Question 1

Which of the following is not an embryonic hemoglobin?

Accepted Answer

A)  Hgb Portland 
B)  Hgb F 
C)  Hgb Gowers I 
D)  Hgb Gowers II 
A)  Hgb Portland 
B)  Hgb F 
C)  Hgb Gowers I 
D)  Hgb Gowers II B

Question 2

What percentage of hemoglobin is synthesized in the reticulocyte stage?

Accepted Answer

A)  65% 
B)  95% 
C)  35% 
D)  45% 
A)  65% 
B)  95% 
C)  35% 
D)  45% C

Question 3

Each hemoglobin molecule consists of heme structures.

Accepted Answer

A)  two 
B)  four 
C)  six 
D)  eight 
A)  two 
B)  four 
C)  six 
D)  eight B

Question 4

90% of in vivo hemolysis is intravascular.

Accepted Answer

A) True 
 B)False

Question 5

Which of the following abnormal hemoglobins will result in a cyanotic condition?

Accepted Answer

A)  Sulfhemoglobin 
B)  Cyanmethemoglobin 
C)  Hemoglobin F 
D)  Hemoglobin M 
A)  Sulfhemoglobin 
B)  Cyanmethemoglobin 
C)  Hemoglobin F 
D)  Hemoglobin M

Question 6

Which of the following factors will result in an immediate increase in oxygen delivery to the tissues?

Accepted Answer

A)  Increased pH 
B)  Increased altitude 
C)  Increased 2,3-DPG 
D)  Increased carboxyhemoglobin 
A)  Increased pH 
B)  Increased altitude 
C)  Increased 2,3-DPG 
D)  Increased carboxyhemoglobin

Question 7

Which organ(s) is the most affected during extravascular lysis?

Accepted Answer

A)  Liver and spleen 
B)  Kidney 
C)  Pancreas 
D)  Heart 
A)  Liver and spleen 
B)  Kidney 
C)  Pancreas 
D)  Heart

Question 8

Abnormal hemoglobins have a lower affinity for oxygen.

Accepted Answer

A) True 
 B)False

Question 9

____may be seen in intravascular hemolysis but not in extravascular hemolysis.

Accepted Answer

A)  Hemoglobinuria 
B)  Splenomegaly 
C)  Increased LDH 
D)  Elevated serum bilirubin 
A)  Hemoglobinuria 
B)  Splenomegaly 
C)  Increased LDH 
D)  Elevated serum bilirubin

Question 10

Hemoglobin begins to be synthesized at the polychromatophilic stage of red cell development.

Accepted Answer

A) True 
 B)False

Question 11

The hemoglobin molecule will either hold onto or release oxygen depending on the:

Accepted Answer

A)  Amount of alpha or beta chains 
B)  Relationship between the pulmonary and venous circulations 
C)  Viscosity of the blood 
D)  M:E ratio 
A)  Amount of alpha or beta chains 
B)  Relationship between the pulmonary and venous circulations 
C)  Viscosity of the blood 
D)  M:E ratio

Question 12

Fetal hemoglobin consists of which of the following chains?

Accepted Answer

A)  F1F1F1S1F1F1F102F1F1F1S1F1F1F102 
B)  F1F1F1S1F1F1F102F1F1F1S1F1F1F102 
C)  F1F1F1S1F1F1F102F1F1F1S1F1F1F102 
D)  F1F1F1S1F1F1F102F1F1F1S1F1F1F102 
A)  F1F1F1S1F1F1F102F1F1F1S1F1F1F102 
B)  F1F1F1S1F1F1F102F1F1F1S1F1F1F102 
C)  F1F1F1S1F1F1F102F1F1F1S1F1F1F102 
D)  F1F1F1S1F1F1F102F1F1F1S1F1F1F102

Question 13

How many genes are responsible for the productions of alpha chains?

Accepted Answer

A)  Two 
B)  One 
C)  Three 
D)  Four 
A)  Two 
B)  One 
C)  Three 
D)  Four

Question 14

Oxygen delivery is the primary purpose of hemoglobin.

Accepted Answer

A) True 
 B)False

Question 15

When iron is present in an oxidized state, as Fe+3 or ferric iron, the resulting hemoglobin is known as:

Accepted Answer

A)  Methemoglobin 
B)  Carboxyhemoglobin 
C)  Sulfhemoglobin 
D)  Deoxyhemoglobin 
A)  Methemoglobin 
B)  Carboxyhemoglobin 
C)  Sulfhemoglobin 
D)  Deoxyhemoglobin

Question 16

What is the term used to define the process by which the bone marrow responds to anemia-induced stress?

Accepted Answer

A)  Ineffective erythropoiesis 
B)  Aplastic anemia 
C)  Erythroid hyperplasia 
D)  Medullary erythropoiesis 
A)  Ineffective erythropoiesis 
B)  Aplastic anemia 
C)  Erythroid hyperplasia 
D)  Medullary erythropoiesis

Question 17

Epsilon and zeta chains are part of which of the following hemoglobins?

Accepted Answer

A)  Hemoglobin Portland 
B)  Hemoglobin F 
C)  Hemoglobin A 
D)  Hemoglobin A2 
A)  Hemoglobin Portland 
B)  Hemoglobin F 
C)  Hemoglobin A 
D)  Hemoglobin A2

Question 18

Which of the following clinical conditions is a definitive sign of intravascular lysis?

