Question 1

Lamisil is an allylamine used to treat dermatomycoses. Lamisil's method of action is similar to that of

Accepted Answer

A)  griseofulvin. 
B)  bacitracin. 
C)  polymyxin B. 
D)  echinocandins. 
E)  azole antibiotics. 
A)  griseofulvin. 
B)  bacitracin. 
C)  polymyxin B. 
D)  echinocandins. 
E)  azole antibiotics.

Question 2

Table 20.1
The following data were obtained from a broth dilution test.
  
-In Table 20.1, the minimal inhibitory concentration of antibiotic X is

Accepted Answer

A)  10 µg/ml. 
B)  15 µg/ml. 
C)  25 µg/ml. 
D)  2 µg/ml. 
E)  The answer cannot be determined based on the information provided. 
A)  10 µg/ml. 
B)  15 µg/ml. 
C)  25 µg/ml. 
D)  2 µg/ml. 
E)  The answer cannot be determined based on the information provided.

Question 3

Table 20.1
The following data were obtained from a broth dilution test.
  
-In Table 20.1, the minimal bactericidal concentration of antibiotic X is

Accepted Answer

A)  2 µg/ml. 
B)  25 µg/ml. 
C)  15 µg/ml. 
D)  10 µg/ml. 
E)  The answer cannot be determined based on the information provided. 
A)  2 µg/ml. 
B)  25 µg/ml. 
C)  15 µg/ml. 
D)  10 µg/ml. 
E)  The answer cannot be determined based on the information provided.

Question 4

Which of the following statements about drugs that competitively inhibit DNA polymerase or RNA polymerase is FALSE?

Accepted Answer

A)  They cause cellular plasmolysis. 
B)  They are used against viral infections. 
C)  They interfere with protein synthesis. 
D)  They cause mutations. 
E)  They can affect host cell DNA. 
A)  They cause cellular plasmolysis. 
B)  They are used against viral infections. 
C)  They interfere with protein synthesis. 
D)  They cause mutations. 
E)  They can affect host cell DNA.

Question 5

Due to its target, rifamycins can be effective over a broad spectrum.

Accepted Answer

A) True 
 B)False

Question 6

To date, most of our natural antibiotics have been found to be produced by members of what genus?

Accepted Answer

A)  Streptomyces 
B)  Cephalosporium 
C)  Penicillium 
D)  Paenibacillus 
E)  Bacillus 
A)  Streptomyces 
B)  Cephalosporium 
C)  Penicillium 
D)  Paenibacillus 
E)  Bacillus

Question 7

Which of the following does NOT constitute an advantage of using two antibiotics together?

Accepted Answer

A)  It lessens the toxicity of individual drugs. 
B)  Two are always twice as effective as one. 
C)  It can prevent drug resistance. 
D)  It allows treatment to be provided prior to diagnosis. 
E)  All of these are advantages of using two antibiotics together. 
A)  It lessens the toxicity of individual drugs. 
B)  Two are always twice as effective as one. 
C)  It can prevent drug resistance. 
D)  It allows treatment to be provided prior to diagnosis. 
E)  All of these are advantages of using two antibiotics together.

Question 8

The antibiotic actinomycin D binds between adjacent G- C pairs, thus interfering with

Accepted Answer

A)  peptide bond formation. 
B)  transcription. 
C)  plasma membrane function. 
D)  cellular respiration. 
E)  translation. 
A)  peptide bond formation. 
B)  transcription. 
C)  plasma membrane function. 
D)  cellular respiration. 
E)  translation.

Question 9

Which of the following statements about drug resistance is FALSE?

Accepted Answer

A)  It may be due to enzymes that degrade some antibiotics. 
B)  It may be carried on a plasmid. 
C)  It is found only in gram- negative bacteria. 
D)  It may be due to increased uptake of a drug. 
E)  It may be transferred from one bacterium to another during conjugation. 
A)  It may be due to enzymes that degrade some antibiotics. 
B)  It may be carried on a plasmid. 
C)  It is found only in gram- negative bacteria. 
D)  It may be due to increased uptake of a drug. 
E)  It may be transferred from one bacterium to another during conjugation.

Question 10

Table 20.2
The following results were obtained from a disk- diffusion test for microbial susceptibility to antibiotics. Staphylococcus aureus was the test organism. $\begin{array} { l l l } 
\text { A ntibiotic } & \text { Zone of Inhibition } \mathrm { A } & 3 \mathrm {~mm} \
\text { B } & 7 \mathrm {~mm} & \
\text { C } & 0 \mathrm {~mm} & \
\text { D } & 10 \mathrm {~mm}
\end{array}$
-In Table 20.2, which antibiotic would be most useful for treating a Salmonella infection?

Accepted Answer

A)  A 
B)  B 
C)  C 
D)  D 
E)  The answer cannot be determined based on the information provided. 
A)  A 
B)  B 
C)  C 
D)  D 
E)  The answer cannot be determined based on the information provided.

Question 11

In the presence of penicillin, a cell dies because

Accepted Answer

A)  it undergoes lysis. 
B)  its contents leak out. 
C)  it plasmolyzes. 
D)  it lacks a cell membrane. 
E)  it lacks a cell wall. 
A)  it undergoes lysis. 
B)  its contents leak out. 
C)  it plasmolyzes. 
D)  it lacks a cell membrane. 
E)  it lacks a cell wall.

