Question 1

Symptoms of delayed-type hypersensitivity may appear several hours to days after secondary exposure to the eliciting antigen.

Accepted Answer

A) True 
 B)False

Question 2

Chemokines produced by activated macrophages include

Accepted Answer

A)  CXCL8. 
B)  TNF-α. 
C)  interleukin-4. 
D)  interleukin-5. 
A)  CXCL8. 
B)  TNF-α. 
C)  interleukin-4. 
D)  interleukin-5.

Question 3

The antigen that induces an antibody or TCR is called the

Accepted Answer

A)  homologous antigen. 
B)  heterologous antigen. 
C)  cross-reactive antigen. 
D)  immunogenic antigen. 
A)  homologous antigen. 
B)  heterologous antigen. 
C)  cross-reactive antigen. 
D)  immunogenic antigen.

Question 4

Design five amino acid peptides that could be bound by a single hypothetical class I MHC protein. The MHC proteins binds peptides that are 10 amino acids long and have two anchor residues, tyrosine and isoleucine, at positions 2 and 5.

Accepted Answer

Answers will vary because diff

Question 5

Which of the following is associated with mucosa-associated lymph tissue that produces IgA?

Accepted Answer

A)  breast milk 
B)  red blood cells 
C)  blood serum 
D)  small intestine 
A)  breast milk 
B)  red blood cells 
C)  blood serum 
D)  small intestine

Question 6

Th2 cells produce a cytokine that promotes growth and activation of other T cells and activates macrophages.

Accepted Answer

A) True 
 B)False

Question 7

The mechanism by which antigen-reactive cells respond to foreign antigens while ignoring self-antigens is called clonal

Accepted Answer

A)  selection. 
B)  deletion. 
C)  anergy. 
D)  expansion. 
A)  selection. 
B)  deletion. 
C)  anergy. 
D)  expansion.

Question 8

The measurable strength of the binding of an antibody to antigen is called

Accepted Answer

A)  binding affinity. 
B)  epitope. 
C)  tolerance. 
D)  virulence. 
A)  binding affinity. 
B)  epitope. 
C)  tolerance. 
D)  virulence.

Question 9

HLAs are responsible for immune-mediated organ transplant rejection.

Accepted Answer

A) True 
 B)False

Question 10

In clonal selection, cells that have not interacted with an antigen do not proliferate.

Accepted Answer

A) True 
 B)False

Question 11

The complete second signal for B cell activation requires which of the following interactions?

Accepted Answer

A)  Interleukin-4 release 
B)  cytokine-cytokine receptor interaction 
C)  TH-B cell interaction 
D)  All of these are necessary. 
A)  Interleukin-4 release 
B)  cytokine-cytokine receptor interaction 
C)  TH-B cell interaction 
D)  All of these are necessary.

Question 12

Which of the following is involved in B cell selection and tolerance?

Accepted Answer

A)  clonal anergy 
B)  clonal deletion 
C)  clonal anergy and deletion 
D)  allelic exclusion 
A)  clonal anergy 
B)  clonal deletion 
C)  clonal anergy and deletion 
D)  allelic exclusion

Question 13

There are ________ different complementarity-determining regions in each V domain of an immunoglobulin (meaning ________ total in the V region).

Accepted Answer

A)  one / two 
B)  two / four 
C)  three / six 
D)  four / eight 
A)  one / two 
B)  two / four 
C)  three / six 
D)  four / eight

Question 14

The C domain of antigen-binding proteins functions to

Accepted Answer

A)  attach the antigen-binding domain to the cytoplasmic membrane. 
B)  bind to the cytoplasmic membrane of foreign cells. 
C)  complex multiple antigen-binding proteins together. 
D)  bind to epitopes. 
A)  attach the antigen-binding domain to the cytoplasmic membrane. 
B)  bind to the cytoplasmic membrane of foreign cells. 
C)  complex multiple antigen-binding proteins together. 
D)  bind to epitopes.

Question 15

Which of the following is/are MHC class I genes?

Accepted Answer

A)  HLA-A 
B)  HLA-B 
C)  HLA-C 
D)  HLA-A, HLA-B, and HLA-C 
A)  HLA-A 
B)  HLA-B 
C)  HLA-C 
D)  HLA-A, HLA-B, and HLA-C

Question 16

Which of the following are found on the surfaces of all nucleated cells?

Accepted Answer

A)  Class I MHC proteins 
B)  Class II MHC proteins 
C)  G proteins 
D)  M proteins 
A)  Class I MHC proteins 
B)  Class II MHC proteins 
C)  G proteins 
D)  M proteins

Question 17

Immunoglobulin, TCR, and MHC proteins share structural features and have evolved by duplication and selection of primordial antigen receptors.

Accepted Answer

A) True 
 B)False

Question 18

Intrinsic properties of immunogens include

Accepted Answer

A)  appropriate physical form. 
B)  molecular size. 
C)  sufficient molecular complexity. 
D)  appropriate physical form, molecular size, and molecular complexity. 
A)  appropriate physical form. 
B)  molecular size. 
C)  sufficient molecular complexity. 
D)  appropriate physical form, molecular size, and molecular complexity.

Question 19

Major histocompatibility complex (MHC) proteins, antibodies, and T cell receptors are all highly variable so that they can interact with a large number of different antigens. How is variability generated for each of these important antigen-binding proteins?

Accepted Answer

MHC proteins are polygenic. Three differ

Question 20

Men are 20 times more likely to develop systemic lupus erythematosus (SLE) than women.

Accepted Answer

A) True 
 B)False

Exam 27: Adaptive Immunity: Highly Specific Host Defenses

Symptoms of delayed-type hypersensitivity may appear several hours to days after secondary exposure to the eliciting antigen.

Chemokines produced by activated macrophages include

The antigen that induces an antibody or TCR is called the

Design five amino acid peptides that could be bound by a single hypothetical class I MHC protein. The MHC proteins binds peptides that are 10 amino acids long and have two anchor residues, tyrosine and isoleucine, at positions 2 and 5.

Which of the following is associated with mucosa-associated lymph tissue that produces IgA?

Th2 cells produce a cytokine that promotes growth and activation of other T cells and activates macrophages.

The mechanism by which antigen-reactive cells respond to foreign antigens while ignoring self-antigens is called clonal

The measurable strength of the binding of an antibody to antigen is called

HLAs are responsible for immune-mediated organ transplant rejection.

In clonal selection, cells that have not interacted with an antigen do not proliferate.

The complete second signal for B cell activation requires which of the following interactions?

Which of the following is involved in B cell selection and tolerance?

There are ________ different complementarity-determining regions in each V domain of an immunoglobulin (meaning ________ total in the V region).

The C domain of antigen-binding proteins functions to

Which of the following is/are MHC class I genes?

Which of the following are found on the surfaces of all nucleated cells?

Immunoglobulin, TCR, and MHC proteins share structural features and have evolved by duplication and selection of primordial antigen receptors.

Intrinsic properties of immunogens include

Major histocompatibility complex (MHC) proteins, antibodies, and T cell receptors are all highly variable so that they can interact with a large number of different antigens. How is variability generated for each of these important antigen-binding proteins?

Men are 20 times more likely to develop systemic lupus erythematosus (SLE) than women.

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There are different complementarity-determining regions in each V domain of an immunoglobulin (meaning total in the V region).