Question 1

The substrate upon which the coagulation cascade is centered is:

Accepted Answer

A)  Thrombin 
B)  Vitamin K 
C)  Fibrinogen 
D)  Fibrin 
A)  Thrombin 
B)  Vitamin K 
C)  Fibrinogen 
D)  Fibrin C

Question 2

The best component to use for patients with afibrinogenemia is:

Accepted Answer

A)  Whole blood 
B)  Fresh frozen plasma 
C)  Tissue plasminogen activator 
D)  Factor XIII 
A)  Whole blood 
B)  Fresh frozen plasma 
C)  Tissue plasminogen activator 
D)  Factor XIII B

Question 3

A prolonged thrombin time and a normal reptilase time is indicative of:

Accepted Answer

A)  Aspirin therapy 
B)  FDPs 
C)  Heparin therapy 
D)  Warfarin therapy 
A)  Aspirin therapy 
B)  FDPs 
C)  Heparin therapy 
D)  Warfarin therapy C

Question 4

An excess of which of the following is indicative of the breakdown of fibrin products within the circulating blood?

Accepted Answer

A)  D-dimers 
B)  Alpha-2-antiplasmin 
C)  Protein C 
D)  Plasmin 
A)  D-dimers 
B)  Alpha-2-antiplasmin 
C)  Protein C 
D)  Plasmin

Question 5

A primary inhibitor of the fibrinolytic system is:

Accepted Answer

A)  Alpha 2 antiplasmin 
B)  Alpha 2 macroglobulin 
C)  Antithrombin 
D)  Protein C 
A)  Alpha 2 antiplasmin 
B)  Alpha 2 macroglobulin 
C)  Antithrombin 
D)  Protein C

Question 6

Primary fibrinolysis is a disorder closely related to DIC.All of the coagulation profile assays are the same as that for DIC with the exception of the:

Accepted Answer

A)  D-dimer level, which is increased 
B)  Fibrinogen level, which is decreased 
C)  Platelet count, which is normal 
D)  PT/INR, which is increased 
A)  D-dimer level, which is increased 
B)  Fibrinogen level, which is decreased 
C)  Platelet count, which is normal 
D)  PT/INR, which is increased

Question 7

Obstetrical complications like retained placenta or abruptio placenta are leading causes of:

Accepted Answer

A)  Thrombosis 
B)  DIC 
C)  ITP 
D)  TTP 
A)  Thrombosis 
B)  DIC 
C)  ITP 
D)  TTP

Question 8

The D-dimer test measures:

Accepted Answer

A)  Fibrinogen deposition 
B)  Fibrinogen degradation 
C)  Fibrin degradation 
D)  Fibrin deposition 
A)  Fibrinogen deposition 
B)  Fibrinogen degradation 
C)  Fibrin degradation 
D)  Fibrin deposition

Question 9

The process of fibrin degradation is called ______and is controlled by the enzyme _________.

Accepted Answer

A)  fibrination, plasmin 
B)  fibrinolysis, plasmin 
C)  fibrination, protease 
D)  fibrinolysis, protease 
A)  fibrination, plasmin 
B)  fibrinolysis, plasmin 
C)  fibrination, protease 
D)  fibrinolysis, protease

Question 10

Which of the following hematology disorders will likely trigger an episode of DIC?

Accepted Answer

A)  Sickle cell disease 
B)  Iron deficiency anemia 
C)  Idiopathic thrombocythemia 
D)  Acute progranulocytic leukemia 
A)  Sickle cell disease 
B)  Iron deficiency anemia 
C)  Idiopathic thrombocythemia 
D)  Acute progranulocytic leukemia

Question 11

A patient with DIC will have the following coagulation test results except:

Accepted Answer

A)  An increased PT/INR 
B)  An increased aPTT 
C)  An increased fibrinogen 
D)  An increased D-dimer 
A)  An increased PT/INR 
B)  An increased aPTT 
C)  An increased fibrinogen 
D)  An increased D-dimer

