Question 1

The most common hematological malignancy in the adult population is:

Accepted Answer

A)  Acute leukemia 
B)  Multiple myeloma 
C)  Myelodysplastic syndrome 
D)  Chronic leukemias 
A)  Acute leukemia 
B)  Multiple myeloma 
C)  Myelodysplastic syndrome 
D)  Chronic leukemias C

Question 2

All of the following are associated with the development of the MDSs except:

Accepted Answer

A)  Alkylating therapy 
B)  Benzene exposure 
C)  Alcoholism 
D)  Radiation 
A)  Alkylating therapy 
B)  Benzene exposure 
C)  Alcoholism 
D)  Radiation C

Question 3

All of the following are dysplastic changes of platelets frequently seen in MDS except:

Accepted Answer

A)  Abnormal granulation 
B)  Micromega karyocytes 
C)  Giant platelets 
D)  Platelet satellitism 
A)  Abnormal granulation 
B)  Micromega karyocytes 
C)  Giant platelets 
D)  Platelet satellitism D

Question 4

A large percentage of the MDSs end in an acute leukemia.

Accepted Answer

A) True 
 B)False

Question 5

Refractory anemia is an anemia that:

Accepted Answer

A)  Has more than 5% blasts in the peripheral blood 
B)  Is resistant to treatment 
C)  Will usually demonstrate a hypoplastic bone marrow 
D)  Demonstrates a 17g deletion routinely 
A)  Has more than 5% blasts in the peripheral blood 
B)  Is resistant to treatment 
C)  Will usually demonstrate a hypoplastic bone marrow 
D)  Demonstrates a 17g deletion routinely

Question 6

The FAB classification of the MDSs include CML.

Accepted Answer

A) True 
 B)False

Question 7

-The cell at the tip of the pointer is:

Accepted Answer

A)  A basophil 
B)  A malignant cell 
C)  A degenerating neutrophil 
D)  Not a cell; it's an artifact 
A)  A basophil 
B)  A malignant cell 
C)  A degenerating neutrophil 
D)  Not a cell; it's an artifact

Question 8

The morphological classification of anemia in the myelodysplastic syndromes is:

Accepted Answer

A)  Normocytic, normochromic 
B)  Microcytic, hypochromic 
C)  Macrocytic, normochromic 
D)  Microcytic, normochromic 
A)  Normocytic, normochromic 
B)  Microcytic, hypochromic 
C)  Macrocytic, normochromic 
D)  Microcytic, normochromic

Question 9

Which of the following chromosome disorders in MDS has a poor predictive influence?

Accepted Answer

A)  Chromosome 7 disorder 
B)  Trisomy 12 
C)  Trisomy 13 
D)  17q deletion 
A)  Chromosome 7 disorder 
B)  Trisomy 12 
C)  Trisomy 13 
D)  17q deletion

Question 10

Deleted 5q MDS is primarily seen in male patients.

Accepted Answer

A) True 
 B)False

Question 11

Reticulocytopenia is a feature of MDS.Which one of the following is the mechanism behind this process?

Accepted Answer

A)  Heavy tumor burden 
B)  Marrow aplasia 
C)  Ineffective erythropoiesis 
D)  Toxic effects 
A)  Heavy tumor burden 
B)  Marrow aplasia 
C)  Ineffective erythropoiesis 
D)  Toxic effects

Question 12

The most effective means of treating iron overload in the myelodysplastic syndromes is:

Accepted Answer

A)  Therapeutic phlebotomy 
B)  Limiting iron-containing foods 
C)  Iron chelation therapy 
D)  Fasting 
A)  Therapeutic phlebotomy 
B)  Limiting iron-containing foods 
C)  Iron chelation therapy 
D)  Fasting

Question 13

One of the key white cell features in MDS is:

Accepted Answer

A)  Hypersegmented neutrophils 
B)  Auer rods 
C)  Dohle bodies 
D)  Pseudo Pelger-Huët 
A)  Hypersegmented neutrophils 
B)  Auer rods 
C)  Dohle bodies 
D)  Pseudo Pelger-Huët

Question 14

Which of the following bone marrow blast percentages will be consistent with the FAB classification of refractory anemia with excess of blasts (RAEB)?

Accepted Answer

A)  5% to 20% 
B)  20% to 30% 
C)  Greater than 30% 
D)  Less than 5% 
A)  5% to 20% 
B)  20% to 30% 
C)  Greater than 30% 
D)  Less than 5%

Question 15

Typically, patients with MDS will exhibit partial or complete absence of:

Accepted Answer

A)  Chromosomes 5 and 7 
B)  Chromosomes 8 and 12 
C)  The Y chromosome 
D)  Dysplasia 
A)  Chromosomes 5 and 7 
B)  Chromosomes 8 and 12 
C)  The Y chromosome 
D)  Dysplasia

Question 16

-The correct name for the cell at the end of the pointer is a:

Accepted Answer

A)  Ringed sideroblast 
B)  Reticulocyte 
C)  Giant platelet 
D)  Siderocyte 
A)  Ringed sideroblast 
B)  Reticulocyte 
C)  Giant platelet 
D)  Siderocyte

Question 17

All of the following are features of the myelodysplastic syndromes except:

Accepted Answer

A)  Anemia 
B)  Organomegaly 
C)  Dysplasia 
D)  Hypercellular marrow 
A)  Anemia 
B)  Organomegaly 
C)  Dysplasia 
D)  Hypercellular marrow

Question 18

-The cell at the tip of the pointer is a:

Accepted Answer

A)  Hairy cell 
B)  Basket cell 
C)  Degenerating lymphocyte 
D)  Giant platelet 
A)  Hairy cell 
B)  Basket cell 
C)  Degenerating lymphocyte 
D)  Giant platelet

Question 19

The bone marrow and peripheral smear of a patient with an MDS will show dysplastic changes in _over time.

