,K.(2004).Genotype-environment interaction in schizophrenia-spectrum disorder: Long-term follow-up study of Finnish adoptees.The British Journal of Psychiatry,184(3),216-222.doi:10.1192/bjp.184.3.216 Schizophrenia affects approximately 1% of the general population and is characterized by the profound disruption of basic psychological processes;a distorted perception of reality;altered or blunted emotional affect;and disturbances in thought,motivation,and behavior.The symptoms of schizophrenia are varied and are typically classified as either positive or negative.Positive symptoms of schizophrenia refer to thoughts and behaviors typically not observed in those without the disease and can include things like delusions (patently false beliefs),hallucinations (false perceptual experiences),and disorganized speech.Negative symptoms of schizophrenia are deficits or disruptions in normal behaviors,such as social withdrawal.Cognitive deficits in executive functioning,attention span,and working memory may also be observed. The symptoms of schizophrenia usually begin in late adolescence and the disease has a strong genetic component.Over the years,a number of biological factors have been linked to schizophrenia,although none alone adequately accounts for the disorder.One such example is the dopamine hypothesis,which states that schizophrenia is related to an excess in dopamine activity.Another theory points to enlarged brain ventricles and progressive cortex tissue loss as predictive of schizophrenia.Although only a minority of persons with schizophrenia have enlarged ventricles,this structural anomaly can appear in those without the disease,and dopamine antagonists may also produce this effect. Although research into the environmental determinants of schizophrenia has focused largely on the prenatal environment,psychological and social factors also contribute.Tienari and colleagues (2004)compared the risk of developing schizophrenia in children adopted into healthy versus disturbed families,the latter characterized by extreme conflict,volatile relationships,and communication deficits.Some of these children under investigation were identified as at-risk genetically for schizophrenia because their biological mothers were schizophrenic.The remainder were classified at low risk.The investigators utilized a longitudinal design and obtained the diagnostic status of the children with respect to schizophrenia when they reached young adulthood.Fabricated results consistent with this study are shown in Figure 15.2 Figure 15.2 -(Scenario II)The results shown in Figure 15.2 demonstrate that:

Use the following to answer questions Scenario I The following scenario presents fabricated data consistent with the results of the following study: Gilbertson,M.W. ,Shenton,M.E. ,Ciszewski,A. ,Kasai,K. ,Lasko,N .B. ,Orr,S.P. ,& Pitman,R.K.(2002).Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma.Nature Neuroscience,5,1242-1247. Persons who live through a traumatic experience may develop posttraumatic stress disorder (PTSD).PTSD is characterized by chronic physiological arousal,recurrent unwanted thoughts or images,and avoidance of things that bring the trauma to mind,with symptoms persisting for more than 1 month.Persons with PTSD also are at risk for other psychological disorders,with substance abuse disorder being a common comorbid diagnosis.In the last two decades,a number of studies have demonstrated that persons with PTSD have smaller hippocampi than controls.This may result from the neurotoxic effects of stress hormones examined the hippocampal volume of combat veterans with and without PTSD who each had an identical twin who never served in the military.Fabricated results consistent with this study are shown in Figure 15.1. Figure 15.1 -(Scenario I)For a number of years,psychologists with expertise in the stress response hypothesized that glucocorticoid release at and shortly after the time of trauma were neurotoxic and led to smaller hippocampi.The results of the study by Gilbertson and colleagues (2002):

Use the following to answer questions Scenario I The following scenario presents fabricated data consistent with the results of the following study: Gilbertson,M.W. ,Shenton,M.E. ,Ciszewski,A. ,Kasai,K. ,Lasko,N .B. ,Orr,S.P. ,& Pitman,R.K.(2002).Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma.Nature Neuroscience,5,1242-1247. Persons who live through a traumatic experience may develop posttraumatic stress disorder (PTSD).PTSD is characterized by chronic physiological arousal,recurrent unwanted thoughts or images,and avoidance of things that bring the trauma to mind,with symptoms persisting for more than 1 month.Persons with PTSD also are at risk for other psychological disorders,with substance abuse disorder being a common comorbid diagnosis.In the last two decades,a number of studies have demonstrated that persons with PTSD have smaller hippocampi than controls.This may result from the neurotoxic effects of stress hormones examined the hippocampal volume of combat veterans with and without PTSD who each had an identical twin who never served in the military.Fabricated results consistent with this study are shown in Figure 15.1. Figure 15.1 -(Scenario I)The results of the study by Gilbertson and colleagues (2002)are MOST consistent with which model of mental disorders?