Question 12

All of the following are functions of thrombin except:

Accepted Answer

A)  Initiating the platelet release reaction 
B)  Simulating platelets to product PGI2 
C)  Activating factors V and VIII 
D)  Activating thromboplastin 
A)  Initiating the platelet release reaction 
B)  Simulating platelets to product PGI2 
C)  Activating factors V and VIII 
D)  Activating thromboplastin

Question 13

Normal levels of fibrin degradation products are removed by the reticuloendothelial system and usually measure:

Accepted Answer

A)  Less than 20 µg/mL 
B)  Less than 40 µg/mL 
C)  Less than 75 µg/mL 
D)  Less than 100 µg/mL 
A)  Less than 20 µg/mL 
B)  Less than 40 µg/mL 
C)  Less than 75 µg/mL 
D)  Less than 100 µg/mL

Question 14

Patients with the heterozygous form of afibrinogenemia will have plasma levels of fibrinogen in the range of:

Accepted Answer

A)  0 to 20 mg/dL 
B)  20 to 100 mg/dL 
C)  50 to 150 mg/dL 
D)  100 to 200 mg/dL 
A)  0 to 20 mg/dL 
B)  20 to 100 mg/dL 
C)  50 to 150 mg/dL 
D)  100 to 200 mg/dL

Question 15

The reference range for fibrinogen is:

Accepted Answer

A)  100 to 200 mg/dL 
B)  200 to 400 mg/dL 
C)  400 to 600 mg/dL 
D)  600 to 750 mg/dL 
A)  100 to 200 mg/dL 
B)  200 to 400 mg/dL 
C)  400 to 600 mg/dL 
D)  600 to 750 mg/dL

Question 16

D-dimers may be elevated in which of the following?

Accepted Answer

A)  Sickle cell disease 
B)  Glanzmann's thrombasthenia 
C)  Deep vein thrombosis 
D)  Bernard-Soulier syndrome 
A)  Sickle cell disease 
B)  Glanzmann's thrombasthenia 
C)  Deep vein thrombosis 
D)  Bernard-Soulier syndrome

Question 17

The reference range for a thrombin time is:

Accepted Answer

A)  20 to 40 seconds 
B)  100 to 120 seconds 
C)  40 to 60 seconds 
D)  11 to 15 seconds 
A)  20 to 40 seconds 
B)  100 to 120 seconds 
C)  40 to 60 seconds 
D)  11 to 15 seconds

Question 18

Which of these are byproducts of fibrinolysis?

Accepted Answer

A)  Fibrin degradation products and D-dimers 
B)  Fibrinopeptides A and B 
C)  Streptokinase and urokinase 
D)  Alpha 2 antiplasmin 
A)  Fibrin degradation products and D-dimers 
B)  Fibrinopeptides A and B 
C)  Streptokinase and urokinase 
D)  Alpha 2 antiplasmin

Question 19

Plasmin causes the inactivation of factors:

Accepted Answer

A)  V, VII, X, XI 
B)  V, VIII, XI, XII 
C)  VII, VIII, XI, XII 
D)  X, XI, XII, XIII 
A)  V, VII, X, XI 
B)  V, VIII, XI, XII 
C)  VII, VIII, XI, XII 
D)  X, XI, XII, XIII

Question 20

Prothrombin can only be converted to thrombin by the action of factor X, factor V, platelet factor 3, and:

Accepted Answer

A)  Factor II 
B)  Fibrinogen 
C)  Calcium 
D)  Phosphorus 
A)  Factor II 
B)  Fibrinogen 
C)  Calcium 
D)  Phosphorus

The substrate upon which the coagulation cascade is centered is:

The best component to use for patients with afibrinogenemia is:

A prolonged thrombin time and a normal reptilase time is indicative of:

An excess of which of the following is indicative of the breakdown of fibrin products within the circulating blood?

