Question 1

What determines the location of the contractile ring of filaments that mediate cytokinesis in an animal cell?

Accepted Answer

The answer of What determines the location of the contractile...

Question 2

The metaphase-to-anaphase transition in animal cells is triggered by the breakdown of cyclin B.

Accepted Answer

A) True 
 B)False

Question 3

Single-stranded DNA and unreplicated DNA are recognized by ATR, which leads to G2 arrest. What would likely occur with a single-stranded DNA break in a cell with a mutation that prevented phosphorylation of Chk1? What if the mutation prevented phosphorylation of Chk2?

Accepted Answer

Cells with a Chk1 mutation would not arr

Question 4

How is DNA replication prevented from recurring in a single cell cycle?

Accepted Answer

Preceding the first DNA synthe

Question 5

In the absence of growth factor, most animal cells will stop the cell cycle at a restriction point in what stage?

Accepted Answer

A)  S phase 
B)  M phase 
C)  G2 phase 
D)  G1 phase 
A)  S phase 
B)  M phase 
C)  G2 phase 
D)  G1 phase

Question 6

The oocytes in a normal 7-year-old female (prepubertal) would be expected to be arrested in which stage of the cell cycle, until they are hormonally stimulated?

Accepted Answer

A)  G1 
B)  G2 
C)  Interphase 
D)  G0 
A)  G1 
B)  G2 
C)  Interphase 
D)  G0

Question 7

The phase of the cell cycle that corresponds to the interval between mitosis and initiation of DNA replication is referred to as the

Accepted Answer

A)  M phase. 
B)  S phase. 
C)  G1 phase. 
D)  G2 phase. 
A)  M phase. 
B)  S phase. 
C)  G1 phase. 
D)  G2 phase.

Question 8

Cell cycle checkpoints ensure that complete genomes are transmitted to daughter cells. DNA damage checkpoints are found in all of the following phases except

Accepted Answer

A)  M phase. 
B)  G1 phase. 
C)  G2 phase. 
D)  S phase. 
A)  M phase. 
B)  G1 phase. 
C)  G2 phase. 
D)  S phase.

Question 9

The progression from metaphase to anaphase is triggered by

Accepted Answer

A)  activation of protein kinases by MPF. 
B)  ubiquitin-mediated proteolysis of key proteins. 
C)  binding of an inhibitory protein to MPF. 
D)  depolymerization of the mitotic spindle. 
A)  activation of protein kinases by MPF. 
B)  ubiquitin-mediated proteolysis of key proteins. 
C)  binding of an inhibitory protein to MPF. 
D)  depolymerization of the mitotic spindle.

Question 10

The G2 cell cycle checkpoint detects

Accepted Answer

A)  the binding of the MCM proteins to origins of replication. 
B)  chromosome misalignment. 
C)  unreplicated or damaged DNA. 
D)  levels of p53. 
A)  the binding of the MCM proteins to origins of replication. 
B)  chromosome misalignment. 
C)  unreplicated or damaged DNA. 
D)  levels of p53.

Question 11

Studies on cell cycle mutants in budding and fission yeasts demonstrated that cdc2 and cdc28 both encode a

Accepted Answer

A)  protein kinase. 
B)  protein phosphatase. 
C)  ubiquitin ligase. 
D)  growth factor. 
A)  protein kinase. 
B)  protein phosphatase. 
C)  ubiquitin ligase. 
D)  growth factor.

Question 12

Skin fibroblasts near a wound, arrested in G0, are stimulated to enter G1 by _______ growth factor.

Accepted Answer

A)  epidermal 
B)  fibroblast 
C)  platelet-derived 
D)  keratinocyte 
A)  epidermal 
B)  fibroblast 
C)  platelet-derived 
D)  keratinocyte

Question 13

The retinoblastoma protein (Rb) binds to and inhibits

Accepted Answer

A)  transcription factor E2F. 
B)  oncogenes. 
C)  cyclin-dependent kinase. 
D)  p53. 
A)  transcription factor E2F. 
B)  oncogenes. 
C)  cyclin-dependent kinase. 
D)  p53.

