Question 1

When the lysine side chain in a histone is acetylated, the amino group is now

Accepted Answer

A)  positively charged. 
B)  neutral. 
C)  negatively charged. 
D)  removed. 
A)  positively charged. 
B)  neutral. 
C)  negatively charged. 
D)  removed.

Question 2

Lysine methylation has what effect on the histone?

Accepted Answer

A)  leaves a positive charge on the amino acid 
B)  leaves a neutral charge on the amino acid 
C)  binds more strongly to the histone 
D)  removes chromatin docking sites 
A)  leaves a positive charge on the amino acid 
B)  leaves a neutral charge on the amino acid 
C)  binds more strongly to the histone 
D)  removes chromatin docking sites

Question 3

The function of CRP in lac operon expression is to the promoter by causing RNA polymerase to _.

Accepted Answer

A)  stimulate; dissociate 
B)  stimulate; bind tighter 
C)  inhibit; dissociate 
D)  inhibit; bind tighter 
A)  stimulate; dissociate 
B)  stimulate; bind tighter 
C)  inhibit; dissociate 
D)  inhibit; bind tighter

Question 4

Pluripotent state can be defined as a cell.

Accepted Answer

A)  differentiated 
B)  predifferentiated 
C)  G1 state of the 
D)  S state of the 
A)  differentiated 
B)  predifferentiated 
C)  G1 state of the 
D)  S state of the

Question 5

What is the function of the SOS regulatory system in the cell?

Accepted Answer

A)  DNA repair 
B)  DNA translation 
C)  lactose degradation 
D)  glucose inhibition 
A)  DNA repair 
B)  DNA translation 
C)  lactose degradation 
D)  glucose inhibition

Question 6

Once RecA is no longer activated, what happens to the SOS regulon?

Accepted Answer

A)  LexA builds up and represses the SOS regulon. 
B)  LexA autocleaves and SOS regulon is activated. 
C)  LexA binds to the RecA. 
D)  LexA binds to the SOS regulon. 
A)  LexA builds up and represses the SOS regulon. 
B)  LexA autocleaves and SOS regulon is activated. 
C)  LexA binds to the RecA. 
D)  LexA binds to the SOS regulon.

Question 7

Bromodomain-containing complexes bind to __________ lysines in histones.

Accepted Answer

A)  methylated 
B)  acetylated 
C)  brominated 
D)  chlorinated 
A)  methylated 
B)  acetylated 
C)  brominated 
D)  chlorinated

Question 8

Compare negative and positive autoregulation.

Accepted Answer

In negative autoregulation a protein rep

Question 9

An unusual structural feature of the lac repressor is that it is a

Accepted Answer

A)  homodimer. 
B)  homotetramer. 
C)  heterodimer. 
D)  heterotetramer. 
A)  homodimer. 
B)  homotetramer. 
C)  heterodimer. 
D)  heterotetramer.

Question 10

When trp operon is attenuated, what does that mean for the trp operon?

Accepted Answer

A)  inhibition of transcriptional initiation by RNA polymerase 
B)  disruption of transcriptional elongation by RNA polymerase 
C)  initiation by RNA polymerase 
D)  enhancement of transcriptional elongation by RNA polymerase 
A)  inhibition of transcriptional initiation by RNA polymerase 
B)  disruption of transcriptional elongation by RNA polymerase 
C)  initiation by RNA polymerase 
D)  enhancement of transcriptional elongation by RNA polymerase

Question 11

What are the two main types of stem cells?

Accepted Answer

A)  somatic and embryonic 
B)  somatic and epithelial 
C)  stromal and somatic 
D)  stromal and embryonic 
A)  somatic and embryonic 
B)  somatic and epithelial 
C)  stromal and somatic 
D)  stromal and embryonic

Question 12

Name the key elements of the lac operon.

Accepted Answer

The regulatory region and the structural

Question 13

The pioneer factor can be defined as the

Accepted Answer

A)  last transcription factor protein complex to bind. 
B)  first transcription factor protein complex to bind. 
C)  last cis-acting site in a chain. 
D)  first cis-acting site in a chain. 
A)  last transcription factor protein complex to bind. 
B)  first transcription factor protein complex to bind. 
C)  last cis-acting site in a chain. 
D)  first cis-acting site in a chain.

Question 14

If PRM is autoactivated and PR is inhibited, then is/are bound.

