Question 1

All of the following statements describe factor V Leiden except:

Accepted Answer

A)  It is a cause of activated protein C resistance. 
B)  It is associated with thrombocytopenia. 
C)  It is associated with increased risk of thrombosis. 
D)  Is an inherited disorder. 
A)  It is a cause of activated protein C resistance. 
B)  It is associated with thrombocytopenia. 
C)  It is associated with increased risk of thrombosis. 
D)  Is an inherited disorder. B

Question 2

Which of the following PT results would most likely be seen in a patient who is on Coumadin and is stable?

Accepted Answer

A)  Approximately 26 seconds 
B)  Approximately 13 seconds 
C)  Approximately 40 seconds 
D)  Approximately 60 seconds 
A)  Approximately 26 seconds 
B)  Approximately 13 seconds 
C)  Approximately 40 seconds 
D)  Approximately 60 seconds A

Question 3

Heparin-induced thrombocytopenia (HIT) usually:

Accepted Answer

A)  Occurs as a result of protein C deficiency 
B)  Will show an increase in platelets 
C)  Occurs 5 to 14 days after heparin therapy 
D)  Occurs only in males 
A)  Occurs as a result of protein C deficiency 
B)  Will show an increase in platelets 
C)  Occurs 5 to 14 days after heparin therapy 
D)  Occurs only in males C

Question 4

The lupus anticoagulant is directed against:

Accepted Answer

A)  Factor VIII 
B)  Factor X 
C)  Factor IX 
D)  Phospholipids 
A)  Factor VIII 
B)  Factor X 
C)  Factor IX 
D)  Phospholipids

Question 5

The target therapeutic range for an INR in patients with thromboembolic disease is:

Accepted Answer

A)  1 to 2 
B)  1.5 to 2.5 
C)  2 to 3 
D)  2 to 2.5 
A)  1 to 2 
B)  1.5 to 2.5 
C)  2 to 3 
D)  2 to 2.5

Question 6

Primary hemostasis refers to the process by which:

Accepted Answer

A)  The platelet plug is formed 
B)  A cross-linked fibrin clot is formed 
C)  Fibrin degradation products are generated 
D)  None of the above 
A)  The platelet plug is formed 
B)  A cross-linked fibrin clot is formed 
C)  Fibrin degradation products are generated 
D)  None of the above

Question 7

What therapy may be used for a patient with hemophilia A who is bleeding and has a low titer of factor VIII inhibitor?

Accepted Answer

A)  Fresh frozen plasma 
B)  Porcine factor VIII 
C)  Antithrombin concentrate 
D)  High-dosage factor VIII concentrate 
A)  Fresh frozen plasma 
B)  Porcine factor VIII 
C)  Antithrombin concentrate 
D)  High-dosage factor VIII concentrate

Question 8

Coumadin acts in such a way that it:

Accepted Answer

A)  Alters the synthesis of vitamin KF1F1F1S1F1F1F10dependent factors 
B)  Reduces the circulating level of factors III and V 
C)  Reduces the circulating level of factor I 
D)  Cleaves carboxyreductase to generate glutamic acid 
A)  Alters the synthesis of vitamin KF1F1F1S1F1F1F10dependent factors 
B)  Reduces the circulating level of factors III and V 
C)  Reduces the circulating level of factor I 
D)  Cleaves carboxyreductase to generate glutamic acid

Question 9

The primary role of plasmin is:

Accepted Answer

A)  Platelet aggregation 
B)  Fibrin breakdown 
C)  Prevention of thrombotic events 
D)  Coagulation inhibition 
A)  Platelet aggregation 
B)  Fibrin breakdown 
C)  Prevention of thrombotic events 
D)  Coagulation inhibition

Question 10

The most common tests used to detect Lupus anticoagulants include all of the following except:

Accepted Answer

A)  aPTT 
B)  Kaolin clotting time 
C)  PT/INR 
D)  Dilute Russell viper venom test 
A)  aPTT 
B)  Kaolin clotting time 
C)  PT/INR 
D)  Dilute Russell viper venom test

Question 11

All of the following are naturally occurring thrombin inhibitors except:

Accepted Answer

A)  AT 
B)  Prothrombin cofactor II 
C)  Protein C 
D)  Plasmin 
A)  AT 
B)  Prothrombin cofactor II 
C)  Protein C 
D)  Plasmin

Question 12

Factor VIII inhibitors:

Accepted Answer

A)  Are associated with thrombosis 
B)  Are associated with decreased fibrinogen levels 
C)  Are usually time and temperature dependent 
D)  Are corrected with the addition of normal plasma 
A)  Are associated with thrombosis 
B)  Are associated with decreased fibrinogen levels 
C)  Are usually time and temperature dependent 
D)  Are corrected with the addition of normal plasma

Question 13

Protein C is activated by which of the following?

