Question 1

Xeroderma pigmentosum is caused by mutations in _______ genes.

Accepted Answer

nucleotide

Question 2

Which statement describes the first direct evidence for involvement of cellular oncogenes in human tumors?

Accepted Answer

A)  Normal human cells could be transformed by the src-containing Rous sarcoma viruses. 
B)  DNA extracted from a human bladder carcinoma was able to transform recipient mouse cells in culture. 
C)  DNA extracted from a mouse carcinoma was able to transform recipient human cells in culture. 
D)  DNA extracted from a human carcinoma was able to transform recipient chicken cells in culture. 
A)  Normal human cells could be transformed by the src-containing Rous sarcoma viruses. 
B)  DNA extracted from a human bladder carcinoma was able to transform recipient mouse cells in culture. 
C)  DNA extracted from a mouse carcinoma was able to transform recipient human cells in culture. 
D)  DNA extracted from a human carcinoma was able to transform recipient chicken cells in culture.

Question 3

Explain why the disease retinoblastoma is inherited in a dominant fashion, despite the fact that it is caused by a recessive (loss-of-function) mutation in the tumor suppressor gene Rb.

Accepted Answer

Statistically, 50% of the progeny of an

Question 4

Many cases of breast cancer can be traced to the _______ and _______ genes.

Accepted Answer

The answer of Many cases of breast cancer can be...

Question 5

Which of the following behaviors most increases the likelihood of developing cancer?

Accepted Answer

A)  Drinking a glass of wine a day 
B)  Smoking a pack of cigarettes a day 
C)  Kissing a person who has cancer 
D)  Breathing the sawdust from a crown gall tumor 
A)  Drinking a glass of wine a day 
B)  Smoking a pack of cigarettes a day 
C)  Kissing a person who has cancer 
D)  Breathing the sawdust from a crown gall tumor

Question 6

Explain the conditions in which the following oncogene protein products may be oncogenic.
-The Cdk-activating protein cyclin D

Accepted Answer

When it is expressed

Question 7

List three ways in which a proto-oncogene can be activated to become an oncogene.

Accepted Answer

(1) Point mutation,

Question 8

When observed under a microscope, cancer cells often have a more rounded morphology than untransformed cells. What accounts for this difference in morphology?

Accepted Answer

Cancer cells tend to be less dependent o

Question 9

Which statement about cancers is false?

Accepted Answer

A)  Carcinomas are malignancies of epithelial cells. 
B)  Leukemias are malignancies that arise from blood-forming cells. 
C)  Lymphomas are malignancies from colon tissue. 
D)  Sarcomas are malignancies of connective tissue like muscle and bone. 
A)  Carcinomas are malignancies of epithelial cells. 
B)  Leukemias are malignancies that arise from blood-forming cells. 
C)  Lymphomas are malignancies from colon tissue. 
D)  Sarcomas are malignancies of connective tissue like muscle and bone.

Question 10

Angiogenesis contributes to cancer development by

Accepted Answer

A)  providing nutrients and oxygen to tumors and by facilitating metastasis. 
B)  initiating a mutation in a gene that causes uncontrolled cell growth. 
C)  inhibiting apoptosis (programmed cell death). 
D)  preventing the normal inhibition of growth that occurs when cells make contact. 
A)  providing nutrients and oxygen to tumors and by facilitating metastasis. 
B)  initiating a mutation in a gene that causes uncontrolled cell growth. 
C)  inhibiting apoptosis (programmed cell death). 
D)  preventing the normal inhibition of growth that occurs when cells make contact.

Question 11

PTEN is a tumor suppressor gene in the Akt signaling pathway. Which statement about PTEN/Akt is false?

Accepted Answer

A)  PIP2 can be oncogenically mutated to induce cell survival. 
B)  PTEN antagonizes (has the opposite effect) of PI 3-kinase. 
C)  Akt can be oncogenically mutated to induce cell survival. 
D)  It is a lipid phosphatase that dephosphorylates PIP3 to PIP2. 
A)  PIP2 can be oncogenically mutated to induce cell survival. 
B)  PTEN antagonizes (has the opposite effect) of PI 3-kinase. 
C)  Akt can be oncogenically mutated to induce cell survival. 
D)  It is a lipid phosphatase that dephosphorylates PIP3 to PIP2.

Question 12

Why are cancer cells less dependent on growth factors than their normal cellular counterparts?

Accepted Answer

1) Cancer cells frequently secrete their

Question 13

Imatinib (Gleevec) blocks proliferation of chronic myeloid leukemia cells by inhibiting the protein kinase

Accepted Answer

A)  Bcr/Abl. 
B)  Cdk/cyclin. 
C)  MAP kinase. 
D)  ErbB. 
A)  Bcr/Abl. 
B)  Cdk/cyclin. 
C)  MAP kinase. 
D)  ErbB.

Question 14

Explain the conditions in which the following oncogene protein products may be oncogenic.
-The intracellular signal transducing molecule Ras

Accepted Answer

When mutation of its GTPase ac

Question 15

The type of cancer with highest mortality in the United States is cancer of the

Accepted Answer

A)  prostate. 
B)  colon/rectum. 
C)  breast. 
D)  lung. 
A)  prostate. 
B)  colon/rectum. 
C)  breast. 
D)  lung.

Question 16

Tumors would likely develop in _______ of the mice.

