Exam 12: Amines

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Show how each of the following transformations might be best accomplished. More than one step may be required. Show all reagents and all intermediate structures. -Refer to instructions. Show how each of the following transformations might be best accomplished.  More than one step may be required.  Show all reagents and all intermediate structures. -Refer to instructions.

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Instructions: Give the major organic product(s) of each of the following reaction or sequence of reactions. Show all relevant stereochemistry. -Give major product(s): Instructions: Give the major organic product(s) of each of the following reaction or sequence of reactions. Show all relevant stereochemistry. -Give major product(s):

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Which of the following compounds are tertiary (3 °\degree ) amines? 1. (CH3)2CHN(CH3)2 2. CH3CH(CH3)N(CH2CH3)2 3. CH3CH2CH2NHCH3 4. CH3CH2CH2CH2CH2NH2

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A

Show how each of the following transformations might be best accomplished. More than one step may be required. Show all reagents and all intermediate structures. -Refer to instructions. Show how each of the following transformations might be best accomplished.  More than one step may be required.  Show all reagents and all intermediate structures. -Refer to instructions.

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In the following series of compounds, which is the most basic and the least basic? Explain your choices. In the following series of compounds, which is the most basic and the least basic? Explain your choices.

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Instructions: Classify each of the nitrogen atoms in the compound shown below as primary, secondary, tertiary, or quaternary. -Classify: Instructions: Classify each of the nitrogen atoms in the compound shown below as primary, secondary, tertiary, or quaternary. -Classify:

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Instructions: Consider the reaction below to answer the following question(s). Methamphetamine can be synthesized by reacting phenyl-2-propanone with methylamine in the presence of H2/Ni. Instructions: Consider the reaction below to answer the following question(s). Methamphetamine can be synthesized by reacting phenyl-2-propanone with methylamine in the presence of H<sub>2</sub>/Ni.   -Refer to instructions. The synthesis of methamphetamine by reaction of 2-phenyl-2 propanone with methylamine in the presence of H<sub>2</sub>/Ni is referred to as: -Refer to instructions. The synthesis of methamphetamine by reaction of 2-phenyl-2 propanone with methylamine in the presence of H2/Ni is referred to as:

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Instructions: Consider the reaction below to answer the following question(s). Methamphetamine can be synthesized by reacting phenyl-2-propanone with methylamine in the presence of H2/Ni. Instructions: Consider the reaction below to answer the following question(s). Methamphetamine can be synthesized by reacting phenyl-2-propanone with methylamine in the presence of H<sub>2</sub>/Ni.   -Refer to instructions. Although the yield of methamphetamine is good, some unreacted phenyl-2-propanone remains after the reaction is complete. Describe how methamphetamine can be separated from phenyl-2-propanone. -Refer to instructions. Although the yield of methamphetamine is good, some unreacted phenyl-2-propanone remains after the reaction is complete. Describe how methamphetamine can be separated from phenyl-2-propanone.

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Instructions: Classify each of the nitrogen atoms in the compound shown below as primary, secondary, tertiary, or quaternary. -Classify: Instructions: Classify each of the nitrogen atoms in the compound shown below as primary, secondary, tertiary, or quaternary. -Classify:

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Instructions: Draw structures corresponding to each of the IUPAC names given in the following question(s). -Draw: N,N-dimethylcyclopentylamine

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Instructions: Give the major organic product(s) of each of the following reaction or sequence of reactions. Show all relevant stereochemistry. -Give major product(s): Instructions: Give the major organic product(s) of each of the following reaction or sequence of reactions. Show all relevant stereochemistry. -Give major product(s):

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Instructions: Based on the following structures, name the compound. -Name: Instructions: Based on the following structures, name the compound. -Name:

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Instructions: Consider the reaction below to answer the following question(s). Methamphetamine can be synthesized by reacting phenyl-2-propanone with methylamine in the presence of H2/Ni. Instructions: Consider the reaction below to answer the following question(s). Methamphetamine can be synthesized by reacting phenyl-2-propanone with methylamine in the presence of H<sub>2</sub>/Ni.   -Refer to instructions. Intermediate A is an example of: -Refer to instructions. Intermediate A is an example of:

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What is the major organic product obtained from the following reaction? What is the major organic product obtained from the following reaction?

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Instructions: Consider the reaction below to answer the following question(s). Methamphetamine can be synthesized by reacting phenyl-2-propanone with methylamine in the presence of H2/Ni. Instructions: Consider the reaction below to answer the following question(s). Methamphetamine can be synthesized by reacting phenyl-2-propanone with methylamine in the presence of H<sub>2</sub>/Ni.   -Refer to instructions. Identify the nucleophile in the initial reaction of phenyl-2-propanone to yield intermediate A and classify the type of reaction that produces the final product from A. -Refer to instructions. Identify the nucleophile in the initial reaction of phenyl-2-propanone to yield intermediate A and classify the type of reaction that produces the final product from A.

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Instructions: Draw structures corresponding to each of the IUPAC names given in the following question(s). -Draw: hexane-1,6-diamine

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Instructions: Give the major organic product(s) of each of the following reaction or sequence of reactions. Show all relevant stereochemistry. -Give major product(s): Instructions: Give the major organic product(s) of each of the following reaction or sequence of reactions. Show all relevant stereochemistry. -Give major product(s):

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Instructions: Draw structures corresponding to each of the IUPAC names given in the following question(s). -Draw: diisopropylamine

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Instructions: Give the major organic product(s) of each of the following reaction or sequence of reactions. Show all relevant stereochemistry. -Give major product(s): Instructions: Give the major organic product(s) of each of the following reaction or sequence of reactions. Show all relevant stereochemistry. -Give major product(s):

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Instructions: Based on the following structures, name the compound. -Name: Instructions: Based on the following structures, name the compound. -Name:

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