Question 1

Which of the following bleeding tests is abnormal in patients with von Willebrand disease?

Accepted Answer

A)  Prolonged bleeding time 
B)  Thrombocytopenia 
C)  Prolonged prothrombin time 
D)  Shortened partial thromboplastin time 
E)  Increased levels of factor VIII in plasma 
A)  Prolonged bleeding time 
B)  Thrombocytopenia 
C)  Prolonged prothrombin time 
D)  Shortened partial thromboplastin time 
E)  Increased levels of factor VIII in plasma A

Question 2

Which test is abnormal in hemophilia A?

Accepted Answer

A)  Bleeding 
B)  Platelet count 
C)  Prothrombin time 
D)  Partial thromboplastin time 
E)  Clot retraction 
A)  Bleeding 
B)  Platelet count 
C)  Prothrombin time 
D)  Partial thromboplastin time 
E)  Clot retraction D

Question 3

Severe hemophilia develops in patients who have factor VIII reduced below

Accepted Answer

A)  1% 
B)  5% 
C)  10% 
D)  20% 
E)  25% 
A)  1% 
B)  5% 
C)  10% 
D)  20% 
E)  25% A

Question 4

Terminal deoxynucleotidyltransferase is a marker of

Accepted Answer

A)  B cells 
B)  T cells 
C)  Precursors of B and T lymphocytes 
D)  Plasma cells 
E)  Natural killer cells 
A)  B cells 
B)  T cells 
C)  Precursors of B and T lymphocytes 
D)  Plasma cells 
E)  Natural killer cells

Question 5

Hemolytic uremic syndrome (HUS) shares many features with thrombotic thrombocytopenic purpura (TTP), but in contrast with patients with TTP, those with HUS do NOT have

Accepted Answer

A)  anemia 
B)  renal failure 
C)  neurologic deficits 
D)  fever 
E)  thrombocytopenia 
A)  anemia 
B)  renal failure 
C)  neurologic deficits 
D)  fever 
E)  thrombocytopenia

Question 6

Which is the most common histologic form of Hodgkin disease?

Accepted Answer

A)  Lymphocyte predominance 
B)  Nodular sclerosis 
C)  Mixed cellularity 
D)  Lymphocyte depletion 
E)  Nodular lymphocyte predominance 
A)  Lymphocyte predominance 
B)  Nodular sclerosis 
C)  Mixed cellularity 
D)  Lymphocyte depletion 
E)  Nodular lymphocyte predominance

Question 7

The most common form of autosomal dominant hereditary spherocytosis is caused by a mutation of the gene encoding which of the following proteins?

Accepted Answer

A)  Ankyrin 
B)  Spectrin 
C)  Protein 4.1 
D)  Hemoglobin A 
E)  Transferrin 
A)  Ankyrin 
B)  Spectrin 
C)  Protein 4.1 
D)  Hemoglobin A 
E)  Transferrin

Question 8

A 20-year-old woman was diagnosed with Hodgkin disease involving the mediastinum. Which would be the most common histologic form of Hodgkin disease to occur at this site?

Accepted Answer

A)  Lymphocyte predominance 
B)  Nodular sclerosis 
C)  Mixed cellularity 
D)  Lymphocyte depletion 
E)  Nodular lymphoid predominance 
A)  Lymphocyte predominance 
B)  Nodular sclerosis 
C)  Mixed cellularity 
D)  Lymphocyte depletion 
E)  Nodular lymphoid predominance

Question 9

Which form of lymphoma tends to arise in the gastrointestinal tract at the site of chronic inflammation, such as chronic sialadenitis in Sjögren disease or chronic gastritis caused by Helicobacter pylori?

Accepted Answer

A)  Pre-B, pre-T lymphoblastic lymphoma 
B)  Mantle cell lymphoma 
C)  Marginal cell lymphoma 
D)  Peripheral T-cell lymphoma 
E)  Burkitt lymphoma 
A)  Pre-B, pre-T lymphoblastic lymphoma 
B)  Mantle cell lymphoma 
C)  Marginal cell lymphoma 
D)  Peripheral T-cell lymphoma 
E)  Burkitt lymphoma

Question 10

What are the mechanisms of thrombocytopenia in patients who have giant hemangiomas?