Use the following to answer questions Scenario II The following scenario presents fabricated data consistent with the results of the following study: Tienari,P. ,Wynne,L.C. ,Sorri,A. ,Lahti,I. ,Läksy,K. ,Moring,J. ,& ...Wahlberg,K.(2004).Genotype-environment interaction in schizophrenia-spectrum disorder: Long-term follow-up study of Finnish adoptees.The British Journal of Psychiatry,184(3),216-222.doi:10.1192/bjp.184.3.216 Schizophrenia affects approximately 1% of the general population and is characterized by the profound disruption of basic psychological processes;a distorted perception of reality;altered or blunted emotional affect;and disturbances in thought,motivation,and behavior.The symptoms of schizophrenia are varied and are typically classified as either positive or negative.Positive symptoms of schizophrenia refer to thoughts and behaviors typically not observed in those without the disease and can include things like delusions (patently false beliefs),hallucinations (false perceptual experiences),and disorganized speech.Negative symptoms of schizophrenia are deficits or disruptions in normal behaviors,such as social withdrawal.Cognitive deficits in executive functioning,attention span,and working memory may also be observed. The symptoms of schizophrenia usually begin in late adolescence and the disease has a strong genetic component.Over the years,a number of biological factors have been linked to schizophrenia,although none alone adequately accounts for the disorder.One such example is the dopamine hypothesis,which states that schizophrenia is related to an excess in dopamine activity.Another theory points to enlarged brain ventricles and progressive cortex tissue loss as predictive of schizophrenia.Although only a minority of persons with schizophrenia have enlarged ventricles,this structural anomaly can appear in those without the disease,and dopamine antagonists may also produce this effect. Although research into the environmental determinants of schizophrenia has focused largely on the prenatal environment,psychological and social factors also contribute.Tienari and colleagues (2004)compared the risk of developing schizophrenia in children adopted into healthy versus disturbed families,the latter characterized by extreme conflict,volatile relationships,and communication deficits.Some of these children under investigation were identified as at-risk genetically for schizophrenia because their biological mothers were schizophrenic.The remainder were classified at low risk.The investigators utilized a longitudinal design and obtained the diagnostic status of the children with respect to schizophrenia when they reached young adulthood.Fabricated results consistent with this study are shown in Figure 15.2 Figure 15.2 -(Scenario II)The fabricated results consistent with those obtained by Tienari and colleagues (2004)and shown in Figure 15.2 suggest that:

Use the following to answer questions Scenario I The following scenario presents fabricated data consistent with the results of the following study: Gilbertson,M.W. ,Shenton,M.E. ,Ciszewski,A. ,Kasai,K. ,Lasko,N .B. ,Orr,S.P. ,& Pitman,R.K.(2002).Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma.Nature Neuroscience,5,1242-1247. Persons who live through a traumatic experience may develop posttraumatic stress disorder (PTSD).PTSD is characterized by chronic physiological arousal,recurrent unwanted thoughts or images,and avoidance of things that bring the trauma to mind,with symptoms persisting for more than 1 month.Persons with PTSD also are at risk for other psychological disorders,with substance abuse disorder being a common comorbid diagnosis.In the last two decades,a number of studies have demonstrated that persons with PTSD have smaller hippocampi than controls.This may result from the neurotoxic effects of stress hormones examined the hippocampal volume of combat veterans with and without PTSD who each had an identical twin who never served in the military.Fabricated results consistent with this study are shown in Figure 15.1. Figure 15.1 -(Scenario I)The purpose of studying monozygotic twins of combat veterans in the Gilbertson and colleagues (2002)study was to:

Use the following to answer questions Scenario II The following scenario presents fabricated data consistent with the results of the following study: Tienari,P. ,Wynne,L.C. ,Sorri,A. ,Lahti,I. ,Läksy,K. ,Moring,J. ,& ...Wahlberg,K.(2004).Genotype-environment interaction in schizophrenia-spectrum disorder: Long-term follow-up study of Finnish adoptees.The British Journal of Psychiatry,184(3),216-222.doi:10.1192/bjp.184.3.216 Schizophrenia affects approximately 1% of the general population and is characterized by the profound disruption of basic psychological processes;a distorted perception of reality;altered or blunted emotional affect;and disturbances in thought,motivation,and behavior.The symptoms of schizophrenia are varied and are typically classified as either positive or negative.Positive symptoms of schizophrenia refer to thoughts and behaviors typically not observed in those without the disease and can include things like delusions (patently false beliefs),hallucinations (false perceptual experiences),and disorganized speech.Negative symptoms of schizophrenia are deficits or disruptions in normal behaviors,such as social withdrawal.Cognitive deficits in executive functioning,attention span,and working memory may also be observed. The symptoms of schizophrenia usually begin in late adolescence and the disease has a strong genetic component.Over the years,a number of biological factors have been linked to schizophrenia,although none alone adequately accounts for the disorder.One such example is the dopamine hypothesis,which states that schizophrenia is related to an excess in dopamine activity.Another theory points to enlarged brain ventricles and progressive cortex tissue loss as predictive of schizophrenia.Although only a minority of persons with schizophrenia have enlarged ventricles,this structural anomaly can appear in those without the disease,and dopamine antagonists may also produce this effect. Although research into the environmental determinants of schizophrenia has focused largely on the prenatal environment,psychological and social factors also contribute.Tienari and colleagues (2004)compared the risk of developing schizophrenia in children adopted into healthy versus disturbed families,the latter characterized by extreme conflict,volatile relationships,and communication deficits.Some of these children under investigation were identified as at-risk genetically for schizophrenia because their biological mothers were schizophrenic.The remainder were classified at low risk.The investigators utilized a longitudinal design and obtained the diagnostic status of the children with respect to schizophrenia when they reached young adulthood.Fabricated results consistent with this study are shown in Figure 15.2 Figure 15.2 -(Scenario II)The dopamine hypothesis of schizophrenia was developed in large part due to research on the effects of psychoactive drugs in the brain.Which statement does that research NOT support?

