Exam 4: Diseases of the Immune System

Amyloid deposited in the tissue of patients who are on dialysis for chronic renal failure is most often biochemically related to which precursor protein?

A 23-year-old woman was given an intradermal injection of purified protein derivative of tubercle bacilli (PPD) as part of the yearly testing for tuberculosis. A positive reaction was elicited. Which cells secrete the cytokines needed for the formation of granulomas at the site of injection?

The most common and the most serious form of renal disease encountered in systemic lupus erythematosus (SLE) is classified as x. Most of the lesions found in SLE are mediated by the deposition of immune complexes (type III hypersensitivity reaction). Which pathologic reaction is due to type II hypersensitivity (cytotoxic) reaction?

Which of the following is the predominant and most common cardiovascular manifestation of systemic lupus erythematosus?

Deposition of AL amyloid in the kidneys of patients with multiple myeloma usually results in

The most common fungal pathogen infecting the mouth and the esophagus of patients with AIDS is

A 10-year-old girl presented with lilac or heliotrope discoloration of the upper eyelids, muscle weakness, and dusky red patches over the knuckles, elbows, and knees. Which antibody was most likely found in this patient's blood?

Which of the following blood studies is the best evidence of microvascular endothelial cell injury that typically occurs in systemic sclerosis (scleroderma)?

Autoantibodies to IgA are found in approximately 40% of patients who have

The formation of vesicles in contact dermatitis caused by poison ivy is primarily mediated by

Which molecule on the surface of lymphocytes serves as the receptor for the human immunodeficiency virus (HIV)?

Antigen-antibody reaction in polyarteritis nodosa is characterized by which form of necrosis of the arterial wall?

A 40-year-old man presents with hemoptysis and renal failure. A kidney biopsy specimen revealed linear deposits of IgG in glomerular basement membranes and crescents between the glomerular capillary loops and the Bowman capsule. The antibodies causing these pathologic changes react with

In addition to T-helper lymphocytes, which other cells serve as a major reservoir for the human immunodeficiency virus in lymph nodes?

Which of the following is the most abundant bronchospasm-inducing arachidonic acid derivative generated by cyclooxygenase in the mast cells?

Mutation of the gene encoding the enzyme that is essential for the maturation of pre-B cells to mature B lymphocytes is the cause of

Generic antinuclear antibodies are found in more than 95% of patients with systemic lupus erythematosus. Which pattern of staining seen on tissue culture cells in the indirect antibody immunofluorescence microscopy test signifies the presence of these antibodies?

Which antibodies are considered to be markers of Sjögren syndrome?

Which antibody can most effectively activate complement by the alternate pathway, even without prior forming an antigen-antibody complex?

Antibodies to centromere are found in patients who have