Accepted Answer

A)  Autoimmune destruction of platelets 
B)  Inhibition of bone marrow 
C)  Mechanical destruction of platelets 
D)  Increased consumption of platelets in peripheral blood vessels 
E)  Disseminated intravascular hemolysis 
A)  Autoimmune destruction of platelets 
B)  Inhibition of bone marrow 
C)  Mechanical destruction of platelets 
D)  Increased consumption of platelets in peripheral blood vessels 
E)  Disseminated intravascular hemolysis

Question 11

Which of the following is the most common aggressive form of non-Hodgkin lymphoma in the United States?

Accepted Answer

A)  Follicular lymphoma 
B)  Diffuse large B-cell lymphoma 
C)  Mantle cell lymphoma 
D)  Peripheral T-cell lymphoma 
E)  Angiocentric lymphoma 
A)  Follicular lymphoma 
B)  Diffuse large B-cell lymphoma 
C)  Mantle cell lymphoma 
D)  Peripheral T-cell lymphoma 
E)  Angiocentric lymphoma

Question 12

What is the most common form of non-Hodgkin lymphoma in the United States?

Accepted Answer

A)  Follicular lymphoma 
B)  Diffuse large B-cell lymphoma 
C)  Mantle cell lymphoma 
D)  Peripheral T-cell lymphoma 
E)  Angiocentric lymphoma 
A)  Follicular lymphoma 
B)  Diffuse large B-cell lymphoma 
C)  Mantle cell lymphoma 
D)  Peripheral T-cell lymphoma 
E)  Angiocentric lymphoma

Question 13

Which is the most common cause of microcytic hypochromic anemia in American women aged 20 to 50 years?

Accepted Answer

A)  Autoimmune hemolysis 
B)  Iron deficiency 
C)  Vitamin B12 deficiency 
D)  Thalassemia minor 
E)  Viral infection 
A)  Autoimmune hemolysis 
B)  Iron deficiency 
C)  Vitamin B12 deficiency 
D)  Thalassemia minor 
E)  Viral infection

Question 14

Peripheral blood cytopenia is a feature of

Accepted Answer

A)  chronic myelogenous leukemia 
B)  chronic myeloproliferative disorders 
C)  myelodysplastic syndrome 
D)  polycythemia vera 
E)  essential thrombocytopenia 
A)  chronic myelogenous leukemia 
B)  chronic myeloproliferative disorders 
C)  myelodysplastic syndrome 
D)  polycythemia vera 
E)  essential thrombocytopenia

Question 15

A 15-year-old boy developed generalized lymphadenopathy, accompanied by fever and malaise. A lymph node biopsy specimen showed that the architecture of the lymph nodes was erased and the nodes were infiltrated with moderately large lymphoid cells. There were numerous mitoses and apoptotic bodies. Between the B lymphocytes, there were phagocytic macrophages, imparting a "starry-sky" appearance to the lymph node. Which of the following is the most likely diagnosis?

Accepted Answer

A)  Follicular lymphoma 
B)  Large B-cell lymphoma 
C)  Chronic lymphocytic leukemia/small lymphocytic lymphoma 
D)  Burkitt lymphoma 
E)  Multiple myeloma 
A)  Follicular lymphoma 
B)  Large B-cell lymphoma 
C)  Chronic lymphocytic leukemia/small lymphocytic lymphoma 
D)  Burkitt lymphoma 
E)  Multiple myeloma

Question 16

The deletion of two α -globin chains of hemoglobin is the cause of

Accepted Answer

A)  α -thalassemia trait 
B)  α -thalassemia minor 
C)  salient carrier state 
D)  hemoglobin H disease 
E)  hydrops fetalis 
A)  α -thalassemia trait 
B)  α -thalassemia minor 
C)  salient carrier state 
D)  hemoglobin H disease 
E)  hydrops fetalis

Question 17

The most common cause of myelophthisic anemia is

Accepted Answer

A)  metastatic carcinoma to the bones 
B)  multiple myeloma 
C)  lymphoma 
D)  leukemia 
E)  osteosclerosis 
A)  metastatic carcinoma to the bones 
B)  multiple myeloma 
C)  lymphoma 
D)  leukemia 
E)  osteosclerosis