Use the following to answer questions Scenario I The following scenario presents fabricated data consistent with the results of the following study: Gilbertson,M.W. ,Shenton,M.E. ,Ciszewski,A. ,Kasai,K. ,Lasko,N .B. ,Orr,S.P. ,& Pitman,R.K.(2002).Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma.Nature Neuroscience,5,1242-1247. Persons who live through a traumatic experience may develop posttraumatic stress disorder (PTSD).PTSD is characterized by chronic physiological arousal,recurrent unwanted thoughts or images,and avoidance of things that bring the trauma to mind,with symptoms persisting for more than 1 month.Persons with PTSD also are at risk for other psychological disorders,with substance abuse disorder being a common comorbid diagnosis.In the last two decades,a number of studies have demonstrated that persons with PTSD have smaller hippocampi than controls.This may result from the neurotoxic effects of stress hormones examined the hippocampal volume of combat veterans with and without PTSD who each had an identical twin who never served in the military.Fabricated results consistent with this study are shown in Figure 15.1. Figure 15.1 -(Scenario I)The results of the study by Gilbertson and colleagues (2002)suggest that:

Use the following to answer questions Scenario II The following scenario presents fabricated data consistent with the results of the following study: Tienari,P. ,Wynne,L.C. ,Sorri,A. ,Lahti,I. ,Läksy,K. ,Moring,J. ,& ...Wahlberg,K.(2004).Genotype-environment interaction in schizophrenia-spectrum disorder: Long-term follow-up study of Finnish adoptees.The British Journal of Psychiatry,184(3),216-222.doi:10.1192/bjp.184.3.216 Schizophrenia affects approximately 1% of the general population and is characterized by the profound disruption of basic psychological processes;a distorted perception of reality;altered or blunted emotional affect;and disturbances in thought,motivation,and behavior.The symptoms of schizophrenia are varied and are typically classified as either positive or negative.Positive symptoms of schizophrenia refer to thoughts and behaviors typically not observed in those without the disease and can include things like delusions (patently false beliefs),hallucinations (false perceptual experiences),and disorganized speech.Negative symptoms of schizophrenia are deficits or disruptions in normal behaviors,such as social withdrawal.Cognitive deficits in executive functioning,attention span,and working memory may also be observed. The symptoms of schizophrenia usually begin in late adolescence and the disease has a strong genetic component.Over the years,a number of biological factors have been linked to schizophrenia,although none alone adequately accounts for the disorder.One such example is the dopamine hypothesis,which states that schizophrenia is related to an excess in dopamine activity.Another theory points to enlarged brain ventricles and progressive cortex tissue loss as predictive of schizophrenia.Although only a minority of persons with schizophrenia have enlarged ventricles,this structural anomaly can appear in those without the disease,and dopamine antagonists may also produce this effect. Although research into the environmental determinants of schizophrenia has focused largely on the prenatal environment,psychological and social factors also contribute.Tienari and colleagues (2004)compared the risk of developing schizophrenia in children adopted into healthy versus disturbed families,the latter characterized by extreme conflict,volatile relationships,and communication deficits.Some of these children under investigation were identified as at-risk genetically for schizophrenia because their biological mothers were schizophrenic.The remainder were classified at low risk.The investigators utilized a longitudinal design and obtained the diagnostic status of the children with respect to schizophrenia when they reached young adulthood.Fabricated results consistent with this study are shown in Figure 15.2 Figure 15.2 -(Scenario II)Which prediction is CONSISTENT with the dopamine hypothesis of schizophrenia?

