Question 1

When the bone marrow temporarily ceases to produce cells in a sickle cell patient, a(n) _____crisis has occurred.

Accepted Answer

A)  aplastic 
B)  hemolytic 
C)  vaso-occlusive 
D)  cardiac 
A)  aplastic 
B)  hemolytic 
C)  vaso-occlusive 
D)  cardiac A

Question 2

The Benin haplotype of sickle cell disease is prevalent in which country or countries?

Accepted Answer

A)  Saudi Arabia and Asia 
B)  Senegal 
C)  West Africa 
D)  Central and South Africa 
A)  Saudi Arabia and Asia 
B)  Senegal 
C)  West Africa 
D)  Central and South Africa C

Question 3

In hemoglobin C disease, the majority of the red cells appear as:

Accepted Answer

A)  Target cells 
B)  Spherocytes 
C)  Elliptocytes 
D)  "Bars of gold" 
A)  Target cells 
B)  Spherocytes 
C)  Elliptocytes 
D)  "Bars of gold" A

Question 4

Mr.Bennett was admitted with a hematocrit of 28%.He has a history of chronic anemia, moderate splenomegaly, and recent retinal hemorrhages.His peripheral smear reveals target cells, and some show structures jutting from the red cell membrane.The most probable diagnosis is:

Accepted Answer

A)  Hgb S-S 
B)  Hgb A-C 
C)  Hgb S-C 
D)  Hgb A-A 
A)  Hgb S-S 
B)  Hgb A-C 
C)  Hgb S-C 
D)  Hgb A-A

Question 5

is the second most common hemoglobin variant worldwide.

Accepted Answer

A)  Hemoglobin S 
B)  Hemoglobin E 
C)  Hemoglobin C 
D)  Hemoglobin D 
A)  Hemoglobin S 
B)  Hemoglobin E 
C)  Hemoglobin C 
D)  Hemoglobin D

Question 6

A patient with sickle cell anemia may develop cardiopulmonary disease due to:

Accepted Answer

A)  Untreated leg ulcers 
B)  High blood viscosity 
C)  Increased Hgb F levels 
D)  Hemolytic crisis 
A)  Untreated leg ulcers 
B)  High blood viscosity 
C)  Increased Hgb F levels 
D)  Hemolytic crisis

Question 7

Which of the following is an alpha chain variant?

Accepted Answer

A)  Hemoglobin C 
B)  Hemoglobin G 
C)  Hemoglobin S 
D)  Hemoglobin A2 
A)  Hemoglobin C 
B)  Hemoglobin G 
C)  Hemoglobin S 
D)  Hemoglobin A2

Question 8

In sickle cell anemia, _____is substituted for glutamine.

Accepted Answer

A)  valine 
B)  lysine 
C)  adenine 
D)  leucine 
A)  valine 
B)  lysine 
C)  adenine 
D)  leucine

Question 9

A blood smear from a patient with sickle cell crisis shows 80 nucleated red cells per 100 leukocytes.The total leukocyte count is 18 F1F1F1S1F1F1F10 109/L.The corrected white cell count is:

Accepted Answer

A)  17,200 
B)  9,000 
C)  10,000 
D)  13,400 
A)  17,200 
B)  9,000 
C)  10,000 
D)  13,400

Question 10

Autosplenectomy is characteristic of:

Accepted Answer

A)  Sickle cell trait 
B)  Hgb C disease 
C)  Thalassemia 
D)  Sickle cell anemia 
A)  Sickle cell trait 
B)  Hgb C disease 
C)  Thalassemia 
D)  Sickle cell anemia

Question 11

The hemoglobin that cannot be separated from Hgb S through electrophoresis in buffer at pH 8.6 is:

Accepted Answer

A)  Hgb D 
B)  Hgb C 
C)  Hgb A 
D)  Hgb F 
A)  Hgb D 
B)  Hgb C 
C)  Hgb A 
D)  Hgb F

Question 12

-The cell at the tip of the pointer would be described as a/an:

Accepted Answer

A)  Acanthocyte 
B)  Elliptocyte 
C)  Sickle cell 
D)  Stomatocyte 
A)  Acanthocyte 
B)  Elliptocyte 
C)  Sickle cell 
D)  Stomatocyte

Question 13

Which of the following "poikilocytes" are classically associated with hemoglobinopathies and liver disease?

