Question 1

A platelet release defect in which there is a severe lack of alpha granules in platelets is known as:

Accepted Answer

A)  Bernard-Soulier syndrome 
B)  Chediak-Higashi syndrome 
C)  Glanzmann's thrombasthenia 
D)  Gray platelet syndrome 
A)  Bernard-Soulier syndrome 
B)  Chediak-Higashi syndrome 
C)  Glanzmann's thrombasthenia 
D)  Gray platelet syndrome D

Question 2

Which of the following is an autoimmune thrombocytopenic disease process?

Accepted Answer

A)  Chronic idiopathic thrombocytopenic purpura 
B)  Hemolytic uremic syndrome 
C)  von Willebrand's disease 
D)  Thrombocytopenia with absent radii 
A)  Chronic idiopathic thrombocytopenic purpura 
B)  Hemolytic uremic syndrome 
C)  von Willebrand's disease 
D)  Thrombocytopenia with absent radii A

Question 3

Platelet aggregation cannot occur if ___is absent.

Accepted Answer

A)  vWF 
B)  GP IIb/IIIa 
C)  cadmium 
D)  GP Ib 
A)  vWF 
B)  GP IIb/IIIa 
C)  cadmium 
D)  GP Ib B

Question 4

Desmopressin acetate (DDAVP) is an effective treatment for vWD because it:

Accepted Answer

A)  Causes platelets to be mobilized from the spleen 
B)  Activates the intrinsic system 
C)  Demobilizes factor VIII 
D)  Causes the release of endothelial vWF 
A)  Causes platelets to be mobilized from the spleen 
B)  Activates the intrinsic system 
C)  Demobilizes factor VIII 
D)  Causes the release of endothelial vWF

Question 5

The anticoagulant of choice for routine coagulation procedure is:

Accepted Answer

A)  Sodium oxalate 
B)  Sodium citrate 
C)  Heparin 
D)  Sodium fluoride 
A)  Sodium oxalate 
B)  Sodium citrate 
C)  Heparin 
D)  Sodium fluoride

Question 6

Which of the following are platelet adhesion disorders?

Accepted Answer

A)  von Willebrand's disease and Glanzmann's thrombasthenia 
B)  von Willebrand's disease and Bernard-Soulier 
C)  Glanzmann's thrombasthenia and Bernard-Soulier 
D)  Glanzmann's thrombasthenia and congenital fibrinogenemia 
A)  von Willebrand's disease and Glanzmann's thrombasthenia 
B)  von Willebrand's disease and Bernard-Soulier 
C)  Glanzmann's thrombasthenia and Bernard-Soulier 
D)  Glanzmann's thrombasthenia and congenital fibrinogenemia

Question 7

Which of the following causes irreversible inactivation of platelets?

Accepted Answer

A)  Heparin 
B)  Coumadin 
C)  Aspirin 
D)  Vitamin K 
A)  Heparin 
B)  Coumadin 
C)  Aspirin 
D)  Vitamin K

Question 8

A platelet release defect in which there is a severe deficiency of dense granules in platelets is known as:

Accepted Answer

A)  Chediak-Higashi syndrome 
B)  Hermansky-Pudlak syndrome 
C)  Wiskott-Aldrich syndrome 
D)  Bernard-Soulier syndrome 
A)  Chediak-Higashi syndrome 
B)  Hermansky-Pudlak syndrome 
C)  Wiskott-Aldrich syndrome 
D)  Bernard-Soulier syndrome

Question 9

Hyperviscosity syndrome and paraproteinemia are associated with:

Accepted Answer

A)  Chediak-Higashi syndrome 
B)  Wiskott-Aldrich syndrome 
C)  Multiple myeloma and Waldenström's macroglobulinemia 
D)  ITP 
A)  Chediak-Higashi syndrome 
B)  Wiskott-Aldrich syndrome 
C)  Multiple myeloma and Waldenström's macroglobulinemia 
D)  ITP

Question 10

The single best predictive assay for von Willebrand factor is:

Accepted Answer

A)  Ristocetin co-factor activity 
B)  Bleeding time 
C)  aPTT 
D)  Platelet count 
A)  Ristocetin co-factor activity 
B)  Bleeding time 
C)  aPTT 
D)  Platelet count

Question 11

All of the following are associated with platelet disorders except:

Accepted Answer

A)  Thrombocytopenia 
B)  Deep muscle hemorrhages 
C)  Epistaxis and menorrhagia 
D)  Abnormal platelet morphology 
A)  Thrombocytopenia 
B)  Deep muscle hemorrhages 
C)  Epistaxis and menorrhagia 
D)  Abnormal platelet morphology

Question 12

Aspirin therapy irreversibly inhibits the synthesis of:

Accepted Answer

A)  ATP 
B)  GP 1 
C)  Prostaglandins 
D)  GP IIb and IIIa 
A)  ATP 
B)  GP 1 
C)  Prostaglandins 
D)  GP IIb and IIIa

Question 13

Which of the following conditions may result in thrombocytosis?