Accepted Answer

A)  Heparin cofactor II 
B)  Factor VIII a 
C)  Antithrombin 
D)  Protein S 
A)  Heparin cofactor II 
B)  Factor VIII a 
C)  Antithrombin 
D)  Protein S

Question 14

Heparin therapy is monitored best by performing routine:

Accepted Answer

A)  PT/INRs 
B)  anti-factor Xa 
C)  Fibrinogen levels 
D)  Bleeding time tests 
A)  PT/INRs 
B)  anti-factor Xa 
C)  Fibrinogen levels 
D)  Bleeding time tests

Question 15

Arterial thrombosis is associated with:

Accepted Answer

A)  Slow blood flow 
B)  Impairment of the fibrinolytic system 
C)  Atherosclerosis 
D)  A deficiency of physiologic inhibitors 
A)  Slow blood flow 
B)  Impairment of the fibrinolytic system 
C)  Atherosclerosis 
D)  A deficiency of physiologic inhibitors

Question 16

Heparin:

Accepted Answer

A)  Inhibits PF3 
B)  Inhibits thrombin 
C)  Degrades antithrombin 
D)  Complexes with protein C 
A)  Inhibits PF3 
B)  Inhibits thrombin 
C)  Degrades antithrombin 
D)  Complexes with protein C

Question 17

The international normalized ratio (INR) is useful in:

Accepted Answer

A)  The detection of coagulation factor deficiencies 
B)  Monitoring heparin therapy 
C)  The detection of inhibitors 
D)  Monitoring Coumadin therapy 
A)  The detection of coagulation factor deficiencies 
B)  Monitoring heparin therapy 
C)  The detection of inhibitors 
D)  Monitoring Coumadin therapy

Question 18

All of the following statements are true regarding Coumadin except:

Accepted Answer

A)  It is a vitamin K antagonist. 
B)  It needs antithrombin as a cofactor. 
C)  PT is used to monitor its dosage. 
D)  It is not recommended for pregnant and lactating women. 
A)  It is a vitamin K antagonist. 
B)  It needs antithrombin as a cofactor. 
C)  PT is used to monitor its dosage. 
D)  It is not recommended for pregnant and lactating women.

Question 19

Antithrombin inhibits all of the following factors except:

Accepted Answer

A)  II a 
B)  VII a 
C)  IX a 
D)  XI a 
A)  II a 
B)  VII a 
C)  IX a 
D)  XI a

Question 20

Drug alternatives for patients with heparin-induced thrombocytopenia include:

Accepted Answer

A)  Danaparoid 
B)  Warfarin 
C)  Streptokinase 
D)  Aspirin 
A)  Danaparoid 
B)  Warfarin 
C)  Streptokinase 
D)  Aspirin

All of the following statements describe factor V Leiden except:

Which of the following PT results would most likely be seen in a patient who is on Coumadin and is stable?

Heparin-induced thrombocytopenia (HIT) usually:

The lupus anticoagulant is directed against:

The target therapeutic range for an INR in patients with thromboembolic disease is:

Primary hemostasis refers to the process by which:

What therapy may be used for a patient with hemophilia A who is bleeding and has a low titer of factor VIII inhibitor?

Coumadin acts in such a way that it:

The primary role of plasmin is:

The most common tests used to detect Lupus anticoagulants include all of the following except:

All of the following are naturally occurring thrombin inhibitors except:

Factor VIII inhibitors:

Protein C is activated by which of the following?

Heparin therapy is monitored best by performing routine:

Arterial thrombosis is associated with:

Heparin:

The international normalized ratio (INR) is useful in:

All of the following statements are true regarding Coumadin except:

Antithrombin inhibits all of the following factors except:

Drug alternatives for patients with heparin-induced thrombocytopenia include:

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Red Blood Cell Production, Function, and Relevant Red Blood Cell Morphology

Hemoglobin Function and Principles of Hemolysis

The Microcytic Anemias

The Macrocytic Anemias

Normochromic Anemias: Biochemical, Membrane, and Miscellaneous Red Blood Cell Disorders

The Normochromic Anemias Caused by Hemoglobinopathies

Leukopoiesis and Leukopoietic Function

Abnormalities of White Blood Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Chronic Myeloproliferative Disorders

Lymphoproliferative Disorders and Related Plasma Cell Disorders

The Myelodysplastic Syndromes

Overview of Hemostasis and Platelet Physiology

Quantitative and Qualitative Platelet Disorders

Defects of Plasma Clotting Factors

Fibrinogen, Thrombin, and the Fibrinolytic System

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Exam 19: Introduction to Thrombosis and Anticoagulant Therapy

All of the following statements describe factor V Leiden except:

Which of the following PT results would most likely be seen in a patient who is on Coumadin and is stable?

Heparin-induced thrombocytopenia (HIT) usually:

The lupus anticoagulant is directed against:

The target therapeutic range for an INR in patients with thromboembolic disease is:

Primary hemostasis refers to the process by which:

What therapy may be used for a patient with hemophilia A who is bleeding and has a low titer of factor VIII inhibitor?

Coumadin acts in such a way that it:

The primary role of plasmin is:

The most common tests used to detect Lupus anticoagulants include all of the following except:

All of the following are naturally occurring thrombin inhibitors except:

Factor VIII inhibitors:

Protein C is activated by which of the following?

Heparin therapy is monitored best by performing routine:

Arterial thrombosis is associated with:

Heparin:

The international normalized ratio (INR) is useful in:

All of the following statements are true regarding Coumadin except:

Antithrombin inhibits all of the following factors except:

Drug alternatives for patients with heparin-induced thrombocytopenia include:

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Red Blood Cell Production, Function, and Relevant Red Blood Cell Morphology

Hemoglobin Function and Principles of Hemolysis

The Microcytic Anemias

The Macrocytic Anemias

Normochromic Anemias: Biochemical, Membrane, and Miscellaneous Red Blood Cell Disorders

The Normochromic Anemias Caused by Hemoglobinopathies

Leukopoiesis and Leukopoietic Function

Abnormalities of White Blood Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Chronic Myeloproliferative Disorders

Lymphoproliferative Disorders and Related Plasma Cell Disorders

The Myelodysplastic Syndromes

Overview of Hemostasis and Platelet Physiology

Quantitative and Qualitative Platelet Disorders

Defects of Plasma Clotting Factors

Fibrinogen, Thrombin, and the Fibrinolytic System

Filters