Question 1

The following questions refer to the structure below:  
-____ serves as a substrate of ___ to produce this molecule.

Accepted Answer

A)  ATP; adenylate cyclase 
B)  ADP; adenylate cyclase 
C)  GDP; guanylate cylcase 
D)  GTP; G-protein 
E)  ADP; ATP synthase 
A)  ATP; adenylate cyclase 
B)  ADP; adenylate cyclase 
C)  GDP; guanylate cylcase 
D)  GTP; G-protein 
E)  ADP; ATP synthase

Question 2

Some cell signaling pathways, such as the toll-like receptors (TLRs), are expressed in all cell types. Most signaling pathways have "cross points" that allow them to modulate each other.

Accepted Answer

A)  Both sentences are true 
B)  Both sentences are false 
C)  The first sentence is true and the second sentence is false 
D)  The first sentence is false and the second sentence is true 
A)  Both sentences are true 
B)  Both sentences are false 
C)  The first sentence is true and the second sentence is false 
D)  The first sentence is false and the second sentence is true

Question 3

By lacking an essential serine or tyrosine, proteins with pseudosubstrate domains regulate signaling pathways by blocking kinase

Accepted Answer

A)  separation of regulatory subunits from catalytic subunits 
B)  phosphorylation 
C)  phosphatase ability 
D)  interaction with AMP 
E)  interaction with SH2 domains 
A)  separation of regulatory subunits from catalytic subunits 
B)  phosphorylation 
C)  phosphatase ability 
D)  interaction with AMP 
E)  interaction with SH2 domains

Question 4

PKG and PKA are similar in that both
I. are activated by a cyclic nucleotide monophosphate
II. have nucleotide-binding and kinase domains
III. release their catalytic subunits when activated
IV. phosphorylate downstream proteins to effect cellular change

Accepted Answer

A)  I and II 
B)  III and IV 
C)  I, II and III 
D)  I, II and IV 
E)  I only 
A)  I and II 
B)  III and IV 
C)  I, II and III 
D)  I, II and IV 
E)  I only

Question 5

Proteins that bind molecules and elicit a cellular response are called _____.

Accepted Answer

The answer of Proteins that bind molecules and elicit a...

Question 6

Phospholipase C cleaves PIP2, resulting in an increased cytosolic concentration of
I. IP3 (inositolpolyphosphate-3)
II. protein kinase C
III. cAMP
IV. Ca2+

Accepted Answer

A)  I only 
B)  II only 
C)  I, III 
D)  I, IV 
E)  IV only 
A)  I only 
B)  II only 
C)  I, III 
D)  I, IV 
E)  IV only

Question 7

You would expect the AMPK pathway to be activated when

Accepted Answer

A)  blood [nutrients] are high 
B)  blood [insulin]/[glucagon] is high 
C)  blood [glucagon]/[insulin] is high 
D)  liver gluconeogenesis is high 
E)  Both A and B are correct 
A)  blood [nutrients] are high 
B)  blood [insulin]/[glucagon] is high 
C)  blood [glucagon]/[insulin] is high 
D)  liver gluconeogenesis is high 
E)  Both A and B are correct

Question 8

The following questions refer to the structure below:  
-To affect cellular change this molecule

Accepted Answer

A)  inhibits the catalytic subunit of protein kinase A 
B)  binds the regulatory subunit of protein kinase A and inhibits the enzyme's catalytic activity 
C)  binds the regulatory subunit of protein kinase A and encourages release of the enzyme's catalytic subunits 
D)  binds G-proteins to activate them when a hormone binds a G-protein coupled receptor 
A)  inhibits the catalytic subunit of protein kinase A 
B)  binds the regulatory subunit of protein kinase A and inhibits the enzyme's catalytic activity 
C)  binds the regulatory subunit of protein kinase A and encourages release of the enzyme's catalytic subunits 
D)  binds G-proteins to activate them when a hormone binds a G-protein coupled receptor

Question 9

The phosphoinositol pathway can respond to tumor promotors to elicit tumor formation. Tumor promoters are

Accepted Answer

A)  primary messengers 
B)  activated by Ca+2 
C)  inhibited by particular G proteins 
D)  proteins that facilitate the growth of tumors 
E)  Both A and B are correct 
A)  primary messengers 
B)  activated by Ca+2 
C)  inhibited by particular G proteins 
D)  proteins that facilitate the growth of tumors 
E)  Both A and B are correct

Question 10

Desensitization of a G protein-coupled receptor is caused by phosphorylation of the receptor by a specific kinase. What protein recognizes the phosphorylated receptor?

