Question 1

Essential thrombocytosis can affect all three cell lines, but the main cell line affected is the:

Accepted Answer

A)  Megakaryocytes 
B)  Erythrocytes 
C)  Granulocytes 
D)  Lymphocytes 
A)  Megakaryocytes 
B)  Erythrocytes 
C)  Granulocytes 
D)  Lymphocytes A

Question 2

Which of the following is associated with CML but not AML?

Accepted Answer

A)  Infections 
B)  WBC greater than 20,000 
C)  Hemorrhage 
D)  Splenomegaly 
A)  Infections 
B)  WBC greater than 20,000 
C)  Hemorrhage 
D)  Splenomegaly D

Question 3

To calculate the LAP score on a blood smear:

Accepted Answer

A)  Add the scores for the 100 neutrophils counted 
B)  Average the scores for all cells counted 
C)  Add the scores for the 100 leukocytes counted 
D)  Calculate the percentage of positive reacting cells 
A)  Add the scores for the 100 neutrophils counted 
B)  Average the scores for all cells counted 
C)  Add the scores for the 100 leukocytes counted 
D)  Calculate the percentage of positive reacting cells A

Question 4

The translocation of genetic material, t9:22, is associated with:

Accepted Answer

A)  The Philadelphia chromosome 
B)  ALL 
C)  A leukemoid reaction 
D)  Polycythemia vera 
A)  The Philadelphia chromosome 
B)  ALL 
C)  A leukemoid reaction 
D)  Polycythemia vera

Question 5

A term describing a peripheral blood finding of leukocytosis with a shift to the left accompanied by occasional nucleated red cells and platelet abnormalities is:

Accepted Answer

A)  Dysplasia 
B)  Leukoerythroblastic 
C)  Megaloblastoid 
D)  Leukemoid 
A)  Dysplasia 
B)  Leukoerythroblastic 
C)  Megaloblastoid 
D)  Leukemoid

Question 6

Pancytosis is a prominent feature of which of the following disorders?

Accepted Answer

A)  Chronic myelocytic leukemia 
B)  Idiopathic myelofibrosis 
C)  Polycythemia vera 
D)  Essential thrombocythemia 
A)  Chronic myelocytic leukemia 
B)  Idiopathic myelofibrosis 
C)  Polycythemia vera 
D)  Essential thrombocythemia

Question 7

A patient has the following CBC results:
WBC count: 35 F1F1F1S1F1F1F10 109/L
Differential:
60 segmented neutrophils
12 lymphocytes
8 metamyelocytes
10 band neutrophils
7 monocytes
3 eosinophils
Platelets: Normal
RBC morphology: Normocytic, normochromic
LAP score: 5
These results are consistent with:

Accepted Answer

A)  Chronic myelocytic leukemia 
B)  Reaction to severe infection 
C)  Acute leukemia 
D)  Polycythemia vera 
A)  Chronic myelocytic leukemia 
B)  Reaction to severe infection 
C)  Acute leukemia 
D)  Polycythemia vera

Question 8

A "dry tap" is a characteristic of myeloid fibrosis with myeloid metaplasia due to:

Accepted Answer

A)  Increased infiltration of blast cells 
B)  Increased infiltration of abnormal platelets 
C)  Increased infiltration of abnormal red cells 
D)  Increased infiltration of fibrotic elements 
A)  Increased infiltration of blast cells 
B)  Increased infiltration of abnormal platelets 
C)  Increased infiltration of abnormal red cells 
D)  Increased infiltration of fibrotic elements

Question 9

What effect does the Ph chromosome have on the prognosis of patients with chronic myelocytic leukemia?

Accepted Answer

A)  It is not predictive. 
B)  The prognosis is better if the Ph chromosome is present. 
C)  The prognosis is worse if the Ph chromosome is present. 
D)  The disease usually transforms into AML when the Ph chromosome is present. 
A)  It is not predictive. 
B)  The prognosis is better if the Ph chromosome is present. 
C)  The prognosis is worse if the Ph chromosome is present. 
D)  The disease usually transforms into AML when the Ph chromosome is present.