Question 14

Rb is a member of the family of tumor suppressor genes.

Accepted Answer

A) True 
 B)False

Question 15

Cells in the quiescent phase of the cell cycle are said to be in the _______ phase.

Accepted Answer

A)  G0 
B)  G1 
C)  G2 
D)  M 
A)  G0 
B)  G1 
C)  G2 
D)  M

Question 16

Cyclin B and _______ are ubiquitylated and degraded by active APC/C.

Accepted Answer

The answer of Cyclin B and _______ are ubiquitylated and...

Question 17

The beginning of anaphase occurs when cohesins, holding the sister chromatids together, are degraded by

Accepted Answer

A)  anaphase-promoting complex. 
B)  ATM. 
C)  proteasome. 
D)  separase. 
A)  anaphase-promoting complex. 
B)  ATM. 
C)  proteasome. 
D)  separase.

Question 18

The G1 checkpoint in animal cells is called

Accepted Answer

A)  START. 
B)  the restriction point. 
C)  the decision point. 
D)  the G1/S boundary. 
A)  START. 
B)  the restriction point. 
C)  the decision point. 
D)  the G1/S boundary.

Question 19

Growth-factor stimulation of the Ras/Raf/MEK/ERK pathway initially stimulates the synthesis of cyclin

Accepted Answer

A)  A. 
B)  B. 
C)  E. 
D)  D. 
A)  A. 
B)  B. 
C)  E. 
D)  D.

Question 20

Which cyclin(s) is(are) required to pass the G1 restriction point in animal cells?

Accepted Answer

A)  Cyclin A 
B)  Cyclin A and Cyclin B 
C)  Cyclin D 
D)  Cyclin D and Cyclin E 
A)  Cyclin A 
B)  Cyclin A and Cyclin B 
C)  Cyclin D 
D)  Cyclin D and Cyclin E

What determines the location of the contractile ring of filaments that mediate cytokinesis in an animal cell?

The metaphase-to-anaphase transition in animal cells is triggered by the breakdown of cyclin B.

Single-stranded DNA and unreplicated DNA are recognized by ATR, which leads to G₂ arrest. What would likely occur with a single-stranded DNA break in a cell with a mutation that prevented phosphorylation of Chk1? What if the mutation prevented phosphorylation of Chk2?

How is DNA replication prevented from recurring in a single cell cycle?

In the absence of growth factor, most animal cells will stop the cell cycle at a restriction point in what stage?

The oocytes in a normal 7-year-old female (prepubertal) would be expected to be arrested in which stage of the cell cycle, until they are hormonally stimulated?

The phase of the cell cycle that corresponds to the interval between mitosis and initiation of DNA replication is referred to as the

Cell cycle checkpoints ensure that complete genomes are transmitted to daughter cells. DNA damage checkpoints are found in all of the following phases except

The progression from metaphase to anaphase is triggered by

The G₂ cell cycle checkpoint detects

Studies on cell cycle mutants in budding and fission yeasts demonstrated that cdc2 and cdc28 both encode a

Skin fibroblasts near a wound, arrested in G₀,are stimulated to enter G₁ by _______ growth factor.

The retinoblastoma protein (Rb) binds to and inhibits

Rb is a member of the family of tumor suppressor genes.

Cells in the quiescent phase of the cell cycle are said to be in the _______ phase.

Cyclin B and _______ are ubiquitylated and degraded by active APC/C.

The beginning of anaphase occurs when cohesins, holding the sister chromatids together, are degraded by

The G₁ checkpoint in animal cells is called

Growth-factor stimulation of the Ras/Raf/MEK/ERK pathway initially stimulates the synthesis of cyclin

Which cyclin(s) is(are) required to pass the G₁ restriction point in animal cells?

