Question 1

Hemophilia B is best treated with:

Accepted Answer

A)  A mixture of factors II, VII, IX, and X 
B)  Factor X concentrate 
C)  Factor VIII concentrate 
D)  Vitamin K 
A)  A mixture of factors II, VII, IX, and X 
B)  Factor X concentrate 
C)  Factor VIII concentrate 
D)  Vitamin K A

Question 2

Treatment of patients with factor II, VII, or X deficiency consists of:

Accepted Answer

A)  Administration of prothrombin complex concentrate 
B)  Administration of cryoprecipitate 
C)  Administration of FFP 
D)  Administration of whole blood 
A)  Administration of prothrombin complex concentrate 
B)  Administration of cryoprecipitate 
C)  Administration of FFP 
D)  Administration of whole blood A

Question 3

Which platelet response(s) is usually associated with hemophilia A?

Accepted Answer

A)  Defective ADP release; normal response to ADP 
B)  Decreased amount of ADP in platelets 
C)  Absent aggregation to epinephrine, ADP, and collagen 
D)  Normal platelet aggregation 
A)  Defective ADP release; normal response to ADP 
B)  Decreased amount of ADP in platelets 
C)  Absent aggregation to epinephrine, ADP, and collagen 
D)  Normal platelet aggregation D

Question 4

Which of the following is the most useful in differentiating hemophilia A from hemophilia B?

Accepted Answer

A)  A familial pattern of inheritance 
B)  Patient's history 
C)  Activated partial thromboplastin time 
D)  Factor assays 
A)  A familial pattern of inheritance 
B)  Patient's history 
C)  Activated partial thromboplastin time 
D)  Factor assays

Question 5

All of the following may lead to deficiencies of clotting factors except:

Accepted Answer

A)  Renal disease 
B)  Liver disease 
C)  Autoimmune disease 
D)  Cardiovascular disease 
A)  Renal disease 
B)  Liver disease 
C)  Autoimmune disease 
D)  Cardiovascular disease

Question 6

Factor assays measure the percentage of activity of a given factor by mixing the patient's plasma with:

Accepted Answer

A)  Normal plasma 
B)  Adsorbed plasma 
C)  Factor-deficient plasma 
D)  Factor-specific plasma 
A)  Normal plasma 
B)  Adsorbed plasma 
C)  Factor-deficient plasma 
D)  Factor-specific plasma

Question 7

The treatment of choice for hemophilia A individuals is:

Accepted Answer

A)  Cryoprecipitate 
B)  Factor VIII concentrate 
C)  Prothrombin complex 
D)  DDAVP 
A)  Cryoprecipitate 
B)  Factor VIII concentrate 
C)  Prothrombin complex 
D)  DDAVP

Question 8

Clotting factors must be present at a minimum of which percentage for hemostasis to be achieved?

Accepted Answer

A)  20% 
B)  30% 
C)  50% 
D)  75% 
A)  20% 
B)  30% 
C)  50% 
D)  75%

Question 9

Factor V Leiden is a genetic mutation of:

Accepted Answer

A)  Factor IV 
B)  Factor V 
C)  The prothrombin molecule 
D)  Hemophilia A 
A)  Factor IV 
B)  Factor V 
C)  The prothrombin molecule 
D)  Hemophilia A

Question 10

The following laboratory results have been obtained for a 40-year-old woman: PT = 20 seconds (reference range is 11 to 15 seconds), aPTT = 50 seconds (reference range is 22 to 40 seconds), and thrombin time = 18 seconds (reference range is 11 to 15 seconds).What factor deficiency is most likely?

Accepted Answer

A)  Factor VII deficiency 
B)  Factor VIII deficiency 
C)  Factor X deficiency 
D)  Factor XIII deficiency 
A)  Factor VII deficiency 
B)  Factor VIII deficiency 
C)  Factor X deficiency 
D)  Factor XIII deficiency

Question 11

A prolonged aPTT is corrected with factor VIIIF1F1F1S1F1F1F10deficient plasma but not with factor IXF1F1F1S1F1F1F10deficient plasma.What factor is deficient?