Accepted Answer

A)  phospholipase C 
B)  the G protein $\gamma$ subunit 
C)  cAMP phosphodiesterase 
D)  adenosine receptor 
E)  arrestin 
A)  phospholipase C 
B)  the G protein $\gamma$ subunit 
C)  cAMP phosphodiesterase 
D)  adenosine receptor 
E)  arrestin

Question 11

Where are the ultimate targets of the Ras-dependent signaling cascade located within the cell?

Accepted Answer

A)  cytoplasm 
B)  nucleus 
C)  endoplasmic reticulum 
D)  mitochondria 
E)  cell membrane 
A)  cytoplasm 
B)  nucleus 
C)  endoplasmic reticulum 
D)  mitochondria 
E)  cell membrane

The following questions refer to the structure below: -__ serves as a substrate of _ to produce this molecule.

Some cell signaling pathways, such as the toll-like receptors (TLRs), are expressed in all cell types. Most signaling pathways have "cross points" that allow them to modulate each other.

By lacking an essential serine or tyrosine, proteins with pseudosubstrate domains regulate signaling pathways by blocking kinase

PKG and PKA are similar in that both I. are activated by a cyclic nucleotide monophosphate II. have nucleotide-binding and kinase domains III. release their catalytic subunits when activated IV. phosphorylate downstream proteins to effect cellular change

Proteins that bind molecules and elicit a cellular response are called _____.

Phospholipase C cleaves PIP2, resulting in an increased cytosolic concentration of I. IP3 (inositolpolyphosphate-3) II. protein kinase C III. cAMP IV. Ca²⁺

You would expect the AMPK pathway to be activated when

The following questions refer to the structure below: -To affect cellular change this molecule

The phosphoinositol pathway can respond to tumor promotors to elicit tumor formation. Tumor promoters are

Desensitization of a G protein-coupled receptor is caused by phosphorylation of the receptor by a specific kinase. What protein recognizes the phosphorylated receptor?

Where are the ultimate targets of the Ras-dependent signaling cascade located within the cell?

The Chemical Foundations of Biochemistry

Nucleic Acids

Proteins I

Proteins Iienzymes

Membranes and an Introduction to Signal Transduction

Carbohydrates I

The Common Catabolic Pathway

Carbohydrates II

Lipids I

Lipids II

Amine Metabolism

Metabolism Integration

Nucleotide Deoxynucleotide Metabolism

Dna Replication, Damage and Repair

Rna Synthesis

Protein

Control of Gene

Determination of Macromolecular Structure

Allosterism and Receptor-Ligand

Designer Proteins and Protein Folding

Biomolecule Purification

Bioinformatics and Omics

Protein Trafficking

Photosynthesis Nitrogen

Filters

Exam 23: Signal

The following questions refer to the structure below: -____ serves as a substrate of ___ to produce this molecule.

Some cell signaling pathways, such as the toll-like receptors (TLRs), are expressed in all cell types. Most signaling pathways have "cross points" that allow them to modulate each other.

By lacking an essential serine or tyrosine, proteins with pseudosubstrate domains regulate signaling pathways by blocking kinase

PKG and PKA are similar in that both I. are activated by a cyclic nucleotide monophosphate II. have nucleotide-binding and kinase domains III. release their catalytic subunits when activated IV. phosphorylate downstream proteins to effect cellular change

Proteins that bind molecules and elicit a cellular response are called _____.

Phospholipase C cleaves PIP2, resulting in an increased cytosolic concentration of I. IP3 (inositolpolyphosphate-3) II. protein kinase C III. cAMP IV. Ca2+

You would expect the AMPK pathway to be activated when

The following questions refer to the structure below: -To affect cellular change this molecule

The phosphoinositol pathway can respond to tumor promotors to elicit tumor formation. Tumor promoters are

Desensitization of a G protein-coupled receptor is caused by phosphorylation of the receptor by a specific kinase. What protein recognizes the phosphorylated receptor?

Where are the ultimate targets of the Ras-dependent signaling cascade located within the cell?

The Chemical Foundations of Biochemistry

Nucleic Acids

Proteins I

Proteins Iienzymes

Membranes and an Introduction to Signal Transduction

Carbohydrates I

The Common Catabolic Pathway

Carbohydrates II

Lipids I

Lipids II

Amine Metabolism

Metabolism Integration

Nucleotide Deoxynucleotide Metabolism

Dna Replication, Damage and Repair

Rna Synthesis

Protein

Control of Gene

Determination of Macromolecular Structure

Allosterism and Receptor-Ligand

Designer Proteins and Protein Folding

Biomolecule Purification

Bioinformatics and Omics

Protein Trafficking

Photosynthesis Nitrogen

Filters

The following questions refer to the structure below: -__ serves as a substrate of _ to produce this molecule.

Phospholipase C cleaves PIP2, resulting in an increased cytosolic concentration of I. IP3 (inositolpolyphosphate-3) II. protein kinase C III. cAMP IV. Ca²⁺