Question 12

Antiviral drugs target viral processes that occur during viral infection.

Accepted Answer

A) True 
 B)False

Question 13

Which of the following antimicrobial agents has the fewest side effects?

Accepted Answer

A)  penicillin 
B)  streptomycin 
C)  chloramphenicol 
D)  erythromycin 
E)  tetracycline 
A)  penicillin 
B)  streptomycin 
C)  chloramphenicol 
D)  erythromycin 
E)  tetracycline

Question 14

The antimicrobial drugs with the broadest spectrum of activity are

Accepted Answer

A)  chloramphenicol. 
B)  aminoglycosides. 
C)  penicillin G. 
D)  tetracyclines. 
E)  macrolides. 
A)  chloramphenicol. 
B)  aminoglycosides. 
C)  penicillin G. 
D)  tetracyclines. 
E)  macrolides.

Question 15

A drug that inhibits mitosis, such as griseofulvin, would be more effective against

Accepted Answer

A)  fungi. 
B)  mycobacteria. 
C)  gram- positive bacteria. 
D)  wall- less bacteria. 
E)  gram- negative bacteria. 
A)  fungi. 
B)  mycobacteria. 
C)  gram- positive bacteria. 
D)  wall- less bacteria. 
E)  gram- negative bacteria.

Question 16

Undergrowth of fungi after antibiotic use is commonly referred to as a superinfection.

Accepted Answer

A) True 
 B)False

Question 17

Which of the following does NOT affect eukaryotic cells?

Accepted Answer

A)  antihelminthic drugs 
B)  semisynthetic penicillins 
C)  antiprotozoan drugs 
D)  antifungal drugs 
E)  nucleotide analogs 
A)  antihelminthic drugs 
B)  semisynthetic penicillins 
C)  antiprotozoan drugs 
D)  antifungal drugs 
E)  nucleotide analogs

Question 18

Community- acquired MRSA is typically more virulent than health care- associated MRSA.

Accepted Answer

A) True 
 B)False

Question 19

Only microbes produce antimicrobial peptides.

Accepted Answer

A) True 
 B)False

Question 20

Which of the following antibiotics is NOT bactericidal?

Accepted Answer

A)  rifampins 
B)  aminoglycosides 
C)  cephalosporins 
D)  penicillin 
E)  polyenes 
A)  rifampins 
B)  aminoglycosides 
C)  cephalosporins 
D)  penicillin 
E)  polyenes

Exam 20: Antimicrobial Drugs

Lamisil is an allylamine used to treat dermatomycoses. Lamisil's method of action is similar to that of

Table 20.1 The following data were obtained from a broth dilution test. -In Table 20.1, the minimal inhibitory concentration of antibiotic X is

Table 20.1 The following data were obtained from a broth dilution test. -In Table 20.1, the minimal bactericidal concentration of antibiotic X is

Which of the following statements about drugs that competitively inhibit DNA polymerase or RNA polymerase is FALSE?

Due to its target, rifamycins can be effective over a broad spectrum.

To date, most of our natural antibiotics have been found to be produced by members of what genus?

Which of the following does NOT constitute an advantage of using two antibiotics together?

The antibiotic actinomycin D binds between adjacent G- C pairs, thus interfering with

Which of the following statements about drug resistance is FALSE?

In the presence of penicillin, a cell dies because

Antiviral drugs target viral processes that occur during viral infection.

Which of the following antimicrobial agents has the fewest side effects?

The antimicrobial drugs with the broadest spectrum of activity are

A drug that inhibits mitosis, such as griseofulvin, would be more effective against

Undergrowth of fungi after antibiotic use is commonly referred to as a superinfection.

Which of the following does NOT affect eukaryotic cells?

Community- acquired MRSA is typically more virulent than health care- associated MRSA.

Only microbes produce antimicrobial peptides.

Which of the following antibiotics is NOT bactericidal?

The Microbial World and You

Chemical Principles

Observing Microorganisms Through a Microscope

Functional Anatomy of Prokaryotic and Eukaryotic Cells

Microbial Metabolism

Microbial Growth

The Control of Microbial Growth

Microbial Genetics

Biotechnology and Recombinant Dna

Classification of Microorganisms

The Prokaryotes: Domains Bacteria and Archaea

The Eukaryotes: Fungi, Algae, Protozoa, and Helminths

Viruses, Viroids, and Prions

Principles of Disease and Epidemiology

Microbial Mechanisms of Pathogenicity

Innate Immunity: Nonspecific Defenses of the Host

Adaptive Immunity: Specific Defenses of the Host

Practical Applications of Immunology

Disorders Associated With the Immune System

Microbial Diseases of the Skin and Eyes

Microbial Diseases of the Nervous System

Microbial Diseases of the Cardiovascular and Lymphatic Systems

Microbial Diseases of the Respiratory System

Microbial Diseases of the Digestive System

Microbial Diseases of the Urinary and Reproductive Systems

Environmental Microbiology

Applied and Industrial Microbiology

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