Question 1

What is a possible reason that carcinomas, which are tumors derived from epithelial cells, are the most common types of cancer in humans?

Accepted Answer

Most cells in adults have ceased to prol

Question 2

The cure rate for carcinomas detected early, when they have not spread from their site of origin, is 50%.

Accepted Answer

A) True 
 B)False

Question 3

Explain the conditions in which the following oncogene protein products may be oncogenic.
-The growth factor receptor PDGFR

Accepted Answer

When translocation (deletion o

Question 4

SV40, papillomaviruses, and adenoviruses are _______ tumor viruses.

Accepted Answer

The answer of SV40, papillomaviruses, and adenoviruses are _______ tumor...

Question 5

The more than 40 oncogenic retroviruses that have been identified share expression of all of the following genes except

Accepted Answer

A)  src. 
B)  pol. 
C)  env. 
D)  gag. 
A)  src. 
B)  pol. 
C)  env. 
D)  gag.

Question 6

Transformation can be assayed in cell culture.

Accepted Answer

A) True 
 B)False

Question 7

Which statement concerning the difference between cancer cells and normal cells is false?

Accepted Answer

A)  Normal cells display density-dependent inhibition of cell proliferation. 
B)  Cancer cells have reduced requirements for extracellular growth factors. 
C)  Malignant cells generally secrete proteases that digest extracellular matrix components. 
D)  Cancer cells undergo normal differentiation, but excessive proliferation. 
A)  Normal cells display density-dependent inhibition of cell proliferation. 
B)  Cancer cells have reduced requirements for extracellular growth factors. 
C)  Malignant cells generally secrete proteases that digest extracellular matrix components. 
D)  Cancer cells undergo normal differentiation, but excessive proliferation.

Question 8

Infection with which of the following viruses is associated with development of liver cancer in humans?

Accepted Answer

A)  Simian virus 40 (SV40) 
B)  Hepatitis B viruses 
C)  Epstein-Barr virus 
D)  Papillomaviruses 
A)  Simian virus 40 (SV40) 
B)  Hepatitis B viruses 
C)  Epstein-Barr virus 
D)  Papillomaviruses

Question 9

The most frequently encountered oncogene in human tumors is

Accepted Answer

A)  fos. 
B)  myc. 
C)  ras. 
D)  src. 
A)  fos. 
B)  myc. 
C)  ras. 
D)  src.

Question 10

Explain the conditions in which the following oncogene protein products may be oncogenic.
-The cell-differentiation-inducing receptor ErbA (thyroid hormone receptor) or PML/RAR? (retinoic acid receptor)

Accepted Answer

When mutant receptor

Question 11

Tumor initiation occurs in a

Accepted Answer

A)  single protein molecule. 
B)  single cell. 
C)  few cells. 
D)  single tissue. 
A)  single protein molecule. 
B)  single cell. 
C)  few cells. 
D)  single tissue.

Question 12

Apoptosis is induced by p53 when

Accepted Answer

A)  a cell is programmed to die during development. 
B)  growth factor levels decline to zero. 
C)  any DNA damage is detected. 
D)  severe DNA damage is detected and cannot be repaired. 
A)  a cell is programmed to die during development. 
B)  growth factor levels decline to zero. 
C)  any DNA damage is detected. 
D)  severe DNA damage is detected and cannot be repaired.

Question 13

What normal cellular process would be affected in a cell line in which Bcl-2 was mutated?

Accepted Answer

A)  Cell cycle 
B)  Apoptosis 
C)  cAMP signaling 
D)  Terminal differentiation 
A)  Cell cycle 
B)  Apoptosis 
C)  cAMP signaling 
D)  Terminal differentiation

Question 14

The sensitivity of tumors to inhibition of activated oncogenes is called oncogene addiction.

Accepted Answer

A) True 
 B)False

Question 15

Oncogenic conversion of the two dimerizing proto-oncogene components of the AP-1 transcription factor can lead to abnormal cell proliferation. Which two gene products form the active AP-1 transcription factor complex?

Accepted Answer

A)  Fos and Jun 
B)  Fos and Myc 
C)  Myc and Jun 
D)  Raf and Myc 
A)  Fos and Jun 
B)  Fos and Myc 
C)  Myc and Jun 
D)  Raf and Myc

Question 16

The normal function of the tumor suppressor protein Rb is to

Accepted Answer

A)  induce apoptosis. 
B)  inhibit Ras. 
C)  inhibit progression through the G1 restriction point. 
D)  inhibit Cdk4/cyclin B activity. 
A)  induce apoptosis. 
B)  inhibit Ras. 
C)  inhibit progression through the G1 restriction point. 
D)  inhibit Cdk4/cyclin B activity.

Question 17

_______ treatment of promyelocytic leukemia induces terminal differentiation, forcing the cancer cells to withdraw from the cell cycle.

Accepted Answer

The answer of _______ treatment of promyelocytic leukemia induces terminal...

Question 18

A tumor is

Accepted Answer

A)  a malignant growth. 
B)  any abnormal growth of cells. 
C)  a benign growth. 
D)  a cancerous growth. 
A)  a malignant growth. 
B)  any abnormal growth of cells. 
C)  a benign growth. 
D)  a cancerous growth.

Question 19

The mechanism by which normal cells stop proliferating as a result of reduced availability of growth factors is called

Accepted Answer

A)  density dependent inhibition. 
B)  contact inhibition. 
C)  differentiation. 
D)  senescence. 
A)  density dependent inhibition. 
B)  contact inhibition. 
C)  differentiation. 
D)  senescence.