A primary inhibitor of the fibrinolytic system is:

Primary fibrinolysis is a disorder closely related to DIC.All of the coagulation profile assays are the same as that for DIC with the exception of the:

Obstetrical complications like retained placenta or abruptio placenta are leading causes of:

The D-dimer test measures:

The process of fibrin degradation is called and is controlled by the enzyme ___.

Which of the following hematology disorders will likely trigger an episode of DIC?

A patient with DIC will have the following coagulation test results except:

All of the following are functions of thrombin except:

Normal levels of fibrin degradation products are removed by the reticuloendothelial system and usually measure:

Patients with the heterozygous form of afibrinogenemia will have plasma levels of fibrinogen in the range of:

The reference range for fibrinogen is:

D-dimers may be elevated in which of the following?

The reference range for a thrombin time is:

Which of these are byproducts of fibrinolysis?

Plasmin causes the inactivation of factors:

Prothrombin can only be converted to thrombin by the action of factor X, factor V, platelet factor 3, and:

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Red Blood Cell Production, Function, and Relevant Red Blood Cell Morphology

Hemoglobin Function and Principles of Hemolysis

The Microcytic Anemias

The Macrocytic Anemias

Normochromic Anemias: Biochemical, Membrane, and Miscellaneous Red Blood Cell Disorders

The Normochromic Anemias Caused by Hemoglobinopathies

Leukopoiesis and Leukopoietic Function

Abnormalities of White Blood Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Chronic Myeloproliferative Disorders

Lymphoproliferative Disorders and Related Plasma Cell Disorders

The Myelodysplastic Syndromes

Overview of Hemostasis and Platelet Physiology

Quantitative and Qualitative Platelet Disorders

Defects of Plasma Clotting Factors

Introduction to Thrombosis and Anticoagulant Therapy

Filters

Exam 18: Fibrinogen, Thrombin, and the Fibrinolytic System

The substrate upon which the coagulation cascade is centered is:

The best component to use for patients with afibrinogenemia is:

A prolonged thrombin time and a normal reptilase time is indicative of:

An excess of which of the following is indicative of the breakdown of fibrin products within the circulating blood?

A primary inhibitor of the fibrinolytic system is:

Primary fibrinolysis is a disorder closely related to DIC.All of the coagulation profile assays are the same as that for DIC with the exception of the:

Obstetrical complications like retained placenta or abruptio placenta are leading causes of:

The D-dimer test measures:

The process of fibrin degradation is called ______and is controlled by the enzyme _________.

Which of the following hematology disorders will likely trigger an episode of DIC?

A patient with DIC will have the following coagulation test results except:

All of the following are functions of thrombin except:

Normal levels of fibrin degradation products are removed by the reticuloendothelial system and usually measure:

Patients with the heterozygous form of afibrinogenemia will have plasma levels of fibrinogen in the range of:

The reference range for fibrinogen is:

D-dimers may be elevated in which of the following?

The reference range for a thrombin time is:

Which of these are byproducts of fibrinolysis?

Plasmin causes the inactivation of factors:

Prothrombin can only be converted to thrombin by the action of factor X, factor V, platelet factor 3, and:

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Red Blood Cell Production, Function, and Relevant Red Blood Cell Morphology

Hemoglobin Function and Principles of Hemolysis

The Microcytic Anemias

The Macrocytic Anemias

Normochromic Anemias: Biochemical, Membrane, and Miscellaneous Red Blood Cell Disorders

The Normochromic Anemias Caused by Hemoglobinopathies

Leukopoiesis and Leukopoietic Function

Abnormalities of White Blood Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Chronic Myeloproliferative Disorders

Lymphoproliferative Disorders and Related Plasma Cell Disorders

The Myelodysplastic Syndromes

Overview of Hemostasis and Platelet Physiology

Quantitative and Qualitative Platelet Disorders

Defects of Plasma Clotting Factors

Introduction to Thrombosis and Anticoagulant Therapy

Filters

The process of fibrin degradation is called and is controlled by the enzyme ___.