An Overview of Cells and Cell Research

Molecules and Membranes

Bioenergetics and Metabolism

Fundamentals of Molecular Biology

Genomics, Proteomics, and Systems Biology

Genes and Genomes

Replication, Maintenance, and Rearrangements of Genomic Dna

RNA Synthesis and Processing

Transcriptional Regulation and Epigenetics

Protein Synthesis, Processing, and Regulation

The Nucleus

Protein Sorting and Transport

Mitochondria, Chloroplasts, and Peroxisomes

The Cytoskeleton and Cell Movement

The Plasma Membrane

Cell Walls, the Extracellular Matrix, and Cell Interactions

Cell Signaling

Cell Death and Cell Renewal

Cancer

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Exam 18: The Cell Cycle

What determines the location of the contractile ring of filaments that mediate cytokinesis in an animal cell?

The metaphase-to-anaphase transition in animal cells is triggered by the breakdown of cyclin B.

Single-stranded DNA and unreplicated DNA are recognized by ATR, which leads to G2 arrest. What would likely occur with a single-stranded DNA break in a cell with a mutation that prevented phosphorylation of Chk1? What if the mutation prevented phosphorylation of Chk2?

How is DNA replication prevented from recurring in a single cell cycle?

In the absence of growth factor, most animal cells will stop the cell cycle at a restriction point in what stage?

The oocytes in a normal 7-year-old female (prepubertal) would be expected to be arrested in which stage of the cell cycle, until they are hormonally stimulated?

The phase of the cell cycle that corresponds to the interval between mitosis and initiation of DNA replication is referred to as the

Cell cycle checkpoints ensure that complete genomes are transmitted to daughter cells. DNA damage checkpoints are found in all of the following phases except

The progression from metaphase to anaphase is triggered by

The G2 cell cycle checkpoint detects

Studies on cell cycle mutants in budding and fission yeasts demonstrated that cdc2 and cdc28 both encode a

Skin fibroblasts near a wound, arrested in G0, are stimulated to enter G1 by _______ growth factor.

The retinoblastoma protein (Rb) binds to and inhibits

Rb is a member of the family of tumor suppressor genes.

Cells in the quiescent phase of the cell cycle are said to be in the _______ phase.

Cyclin B and _______ are ubiquitylated and degraded by active APC/C.

The beginning of anaphase occurs when cohesins, holding the sister chromatids together, are degraded by

The G1 checkpoint in animal cells is called

Growth-factor stimulation of the Ras/Raf/MEK/ERK pathway initially stimulates the synthesis of cyclin

Which cyclin(s) is(are) required to pass the G1 restriction point in animal cells?

An Overview of Cells and Cell Research

Molecules and Membranes

Bioenergetics and Metabolism

Fundamentals of Molecular Biology

Genomics, Proteomics, and Systems Biology

Genes and Genomes

Replication, Maintenance, and Rearrangements of Genomic Dna

RNA Synthesis and Processing

Transcriptional Regulation and Epigenetics

Protein Synthesis, Processing, and Regulation

The Nucleus

Protein Sorting and Transport

Mitochondria, Chloroplasts, and Peroxisomes

The Cytoskeleton and Cell Movement

The Plasma Membrane

Cell Walls, the Extracellular Matrix, and Cell Interactions

Cell Signaling

Cell Death and Cell Renewal

Cancer

Filters

Single-stranded DNA and unreplicated DNA are recognized by ATR, which leads to G₂ arrest. What would likely occur with a single-stranded DNA break in a cell with a mutation that prevented phosphorylation of Chk1? What if the mutation prevented phosphorylation of Chk2?

The G₂ cell cycle checkpoint detects

Skin fibroblasts near a wound, arrested in G₀,are stimulated to enter G₁ by _______ growth factor.

The G₁ checkpoint in animal cells is called

Which cyclin(s) is(are) required to pass the G₁ restriction point in animal cells?