Accepted Answer

A)  CI 
B)  Cro 
C)  both CI and Cro 
D)  neither CI and Cro 
A)  CI 
B)  Cro 
C)  both CI and Cro 
D)  neither CI and Cro

Question 15

A function of transcriptional activator proteins is to

Accepted Answer

A)  recruit gene promotors. 
B)  initiate RNA synthesis. 
C)  recruit chromatin modifiers. 
D)  initiate DNA synthesis. 
A)  recruit gene promotors. 
B)  initiate RNA synthesis. 
C)  recruit chromatin modifiers. 
D)  initiate DNA synthesis.

Question 16

Why are long tracts of A residues not found in regions of stable nucleosome positioning?

Accepted Answer

A)  They are too flexible. 
B)  They are too stiff. 
C)  DNA cannot have long tracts of A residues. 
D)  DNA cannot have A residues. 
A)  They are too flexible. 
B)  They are too stiff. 
C)  DNA cannot have long tracts of A residues. 
D)  DNA cannot have A residues.

Question 17

The function of an insulator sequence in DNA is to

Accepted Answer

A)  amplify the action of enhancers. 
B)  counteract the action of enhancers. 
C)  inhibit promoters. 
D)  activate RNA synthesis. 
A)  amplify the action of enhancers. 
B)  counteract the action of enhancers. 
C)  inhibit promoters. 
D)  activate RNA synthesis.

Question 18

When there is a large presence of tryptophan, what effect that does that have on the Trp repressor?

Accepted Answer

A)  Trp repressor is bound. 
B)  Trp repressor is not bound. 
C)  There is initiation of RNA polymerase. 
D)  Transcriptional elongation by RNA polymerase is enhanced. 
A)  Trp repressor is bound. 
B)  Trp repressor is not bound. 
C)  There is initiation of RNA polymerase. 
D)  Transcriptional elongation by RNA polymerase is enhanced.

Question 19

A reporter gene can be defined as a gene that

Accepted Answer

A)  has a product that is easy to detect. 
B)  prevents protein synthesis. 
C)  overproduces proteins. 
D)  causes an epigenetic sate. 
A)  has a product that is easy to detect. 
B)  prevents protein synthesis. 
C)  overproduces proteins. 
D)  causes an epigenetic sate.

Question 20

What are two medical applications that iPS could be used for?

Accepted Answer

A)  type 1 diabetes and Parkinson's 
B)  type 2 diabetes and Parkinson's 
C)  Alzheimer's and Parkinson's 
D)  Alzheimer's and type 2 diabetes 
A)  type 1 diabetes and Parkinson's 
B)  type 2 diabetes and Parkinson's 
C)  Alzheimer's and Parkinson's 
D)  Alzheimer's and type 2 diabetes

Exam 23: Gene Regulation

When the lysine side chain in a histone is acetylated, the amino group is now

Lysine methylation has what effect on the histone?

The function of CRP in lac operon expression is to the promoter by causing RNA polymerase to _.

Pluripotent state can be defined as a cell.

What is the function of the SOS regulatory system in the cell?

Once RecA is no longer activated, what happens to the SOS regulon?

Bromodomain-containing complexes bind to __________ lysines in histones.

Compare negative and positive autoregulation.

An unusual structural feature of the lac repressor is that it is a

When trp operon is attenuated, what does that mean for the trp operon?

What are the two main types of stem cells?

Name the key elements of the lac operon.

The pioneer factor can be defined as the

If PRM is autoactivated and PR is inhibited, then is/are bound.

A function of transcriptional activator proteins is to

Why are long tracts of A residues not found in regions of stable nucleosome positioning?

The function of an insulator sequence in DNA is to

When there is a large presence of tryptophan, what effect that does that have on the Trp repressor?

A reporter gene can be defined as a gene that

What are two medical applications that iPS could be used for?

Principles of Biochemistry

Physical Biochemistry: Energy Conversion, Water, and Membranes

Nucleic Acid Structure and Function

Protein Structure

Methods in Protein Biochemistry

Protein Function

Enzyme Mechanisms

Cell Signaling Systems

Glycolysis: a Paradigm of Metabolic Regulation

The Citrate Cycle

Oxidative Phosphorylation

Photosynthesis

Carbohydrate Structure and Function

Carbohydrate Metabolism

Lipid Structure and Function

Lipid Metabolism

Amino Acid Metabolism

Nucleotide Metabolism

Metabolic Integration

DNA Replication, Repair, and Recombination

RNA Synthesis, Processing, and Gene Silencing

Protein Synthesis, Posttranslational Modification, and Transport

Filters

If P_RM is autoactivated and P_R is inhibited, then is/are bound.