Accepted Answer

A)  Bilirubinemia 
B)  Decreased RBC count 
C)  Hemoglobinuria 
D)  Elevated LDH 
A)  Bilirubinemia 
B)  Decreased RBC count 
C)  Hemoglobinuria 
D)  Elevated LDH

Question 19

Intrinsic red cell defects that can lead to hemolysis include:

Accepted Answer

A)  Environmental effects 
B)  Inherited deficiencies 
C)  A shift in pH 
D)  A decrease in G6PD 
A)  Environmental effects 
B)  Inherited deficiencies 
C)  A shift in pH 
D)  A decrease in G6PD

Question 20

Physiologic conditions in the body that can decrease hemoglobin's oxygen affinity include:

Accepted Answer

A)  Increased pH 
B)  Decreased 2,3-DPG 
C)  Increased body temp 
D)  The presence of abnormal hemoglobins 
A)  Increased pH 
B)  Decreased 2,3-DPG 
C)  Increased body temp 
D)  The presence of abnormal hemoglobins

Which of the following is not an embryonic hemoglobin?

What percentage of hemoglobin is synthesized in the reticulocyte stage?

Each hemoglobin molecule consists of heme structures.

90% of in vivo hemolysis is intravascular.

Which of the following abnormal hemoglobins will result in a cyanotic condition?

Which of the following factors will result in an immediate increase in oxygen delivery to the tissues?

Which organ(s) is the most affected during extravascular lysis?

Abnormal hemoglobins have a lower affinity for oxygen.

____may be seen in intravascular hemolysis but not in extravascular hemolysis.

Hemoglobin begins to be synthesized at the polychromatophilic stage of red cell development.

The hemoglobin molecule will either hold onto or release oxygen depending on the:

Fetal hemoglobin consists of which of the following chains?

How many genes are responsible for the productions of alpha chains?

Oxygen delivery is the primary purpose of hemoglobin.

When iron is present in an oxidized state, as Fe⁺³ or ferric iron, the resulting hemoglobin is known as:

What is the term used to define the process by which the bone marrow responds to anemia-induced stress?

Epsilon and zeta chains are part of which of the following hemoglobins?

Which of the following clinical conditions is a definitive sign of intravascular lysis?

Intrinsic red cell defects that can lead to hemolysis include:

Physiologic conditions in the body that can decrease hemoglobin's oxygen affinity include:

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Red Blood Cell Production, Function, and Relevant Red Blood Cell Morphology

The Microcytic Anemias

The Macrocytic Anemias

Normochromic Anemias: Biochemical, Membrane, and Miscellaneous Red Blood Cell Disorders

The Normochromic Anemias Caused by Hemoglobinopathies

Leukopoiesis and Leukopoietic Function

Abnormalities of White Blood Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Chronic Myeloproliferative Disorders

Lymphoproliferative Disorders and Related Plasma Cell Disorders

The Myelodysplastic Syndromes

Overview of Hemostasis and Platelet Physiology

Quantitative and Qualitative Platelet Disorders

Defects of Plasma Clotting Factors

Fibrinogen, Thrombin, and the Fibrinolytic System

Introduction to Thrombosis and Anticoagulant Therapy

Filters

Exam 4: Hemoglobin Function and Principles of Hemolysis

Which of the following is not an embryonic hemoglobin?

What percentage of hemoglobin is synthesized in the reticulocyte stage?

Each hemoglobin molecule consists of heme structures.

90% of in vivo hemolysis is intravascular.

Which of the following abnormal hemoglobins will result in a cyanotic condition?

Which of the following factors will result in an immediate increase in oxygen delivery to the tissues?

Which organ(s) is the most affected during extravascular lysis?

Abnormal hemoglobins have a lower affinity for oxygen.

____may be seen in intravascular hemolysis but not in extravascular hemolysis.

Hemoglobin begins to be synthesized at the polychromatophilic stage of red cell development.

The hemoglobin molecule will either hold onto or release oxygen depending on the:

Fetal hemoglobin consists of which of the following chains?

How many genes are responsible for the productions of alpha chains?

Oxygen delivery is the primary purpose of hemoglobin.

When iron is present in an oxidized state, as Fe+3 or ferric iron, the resulting hemoglobin is known as:

What is the term used to define the process by which the bone marrow responds to anemia-induced stress?

Epsilon and zeta chains are part of which of the following hemoglobins?

Which of the following clinical conditions is a definitive sign of intravascular lysis?

Intrinsic red cell defects that can lead to hemolysis include:

Physiologic conditions in the body that can decrease hemoglobin's oxygen affinity include:

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Red Blood Cell Production, Function, and Relevant Red Blood Cell Morphology

The Microcytic Anemias

The Macrocytic Anemias

Normochromic Anemias: Biochemical, Membrane, and Miscellaneous Red Blood Cell Disorders

The Normochromic Anemias Caused by Hemoglobinopathies

Leukopoiesis and Leukopoietic Function

Abnormalities of White Blood Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Chronic Myeloproliferative Disorders

Lymphoproliferative Disorders and Related Plasma Cell Disorders

The Myelodysplastic Syndromes

Overview of Hemostasis and Platelet Physiology

Quantitative and Qualitative Platelet Disorders

Defects of Plasma Clotting Factors

Fibrinogen, Thrombin, and the Fibrinolytic System

Introduction to Thrombosis and Anticoagulant Therapy

Filters

When iron is present in an oxidized state, as Fe⁺³ or ferric iron, the resulting hemoglobin is known as: