Question 1

Compare bacteriophage lytic and lysogenic cycles.

Accepted Answer

After bacteriophage infections,the viral

Question 2

If a strand of DNA has a large lesion that distorts the helical nature of the DNA,what would be the mechanism of repair?

Accepted Answer

A)  mismatch repair 
B)  abasic repair 
C)  base excision 
D)  nucleotide excision 
A)  mismatch repair 
B)  abasic repair 
C)  base excision 
D)  nucleotide excision

Question 3

Individuals with mutations of BRCA have increased incidence of cancer because of their

Accepted Answer

A)  increased ability to form pyrimidine dimers. 
B)  decreased ability to repair single-strand DNA breaks. 
C)  decreased ability to repair double-strand DNA breaks. 
D)  increased ability to form methylated guanine. 
A)  increased ability to form pyrimidine dimers. 
B)  decreased ability to repair single-strand DNA breaks. 
C)  decreased ability to repair double-strand DNA breaks. 
D)  increased ability to form methylated guanine.

Question 4

Describe the HIV infection cycle.

Accepted Answer

The HIV infection (as shown in Figure 20

Question 5

Use the following figure to distinguish between the two possible outcomes from Holliday junctions.

Accepted Answer

A resolvase can bind at either sites 1 o

Question 6

Homologous recombination repairs what kind of DNA damage?

Accepted Answer

A)  single-strand break 
B)  double-strand break 
C)  mismatched pairs 
D)  pyrimidine dimers 
A)  single-strand break 
B)  double-strand break 
C)  mismatched pairs 
D)  pyrimidine dimers

Question 7

Distinguish between base excision and nucleotide excision repair.

Accepted Answer

Base excision repair is responsible for

Question 8

If a cell has many ROS species,what is the most likely reaction with DNA?

Accepted Answer

A)  Nothing, because ROS do not react with DNA. 
B)  G-C to T-A replacement 
C)  O-alkylation of thymine 
D)  single point excision 
A)  Nothing, because ROS do not react with DNA. 
B)  G-C to T-A replacement 
C)  O-alkylation of thymine 
D)  single point excision

Question 9

The most common DNA mutation is the substitution of one base for another.What is the likely outcome from that mutation?

Accepted Answer

A)  increased DNA replication 
B)  an alteration of the protein's coding sequence 
C)  prevention of further synthesis 
D)  cell death 
A)  increased DNA replication 
B)  an alteration of the protein's coding sequence 
C)  prevention of further synthesis 
D)  cell death

Question 10

The complete complex that contains the enzymes and proteins required to replicate DNA is called the

Accepted Answer

A)  primase. 
B)  polymerase. 
C)  replisome. 
D)  DNA gyrase. 
A)  primase. 
B)  polymerase. 
C)  replisome. 
D)  DNA gyrase.

Question 11

DNA crossover is important during meiosis because it allows

Accepted Answer

A)  the organization of genes on the chromosome to change. 
B)  DNA repair to occur. 
C)  exchange of genetic information. 
D)  base excision to occur. 
A)  the organization of genes on the chromosome to change. 
B)  DNA repair to occur. 
C)  exchange of genetic information. 
D)  base excision to occur.

Question 12

The two key elements of the oriC include

Accepted Answer

A)  three 13-bp repeats and four 9-bp repeats with enriched G-C base pairs. 
B)  three 13-bp repeats and four 9-bp repeats with enriched A-T pairs. 
C)  20 subunits of A-T pairs. 
D)  the RNA primer. 
A)  three 13-bp repeats and four 9-bp repeats with enriched G-C base pairs. 
B)  three 13-bp repeats and four 9-bp repeats with enriched A-T pairs. 
C)  20 subunits of A-T pairs. 
D)  the RNA primer.

Question 13

An HIV infection begins with what first step?