Accepted Answer

A)  Spherocytes 
B)  Sickle cells 
C)  Acanthocytes 
D)  Target cells 
A)  Spherocytes 
B)  Sickle cells 
C)  Acanthocytes 
D)  Target cells

Question 14

Painful swelling of hands and feet caused by sickle cells in the microcirculation of sickle cells infants is termed:

Accepted Answer

A)  Dactylitis 
B)  Necrosis 
C)  Apoptosis 
D)  Fibrosis 
A)  Dactylitis 
B)  Necrosis 
C)  Apoptosis 
D)  Fibrosis

Question 15

Patients with sickle cell anemia generally have a hemoglobin value between:

Accepted Answer

A)  2 and 4 g/dL 
B)  6 and 8 g/dL 
C)  8 and 10 g/dL 
D)  10 and 12 g/dL 
A)  2 and 4 g/dL 
B)  6 and 8 g/dL 
C)  8 and 10 g/dL 
D)  10 and 12 g/dL

Question 16

The hemoglobin variant that is seen frequently in the Southeast Asian population, and migrates with Hgb C at pH 8.6, is:

Accepted Answer

A)  Bart's 
B)  F 
C)  E 
D)  H 
A)  Bart's 
B)  F 
C)  E 
D)  H

Question 17

Sickle cell disease is best differentiated from sickle cell trait by:

Accepted Answer

A)  Wright smear examination 
B)  Determination of fetal hemoglobin 
C)  Genetic testing 
D)  Hemoglobin electrophoresis 
A)  Wright smear examination 
B)  Determination of fetal hemoglobin 
C)  Genetic testing 
D)  Hemoglobin electrophoresis

Question 18

In hemoglobin C disease, is substituted for glutamic acid.

Accepted Answer

A)  valine 
B)  adenine 
C)  lysine 
D)  leucine 
A)  valine 
B)  adenine 
C)  lysine 
D)  leucine

Question 19

In patients with sickle cell trait and no complicating disease:

Accepted Answer

A)  NRBCs and polychromasia are usually seen on the peripheral smear 
B)  Sickle cells are prevalent in the peripheral blood 
C)  There may be occasional hematuria 
D)  There is a severe decrease in Hgb, Hct, and RBC count 
A)  NRBCs and polychromasia are usually seen on the peripheral smear 
B)  Sickle cells are prevalent in the peripheral blood 
C)  There may be occasional hematuria 
D)  There is a severe decrease in Hgb, Hct, and RBC count

Question 20

Alkaline electrophoresis will not separate hemoglobin C from:

Accepted Answer

A)  Hemoglobin A2 
B)  Hemoglobin F 
C)  Hemoglobin S 
D)  Hemoglobin A 
A)  Hemoglobin A2 
B)  Hemoglobin F 
C)  Hemoglobin S 
D)  Hemoglobin A

When the bone marrow temporarily ceases to produce cells in a sickle cell patient, a(n) _____crisis has occurred.

The Benin haplotype of sickle cell disease is prevalent in which country or countries?

In hemoglobin C disease, the majority of the red cells appear as:

Mr.Bennett was admitted with a hematocrit of 28%.He has a history of chronic anemia, moderate splenomegaly, and recent retinal hemorrhages.His peripheral smear reveals target cells, and some show structures jutting from the red cell membrane.The most probable diagnosis is:

is the second most common hemoglobin variant worldwide.

A patient with sickle cell anemia may develop cardiopulmonary disease due to:

Which of the following is an alpha chain variant?

In sickle cell anemia, _____is substituted for glutamine.

A blood smear from a patient with sickle cell crisis shows 80 nucleated red cells per 100 leukocytes.The total leukocyte count is 18  10⁹/L.The corrected white cell count is:

Autosplenectomy is characteristic of:

The hemoglobin that cannot be separated from Hgb S through electrophoresis in buffer at pH 8.6 is:

-The cell at the tip of the pointer would be described as a/an:

Which of the following "poikilocytes" are classically associated with hemoglobinopathies and liver disease?

