Question 1

Several oncogenes encode antiapoptotic proteins that promote cell survival.

Accepted Answer

A) True 
 B)False

Question 2

Which of the following genes has been associated with colon cancer?

Accepted Answer

A)  APC 
B)  bcl-2 
C)  Rb 
D)  erbB-2 
A)  APC 
B)  bcl-2 
C)  Rb 
D)  erbB-2

Question 3

Acute promyelocytic leukemia results from a mutated retinoic acid receptor, effectively blocking cell differentiation and allowing leukemic cells to continue proliferation.

Accepted Answer

A) True 
 B)False

Question 4

Common human cancers caused by viruses include cervical carcinoma and _______ cancer.

Accepted Answer

The answer of Common human cancers caused by viruses include...

Question 5

One function of the tumor suppressor protein p53 is to

Accepted Answer

A)  activate synthesis of p21, a Cdk inhibitor. 
B)  inhibit phosphodiesterase. 
C)  stimulate cell cycle progression. 
D)  phosphorylate cyclin-dependent kinases on an inhibitory site. 
A)  activate synthesis of p21, a Cdk inhibitor. 
B)  inhibit phosphodiesterase. 
C)  stimulate cell cycle progression. 
D)  phosphorylate cyclin-dependent kinases on an inhibitory site.

Question 6

Traditional drugs used to treat cancer patients

Accepted Answer

A)  target oncogene function. 
B)  kill cancer cells specifically. 
C)  damage DNA or inhibit DNA replication. 
D)  target tumor suppressor protein function. 
A)  target oncogene function. 
B)  kill cancer cells specifically. 
C)  damage DNA or inhibit DNA replication. 
D)  target tumor suppressor protein function.

Question 7

How do cancer cells become able to proliferate indefinitely, while normal cells become senescent after a limited number of cell divisions?

Accepted Answer

With each cell division, the chromosomes

Question 8

Oncogenic mutations in ras promote accumulation of the GDP bound form of the protein.

Accepted Answer

A) True 
 B)False

Question 9

The therapeutic use of monoclonal antibodies against oncogene proteins is limited to

Accepted Answer

A)  secreted targets, such as growth factors. 
B)  extracellular targets, such as cell surface receptors. 
C)  extracellular and cytosolic targets. 
D)  protein targets. 
A)  secreted targets, such as growth factors. 
B)  extracellular targets, such as cell surface receptors. 
C)  extracellular and cytosolic targets. 
D)  protein targets.

Question 10

Herpes viruses (HSV) can induce _______ sarcoma.

Accepted Answer

The answer of Herpes viruses (HSV) can induce _______ sarcoma....

Question 11

Nonhereditary retinoblastoma develops only when

Accepted Answer

A)  a somatic mutation inactivates the Rb gene. 
B)  a somatic mutation activates the Rb gene. 
C)  two somatic mutations inactivate two separate Rb genes. 
D)  one germ-line mutation and one somatic mutation inactivate Rb genes. 
A)  a somatic mutation inactivates the Rb gene. 
B)  a somatic mutation activates the Rb gene. 
C)  two somatic mutations inactivate two separate Rb genes. 
D)  one germ-line mutation and one somatic mutation inactivate Rb genes.

Question 12

The form of cancer with the highest mortality rate in the United States is _______ cancer.

Accepted Answer

A)  breast 
B)  prostate 
C)  lung 
D)  colon 
A)  breast 
B)  prostate 
C)  lung 
D)  colon

Question 13

An increase in p53 activity usually results after a cell receives

Accepted Answer

A)  extracellular growth inhibition signals. 
B)  DNA damage. 
C)  heat shock. 
D)  extracellular growth stimulating signals. 
A)  extracellular growth inhibition signals. 
B)  DNA damage. 
C)  heat shock. 
D)  extracellular growth stimulating signals.

Question 14

Loss-of-function mutations can be oncogenic if the mutant gene codes for a

Accepted Answer

A)  telomerase. 
B)  tumor suppressor protein. 
C)  cyclin-dependent kinase. 
D)  DNA synthesis enzyme. 
A)  telomerase. 
B)  tumor suppressor protein. 
C)  cyclin-dependent kinase. 
D)  DNA synthesis enzyme.

Question 15

The process by which tumor cells whose mutations give them a selective advantage grow preferentially is called _______.

Accepted Answer

The answer of The process by which tumor cells whose...

Question 16

When does autocrine induction of cell proliferation occur?

Accepted Answer

When a mutation caus

Question 17

Leukemias arise from cells of the immune system.

Accepted Answer

A) True 
 B)False

Question 18

What is the reason for the likely result of the experiment described?

Accepted Answer

A)  Tumorigenicity is dominant. 
B)  50% of the cells get a tumor suppressor gene. 
C)  Tumor suppressor genes are recessive. 
D)  Tumor suppressor genes are dominant. 
A)  Tumorigenicity is dominant. 
B)  50% of the cells get a tumor suppressor gene. 
C)  Tumor suppressor genes are recessive. 
D)  Tumor suppressor genes are dominant.