Use the following to answer questions Scenario II The following scenario presents fabricated data consistent with the results of the following study: Tienari,P. ,Wynne,L.C. ,Sorri,A. ,Lahti,I. ,Läksy,K. ,Moring,J. ,& ...Wahlberg,K.(2004).Genotype-environment interaction in schizophrenia-spectrum disorder: Long-term follow-up study of Finnish adoptees.The British Journal of Psychiatry,184(3),216-222.doi:10.1192/bjp.184.3.216 Schizophrenia affects approximately 1% of the general population and is characterized by the profound disruption of basic psychological processes;a distorted perception of reality;altered or blunted emotional affect;and disturbances in thought,motivation,and behavior.The symptoms of schizophrenia are varied and are typically classified as either positive or negative.Positive symptoms of schizophrenia refer to thoughts and behaviors typically not observed in those without the disease and can include things like delusions (patently false beliefs),hallucinations (false perceptual experiences),and disorganized speech.Negative symptoms of schizophrenia are deficits or disruptions in normal behaviors,such as social withdrawal.Cognitive deficits in executive functioning,attention span,and working memory may also be observed. The symptoms of schizophrenia usually begin in late adolescence and the disease has a strong genetic component.Over the years,a number of biological factors have been linked to schizophrenia,although none alone adequately accounts for the disorder.One such example is the dopamine hypothesis,which states that schizophrenia is related to an excess in dopamine activity.Another theory points to enlarged brain ventricles and progressive cortex tissue loss as predictive of schizophrenia.Although only a minority of persons with schizophrenia have enlarged ventricles,this structural anomaly can appear in those without the disease,and dopamine antagonists may also produce this effect. Although research into the environmental determinants of schizophrenia has focused largely on the prenatal environment,psychological and social factors also contribute.Tienari and colleagues (2004)compared the risk of developing schizophrenia in children adopted into healthy versus disturbed families,the latter characterized by extreme conflict,volatile relationships,and communication deficits.Some of these children under investigation were identified as at-risk genetically for schizophrenia because their biological mothers were schizophrenic.The remainder were classified at low risk.The investigators utilized a longitudinal design and obtained the diagnostic status of the children with respect to schizophrenia when they reached young adulthood.Fabricated results consistent with this study are shown in Figure 15.2 Figure 15.2 -(Scenario II)Which symptom is positive of schizophrenia?

Use the following to answer questions Scenario I The following scenario presents fabricated data consistent with the results of the following study: Gilbertson,M.W. ,Shenton,M.E. ,Ciszewski,A. ,Kasai,K. ,Lasko,N .B. ,Orr,S.P. ,& Pitman,R.K.(2002).Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma.Nature Neuroscience,5,1242-1247. Persons who live through a traumatic experience may develop posttraumatic stress disorder (PTSD).PTSD is characterized by chronic physiological arousal,recurrent unwanted thoughts or images,and avoidance of things that bring the trauma to mind,with symptoms persisting for more than 1 month.Persons with PTSD also are at risk for other psychological disorders,with substance abuse disorder being a common comorbid diagnosis.In the last two decades,a number of studies have demonstrated that persons with PTSD have smaller hippocampi than controls.This may result from the neurotoxic effects of stress hormones examined the hippocampal volume of combat veterans with and without PTSD who each had an identical twin who never served in the military.Fabricated results consistent with this study are shown in Figure 15.1. Figure 15.1 -(Scenario I)Which factor BEST distinguishes PTSD from a normal reaction to a traumatic event?

Use the following to answer questions Scenario I The following scenario presents fabricated data consistent with the results of the following study: Gilbertson,M.W. ,Shenton,M.E. ,Ciszewski,A. ,Kasai,K. ,Lasko,N .B. ,Orr,S.P. ,& Pitman,R.K.(2002).Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma.Nature Neuroscience,5,1242-1247. Persons who live through a traumatic experience may develop posttraumatic stress disorder (PTSD).PTSD is characterized by chronic physiological arousal,recurrent unwanted thoughts or images,and avoidance of things that bring the trauma to mind,with symptoms persisting for more than 1 month.Persons with PTSD also are at risk for other psychological disorders,with substance abuse disorder being a common comorbid diagnosis.In the last two decades,a number of studies have demonstrated that persons with PTSD have smaller hippocampi than controls.This may result from the neurotoxic effects of stress hormones examined the hippocampal volume of combat veterans with and without PTSD who each had an identical twin who never served in the military.Fabricated results consistent with this study are shown in Figure 15.1. Figure 15.1 -(Scenario I)Which conclusion is STRONGEST,justified solely on the basis that comorbidity exists between PTSD and alcoholism?