Accepted Answer

A)  white cells 
B)  red cells 
C)  platelets 
D)  All of the above 
A)  white cells 
B)  red cells 
C)  platelets 
D)  All of the above

Question 20

The blast count in most individuals with MDS is:

Accepted Answer

A)  Less than 10% 
B)  Less than 40% 
C)  Less than 5% 
D)  Less than 20% 
A)  Less than 10% 
B)  Less than 40% 
C)  Less than 5% 
D)  Less than 20%

The most common hematological malignancy in the adult population is:

All of the following are associated with the development of the MDSs except:

All of the following are dysplastic changes of platelets frequently seen in MDS except:

A large percentage of the MDSs end in an acute leukemia.

Refractory anemia is an anemia that:

The FAB classification of the MDSs include CML.

-The cell at the tip of the pointer is:

The morphological classification of anemia in the myelodysplastic syndromes is:

Which of the following chromosome disorders in MDS has a poor predictive influence?

Deleted 5q MDS is primarily seen in male patients.

Reticulocytopenia is a feature of MDS.Which one of the following is the mechanism behind this process?

The most effective means of treating iron overload in the myelodysplastic syndromes is:

One of the key white cell features in MDS is:

Which of the following bone marrow blast percentages will be consistent with the FAB classification of refractory anemia with excess of blasts (RAEB)?

Typically, patients with MDS will exhibit partial or complete absence of:

-The correct name for the cell at the end of the pointer is a:

All of the following are features of the myelodysplastic syndromes except:

-The cell at the tip of the pointer is a:

The bone marrow and peripheral smear of a patient with an MDS will show dysplastic changes in _over time.

The blast count in most individuals with MDS is:

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Red Blood Cell Production, Function, and Relevant Red Blood Cell Morphology

Hemoglobin Function and Principles of Hemolysis

The Microcytic Anemias

The Macrocytic Anemias

Normochromic Anemias: Biochemical, Membrane, and Miscellaneous Red Blood Cell Disorders

The Normochromic Anemias Caused by Hemoglobinopathies

Leukopoiesis and Leukopoietic Function

Abnormalities of White Blood Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Chronic Myeloproliferative Disorders

Lymphoproliferative Disorders and Related Plasma Cell Disorders

Overview of Hemostasis and Platelet Physiology

Quantitative and Qualitative Platelet Disorders

Defects of Plasma Clotting Factors

Fibrinogen, Thrombin, and the Fibrinolytic System

Introduction to Thrombosis and Anticoagulant Therapy

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Exam 14: The Myelodysplastic Syndromes

The most common hematological malignancy in the adult population is:

All of the following are associated with the development of the MDSs except:

All of the following are dysplastic changes of platelets frequently seen in MDS except:

A large percentage of the MDSs end in an acute leukemia.

Refractory anemia is an anemia that:

The FAB classification of the MDSs include CML.

-The cell at the tip of the pointer is:

The morphological classification of anemia in the myelodysplastic syndromes is:

Which of the following chromosome disorders in MDS has a poor predictive influence?

Deleted 5q MDS is primarily seen in male patients.

Reticulocytopenia is a feature of MDS.Which one of the following is the mechanism behind this process?

The most effective means of treating iron overload in the myelodysplastic syndromes is:

One of the key white cell features in MDS is:

Which of the following bone marrow blast percentages will be consistent with the FAB classification of refractory anemia with excess of blasts (RAEB)?

Typically, patients with MDS will exhibit partial or complete absence of:

-The correct name for the cell at the end of the pointer is a:

All of the following are features of the myelodysplastic syndromes except:

-The cell at the tip of the pointer is a:

The bone marrow and peripheral smear of a patient with an MDS will show dysplastic changes in _over time.

The blast count in most individuals with MDS is:

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Red Blood Cell Production, Function, and Relevant Red Blood Cell Morphology

Hemoglobin Function and Principles of Hemolysis

The Microcytic Anemias

The Macrocytic Anemias

Normochromic Anemias: Biochemical, Membrane, and Miscellaneous Red Blood Cell Disorders

The Normochromic Anemias Caused by Hemoglobinopathies

Leukopoiesis and Leukopoietic Function

Abnormalities of White Blood Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Chronic Myeloproliferative Disorders

Lymphoproliferative Disorders and Related Plasma Cell Disorders

Overview of Hemostasis and Platelet Physiology

Quantitative and Qualitative Platelet Disorders

Defects of Plasma Clotting Factors

Fibrinogen, Thrombin, and the Fibrinolytic System

Introduction to Thrombosis and Anticoagulant Therapy

Filters