Question 18

Aplastic crisis, which can be encountered in patients with hereditary spherocytosis or sickle cell anemia, is most often precipitated by

Accepted Answer

A)  deficiency of erythropoietin 
B)  negative feedback inhibition by bilirubin 
C)  adverse effect of iron released from hemolyzed erythrocytes 
D)  autoimmune mechanisms 
E)  parvovirus infection 
A)  deficiency of erythropoietin 
B)  negative feedback inhibition by bilirubin 
C)  adverse effect of iron released from hemolyzed erythrocytes 
D)  autoimmune mechanisms 
E)  parvovirus infection

Question 19

The monoclonal immunoglobulin, the so-called M protein of multiple myeloma, belongs to which class of immunoglobulins?

Accepted Answer

A)  IgA 
B)  IgD 
C)  IgE 
D)  IgG 
E)  IgM 
A)  IgA 
B)  IgD 
C)  IgE 
D)  IgG 
E)  IgM

Question 20

Transformation of chronic lymphocytic leukemia or small cell lymphocytic lymphoma into a large B-cell lymphoma is called

Accepted Answer

A)  Burkitt lymphoma 
B)  Waldenstrom macroglobulinemia 
C)  Richter syndrome 
D)  myelodysplastic syndrome 
E)  mycosis fungoides 
A)  Burkitt lymphoma 
B)  Waldenstrom macroglobulinemia 
C)  Richter syndrome 
D)  myelodysplastic syndrome 
E)  mycosis fungoides

Exam 11: Hematopoietic and Lymphoid Systems

Which of the following bleeding tests is abnormal in patients with von Willebrand disease?

Which test is abnormal in hemophilia A?

Severe hemophilia develops in patients who have factor VIII reduced below

Terminal deoxynucleotidyltransferase is a marker of

Hemolytic uremic syndrome (HUS) shares many features with thrombotic thrombocytopenic purpura (TTP), but in contrast with patients with TTP, those with HUS do NOT have

Which is the most common histologic form of Hodgkin disease?

The most common form of autosomal dominant hereditary spherocytosis is caused by a mutation of the gene encoding which of the following proteins?

A 20-year-old woman was diagnosed with Hodgkin disease involving the mediastinum. Which would be the most common histologic form of Hodgkin disease to occur at this site?

Which form of lymphoma tends to arise in the gastrointestinal tract at the site of chronic inflammation, such as chronic sialadenitis in Sjögren disease or chronic gastritis caused by Helicobacter pylori?

What are the mechanisms of thrombocytopenia in patients who have giant hemangiomas?

Which of the following is the most common aggressive form of non-Hodgkin lymphoma in the United States?

What is the most common form of non-Hodgkin lymphoma in the United States?

Which is the most common cause of microcytic hypochromic anemia in American women aged 20 to 50 years?

Peripheral blood cytopenia is a feature of

The deletion of two α -globin chains of hemoglobin is the cause of

The most common cause of myelophthisic anemia is

Aplastic crisis, which can be encountered in patients with hereditary spherocytosis or sickle cell anemia, is most often precipitated by

The monoclonal immunoglobulin, the so-called M protein of multiple myeloma, belongs to which class of immunoglobulins?

Transformation of chronic lymphocytic leukemia or small cell lymphocytic lymphoma into a large B-cell lymphoma is called

Cell Injury, Cell Death, and Adaptations

Inflammation and Repair

Hemodynamic Disorders, Thromboembolism, and Shock

Diseases of the Immune System

Neoplasia

Genetic and Pediatric Diseases

Environmental and Nutritional Diseases

General Pathology of Infectious Diseases

Blood Vessels

Heart

Lung

Kidney and Its Collecting System

Oral Cavity and Gastrointestinal Tract

Liver, Gallbladder, and Biliary Tract

Pancreas

Male Genital System and Lower Urinary Tract

Female Genital System and Breast

Endocrine System

Bones, Joints, and Soft Tissue Tumors

Peripheral Nerves and Muscles

Central Nervous System

Skin

Filters