Painful swelling of hands and feet caused by sickle cells in the microcirculation of sickle cells infants is termed:

Patients with sickle cell anemia generally have a hemoglobin value between:

The hemoglobin variant that is seen frequently in the Southeast Asian population, and migrates with Hgb C at pH 8.6, is:

Sickle cell disease is best differentiated from sickle cell trait by:

In hemoglobin C disease, is substituted for glutamic acid.

In patients with sickle cell trait and no complicating disease:

Alkaline electrophoresis will not separate hemoglobin C from:

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Red Blood Cell Production, Function, and Relevant Red Blood Cell Morphology

Hemoglobin Function and Principles of Hemolysis

The Microcytic Anemias

The Macrocytic Anemias

Normochromic Anemias: Biochemical, Membrane, and Miscellaneous Red Blood Cell Disorders

Leukopoiesis and Leukopoietic Function

Abnormalities of White Blood Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Chronic Myeloproliferative Disorders

Lymphoproliferative Disorders and Related Plasma Cell Disorders

The Myelodysplastic Syndromes

Overview of Hemostasis and Platelet Physiology

Quantitative and Qualitative Platelet Disorders

Defects of Plasma Clotting Factors

Fibrinogen, Thrombin, and the Fibrinolytic System

Introduction to Thrombosis and Anticoagulant Therapy

Filters

Exam 8: The Normochromic Anemias Caused by Hemoglobinopathies

When the bone marrow temporarily ceases to produce cells in a sickle cell patient, a(n) _____crisis has occurred.

The Benin haplotype of sickle cell disease is prevalent in which country or countries?

In hemoglobin C disease, the majority of the red cells appear as:

Mr.Bennett was admitted with a hematocrit of 28%.He has a history of chronic anemia, moderate splenomegaly, and recent retinal hemorrhages.His peripheral smear reveals target cells, and some show structures jutting from the red cell membrane.The most probable diagnosis is:

is the second most common hemoglobin variant worldwide.

A patient with sickle cell anemia may develop cardiopulmonary disease due to:

Which of the following is an alpha chain variant?

In sickle cell anemia, _____is substituted for glutamine.

A blood smear from a patient with sickle cell crisis shows 80 nucleated red cells per 100 leukocytes.The total leukocyte count is 18  109/L.The corrected white cell count is:

Autosplenectomy is characteristic of:

The hemoglobin that cannot be separated from Hgb S through electrophoresis in buffer at pH 8.6 is:

-The cell at the tip of the pointer would be described as a/an:

Which of the following "poikilocytes" are classically associated with hemoglobinopathies and liver disease?

Painful swelling of hands and feet caused by sickle cells in the microcirculation of sickle cells infants is termed:

Patients with sickle cell anemia generally have a hemoglobin value between:

The hemoglobin variant that is seen frequently in the Southeast Asian population, and migrates with Hgb C at pH 8.6, is:

Sickle cell disease is best differentiated from sickle cell trait by:

In hemoglobin C disease, is substituted for glutamic acid.

In patients with sickle cell trait and no complicating disease:

Alkaline electrophoresis will not separate hemoglobin C from:

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Red Blood Cell Production, Function, and Relevant Red Blood Cell Morphology

Hemoglobin Function and Principles of Hemolysis

The Microcytic Anemias

The Macrocytic Anemias

Normochromic Anemias: Biochemical, Membrane, and Miscellaneous Red Blood Cell Disorders

Leukopoiesis and Leukopoietic Function

Abnormalities of White Blood Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Chronic Myeloproliferative Disorders

Lymphoproliferative Disorders and Related Plasma Cell Disorders

The Myelodysplastic Syndromes

Overview of Hemostasis and Platelet Physiology

Quantitative and Qualitative Platelet Disorders

Defects of Plasma Clotting Factors

Fibrinogen, Thrombin, and the Fibrinolytic System

Introduction to Thrombosis and Anticoagulant Therapy

Filters

A blood smear from a patient with sickle cell crisis shows 80 nucleated red cells per 100 leukocytes.The total leukocyte count is 18  10⁹/L.The corrected white cell count is: