Exam 19: Cell Death and Cell Renewal

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Liver cell injury induces proliferation of liver stem cells.

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The clinical application of adult stem cells is limited by difficulties in isolating and culturing the appropriate stem cell populations.

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Which of the following cells cannot develop from hematopoietic stem cells?

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Bone marrow transplants are used to treat patients with

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Why are skin, hair, intestinal epithelia, and blood cells particularly problematic areas after radiation exposure or chemotherapy for cancer?

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Each of the three cell types in the adult intestinal epithelium is derived from a different stem cell.

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Which of the following stem cells can give rise to all the differentiated cell types of adult organisms?

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The two proapoptotic proteins that enable the release of cytochrome c from the mitochondria are _______ and _______.

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Intestinal epithelial stem cells are located _______ the crypt.

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Which of the following transcription factors has the potential to act as an oncogene, resulting in a high risk of cancer?

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The reprogramming of somatic cells into other types of differentiated cells (other than induced pluripotent stem cells) is referred to as

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Which of the following is not phosphorylated by Akt?

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Cell death in cancer cells can be caused by the cytokine _______.

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Satellite cells are located beneath the basal lamina of muscle fibers.

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A mutant bcl-2 gene can be an oncogene.

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What do skeletal muscle stem cells do when activated?

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The following represents a signal transduction cascade initiated by double-stranded DNA damage and ending with activation of apoptosis by the BH3-only proteins PUMA and Noxa. Double-stranded DNA damage; Chk2; _______; PUMA/Noxa; apoptosis. Which protein belongs in the blank?

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Mammalian embryonic stem cells are cultured from cells taken from

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Of the offspring that result from the reproductive cloning of mammals by somatic nuclear transfer, _______% are viable.

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Using approaches similar to those of Takahashi and Yamanaka, scientists have now reprogrammed adult fibroblasts to become

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