Question 1

Eukaryotic cells have many different DNA polymerases, one or more of which function primarily in repair of damaged DNA.

Accepted Answer

A) True 
 B)False

Question 2

Some DNA polymerases have a nuclease activity that allows them to remove mismatched nucleotides and repair a sequence.

Accepted Answer

A) True 
 B)False

Question 3

Describe the two major forms of spontaneous DNA damage.

Accepted Answer

One form of spontaneous damage is simple

Question 4

How do DNA polymerases differ from RNA polymerases in terms of primer requirement?

Accepted Answer

DNA polymerases requ

Question 5

Explain why accuracy is more important for DNA replication than for transcription.

Accepted Answer

Mistakes made during DNA replication are

Question 6

Which statement about pyrimidine dimers is false?

Accepted Answer

A)  They are lesions in DNA caused by UV radiation. 
B)  They are formed between adjacent pyrimidines on a DNA strand. 
C)  Their formation blocks DNA replication and transcription. 
D)  They can be repaired by photoreactivation in human cells. 
A)  They are lesions in DNA caused by UV radiation. 
B)  They are formed between adjacent pyrimidines on a DNA strand. 
C)  Their formation blocks DNA replication and transcription. 
D)  They can be repaired by photoreactivation in human cells.

Question 7

T cell receptors bind to _______ on the surface of other cells during immune responses.

Accepted Answer

The answer of T cell receptors bind to _______ on...

Question 8

Which statement is true of all known DNA polymerases?

Accepted Answer

A)  They synthesize DNA in the 5ʹ to 3ʹ direction, and they require a preformed primer hydrogen-bonded to the template. 
B)  They synthesize DNA in the 5ʹ to 3ʹ direction, and they possess primase activity. 
C)  They require a preformed primer, and they possess helicase activity. 
D)  They synthesize DNA in the 3ʹ to 5ʹ direction, and they possess exonuclease activity. 
A)  They synthesize DNA in the 5ʹ to 3ʹ direction, and they require a preformed primer hydrogen-bonded to the template. 
B)  They synthesize DNA in the 5ʹ to 3ʹ direction, and they possess primase activity. 
C)  They require a preformed primer, and they possess helicase activity. 
D)  They synthesize DNA in the 3ʹ to 5ʹ direction, and they possess exonuclease activity.

Question 9

Pyrimidine dimers

Accepted Answer

A)  block DNA replication and transcription. 
B)  can be repaired by photoreactivation. 
C)  can be repaired by nucleotide-excision repair. 
D)  All of the above 
A)  block DNA replication and transcription. 
B)  can be repaired by photoreactivation. 
C)  can be repaired by nucleotide-excision repair. 
D)  All of the above

Question 10

The short fragments of DNA produced during DNA replication are joined together by

Accepted Answer

A)  RNA polymerase. 
B)  DNA polymerase. 
C)  DNA helicase. 
D)  DNA ligase. 
A)  RNA polymerase. 
B)  DNA polymerase. 
C)  DNA helicase. 
D)  DNA ligase.

Question 11

Primase synthesizes short sequences of _______ complementary to the _______ strand.

Accepted Answer

A)  DNA; leading 
B)  RNA; lagging 
C)  DNA; lagging 
D)  All of the above 
A)  DNA; leading 
B)  RNA; lagging 
C)  DNA; lagging 
D)  All of the above

Question 12

Site-specific recombination occurs commonly during

Accepted Answer

A)  mitosis of somatic cells. 
B)  meiosis of germ cells. 
C)  development of immune-system cells. 
D)  prokaryotic cell division. 
A)  mitosis of somatic cells. 
B)  meiosis of germ cells. 
C)  development of immune-system cells. 
D)  prokaryotic cell division.

Question 13

T cell receptors resemble _______ in many ways.

Accepted Answer

The answer of T cell receptors resemble _______ in many...

Question 14

On a typical prokaryotic chromosome the number of telomeres and origins of replication is _______ telomere(s) and _______ origin(s) of replication.

Accepted Answer

The answer of On a typical prokaryotic chromosome the number...

Question 15

During DNA replication, the overall error frequency is 1 in _______ base pairs.

Accepted Answer

A)  105 
B)  106 
C)  108 
D)  109 
A)  105 
B)  106 
C)  108 
D)  109

Question 16

Which of the following enzymes serves an important role in both somatic hypermutation and class switch recombination?

Accepted Answer

A)  Helicase 
B)  Exonuclease 
C)  DNA glycosylase 
D)  Activation-induced deaminase 
A)  Helicase 
B)  Exonuclease 
C)  DNA glycosylase 
D)  Activation-induced deaminase

Question 17

In the mouse, the total number of heavy chains that can be generated by site-specific recombination events is about

Accepted Answer

A)  600. 
B)  7,200. 
C)  105. 
D)  106. 
A)  600. 
B)  7,200. 
C)  105. 
D)  106.

Question 18

Why do E. coli chromosomes not have telomeres?

Accepted Answer

The E. coli chromosome is circular and t

Question 19

Proliferating cell nuclear antigen (PCNA) is a(n) _______ in eukaryotes.