Accepted Answer

A)  IX 
B)  XIII 
C)  V 
D)  X 
A)  IX 
B)  XIII 
C)  V 
D)  X

Question 12

Which result will be within reference range in a patient with dysfibrinogenemia?

Accepted Answer

A)  Thrombin time 
B)  Activated partial thromboplastin time 
C)  Immunologic fibrinogen level 
D)  Protein electrophoresis 
A)  Thrombin time 
B)  Activated partial thromboplastin time 
C)  Immunologic fibrinogen level 
D)  Protein electrophoresis

Question 13

Keloid scar formation is most commonly associated with:

Accepted Answer

A)  Factor VIII deficiency 
B)  Factor IX deficiency 
C)  Factor XII deficiency 
D)  Factor XIII deficiency 
A)  Factor VIII deficiency 
B)  Factor IX deficiency 
C)  Factor XII deficiency 
D)  Factor XIII deficiency

Question 14

Christmas disease is another name for:

Accepted Answer

A)  Hemophilia A 
B)  Hemophilia B 
C)  von Willebrand's disease 
D)  Factor VII deficiency 
A)  Hemophilia A 
B)  Hemophilia B 
C)  von Willebrand's disease 
D)  Factor VII deficiency

Question 15

Which of the following assays will be abnormal with hemophilia A?

Accepted Answer

A)  Platelet count 
B)  Bleeding time 
C)  PT 
D)  aPTT 
A)  Platelet count 
B)  Bleeding time 
C)  PT 
D)  aPTT

Question 16

Long-term antibiotic therapy is a cause of bleeding because it disrupts:

Accepted Answer

A)  Vitamin K synthesis 
B)  Contact activation 
C)  Platelet aggregation 
D)  Fibrinolytic activity 
A)  Vitamin K synthesis 
B)  Contact activation 
C)  Platelet aggregation 
D)  Fibrinolytic activity

Question 17

A man with hemophilia A and an unaffected female can produce a:

Accepted Answer

A)  Female carrier 
B)  Male carrier 
C)  Male with hemophilia A 
D)  Normal female 
A)  Female carrier 
B)  Male carrier 
C)  Male with hemophilia A 
D)  Normal female

Question 18

Factor XI deficiency is also known as:

Accepted Answer

A)  Christmas disease 
B)  Hemophilia A 
C)  Hemophilia C 
D)  Fitzgerald factor deficiency 
A)  Christmas disease 
B)  Hemophilia A 
C)  Hemophilia C 
D)  Fitzgerald factor deficiency

Question 19

Which of the following is the most prevalent inherited bleeding disorder?

Accepted Answer

A)  von Willebrand disease 
B)  Hemophilia A 
C)  Factor VII deficiency 
D)  Factor XII deficiency 
A)  von Willebrand disease 
B)  Hemophilia A 
C)  Factor VII deficiency 
D)  Factor XII deficiency

Question 20

The only clotting factor not synthesized exclusively by the liver is:

Accepted Answer

A)  Factor V 
B)  Factor VII 
C)  Factor VIII 
D)  Factor IX 
A)  Factor V 
B)  Factor VII 
C)  Factor VIII 
D)  Factor IX

Hemophilia B is best treated with:

Treatment of patients with factor II, VII, or X deficiency consists of:

Which platelet response(s) is usually associated with hemophilia A?

Which of the following is the most useful in differentiating hemophilia A from hemophilia B?

All of the following may lead to deficiencies of clotting factors except:

Factor assays measure the percentage of activity of a given factor by mixing the patient's plasma with:

The treatment of choice for hemophilia A individuals is:

Clotting factors must be present at a minimum of which percentage for hemostasis to be achieved?