Accepted Answer

A)  less than 1% 
B)  25% 
C)  50% 
D)  nearly 100% 
A)  less than 1% 
B)  25% 
C)  50% 
D)  nearly 100%

Question 17

What is the therapeutic strategy for using Herceptin to treat breast cancer?

Accepted Answer

In about 30% of breast cancers, ErbB-2 (

Question 18

The first drug developed against a specific oncogene and approved for clinical use was a monoclonal antibody against ErbB-2.

Accepted Answer

A) True 
 B)False

Question 19

Describe how growth of transformed cells in a tissue culture dish differs from growth of untransformed cells.

Accepted Answer

Transformed cells display three properti

Question 20

Describe how the first oncogene was discovered.

Accepted Answer

The src oncogene was discovered in a stu

Xeroderma pigmentosum is caused by mutations in _______ genes.

Which statement describes the first direct evidence for involvement of cellular oncogenes in human tumors?

Explain why the disease retinoblastoma is inherited in a dominant fashion, despite the fact that it is caused by a recessive (loss-of-function) mutation in the tumor suppressor gene Rb.

Many cases of breast cancer can be traced to the _ and _ genes.

Which of the following behaviors most increases the likelihood of developing cancer?

Explain the conditions in which the following oncogene protein products may be oncogenic. -The Cdk-activating protein cyclin D

List three ways in which a proto-oncogene can be activated to become an oncogene.

When observed under a microscope, cancer cells often have a more rounded morphology than untransformed cells. What accounts for this difference in morphology?

Which statement about cancers is false?

Angiogenesis contributes to cancer development by

PTEN is a tumor suppressor gene in the Akt signaling pathway. Which statement about PTEN/Akt is false?

Why are cancer cells less dependent on growth factors than their normal cellular counterparts?

Imatinib (Gleevec) blocks proliferation of chronic myeloid leukemia cells by inhibiting the protein kinase

Explain the conditions in which the following oncogene protein products may be oncogenic. -The intracellular signal transducing molecule Ras

The type of cancer with highest mortality in the United States is cancer of the

Tumors would likely develop in _______ of the mice.

What is the therapeutic strategy for using Herceptin to treat breast cancer?

The first drug developed against a specific oncogene and approved for clinical use was a monoclonal antibody against ErbB-2.

Describe how growth of transformed cells in a tissue culture dish differs from growth of untransformed cells.

Describe how the first oncogene was discovered.

An Overview of Cells and Cell Research

Molecules and Membranes

Bioenergetics and Metabolism

Fundamentals of Molecular Biology

Genomics, Proteomics, and Systems Biology

Genes and Genomes

Replication, Maintenance, and Rearrangements of Genomic Dna

RNA Synthesis and Processing

Transcriptional Regulation and Epigenetics

Protein Synthesis, Processing, and Regulation

The Nucleus

Protein Sorting and Transport

Mitochondria, Chloroplasts, and Peroxisomes

The Cytoskeleton and Cell Movement

The Plasma Membrane

Cell Walls, the Extracellular Matrix, and Cell Interactions

Cell Signaling

The Cell Cycle

Cell Death and Cell Renewal

Filters

Exam 20: Cancer

Xeroderma pigmentosum is caused by mutations in _______ genes.

Which statement describes the first direct evidence for involvement of cellular oncogenes in human tumors?

Explain why the disease retinoblastoma is inherited in a dominant fashion, despite the fact that it is caused by a recessive (loss-of-function) mutation in the tumor suppressor gene Rb.

Many cases of breast cancer can be traced to the _______ and _______ genes.

Which of the following behaviors most increases the likelihood of developing cancer?

Explain the conditions in which the following oncogene protein products may be oncogenic. -The Cdk-activating protein cyclin D

List three ways in which a proto-oncogene can be activated to become an oncogene.

When observed under a microscope, cancer cells often have a more rounded morphology than untransformed cells. What accounts for this difference in morphology?

Which statement about cancers is false?

Angiogenesis contributes to cancer development by

PTEN is a tumor suppressor gene in the Akt signaling pathway. Which statement about PTEN/Akt is false?

Why are cancer cells less dependent on growth factors than their normal cellular counterparts?

Imatinib (Gleevec) blocks proliferation of chronic myeloid leukemia cells by inhibiting the protein kinase

Explain the conditions in which the following oncogene protein products may be oncogenic. -The intracellular signal transducing molecule Ras

The type of cancer with highest mortality in the United States is cancer of the

Tumors would likely develop in _______ of the mice.

What is the therapeutic strategy for using Herceptin to treat breast cancer?

The first drug developed against a specific oncogene and approved for clinical use was a monoclonal antibody against ErbB-2.

Describe how growth of transformed cells in a tissue culture dish differs from growth of untransformed cells.

Describe how the first oncogene was discovered.

An Overview of Cells and Cell Research

Molecules and Membranes

Bioenergetics and Metabolism

Fundamentals of Molecular Biology

Genomics, Proteomics, and Systems Biology

Genes and Genomes

Replication, Maintenance, and Rearrangements of Genomic Dna

RNA Synthesis and Processing

Transcriptional Regulation and Epigenetics

Protein Synthesis, Processing, and Regulation

The Nucleus

Protein Sorting and Transport

Mitochondria, Chloroplasts, and Peroxisomes

The Cytoskeleton and Cell Movement

The Plasma Membrane

Cell Walls, the Extracellular Matrix, and Cell Interactions

Cell Signaling

The Cell Cycle

Cell Death and Cell Renewal

Filters

Many cases of breast cancer can be traced to the _ and _ genes.