Accepted Answer

A)  DNA polymerase 
B)  sliding-clamp protein 
C)  single-stranded DNA binding protein 
D)  origin-of-replication binding protein 
A)  DNA polymerase 
B)  sliding-clamp protein 
C)  single-stranded DNA binding protein 
D)  origin-of-replication binding protein

Question 20

On one typical eukaryotic chromosome there are, in number, _______ telomere(s) and _______ origin(s) of replication.

Accepted Answer

two (or 2)

Eukaryotic cells have many different DNA polymerases, one or more of which function primarily in repair of damaged DNA.

Some DNA polymerases have a nuclease activity that allows them to remove mismatched nucleotides and repair a sequence.

Describe the two major forms of spontaneous DNA damage.

How do DNA polymerases differ from RNA polymerases in terms of primer requirement?

Explain why accuracy is more important for DNA replication than for transcription.

Which statement about pyrimidine dimers is false?

T cell receptors bind to _______ on the surface of other cells during immune responses.

Which statement is true of all known DNA polymerases?

Pyrimidine dimers

The short fragments of DNA produced during DNA replication are joined together by

Primase synthesizes short sequences of _ complementary to the _ strand.

Site-specific recombination occurs commonly during

T cell receptors resemble _______ in many ways.

On a typical prokaryotic chromosome the number of telomeres and origins of replication is _ telomere(s) and _ origin(s) of replication.

During DNA replication, the overall error frequency is 1 in _______ base pairs.

Which of the following enzymes serves an important role in both somatic hypermutation and class switch recombination?

In the mouse, the total number of heavy chains that can be generated by site-specific recombination events is about

Why do E. coli chromosomes not have telomeres?

Proliferating cell nuclear antigen (PCNA) is a(n) _______ in eukaryotes.

On one typical eukaryotic chromosome there are, in number, _ telomere(s) and _ origin(s) of replication.

An Overview of Cells and Cell Research

Molecules and Membranes

Bioenergetics and Metabolism

Fundamentals of Molecular Biology

Genomics, Proteomics, and Systems Biology

Genes and Genomes

RNA Synthesis and Processing

Transcriptional Regulation and Epigenetics

Protein Synthesis, Processing, and Regulation

The Nucleus

Protein Sorting and Transport

Mitochondria, Chloroplasts, and Peroxisomes

The Cytoskeleton and Cell Movement

The Plasma Membrane

Cell Walls, the Extracellular Matrix, and Cell Interactions

Cell Signaling

The Cell Cycle

Cell Death and Cell Renewal

Cancer

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Exam 7: Replication, Maintenance, and Rearrangements of Genomic Dna

Eukaryotic cells have many different DNA polymerases, one or more of which function primarily in repair of damaged DNA.

Some DNA polymerases have a nuclease activity that allows them to remove mismatched nucleotides and repair a sequence.

Describe the two major forms of spontaneous DNA damage.

How do DNA polymerases differ from RNA polymerases in terms of primer requirement?

Explain why accuracy is more important for DNA replication than for transcription.

Which statement about pyrimidine dimers is false?

T cell receptors bind to _______ on the surface of other cells during immune responses.

Which statement is true of all known DNA polymerases?

Pyrimidine dimers

The short fragments of DNA produced during DNA replication are joined together by

Primase synthesizes short sequences of _______ complementary to the _______ strand.

Site-specific recombination occurs commonly during

T cell receptors resemble _______ in many ways.

On a typical prokaryotic chromosome the number of telomeres and origins of replication is _______ telomere(s) and _______ origin(s) of replication.

During DNA replication, the overall error frequency is 1 in _______ base pairs.

Which of the following enzymes serves an important role in both somatic hypermutation and class switch recombination?

In the mouse, the total number of heavy chains that can be generated by site-specific recombination events is about

Why do E. coli chromosomes not have telomeres?

Proliferating cell nuclear antigen (PCNA) is a(n) _______ in eukaryotes.

On one typical eukaryotic chromosome there are, in number, _______ telomere(s) and _______ origin(s) of replication.

An Overview of Cells and Cell Research

Molecules and Membranes

Bioenergetics and Metabolism

Fundamentals of Molecular Biology

Genomics, Proteomics, and Systems Biology

Genes and Genomes

RNA Synthesis and Processing

Transcriptional Regulation and Epigenetics

Protein Synthesis, Processing, and Regulation

The Nucleus

Protein Sorting and Transport

Mitochondria, Chloroplasts, and Peroxisomes

The Cytoskeleton and Cell Movement

The Plasma Membrane

Cell Walls, the Extracellular Matrix, and Cell Interactions

Cell Signaling

The Cell Cycle

Cell Death and Cell Renewal

Cancer

Filters

Primase synthesizes short sequences of _ complementary to the _ strand.

On a typical prokaryotic chromosome the number of telomeres and origins of replication is _ telomere(s) and _ origin(s) of replication.

On one typical eukaryotic chromosome there are, in number, _ telomere(s) and _ origin(s) of replication.