Question 20

Which statement about the tumor suppressor gene p53 is false?

Accepted Answer

A)  It plays a role in up to 50% of human cancers. 
B)  Its loss causes retinoblastoma, a rare childhood cancer of the eye. 
C)  It blocks cell cycle progression in response to DNA damage. 
D)  It is required for apoptosis in response to DNA damage. 
A)  It plays a role in up to 50% of human cancers. 
B)  Its loss causes retinoblastoma, a rare childhood cancer of the eye. 
C)  It blocks cell cycle progression in response to DNA damage. 
D)  It is required for apoptosis in response to DNA damage.

What is a possible reason that carcinomas, which are tumors derived from epithelial cells, are the most common types of cancer in humans?

The cure rate for carcinomas detected early, when they have not spread from their site of origin, is 50%.

Explain the conditions in which the following oncogene protein products may be oncogenic. -The growth factor receptor PDGFR

SV40, papillomaviruses, and adenoviruses are _______ tumor viruses.

The more than 40 oncogenic retroviruses that have been identified share expression of all of the following genes except

Transformation can be assayed in cell culture.

Which statement concerning the difference between cancer cells and normal cells is false?

Infection with which of the following viruses is associated with development of liver cancer in humans?

The most frequently encountered oncogene in human tumors is

Explain the conditions in which the following oncogene protein products may be oncogenic. -The cell-differentiation-inducing receptor ErbA (thyroid hormone receptor) or PML/RAR? (retinoic acid receptor)

Tumor initiation occurs in a

Apoptosis is induced by p53 when

What normal cellular process would be affected in a cell line in which Bcl-2 was mutated?

The sensitivity of tumors to inhibition of activated oncogenes is called oncogene addiction.

Oncogenic conversion of the two dimerizing proto-oncogene components of the AP-1 transcription factor can lead to abnormal cell proliferation. Which two gene products form the active AP-1 transcription factor complex?

The normal function of the tumor suppressor protein Rb is to

_______ treatment of promyelocytic leukemia induces terminal differentiation, forcing the cancer cells to withdraw from the cell cycle.

A tumor is

The mechanism by which normal cells stop proliferating as a result of reduced availability of growth factors is called

Which statement about the tumor suppressor gene p53 is false?

An Overview of Cells and Cell Research

Molecules and Membranes

Bioenergetics and Metabolism

Fundamentals of Molecular Biology

Genomics, Proteomics, and Systems Biology

Genes and Genomes

Replication, Maintenance, and Rearrangements of Genomic Dna

RNA Synthesis and Processing

Transcriptional Regulation and Epigenetics

Protein Synthesis, Processing, and Regulation

The Nucleus

Protein Sorting and Transport

Mitochondria, Chloroplasts, and Peroxisomes

The Cytoskeleton and Cell Movement

The Plasma Membrane

Cell Walls, the Extracellular Matrix, and Cell Interactions

Cell Signaling

The Cell Cycle

Cell Death and Cell Renewal

Filters

Exam 20: Cancer

What is a possible reason that carcinomas, which are tumors derived from epithelial cells, are the most common types of cancer in humans?

The cure rate for carcinomas detected early, when they have not spread from their site of origin, is 50%.

Explain the conditions in which the following oncogene protein products may be oncogenic. -The growth factor receptor PDGFR

SV40, papillomaviruses, and adenoviruses are _______ tumor viruses.

The more than 40 oncogenic retroviruses that have been identified share expression of all of the following genes except

Transformation can be assayed in cell culture.

Which statement concerning the difference between cancer cells and normal cells is false?

Infection with which of the following viruses is associated with development of liver cancer in humans?

The most frequently encountered oncogene in human tumors is

Explain the conditions in which the following oncogene protein products may be oncogenic. -The cell-differentiation-inducing receptor ErbA (thyroid hormone receptor) or PML/RAR? (retinoic acid receptor)

Tumor initiation occurs in a

Apoptosis is induced by p53 when

What normal cellular process would be affected in a cell line in which Bcl-2 was mutated?

The sensitivity of tumors to inhibition of activated oncogenes is called oncogene addiction.

Oncogenic conversion of the two dimerizing proto-oncogene components of the AP-1 transcription factor can lead to abnormal cell proliferation. Which two gene products form the active AP-1 transcription factor complex?

The normal function of the tumor suppressor protein Rb is to

_______ treatment of promyelocytic leukemia induces terminal differentiation, forcing the cancer cells to withdraw from the cell cycle.

A tumor is

The mechanism by which normal cells stop proliferating as a result of reduced availability of growth factors is called

Which statement about the tumor suppressor gene p53 is false?

An Overview of Cells and Cell Research

Molecules and Membranes

Bioenergetics and Metabolism

Fundamentals of Molecular Biology

Genomics, Proteomics, and Systems Biology

Genes and Genomes

Replication, Maintenance, and Rearrangements of Genomic Dna

RNA Synthesis and Processing

Transcriptional Regulation and Epigenetics

Protein Synthesis, Processing, and Regulation

The Nucleus

Protein Sorting and Transport

Mitochondria, Chloroplasts, and Peroxisomes

The Cytoskeleton and Cell Movement

The Plasma Membrane

Cell Walls, the Extracellular Matrix, and Cell Interactions

Cell Signaling

The Cell Cycle

Cell Death and Cell Renewal

Filters