Factor V Leiden is a genetic mutation of:

The following laboratory results have been obtained for a 40-year-old woman: PT = 20 seconds (reference range is 11 to 15 seconds), aPTT = 50 seconds (reference range is 22 to 40 seconds), and thrombin time = 18 seconds (reference range is 11 to 15 seconds).What factor deficiency is most likely?

A prolonged aPTT is corrected with factor VIIIdeficient plasma but not with factor IXdeficient plasma.What factor is deficient?

Which result will be within reference range in a patient with dysfibrinogenemia?

Keloid scar formation is most commonly associated with:

Christmas disease is another name for:

Which of the following assays will be abnormal with hemophilia A?

Long-term antibiotic therapy is a cause of bleeding because it disrupts:

A man with hemophilia A and an unaffected female can produce a:

Factor XI deficiency is also known as:

Which of the following is the most prevalent inherited bleeding disorder?

The only clotting factor not synthesized exclusively by the liver is:

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Red Blood Cell Production, Function, and Relevant Red Blood Cell Morphology

Hemoglobin Function and Principles of Hemolysis

The Microcytic Anemias

The Macrocytic Anemias

Normochromic Anemias: Biochemical, Membrane, and Miscellaneous Red Blood Cell Disorders

The Normochromic Anemias Caused by Hemoglobinopathies

Leukopoiesis and Leukopoietic Function

Abnormalities of White Blood Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Chronic Myeloproliferative Disorders

Lymphoproliferative Disorders and Related Plasma Cell Disorders

The Myelodysplastic Syndromes

Overview of Hemostasis and Platelet Physiology

Quantitative and Qualitative Platelet Disorders

Fibrinogen, Thrombin, and the Fibrinolytic System

Introduction to Thrombosis and Anticoagulant Therapy

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Exam 17: Defects of Plasma Clotting Factors

Hemophilia B is best treated with:

Treatment of patients with factor II, VII, or X deficiency consists of:

Which platelet response(s) is usually associated with hemophilia A?

Which of the following is the most useful in differentiating hemophilia A from hemophilia B?

All of the following may lead to deficiencies of clotting factors except:

Factor assays measure the percentage of activity of a given factor by mixing the patient's plasma with:

The treatment of choice for hemophilia A individuals is:

Clotting factors must be present at a minimum of which percentage for hemostasis to be achieved?

Factor V Leiden is a genetic mutation of:

The following laboratory results have been obtained for a 40-year-old woman: PT = 20 seconds (reference range is 11 to 15 seconds), aPTT = 50 seconds (reference range is 22 to 40 seconds), and thrombin time = 18 seconds (reference range is 11 to 15 seconds).What factor deficiency is most likely?

A prolonged aPTT is corrected with factor VIIIdeficient plasma but not with factor IXdeficient plasma.What factor is deficient?

Which result will be within reference range in a patient with dysfibrinogenemia?

Keloid scar formation is most commonly associated with:

Christmas disease is another name for:

Which of the following assays will be abnormal with hemophilia A?

Long-term antibiotic therapy is a cause of bleeding because it disrupts:

A man with hemophilia A and an unaffected female can produce a:

Factor XI deficiency is also known as:

Which of the following is the most prevalent inherited bleeding disorder?

The only clotting factor not synthesized exclusively by the liver is:

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Red Blood Cell Production, Function, and Relevant Red Blood Cell Morphology

Hemoglobin Function and Principles of Hemolysis

The Microcytic Anemias

The Macrocytic Anemias

Normochromic Anemias: Biochemical, Membrane, and Miscellaneous Red Blood Cell Disorders

The Normochromic Anemias Caused by Hemoglobinopathies

Leukopoiesis and Leukopoietic Function

Abnormalities of White Blood Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Chronic Myeloproliferative Disorders

Lymphoproliferative Disorders and Related Plasma Cell Disorders

The Myelodysplastic Syndromes

Overview of Hemostasis and Platelet Physiology

Quantitative and Qualitative Platelet Disorders

Fibrinogen, Thrombin, and the Fibrinolytic System

Introduction to Thrombosis and Anticoagulant Therapy

Filters