Question 1

The activity of protein kinase A is affected by which of the following?
(I)caffeine
(II)levels of cAMP
(III)phosphodiesterases
(IV)cholera toxin

Accepted Answer

A) I only 
B) II only 
C) I,IV 
D) I,II,III 
E) I,II,III,IV 
A) I only 
B) II only 
C) I,IV 
D) I,II,III 
E) I,II,III,IV

Question 2

Recently a researcher has discovered several unidentified proteins (UPS-1 through UPS-3)that are up regulated (produced in higher levels)by the cell in response to the inclusion of high levels of an artificial sweetener called "sugarish".The research ran a PAGE gel of the protein samples after the cells were treated with different concentrations of "sugarish" (0-5 nm).One sample was also treated with the detergent SDS.The results are shown below.Which of the following are possible conclusions given these results and the knowledge you have gained from this chapter?  
(I)UPS-1 functions as a dimer.
(II)UPS-1 interacts with UPS-2.
(III)UPS-1 interacts with UPS-3.
(IV)UPS-2 interacts with UPS-3.

Accepted Answer

A) I,II,III,IV 
B) II,III,IV 
C) I,II 
D) I,III 
E) II,III 
A) I,II,III,IV 
B) II,III,IV 
C) I,II 
D) I,III 
E) II,III

Question 3

Which of the following are activated either directly or indirectly by a heterotrimeric G protein subunit?
(I)phospholipase C
(II)Herceptin ®
(III)calmodulin (CaM)sensitive kinase
(IV)MAPK

Accepted Answer

A) I,II,III,IV 
B) I,II 
C) I,III 
D) II,III,IV 
E) I,II,IV 
A) I,II,III,IV 
B) I,II 
C) I,III 
D) II,III,IV 
E) I,II,IV

Question 4

Based on the following figure,which of the following are possible?  
(I)"A" could be adenylate cyclase.
(II)"B" is a receptor protein.
(III)"C" could be an inactive Ras protein.
(IV)"D" could be an SH2 domain.

Accepted Answer

A) I,II,III,IV 
B) I,II,III 
C) II,III,IV 
D) I only 
E) III only 
A) I,II,III,IV 
B) I,II,III 
C) II,III,IV 
D) I only 
E) III only

Question 5

Ras is an example of
(I)a protein anchoted by prenylation.
(II)a heterotrimeric G protein.
(III)a kinase activated protein.
(IV)a GTP dependent protein.

Accepted Answer

A) I,II,III,IV 
B) I,III,IV 
C) I,III 
D) II,III,IV 
E) IV only 
A) I,II,III,IV 
B) I,III,IV 
C) I,III 
D) II,III,IV 
E) IV only

Question 6

Which of the following generalizations explains how anabolic steroids can affect muscle growth?

Accepted Answer

A) Anabolic steroids increase the level of testosterone,a hormone predominately found in males. 
B) Anabolic steroids easily pass through the membrane and bind steroid receptors which migrate to the nucleus and function as a transcription factor. 
C) Anabolic steroids are water soluble and can transport to the muscle tissue readily. 
D) Anabolic steroids alter the phosphoinositide pathway,thereby increasing levels of calcium in the cytosol and subsequently increase the strength of muscle contraction. 
E) None of the above is correct. 
A) Anabolic steroids increase the level of testosterone,a hormone predominately found in males. 
B) Anabolic steroids easily pass through the membrane and bind steroid receptors which migrate to the nucleus and function as a transcription factor. 
C) Anabolic steroids are water soluble and can transport to the muscle tissue readily. 
D) Anabolic steroids alter the phosphoinositide pathway,thereby increasing levels of calcium in the cytosol and subsequently increase the strength of muscle contraction. 
E) None of the above is correct.

Question 7

Which of the following are produced in the adrenal cortex?
(I)Glucorticoids
(II)mineralcorticoides
(III)androgens
(IV)estrogens

Accepted Answer

A) I only 
B) I,II 
C) II only 
D) II,IV 
E) I,II,III,IV 
A) I only 
B) I,II 
C) II only 
D) II,IV 
E) I,II,III,IV

Question 8

The insulin signaling pathway includes which of the following steps?

Accepted Answer

A) ligand-induced dimerization of the receptor and phosphorylation of IRS-1 and/or IRS-2 proteins 
B) autophosphorylation and phosphorylation of IRS-1 and/or IRS-2 proteins 
C) IRS-1-induced dimerization of the receptor,autophosphorylation,and phosphorylation of SH2 domains 
D) autophosphorylation and dephosphorylation of IRS-1 and/or SH2 domains 
E) none of the above 
A) ligand-induced dimerization of the receptor and phosphorylation of IRS-1 and/or IRS-2 proteins 
B) autophosphorylation and phosphorylation of IRS-1 and/or IRS-2 proteins 
C) IRS-1-induced dimerization of the receptor,autophosphorylation,and phosphorylation of SH2 domains 
D) autophosphorylation and dephosphorylation of IRS-1 and/or SH2 domains 
E) none of the above

Question 9

Sildenafil (Viagra®)

Accepted Answer

A) inhibits activity of a phosphoprotein phosphatase. 
B) increases the relative concentration of cGMP. 
C) increases the relative concentration of nitric oxide in the blood. 
D) A,B,and C 
E) A and B 
A) inhibits activity of a phosphoprotein phosphatase. 
B) increases the relative concentration of cGMP. 
C) increases the relative concentration of nitric oxide in the blood. 
D) A,B,and C 
E) A and B

Question 10

Oncogenes
(I)function as cell cycle inhibitors.
(II)encode a protein which block cell cycle inhibition.
(III)are expressed by cells that have higher levels of human growth hormone.
(IV)can function as transcription factors.

