Question 1

Which reactions in the citrate cycle produce CO2?

Accepted Answer

A)  1 and 2 
B)  2 and 3 
C)  3 and 4 
D)  4 and 5 
A)  1 and 2 
B)  2 and 3 
C)  3 and 4 
D)  4 and 5

Question 2

Coenzyme A is derived from which of the following vitamins?

Accepted Answer

A)  thiamine 
B)  pantothenic acid 
C)  riboflavin 
D)  niacin 
A)  thiamine 
B)  pantothenic acid 
C)  riboflavin 
D)  niacin

Question 3

Which molecule in the net reaction of the citrate cycle contributes to the inhibition of pyruvate dehydrogenase?

Accepted Answer

A)  FAD 
B)  H2O 
C)  H+ 
D)  NADH 
A)  FAD 
B)  H2O 
C)  H+ 
D)  NADH

Question 4

Hypothesize how high concentrations of the following would either inhibit or activate the specific enzymes of the citrate cycle and the citrate cycle as a whole.
A. AMP
B. ATP
C. ADP

Accepted Answer

A. High levels of AMP would activate @#LAT-DLM&-ke

Question 5

Which of the following is a product of the net reaction of the citrate cycle?

Accepted Answer

A)  FAD 
B)  H2O 
C)  H+ 
D)  NAD+ 
A)  FAD 
B)  H2O 
C)  H+ 
D)  NAD+

Question 6

Compare and contrast the functions of NAD+ and FAD in the citrate cycle.

Accepted Answer

Both NAD⁺and FAD act as coenzymes. They a

Question 7

The regulatory mechanism in the citrate cycle involving the NADH to NAD+ ratio is considered to be an example of regulation by

Accepted Answer

A)  pH and protonation state. 
B)  product inhibition. 
C)  covalent modification. 
D)  pH and enzyme conformation. 
A)  pH and protonation state. 
B)  product inhibition. 
C)  covalent modification. 
D)  pH and enzyme conformation.

Question 8

Which reactions in the citrate cycle produce NADH?

Accepted Answer

A)  1, 2, and 4 
B)  3, 4, and 8 
C)  3, 6, and 7 
D)  5, 6, and 8 
A)  1, 2, and 4 
B)  3, 4, and 8 
C)  3, 6, and 7 
D)  5, 6, and 8

Question 9

Which of the following is the cause of the irreversible blockage of the catalytic activity of lipoamide-containing enzymes?

Accepted Answer

A)  cheilosis 
B)  pellagra 
C)  beriberi 
D)  arsenic poisoning 
A)  cheilosis 
B)  pellagra 
C)  beriberi 
D)  arsenic poisoning

Question 10

A patient seeks medical attention for ulcerous skin lesions. The patient is diagnosed with

Accepted Answer

A)  arsenic exposure. 
B)  a deficiency in vitamin B3. 
C)  beriberi. 
D)  cheilosis. 
A)  arsenic exposure. 
B)  a deficiency in vitamin B3. 
C)  beriberi. 
D)  cheilosis.

Question 11

Which reaction in the citrate cycle produces FADH2?

Accepted Answer

A)  3 
B)  4 
C)  5 
D)  6 
A)  3 
B)  4 
C)  5 
D)  6

Question 12

Outline the five reaction steps of the conversion from pyruvate to acetyl-CoA.

Accepted Answer

Step 1: Pyruvate dehydrogenase catalyzes

Question 13

Which reaction in the citrate cycle produces GTP?

Accepted Answer

A)  3 
B)  4 
C)  5 
D)  6 
A)  3 
B)  4 
C)  5 
D)  6

Question 14

What enzyme in the citrate cycle is activated by high concentrations of AMP?

Accepted Answer

A)  "isocitrate dehydrogenase" 
B)  "$\alpha$-ketoglutarate dehydrogenase" 
C)  "citrate synthase" 
D)  "succinyl-CoA synthetase" 
A)  "isocitrate dehydrogenase" 
B)  "$\alpha$-ketoglutarate dehydrogenase" 
C)  "citrate synthase" 
D)  "succinyl-CoA synthetase"

Question 15

Predict the fate of succinyl-CoA in the cell when it is not in the citrate cycle.

Accepted Answer

A)  cholesterol synthesis 
B)  heme synthesis 
C)  gluconeogenesis 
D)  amino acid synthesis 
A)  cholesterol synthesis 
B)  heme synthesis 
C)  gluconeogenesis 
D)  amino acid synthesis

Question 16

You have a patient who has been traveling through India and Bangladesh who is presenting with ulcerous skin lesions. What could cause this issue and what is your recommendation?

Accepted Answer

The symptom plus the travel locales are

Question 17

The disease beriberi is a result of which vitamin deficiency?

Accepted Answer

A)  thiamine 
B)  pantothenic acid 
C)  riboflavin 
D)  niacin 
A)  thiamine 
B)  pantothenic acid 
C)  riboflavin 
D)  niacin

Question 18

Predict the fate of $\alpha$-ketoglutarate when it is not used in the citrate cycle.

Accepted Answer

A)  cholesterol synthesis 
B)  heme synthesis 
C)  gluconeogenesis 
D)  amino acid synthesis 
A)  cholesterol synthesis 
B)  heme synthesis 
C)  gluconeogenesis 
D)  amino acid synthesis

Question 19

The anaplerotic reaction catalyzed by pyruvate carboxylase requires which coenzyme?

Accepted Answer

A)  niacin 
B)  biotin 
C)  riboflavin 
D)  thiamine 
A)  niacin 
B)  biotin 
C)  riboflavin 
D)  thiamine

Question 20

Thiamine pyrophosphate functions as a coenzyme in which reactions in the citrate cycle?

Accepted Answer

A)  pyruvate dehydrogenase and succinate dehydrogenase 
B)  pyruvate dehydrogenase and $\alpha$-ketoglutarate dehydrogenase 
C)  malate dehydrogenase and succinate dehydrogenase 
D)  malate dehydrogenase and $\alpha$-ketoglutarate dehydrogenase 
A)  pyruvate dehydrogenase and succinate dehydrogenase 
B)  pyruvate dehydrogenase and $\alpha$-ketoglutarate dehydrogenase 
C)  malate dehydrogenase and succinate dehydrogenase 
D)  malate dehydrogenase and $\alpha$-ketoglutarate dehydrogenase

Exam 10: The Citrate Cycle

Which reactions in the citrate cycle produce CO2?

Coenzyme A is derived from which of the following vitamins?

Which molecule in the net reaction of the citrate cycle contributes to the inhibition of pyruvate dehydrogenase?

Hypothesize how high concentrations of the following would either inhibit or activate the specific enzymes of the citrate cycle and the citrate cycle as a whole. A. AMP B. ATP C. ADP

Which of the following is a product of the net reaction of the citrate cycle?

Compare and contrast the functions of NAD+ and FAD in the citrate cycle.

The regulatory mechanism in the citrate cycle involving the NADH to NAD+ ratio is considered to be an example of regulation by

Which reactions in the citrate cycle produce NADH?

Which of the following is the cause of the irreversible blockage of the catalytic activity of lipoamide-containing enzymes?

A patient seeks medical attention for ulcerous skin lesions. The patient is diagnosed with

Which reaction in the citrate cycle produces FADH2?

Outline the five reaction steps of the conversion from pyruvate to acetyl-CoA.

Which reaction in the citrate cycle produces GTP?

What enzyme in the citrate cycle is activated by high concentrations of AMP?

Predict the fate of succinyl-CoA in the cell when it is not in the citrate cycle.

You have a patient who has been traveling through India and Bangladesh who is presenting with ulcerous skin lesions. What could cause this issue and what is your recommendation?

The disease beriberi is a result of which vitamin deficiency?

Predict the fate of α\alphaα -ketoglutarate when it is not used in the citrate cycle.

The anaplerotic reaction catalyzed by pyruvate carboxylase requires which coenzyme?

Thiamine pyrophosphate functions as a coenzyme in which reactions in the citrate cycle?

Principles of Biochemistry

Physical Biochemistry: Energy Conversion, Water, and Membranes

Nucleic Acid Structure and Function

Protein Structure

Methods in Protein Biochemistry

Protein Function

Enzyme Mechanisms

Cell Signaling Systems

Glycolysis: a Paradigm of Metabolic Regulation

Oxidative Phosphorylation

Photosynthesis

Carbohydrate Structure and Function

Carbohydrate Metabolism

Lipid Structure and Function

Lipid Metabolism

Amino Acid Metabolism

Nucleotide Metabolism

Metabolic Integration

DNA Replication, Repair, and Recombination

RNA Synthesis, Processing, and Gene Silencing

Protein Synthesis, Posttranslational Modification, and Transport

Gene Regulation

Filters

Which reactions in the citrate cycle produce CO₂?

Compare and contrast the functions of NAD⁺and FAD in the citrate cycle.

The regulatory mechanism in the citrate cycle involving the NADH to NAD⁺ratio is considered to be an example of regulation by

Which reaction in the citrate cycle produces FADH₂?

Predict the fate of $\alpha$ -ketoglutarate when it is not used in the citrate cycle.