Accepted Answer

A)  fusion of the cell membrane and viral envelope 
B)  release of viral DNA and synthesis of cDNA 
C)  protein synthesis and processing 
D)  budding of infectious virus 
A)  fusion of the cell membrane and viral envelope 
B)  release of viral DNA and synthesis of cDNA 
C)  protein synthesis and processing 
D)  budding of infectious virus

Question 14

Explain the mechanism of base excision repair.

Accepted Answer

Base excision repair is mediated by shor

Question 15

Which of the following functions does a reverse transcriptase perform?

Accepted Answer

A)  proofreading 
B)  exonuclease activity 
C)  convert RNA to DNA 
D)  convert DNA to RNA 
A)  proofreading 
B)  exonuclease activity 
C)  convert RNA to DNA 
D)  convert DNA to RNA

Question 16

Lynch syndrome is a genetic deficiency in __________ repairs.

Accepted Answer

A)  DNA excision 
B)  single-strand 
C)  double-strand 
D)  mismatch 
A)  DNA excision 
B)  single-strand 
C)  double-strand 
D)  mismatch

Question 17

Which are the major prokaryotic DNA polymerases?

Accepted Answer

A)  Pol I, Pol III, and Pol $\delta$ 
B)  Pol I, Pol II, and Pol III 
C)  Pol I, Pol II, and Pol $\delta$ 
D)  Pol I, Pol III, and Pol $\varepsilon$ 
A)  Pol I, Pol III, and Pol $\delta$ 
B)  Pol I, Pol II, and Pol III 
C)  Pol I, Pol II, and Pol $\delta$ 
D)  Pol I, Pol III, and Pol $\varepsilon$

Question 18

How does reverse transcriptase convert RNA to DNA?

Accepted Answer

Reverse transcriptase first uses the sin

Question 19

The importance of V(D)J recombination is that it gives rise to new

Accepted Answer

A)  viruses being formed. 
B)  DNA combinations. 
C)  antibodies. 
D)  RNA combinations. 
A)  viruses being formed. 
B)  DNA combinations. 
C)  antibodies. 
D)  RNA combinations.

Exam 20: Dna Replication, repair, and Recombination

Compare bacteriophage lytic and lysogenic cycles.

If a strand of DNA has a large lesion that distorts the helical nature of the DNA,what would be the mechanism of repair?

Individuals with mutations of BRCA have increased incidence of cancer because of their

Describe the HIV infection cycle.

Use the following figure to distinguish between the two possible outcomes from Holliday junctions.

Homologous recombination repairs what kind of DNA damage?

Distinguish between base excision and nucleotide excision repair.

If a cell has many ROS species,what is the most likely reaction with DNA?

The most common DNA mutation is the substitution of one base for another.What is the likely outcome from that mutation?

The complete complex that contains the enzymes and proteins required to replicate DNA is called the

DNA crossover is important during meiosis because it allows

The two key elements of the oriC include

An HIV infection begins with what first step?

Explain the mechanism of base excision repair.

Which of the following functions does a reverse transcriptase perform?

Lynch syndrome is a genetic deficiency in __________ repairs.

Which are the major prokaryotic DNA polymerases?

How does reverse transcriptase convert RNA to DNA?

The importance of V(D)J recombination is that it gives rise to new

Principles of Biochemistry

Physical Biochemistry: Energy Conversion,water,and Membranes

Nucleic Acid Structure and Function

Protein Structure

Methods in Protein Biochemistry

Protein Function

Enzyme Mechanisms

Cell Signaling Systems

Glycolysis: a Paradigm of Metabolic Regulation

The Citrate Cycle

Oxidative Phosphorylation

Photosynthesis

Carbohydrate Structure and Function

Carbohydrate Metabolism

Lipid Structure and Function

Lipid Metabolism

Amino Acid Metabolism

Nucleotide Metabolism

Metabolic Integration

Rna Synthesis, processing, and Gene Silencing

Protein Synthesis, posttranslational Modification, and Transport

Gene Regulation

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