Question 10

Tyrosine kinase is an important mediator in leukocyte metabolic pathways because it suppresses:

Accepted Answer

A)  Opsonization 
B)  Phagocytosis 
C)  Leukoerythroblastosis 
D)  Apoptosis 
A)  Opsonization 
B)  Phagocytosis 
C)  Leukoerythroblastosis 
D)  Apoptosis

Question 11

A high-risk factor for the diagnosis of essential thrombocythemia is:

Accepted Answer

A)  A platelet count of greater than 600,000 
B)  Extramedullary hematopoiesis 
C)  The presence of BCR/ABL 
D)  Fibrotic bone marrow 
A)  A platelet count of greater than 600,000 
B)  Extramedullary hematopoiesis 
C)  The presence of BCR/ABL 
D)  Fibrotic bone marrow

Question 12

The accelerated phase of chronic myeloid leukemia is marked by:

Accepted Answer

A)  Increased basophils 
B)  Thrombocytopenia 
C)  Increase in blasts 
D)  Increased fibrosis 
A)  Increased basophils 
B)  Thrombocytopenia 
C)  Increase in blasts 
D)  Increased fibrosis

Question 13

Plethora is a condition associated with:

Accepted Answer

A)  Polycythemia vera 
B)  CML 
C)  Leukemoid reaction 
D)  Myelofibrosis 
A)  Polycythemia vera 
B)  CML 
C)  Leukemoid reaction 
D)  Myelofibrosis

Question 14

What is the pathophysiology of the myeloproliferative disorders?

Accepted Answer

A)  Fibroid infiltration of major organs 
B)  Neoplastic transformation of multipotential stem cells 
C)  Widespread deterioration of cellular function 
D)  Splenic sequestration of normal blood cells 
A)  Fibroid infiltration of major organs 
B)  Neoplastic transformation of multipotential stem cells 
C)  Widespread deterioration of cellular function 
D)  Splenic sequestration of normal blood cells

Question 15

When referring to a leukemoid reaction, which of the following is a false statement?

Accepted Answer

A)  Toxic granulation is usually seen. 
B)  The LAP score is increased. 
C)  The WBC count shows a shift to the left. 
D)  Anemia is usually present. 
A)  Toxic granulation is usually seen. 
B)  The LAP score is increased. 
C)  The WBC count shows a shift to the left. 
D)  Anemia is usually present.

Question 16

The red cell morphology associated with IMF is:

Accepted Answer

A)  Burr cells 
B)  Acanthocytes 
C)  Teardrop cells 
D)  Target cells 
A)  Burr cells 
B)  Acanthocytes 
C)  Teardrop cells 
D)  Target cells

Question 17

___indicates the transformation of a chronic process to an acute process.

Accepted Answer

A)  An increased WBC count 
B)  Bone marrow fibrosis 
C)  The presence of the Philadelphia chromosome 
D)  An increase in the percentage of blasts in the peripheral blood or bone marrow 
A)  An increased WBC count 
B)  Bone marrow fibrosis 
C)  The presence of the Philadelphia chromosome 
D)  An increase in the percentage of blasts in the peripheral blood or bone marrow

Question 18

The LAP stain is helpful in distinguishing:

Accepted Answer

A)  A leukemoid reaction from CGL 
B)  CML from CLL 
C)  CML from AML 
D)  CML from ALL 
A)  A leukemoid reaction from CGL 
B)  CML from CLL 
C)  CML from AML 
D)  CML from ALL

Question 19

All of the following are causes of thrombocytosis except:

Accepted Answer

A)  Malignancy 
B)  Infection 
C)  Smoking 
D)  Blood loss 
A)  Malignancy 
B)  Infection 
C)  Smoking 
D)  Blood loss

Question 20

Chronic myelogenous leukemia will present with less than _blasts in the peripheral blood.

Accepted Answer

A)  5% 
B)  10% 
C)  20% 
D)  30% 
A)  5% 
B)  10% 
C)  20% 
D)  30%

Essential thrombocytosis can affect all three cell lines, but the main cell line affected is the:

Which of the following is associated with CML but not AML?

To calculate the LAP score on a blood smear:

The translocation of genetic material, t9:22, is associated with:

A term describing a peripheral blood finding of leukocytosis with a shift to the left accompanied by occasional nucleated red cells and platelet abnormalities is:

Pancytosis is a prominent feature of which of the following disorders?

A patient has the following CBC results: WBC count: 35  10⁹/L Differential: 60 segmented neutrophils 12 lymphocytes 8 metamyelocytes 10 band neutrophils 7 monocytes 3 eosinophils Platelets: Normal RBC morphology: Normocytic, normochromic LAP score: 5 These results are consistent with:

A "dry tap" is a characteristic of myeloid fibrosis with myeloid metaplasia due to:

What effect does the Ph chromosome have on the prognosis of patients with chronic myelocytic leukemia?

