Question 1

Which enzyme catalyses the key regulatory step of cholesterol synthesis?

Accepted Answer

A) "$\beta$-ketothiolase" 
B) "HMG-CoA synthase" 
C) "HMG-CoA reductase" 
D) "mevalonate-5-phosphotransferase" 
E) "phenyltransferase" 
A) "$\beta$-ketothiolase" 
B) "HMG-CoA synthase" 
C) "HMG-CoA reductase" 
D) "mevalonate-5-phosphotransferase" 
E) "phenyltransferase"

Question 2

Which of the following diets would most likely promote the formation of ketone bodies?

Accepted Answer

A) high simple carbohydrates,low fat 
B) high complex carbohydrates,high fructose 
C) high fat,high protein,low carbohydrate 
D) low fat,high protein,high complex carbohydrates 
E) high fructose;high whole grain carbohydrates 
A) high simple carbohydrates,low fat 
B) high complex carbohydrates,high fructose 
C) high fat,high protein,low carbohydrate 
D) low fat,high protein,high complex carbohydrates 
E) high fructose;high whole grain carbohydrates

Question 3

Which of the following statements about apolipoproteins (with the possible exception of apoB-100)is TRUE?
(I)The apolipoproteins are water-soluble and loosely associate with the lipoproteins.
(II)The apolipoproteins contain helices with hydrophobic and hydrophilic groups on opposite sides of the helical cylinder.
(III)The apolipoproteins are synthesized in the intestinal tissues.
(IV)The apolipoproteins appear to float on the surface of phospholipids.

Accepted Answer

A) I only 
B) I and II 
C) III,IV 
D) I,II,III 
E) I,II,IV 
A) I only 
B) I and II 
C) III,IV 
D) I,II,III 
E) I,II,IV

Question 4

Which of the following would result in a net increase in uptake of LDL by the liver?

Accepted Answer

A) increased availability of LDL receptors 
B) high levels of cholesterol synthesis 
C) increased availability of clathrin triskelions 
D) all of the above 
E) none of the above 
A) increased availability of LDL receptors 
B) high levels of cholesterol synthesis 
C) increased availability of clathrin triskelions 
D) all of the above 
E) none of the above

Question 5

LDL taken up by the liver is

Accepted Answer

A) broken down into fatty acids and amino acids. 
B) taken up by the ER and used to control synthesis of HMG CoA reductase and LDL receptor synthesis. 
C) converted into clathrin and recycled. 
D) irreversibly bound to LDL receptors. 
E) excreted in a clathrin coated vesicle. 
A) broken down into fatty acids and amino acids. 
B) taken up by the ER and used to control synthesis of HMG CoA reductase and LDL receptor synthesis. 
C) converted into clathrin and recycled. 
D) irreversibly bound to LDL receptors. 
E) excreted in a clathrin coated vesicle.

Question 6

Matching
Choose the correct answer from the list.Not all the answers will be used.

-________ is formed from ordered sequence of condensation of isoprene units.

Accepted Answer

A)  HDL 
B)  propionyl-CoA 
C)  LDL 
D)  Dihydroxyacetone phosphate 
E)  malonyl-CoA
F) ACP
G) chylomicrons
H) phosphopantetheine
I) flavin
J) albumin
K) ketone bodies
L) cholesterol 
A)  HDL 
B)  propionyl-CoA 
C)  LDL 
D)  Dihydroxyacetone phosphate 
E)  malonyl-CoA
F) ACP
G) chylomicrons
H) phosphopantetheine
I) flavin
J) albumin
K) ketone bodies
L) cholesterol

Question 7

Cholesterol is a precursor to
(I)prostaglandins
(II)vitamin K
(III)steroid hormones such as androgens
(IV)bile acids

Accepted Answer

A) I,III,IV 
B) I,II,III,IV 
C) III only 
D) IV only 
E) III,IV 
A) I,III,IV 
B) I,II,III,IV 
C) III only 
D) IV only 
E) III,IV

Question 8

Which of the following is FALSE regarding HMG-CoA reductase?

Accepted Answer

A) HMG-CoA reductase is highly regulated. 
B) The active site is tightly bound by statins. 
C) HMG-CoA reductase levels are increased as a result of high cholesterol concentrations in the ER 
D) HMG-CoA reductase levels are decreased as a result of high cholesterol concentrations in the ER. 
E) HMG-CoA reductase is levels are decreased by the same factor that down regulated production of the LDL receptors 
A) HMG-CoA reductase is highly regulated. 
B) The active site is tightly bound by statins. 
C) HMG-CoA reductase levels are increased as a result of high cholesterol concentrations in the ER 
D) HMG-CoA reductase levels are decreased as a result of high cholesterol concentrations in the ER. 
E) HMG-CoA reductase is levels are decreased by the same factor that down regulated production of the LDL receptors

Question 9

Which of the following components would be condensed to form acetoacetate?

Accepted Answer

A) acetyl CoA and acetyl-CoA 
B) HMG-CoA and acyl-CoA 
C) acetone and betahydroxybutyrate 
D) malonyl-CoA and acyl-CoA 
E) DHAP and glycerol-3-phosphate 
A) acetyl CoA and acetyl-CoA 
B) HMG-CoA and acyl-CoA 
C) acetone and betahydroxybutyrate 
D) malonyl-CoA and acyl-CoA 
E) DHAP and glycerol-3-phosphate

Question 10

Which of the following statements about peroxisomes is FALSE?

Accepted Answer

A) "$\beta$ oxidation in peroxisomes can shorten very long fatty acids." 
B) "Mammalian peroxisomes can synthesize some lipids,including bile salts." 
C) "In plants,peroxisomes and glyoxysomes serve as the site of $\beta$ oxidation." 
D) "Long chain fatty acids are transported into the peroxisome via a carnitine carrier protein where they are activated for oxidation." 
E) "$\beta$ oxidation in peroxisomes varies slightly from the mitochondrial process." 
A) "$\beta$ oxidation in peroxisomes can shorten very long fatty acids." 
B) "Mammalian peroxisomes can synthesize some lipids,including bile salts." 
C) "In plants,peroxisomes and glyoxysomes serve as the site of $\beta$ oxidation." 
D) "Long chain fatty acids are transported into the peroxisome via a carnitine carrier protein where they are activated for oxidation." 
E) "$\beta$ oxidation in peroxisomes varies slightly from the mitochondrial process."

Question 11

Which statement concerning phospholipid synthesis is true?

Accepted Answer

A) Addition of polar "head groups" to diacylglycerol usually involves CDP derivatives. 
B) Addition of polar "head groups" to diacylglycerol usually involves UDP adducts. 
C) Addition of fatty acyl "tails" to glycerol usually involves CDP adducts. 
D) Addition of fatty acyl "tails" to glycerol usually involves UDP adducts. 
E) None of the above is true. 
A) Addition of polar "head groups" to diacylglycerol usually involves CDP derivatives. 
B) Addition of polar "head groups" to diacylglycerol usually involves UDP adducts. 
C) Addition of fatty acyl "tails" to glycerol usually involves CDP adducts. 
D) Addition of fatty acyl "tails" to glycerol usually involves UDP adducts. 
E) None of the above is true.

Which enzyme catalyses the key regulatory step of cholesterol synthesis?

Which of the following diets would most likely promote the formation of ketone bodies?

Which of the following would result in a net increase in uptake of LDL by the liver?

LDL taken up by the liver is

Matching Choose the correct answer from the list.Not all the answers will be used. -________ is formed from ordered sequence of condensation of isoprene units.

Cholesterol is a precursor to (I)prostaglandins (II)vitamin K (III)steroid hormones such as androgens (IV)bile acids

Which of the following is FALSE regarding HMG-CoA reductase?

Which of the following components would be condensed to form acetoacetate?

Which of the following statements about peroxisomes is FALSE?

Which statement concerning phospholipid synthesis is true?

Introduction to the Chemistry of Life

Water

Nucleotides, nucleic Acids, and Genetic Information

Amino Acids

Proteins: Primary Structure

Proteins: Three-Dimensional Structure

Protein Function Part I: Myoglobin and Hemoglobin

Carbohydrates

Lipids and Biological Membranes

Membrane Transport

Enzyme Catalysis

Enzyme Kinetics, inhibition and Control

Biochemical Signaling

Introduction to Metabolism

Glucose Catabolism

Glycogen Metabolism and Gluconeogenesis

Citric Acid Cycle

Electron Transport and Oxidative Phosphorylation

Photosynthesis

Amino Acid Metabolism

Mammalian Fuel Metabolism: Integration and Regulation

Nucleotide Metabolism

Nucleic Acid Structure

DNA Replication, repair and Recombination

Transcription and Rna Processing

Protein Synthesis

Regulation of Gene Expression

Filters

Exam 20: Lipid Metabolism

Which enzyme catalyses the key regulatory step of cholesterol synthesis?

Which of the following diets would most likely promote the formation of ketone bodies?

Which of the following would result in a net increase in uptake of LDL by the liver?

LDL taken up by the liver is

Matching Choose the correct answer from the list.Not all the answers will be used. -________ is formed from ordered sequence of condensation of isoprene units.

Cholesterol is a precursor to (I)prostaglandins (II)vitamin K (III)steroid hormones such as androgens (IV)bile acids

Which of the following is FALSE regarding HMG-CoA reductase?

Which of the following components would be condensed to form acetoacetate?

Which of the following statements about peroxisomes is FALSE?

Which statement concerning phospholipid synthesis is true?

Introduction to the Chemistry of Life

Water

Nucleotides, nucleic Acids, and Genetic Information

Amino Acids

Proteins: Primary Structure

Proteins: Three-Dimensional Structure

Protein Function Part I: Myoglobin and Hemoglobin

Carbohydrates

Lipids and Biological Membranes

Membrane Transport

Enzyme Catalysis

Enzyme Kinetics, inhibition and Control

Biochemical Signaling

Introduction to Metabolism

Glucose Catabolism

Glycogen Metabolism and Gluconeogenesis

Citric Acid Cycle

Electron Transport and Oxidative Phosphorylation

Photosynthesis

Amino Acid Metabolism

Mammalian Fuel Metabolism: Integration and Regulation

Nucleotide Metabolism

Nucleic Acid Structure

DNA Replication, repair and Recombination

Transcription and Rna Processing

Protein Synthesis

Regulation of Gene Expression

Filters