Accepted Answer

A) I,III,IV 
B) II,III 
C) III,IV 
D) II,IV 
E) II 
A) I,III,IV 
B) II,III 
C) III,IV 
D) II,IV 
E) II

The activity of protein kinase A is affected by which of the following? (I)caffeine (II)levels of cAMP (III)phosphodiesterases (IV)cholera toxin

Which of the following are activated either directly or indirectly by a heterotrimeric G protein subunit? (I)phospholipase C (II)Herceptin ® (III)calmodulin (CaM)sensitive kinase (IV)MAPK

Based on the following figure,which of the following are possible? (I)"A" could be adenylate cyclase. (II)"B" is a receptor protein. (III)"C" could be an inactive Ras protein. (IV)"D" could be an SH2 domain.

Ras is an example of (I)a protein anchoted by prenylation. (II)a heterotrimeric G protein. (III)a kinase activated protein. (IV)a GTP dependent protein.

Which of the following generalizations explains how anabolic steroids can affect muscle growth?

Which of the following are produced in the adrenal cortex? (I)Glucorticoids (II)mineralcorticoides (III)androgens (IV)estrogens

The insulin signaling pathway includes which of the following steps?

Sildenafil (Viagra®)

Oncogenes (I)function as cell cycle inhibitors. (II)encode a protein which block cell cycle inhibition. (III)are expressed by cells that have higher levels of human growth hormone. (IV)can function as transcription factors.

Introduction to the Chemistry of Life

Water

Nucleotides, nucleic Acids, and Genetic Information

Amino Acids

Proteins: Primary Structure

Proteins: Three-Dimensional Structure

Protein Function Part I: Myoglobin and Hemoglobin

Carbohydrates

Lipids and Biological Membranes

Membrane Transport

Enzyme Catalysis

Enzyme Kinetics, inhibition and Control

Introduction to Metabolism

Glucose Catabolism

Glycogen Metabolism and Gluconeogenesis

Citric Acid Cycle

Electron Transport and Oxidative Phosphorylation

Photosynthesis

Lipid Metabolism

Amino Acid Metabolism

Mammalian Fuel Metabolism: Integration and Regulation

Nucleotide Metabolism

Nucleic Acid Structure

DNA Replication, repair and Recombination

Transcription and Rna Processing

Protein Synthesis

Regulation of Gene Expression

Filters

Exam 13: Biochemical Signaling

The activity of protein kinase A is affected by which of the following? (I)caffeine (II)levels of cAMP (III)phosphodiesterases (IV)cholera toxin

Which of the following are activated either directly or indirectly by a heterotrimeric G protein subunit? (I)phospholipase C (II)Herceptin ® (III)calmodulin (CaM)sensitive kinase (IV)MAPK

Based on the following figure,which of the following are possible? (I)"A" could be adenylate cyclase. (II)"B" is a receptor protein. (III)"C" could be an inactive Ras protein. (IV)"D" could be an SH2 domain.

Ras is an example of (I)a protein anchoted by prenylation. (II)a heterotrimeric G protein. (III)a kinase activated protein. (IV)a GTP dependent protein.

Which of the following generalizations explains how anabolic steroids can affect muscle growth?

Which of the following are produced in the adrenal cortex? (I)Glucorticoids (II)mineralcorticoides (III)androgens (IV)estrogens

The insulin signaling pathway includes which of the following steps?

Sildenafil (Viagra®)

Oncogenes (I)function as cell cycle inhibitors. (II)encode a protein which block cell cycle inhibition. (III)are expressed by cells that have higher levels of human growth hormone. (IV)can function as transcription factors.

Introduction to the Chemistry of Life

Water

Nucleotides, nucleic Acids, and Genetic Information

Amino Acids

Proteins: Primary Structure

Proteins: Three-Dimensional Structure

Protein Function Part I: Myoglobin and Hemoglobin

Carbohydrates

Lipids and Biological Membranes

Membrane Transport

Enzyme Catalysis

Enzyme Kinetics, inhibition and Control

Introduction to Metabolism

Glucose Catabolism

Glycogen Metabolism and Gluconeogenesis

Citric Acid Cycle

Electron Transport and Oxidative Phosphorylation

Photosynthesis

Lipid Metabolism

Amino Acid Metabolism

Mammalian Fuel Metabolism: Integration and Regulation

Nucleotide Metabolism

Nucleic Acid Structure

DNA Replication, repair and Recombination

Transcription and Rna Processing

Protein Synthesis

Regulation of Gene Expression

Filters