Tyrosine kinase is an important mediator in leukocyte metabolic pathways because it suppresses:

A high-risk factor for the diagnosis of essential thrombocythemia is:

The accelerated phase of chronic myeloid leukemia is marked by:

Plethora is a condition associated with:

What is the pathophysiology of the myeloproliferative disorders?

When referring to a leukemoid reaction, which of the following is a false statement?

The red cell morphology associated with IMF is:

___indicates the transformation of a chronic process to an acute process.

The LAP stain is helpful in distinguishing:

All of the following are causes of thrombocytosis except:

Chronic myelogenous leukemia will present with less than _blasts in the peripheral blood.

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Red Blood Cell Production, Function, and Relevant Red Blood Cell Morphology

Hemoglobin Function and Principles of Hemolysis

The Microcytic Anemias

The Macrocytic Anemias

Normochromic Anemias: Biochemical, Membrane, and Miscellaneous Red Blood Cell Disorders

The Normochromic Anemias Caused by Hemoglobinopathies

Leukopoiesis and Leukopoietic Function

Abnormalities of White Blood Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Lymphoproliferative Disorders and Related Plasma Cell Disorders

The Myelodysplastic Syndromes

Overview of Hemostasis and Platelet Physiology

Quantitative and Qualitative Platelet Disorders

Defects of Plasma Clotting Factors

Fibrinogen, Thrombin, and the Fibrinolytic System

Introduction to Thrombosis and Anticoagulant Therapy

Filters

Exam 12: Chronic Myeloproliferative Disorders

Essential thrombocytosis can affect all three cell lines, but the main cell line affected is the:

Which of the following is associated with CML but not AML?

To calculate the LAP score on a blood smear:

The translocation of genetic material, t9:22, is associated with:

A term describing a peripheral blood finding of leukocytosis with a shift to the left accompanied by occasional nucleated red cells and platelet abnormalities is:

Pancytosis is a prominent feature of which of the following disorders?

A patient has the following CBC results: WBC count: 35  109/L Differential: 60 segmented neutrophils 12 lymphocytes 8 metamyelocytes 10 band neutrophils 7 monocytes 3 eosinophils Platelets: Normal RBC morphology: Normocytic, normochromic LAP score: 5 These results are consistent with:

A "dry tap" is a characteristic of myeloid fibrosis with myeloid metaplasia due to:

What effect does the Ph chromosome have on the prognosis of patients with chronic myelocytic leukemia?

Tyrosine kinase is an important mediator in leukocyte metabolic pathways because it suppresses:

A high-risk factor for the diagnosis of essential thrombocythemia is:

The accelerated phase of chronic myeloid leukemia is marked by:

Plethora is a condition associated with:

What is the pathophysiology of the myeloproliferative disorders?

When referring to a leukemoid reaction, which of the following is a false statement?

The red cell morphology associated with IMF is:

___indicates the transformation of a chronic process to an acute process.

The LAP stain is helpful in distinguishing:

All of the following are causes of thrombocytosis except:

Chronic myelogenous leukemia will present with less than _blasts in the peripheral blood.

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Red Blood Cell Production, Function, and Relevant Red Blood Cell Morphology

Hemoglobin Function and Principles of Hemolysis

The Microcytic Anemias

The Macrocytic Anemias

Normochromic Anemias: Biochemical, Membrane, and Miscellaneous Red Blood Cell Disorders

The Normochromic Anemias Caused by Hemoglobinopathies

Leukopoiesis and Leukopoietic Function

Abnormalities of White Blood Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Lymphoproliferative Disorders and Related Plasma Cell Disorders

The Myelodysplastic Syndromes

Overview of Hemostasis and Platelet Physiology

Quantitative and Qualitative Platelet Disorders

Defects of Plasma Clotting Factors

Fibrinogen, Thrombin, and the Fibrinolytic System

Introduction to Thrombosis and Anticoagulant Therapy

Filters

A patient has the following CBC results: WBC count: 35  10⁹/L Differential: 60 segmented neutrophils 12 lymphocytes 8 metamyelocytes 10 band neutrophils 7 monocytes 3 eosinophils Platelets: Normal RBC morphology: Normocytic, normochromic LAP score: 5 These results are consistent with: