Question 1

Immunoglobulin M (IgM)heterophil antibody is characterized by no reaction with EBV-specific antigens.

Accepted Answer

A) True 
 B)False  True

Question 2

Approximately which percentage of young adults demonstrate antibodies to EBV?

Accepted Answer

A)  Less than 10% 
B)  25% 
C)  50% 
D)  100% 
A)  Less than 10% 
B)  25% 
C)  50% 
D)  100% A

Question 3

Immunoglobulin M (IgM)heterophil antibody is characterized by absorption by guinea pig kidney cells.

Accepted Answer

A) True 
 B)False  False

Question 4

In rapid MonoSlide testing,a false-positive result can be caused by:

Accepted Answer

A)  observing agglutination after the observation time. 
B)  misinterpreting agglutination. 
C)  residual heterophil antibody present after clinical symptoms have subsided. 
D)  all of the above. 
A)  observing agglutination after the observation time. 
B)  misinterpreting agglutination. 
C)  residual heterophil antibody present after clinical symptoms have subsided. 
D)  all of the above.

Question 5

MATCHING
Match each procedure to the appropriate description.

-MonoSlide agglutination test

Accepted Answer

A) Distinguishes between heterophil antibodies;uses beef erythrocytes,guinea pig kidney cells,and sheep erythrocytes 
B) Detects heterophil antibodies and uses horse erythrocytes 
C) Detects heterophil antibodies and uses sheep erythrocytes 
A) Distinguishes between heterophil antibodies;uses beef erythrocytes,guinea pig kidney cells,and sheep erythrocytes 
B) Detects heterophil antibodies and uses horse erythrocytes 
C) Detects heterophil antibodies and uses sheep erythrocytes

Question 6

Anti-VCA immunoglobulin G (IgG)is usually detectable within:

Accepted Answer

A)  24 hours. 
B)  72 hours. 
C)  3 to 5 days. 
D)  4 to 7 days. 
A)  24 hours. 
B)  72 hours. 
C)  3 to 5 days. 
D)  4 to 7 days.

Question 7

Which of the following stages of infectious mononucleosis infection is characterized by antibody to Epstein-Barr nuclear antigen (EBNA)?

Accepted Answer

A)  Recent (acute)infection 
B)  Past infection (convalescent)period 
C)  Reactivation of latent infection 
D)  Both b and c 
A)  Recent (acute)infection 
B)  Past infection (convalescent)period 
C)  Reactivation of latent infection 
D)  Both b and c

Question 8

Viral capsid antigen (VCA)is produced by:

Accepted Answer

A)  phagocytic neutrophils. 
B)  infected T lymphocytes. 
C)  infected B lymphocytes. 
D)  both b and c 
A)  phagocytic neutrophils. 
B)  infected T lymphocytes. 
C)  infected B lymphocytes. 
D)  both b and c

Question 9

A blood transfusion from an immune donor to a nonimmune recipient may produce:

Accepted Answer

A)  no effect. 
B)  a primary infection. 
C)  a secondary infection. 
D)  a reactivated infection. 
A)  no effect. 
B)  a primary infection. 
C)  a secondary infection. 
D)  a reactivated infection.

Question 10

In infectious mononucleosis,EBV:

Accepted Answer

A)  infects B lymphocytes. 
B)  produces lymphocytes in peripheral blood with T cell characteristics. 
C)  induces a cytotoxic response against the EBV-infected circulating B lymphocytes. 
D)  all of the above. 
A)  infects B lymphocytes. 
B)  produces lymphocytes in peripheral blood with T cell characteristics. 
C)  induces a cytotoxic response against the EBV-infected circulating B lymphocytes. 
D)  all of the above.

Question 11

IgM type of heterophil antibodies usually appear during the __________ phase of infectious mononucleosis.

Accepted Answer

A)  acute 
B)  chronic 
C)  latent 
D)  carrier 
A)  acute 
B)  chronic 
C)  latent 
D)  carrier

Question 12

The MonoSlide test is based on the agglutination of:

Accepted Answer

A)  sheep erythrocytes. 
B)  horse erythrocytes. 
C)  latex-coated particles. 
D)  guinea pig antigen. 
A)  sheep erythrocytes. 
B)  horse erythrocytes. 
C)  latex-coated particles. 
D)  guinea pig antigen.

Question 13

EBV is transmitted primarily by:

Accepted Answer

A)  close contact with infectious oropharyngeal secretions. 
B)  blood transfusion. 
C)  transplacental exposure. 
D)  transplanted organs or tissues. 
A)  close contact with infectious oropharyngeal secretions. 
B)  blood transfusion. 
C)  transplacental exposure. 
D)  transplanted organs or tissues.

Question 14

EBV is typically manifested by:

Accepted Answer

A)  young children. 
B)  young adults. 
C)  middle-aged individuals. 
D)  older adults. 
A)  young children. 
B)  young adults. 
C)  middle-aged individuals. 
D)  older adults.

Question 15

Immunoglobulin M (IgM)heterophil antibody is characterized by no absorption by beef erythrocytes.

Accepted Answer

A) True 
 B)False

Question 16

MATCHING
Match each procedure to the appropriate description.

-Davidsohn differential test

Accepted Answer

A) Distinguishes between heterophil antibodies;uses beef erythrocytes,guinea pig kidney cells,and sheep erythrocytes 
B) Detects heterophil antibodies and uses horse erythrocytes 
C) Detects heterophil antibodies and uses sheep erythrocytes 
A) Distinguishes between heterophil antibodies;uses beef erythrocytes,guinea pig kidney cells,and sheep erythrocytes 
B) Detects heterophil antibodies and uses horse erythrocytes 
C) Detects heterophil antibodies and uses sheep erythrocytes

Question 17

In the adult population,________ of individuals with acute infectious mononucleosis do not produce heterophil antibodies.

Accepted Answer

A)  5% to 10% 
B)  10% to 20% 
C)  20% to 50% 
D)  50% to 100% 
A)  5% to 10% 
B)  10% to 20% 
C)  20% to 50% 
D)  50% to 100%

Question 18

All the following statements about Epstein-Barr virus (EBV)are true except that it:

Accepted Answer

A)  usually causes an acute,benign condition. 
B)  usually causes a self-limiting,lymphoproliferative condition. 
C)  is the cause of Burkitt's lymphoma. 
D)  is not an agent in the development of nasopharyngeal carcinoma. 
A)  usually causes an acute,benign condition. 
B)  usually causes a self-limiting,lymphoproliferative condition. 
C)  is the cause of Burkitt's lymphoma. 
D)  is not an agent in the development of nasopharyngeal carcinoma.

Question 19

Fill in the blanks.The incubation period of infectious mononucleosis is from (1)__________days;once fully developed,it lasts for (2)________ weeks.
A)1 to 2
B)1 to 4
C)2 to 4
D)3 to 6
E)5 to 10
F)10 to 50

Accepted Answer

1,F;2,B
The incubation period

Question 20

The use of horse erythrocytes in rapid slide tests for infectious mononucleosis increases the:

Accepted Answer

A)  readability. 
B)  sensitivity. 
C)  specificity. 
D)  all of the above. 
A)  readability. 
B)  sensitivity. 
C)  specificity. 
D)  all of the above.

Exam 22: Infectious Mononucleosis

Immunoglobulin M (IgM)heterophil antibody is characterized by no reaction with EBV-specific antigens.

Approximately which percentage of young adults demonstrate antibodies to EBV?

Immunoglobulin M (IgM)heterophil antibody is characterized by absorption by guinea pig kidney cells.

In rapid MonoSlide testing,a false-positive result can be caused by:

MATCHING Match each procedure to the appropriate description. -MonoSlide agglutination test

Anti-VCA immunoglobulin G (IgG)is usually detectable within:

Which of the following stages of infectious mononucleosis infection is characterized by antibody to Epstein-Barr nuclear antigen (EBNA)?

Viral capsid antigen (VCA)is produced by:

A blood transfusion from an immune donor to a nonimmune recipient may produce:

In infectious mononucleosis,EBV:

IgM type of heterophil antibodies usually appear during the __________ phase of infectious mononucleosis.

The MonoSlide test is based on the agglutination of:

EBV is transmitted primarily by:

EBV is typically manifested by:

Immunoglobulin M (IgM)heterophil antibody is characterized by no absorption by beef erythrocytes.

MATCHING Match each procedure to the appropriate description. -Davidsohn differential test

In the adult population,________ of individuals with acute infectious mononucleosis do not produce heterophil antibodies.

All the following statements about Epstein-Barr virus (EBV)are true except that it:

Fill in the blanks.The incubation period of infectious mononucleosis is from (1)__________days;once fully developed,it lasts for (2)________ weeks. A)1 to 2 B)1 to 4 C)2 to 4 D)3 to 6 E)5 to 10 F)10 to 50

The use of horse erythrocytes in rapid slide tests for infectious mononucleosis increases the:

An Overview of Immunology

Antigens and Antibodies

Cells and Cellular Activities of the Immune System: Granulocytes and Mononuclear Cells

Cells and Cellular Activities of the Immune System: Lymphocytes and Plasma Cells

Soluble Mediators of the Immune System

Safety in the Immunology-Serology Laboratory

Quality Assurance and Quality Control

Basic Serologic Laboratory Techniques

Point-Of-Care Testing

Agglutination Methods

Electrophoresis Techniques

Labeling Techniques in Immunoassay

Automated Procedures

Molecular Techniques

The Immune Response in Infectious Diseases

A Primer on Vaccines

Streptococcal Infections

Syphilis

Vector-Borne Diseases

Toxoplasmosis

Cytomegalovirus

Viral Hepatitis

Rubella and Rubeola Infections

Acquired Immunodeficiency Syndrome

Hypersensitivity Reactions

Immunoproliferative Disorders

Autoimmune Disorders

Systemic Lupus Erythematosus

Rheumatoid Arthritis

Solid Organ Transplantation

Bone Marrow Transplantation

Tumor Immunology

Filters

Fill in the blanks.The incubation period of infectious mononucleosis is from (1)__days;once fully developed,it lasts for (2) weeks. A)1 to 2 B)1 to 4 C)2 to 4 D)3 to 6 E)5 to 10 F)10 to 50