Accepted Answer

A)  Polycythemia vera (PCV) 
B)  Acute leukemia 
C)  Sickle cell disease 
D)  TTP 
A)  Polycythemia vera (PCV) 
B)  Acute leukemia 
C)  Sickle cell disease 
D)  TTP

Question 14

In hemolytic uremic syndrome (HUS), which of the following statements is the most accurate?

Accepted Answer

A)  The organ most affected is the spleen. 
B)  The toxin responsible for this syndrome is produced by E. coli O157:H7. 
C)  Impaired neurological function is one of the primary symptoms. 
D)  Platelets are permanently impaired. 
A)  The organ most affected is the spleen. 
B)  The toxin responsible for this syndrome is produced by E. coli O157:H7. 
C)  Impaired neurological function is one of the primary symptoms. 
D)  Platelets are permanently impaired.

Question 15

Several hours after birth, a baby boy develops the following symptoms, petechiae, purpura, and hemorrhage.The platelet count is 18,000.The most likely explanation is:

Accepted Answer

A)  Drug-induced thrombocytopenia 
B)  Secondary thrombocytopenia 
C)  Isoimmune neonatal thrombocytopenia 
D)  Neonatal DIC 
A)  Drug-induced thrombocytopenia 
B)  Secondary thrombocytopenia 
C)  Isoimmune neonatal thrombocytopenia 
D)  Neonatal DIC

Question 16

-Red cell morphology such as the one at the tip of the pointer are associated with:

Accepted Answer

A)  von Willebrand's disease 
B)  Glanzmann's thrombasthenia 
C)  Thrombotic thrombocytopenic purpura 
D)  All of the above 
A)  von Willebrand's disease 
B)  Glanzmann's thrombasthenia 
C)  Thrombotic thrombocytopenic purpura 
D)  All of the above

Question 17

Which the following test results is normal in a patient with classic von Willebrand's disease?

Accepted Answer

A)  Bleeding time 
B)  Activated partial thromboplastin time 
C)  Platelet count 
D)  Factor VIII and vWF levels 
A)  Bleeding time 
B)  Activated partial thromboplastin time 
C)  Platelet count 
D)  Factor VIII and vWF levels

Question 18

A decreased platelet count is most often anticipated when a patient demonstrates:

Accepted Answer

A)  Rectal bleeding 
B)  Epistaxis 
C)  Genitourinary bleeding 
D)  Severe hemorrhage 
A)  Rectal bleeding 
B)  Epistaxis 
C)  Genitourinary bleeding 
D)  Severe hemorrhage

Question 19

The presence of thrombocytopenia and giant platelets on the peripheral smear of a patient is characteristic of:

Accepted Answer

A)  Classic von Willebrand's disease 
B)  Hemophilia A 
C)  Glanzmann's thrombasthenia 
D)  Bernard-Soulier syndrome 
A)  Classic von Willebrand's disease 
B)  Hemophilia A 
C)  Glanzmann's thrombasthenia 
D)  Bernard-Soulier syndrome

Question 20

Thrombocytosis is defined as a platelet count that is:

Accepted Answer

A)  Greater than 450 F1F1F1S1F1F1F10 109/L 
B)  Less than 450 F1F1F1S1F1F1F10 w109/L 
C)  Greater than 600 F1F1F1S1F1F1F10 109/L 
D)  Less than 300 F1F1F1S1F1F1F10 109/L 
A)  Greater than 450 F1F1F1S1F1F1F10 109/L 
B)  Less than 450 F1F1F1S1F1F1F10 w109/L 
C)  Greater than 600 F1F1F1S1F1F1F10 109/L 
D)  Less than 300 F1F1F1S1F1F1F10 109/L

A platelet release defect in which there is a severe lack of alpha granules in platelets is known as:

Which of the following is an autoimmune thrombocytopenic disease process?