Question 19

Name three tumor suppressor genes.

Accepted Answer

Any three of the fol

Question 20

Malignant colon cancers are usually the result of

Accepted Answer

A)  inherited mutant oncogenes. 
B)  inherited mutant tumor suppressor genes. 
C)  somatic mutation of an oncogene or tumor suppressor gene. 
D)  multiple mutations activating oncogenes and inactivating tumor suppressor genes. 
A)  inherited mutant oncogenes. 
B)  inherited mutant tumor suppressor genes. 
C)  somatic mutation of an oncogene or tumor suppressor gene. 
D)  multiple mutations activating oncogenes and inactivating tumor suppressor genes.

Several oncogenes encode antiapoptotic proteins that promote cell survival.

Which of the following genes has been associated with colon cancer?

Acute promyelocytic leukemia results from a mutated retinoic acid receptor, effectively blocking cell differentiation and allowing leukemic cells to continue proliferation.

Common human cancers caused by viruses include cervical carcinoma and _______ cancer.

One function of the tumor suppressor protein p53 is to

Traditional drugs used to treat cancer patients

How do cancer cells become able to proliferate indefinitely, while normal cells become senescent after a limited number of cell divisions?

Oncogenic mutations in ras promote accumulation of the GDP bound form of the protein.

The therapeutic use of monoclonal antibodies against oncogene proteins is limited to

Herpes viruses (HSV) can induce _______ sarcoma.

Nonhereditary retinoblastoma develops only when

The form of cancer with the highest mortality rate in the United States is _______ cancer.

An increase in p53 activity usually results after a cell receives

Loss-of-function mutations can be oncogenic if the mutant gene codes for a

The process by which tumor cells whose mutations give them a selective advantage grow preferentially is called _______.

When does autocrine induction of cell proliferation occur?

Leukemias arise from cells of the immune system.

What is the reason for the likely result of the experiment described?

Name three tumor suppressor genes.

Malignant colon cancers are usually the result of

An Overview of Cells and Cell Research

Molecules and Membranes

Bioenergetics and Metabolism

Fundamentals of Molecular Biology

Genomics, Proteomics, and Systems Biology

Genes and Genomes

Replication, Maintenance, and Rearrangements of Genomic Dna

RNA Synthesis and Processing

Transcriptional Regulation and Epigenetics

Protein Synthesis, Processing, and Regulation

The Nucleus

Protein Sorting and Transport

Mitochondria, Chloroplasts, and Peroxisomes

The Cytoskeleton and Cell Movement

The Plasma Membrane

Cell Walls, the Extracellular Matrix, and Cell Interactions

Cell Signaling

The Cell Cycle

Cell Death and Cell Renewal

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Exam 20: Cancer

Several oncogenes encode antiapoptotic proteins that promote cell survival.

Which of the following genes has been associated with colon cancer?

Acute promyelocytic leukemia results from a mutated retinoic acid receptor, effectively blocking cell differentiation and allowing leukemic cells to continue proliferation.

Common human cancers caused by viruses include cervical carcinoma and _______ cancer.

One function of the tumor suppressor protein p53 is to

Traditional drugs used to treat cancer patients

How do cancer cells become able to proliferate indefinitely, while normal cells become senescent after a limited number of cell divisions?

Oncogenic mutations in ras promote accumulation of the GDP bound form of the protein.

The therapeutic use of monoclonal antibodies against oncogene proteins is limited to

Herpes viruses (HSV) can induce _______ sarcoma.

Nonhereditary retinoblastoma develops only when

The form of cancer with the highest mortality rate in the United States is _______ cancer.

An increase in p53 activity usually results after a cell receives

Loss-of-function mutations can be oncogenic if the mutant gene codes for a

The process by which tumor cells whose mutations give them a selective advantage grow preferentially is called _______.

When does autocrine induction of cell proliferation occur?

Leukemias arise from cells of the immune system.

What is the reason for the likely result of the experiment described?

Name three tumor suppressor genes.

Malignant colon cancers are usually the result of

An Overview of Cells and Cell Research

Molecules and Membranes

Bioenergetics and Metabolism

Fundamentals of Molecular Biology

Genomics, Proteomics, and Systems Biology

Genes and Genomes

Replication, Maintenance, and Rearrangements of Genomic Dna

RNA Synthesis and Processing

Transcriptional Regulation and Epigenetics

Protein Synthesis, Processing, and Regulation

The Nucleus

Protein Sorting and Transport

Mitochondria, Chloroplasts, and Peroxisomes

The Cytoskeleton and Cell Movement

The Plasma Membrane

Cell Walls, the Extracellular Matrix, and Cell Interactions

Cell Signaling

The Cell Cycle

Cell Death and Cell Renewal

Filters