Exam 2: Inflammation and Repair

A 2-year-old child known to suffer from recurrent bacterial infections and poor wound healing was found to have leukocyte adhesion molecule deficiency 1 (LAD-1). The leukocytes of this patient do not express CD18, a molecule classified as belonging to the family of

Which growth factor is the most potent promotor of angiogenesis in the granulation tissue?

Transmembrane adhesive heterodimeric proteins, composed of an a and a ß chain, are expressed on activated leukocytes during inflammation. They bind primarily to intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1), both of which belong to the family of proteins known as

Which of the following mediators of inflammation causes pain?

Aspirin lowers the body temperature by inhibiting the synthesis of which regulator of the central thermostat in the hypothalamus?

C-reactive protein binds to the surface of microbes in tissues acting as

Nitric oxide synthesis is augmented in endothelial cells by a calmodulin-mediated influx of which element?

A 20-year-old woman suffered extensive burns and developed large irregular scars over her hands. These scars limited the movement of her fingers, and she was unable to fully extend them. What are these lesions called?

Which of the following mediators of inflammation has chemotactic properties and is increased in persons taking aspirin?

Bradykinin is produced from a high-molecular weight kininogen circulating in the blood. This reaction is mediated by

Fibrillin is important for the scaffolding and deposition of which other component of the extracellular matrix?