Platelet aggregation cannot occur if ___is absent.

Desmopressin acetate (DDAVP) is an effective treatment for vWD because it:

The anticoagulant of choice for routine coagulation procedure is:

Which of the following are platelet adhesion disorders?

Which of the following causes irreversible inactivation of platelets?

A platelet release defect in which there is a severe deficiency of dense granules in platelets is known as:

Hyperviscosity syndrome and paraproteinemia are associated with:

The single best predictive assay for von Willebrand factor is:

All of the following are associated with platelet disorders except:

Aspirin therapy irreversibly inhibits the synthesis of:

Which of the following conditions may result in thrombocytosis?

In hemolytic uremic syndrome (HUS), which of the following statements is the most accurate?

Several hours after birth, a baby boy develops the following symptoms, petechiae, purpura, and hemorrhage.The platelet count is 18,000.The most likely explanation is:

-Red cell morphology such as the one at the tip of the pointer are associated with:

Which the following test results is normal in a patient with classic von Willebrand's disease?

A decreased platelet count is most often anticipated when a patient demonstrates:

The presence of thrombocytopenia and giant platelets on the peripheral smear of a patient is characteristic of:

Thrombocytosis is defined as a platelet count that is:

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Red Blood Cell Production, Function, and Relevant Red Blood Cell Morphology

Hemoglobin Function and Principles of Hemolysis

The Microcytic Anemias

The Macrocytic Anemias

Normochromic Anemias: Biochemical, Membrane, and Miscellaneous Red Blood Cell Disorders

The Normochromic Anemias Caused by Hemoglobinopathies

Leukopoiesis and Leukopoietic Function

Abnormalities of White Blood Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Chronic Myeloproliferative Disorders

Lymphoproliferative Disorders and Related Plasma Cell Disorders

The Myelodysplastic Syndromes

Overview of Hemostasis and Platelet Physiology

Defects of Plasma Clotting Factors

Fibrinogen, Thrombin, and the Fibrinolytic System

Introduction to Thrombosis and Anticoagulant Therapy

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Exam 16: Quantitative and Qualitative Platelet Disorders

A platelet release defect in which there is a severe lack of alpha granules in platelets is known as:

Which of the following is an autoimmune thrombocytopenic disease process?

Platelet aggregation cannot occur if ___is absent.

Desmopressin acetate (DDAVP) is an effective treatment for vWD because it:

The anticoagulant of choice for routine coagulation procedure is:

Which of the following are platelet adhesion disorders?

Which of the following causes irreversible inactivation of platelets?

A platelet release defect in which there is a severe deficiency of dense granules in platelets is known as:

Hyperviscosity syndrome and paraproteinemia are associated with:

The single best predictive assay for von Willebrand factor is:

All of the following are associated with platelet disorders except:

Aspirin therapy irreversibly inhibits the synthesis of:

Which of the following conditions may result in thrombocytosis?

In hemolytic uremic syndrome (HUS), which of the following statements is the most accurate?

Several hours after birth, a baby boy develops the following symptoms, petechiae, purpura, and hemorrhage.The platelet count is 18,000.The most likely explanation is:

-Red cell morphology such as the one at the tip of the pointer are associated with:

Which the following test results is normal in a patient with classic von Willebrand's disease?

A decreased platelet count is most often anticipated when a patient demonstrates:

The presence of thrombocytopenia and giant platelets on the peripheral smear of a patient is characteristic of:

Thrombocytosis is defined as a platelet count that is:

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Red Blood Cell Production, Function, and Relevant Red Blood Cell Morphology

Hemoglobin Function and Principles of Hemolysis

The Microcytic Anemias

The Macrocytic Anemias

Normochromic Anemias: Biochemical, Membrane, and Miscellaneous Red Blood Cell Disorders

The Normochromic Anemias Caused by Hemoglobinopathies

Leukopoiesis and Leukopoietic Function

Abnormalities of White Blood Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Chronic Myeloproliferative Disorders

Lymphoproliferative Disorders and Related Plasma Cell Disorders

The Myelodysplastic Syndromes

Overview of Hemostasis and Platelet Physiology

Defects of Plasma Clotting Factors

Fibrinogen, Thrombin, and the Fibrinolytic System

Introduction to Thrombosis and Anticoagulant Therapy

Filters