Exam 18: Female Genital System and Breast

A 55-year-old woman who has diabetes mellitus complains of genital itching. Examination shows whitish plaques on the mucosa of the vulva and vagina. Which of the following infectious agents most likely caused these changes?

A 25-year-old woman had a workup for infertility. During the laparoscopic examination, the gynecologist found foci of endometriosis. Such foci are most often seen on which of the following sites?

Which of the following genital lesions is associated with a greater than expected risk of carcinoma of the vulva?

This uterus was removed from a 58-year-old woman who complained of metrorrhagia. Most likely this lesion is pathogenetically related to

BRCA1 and BRCA2 genes that are mutated in 25% of all women who have familial breast cancer encode proteins. Which of the following functions do these proteins serve?

A high level of expression of the tumor suppressor gene PTEN will most likely be found in which of the following?

This biopsy specimen was taken from an excoriated and oozing nipple of a 50-year-old woman. These histologic findings are most consistent with the diagnosis of

This breast tumor was removed from a 60-year-old woman. On gross examination, the tumor was found to be

Comedocarcinoma of the breast is a type of which of the following carcinomas?

Which of the following nonneoplastic breast lesions is associated with the highest risk of mammary cancer?

This pelvic tumor most likely originated from the

Elevated 17-ketosteroid excretion, masculinization, and hirsutism are found in a woman who has a tumor of the ovary. The tumor is composed of polygonal cells with abundant eosinophilic cytoplasm and occasional Reinke crystals. Which of the following is the most likely classification of this tumor?

The solitary nodular lesion in this uterus removed from a 55-year-old woman is most likely composed of

These ovaries were removed from an infertile, obese, slightly hirsute 30-year-old woman with persistent menstrual irregularities. The cystic spaces seen in the ovaries represent

Assuming that a vaccination will be discovered for the human papillomavirus in women, it is expected that the vaccination will reduce the incidence of carcinoma at which of the following sites?

A physical examination of a 5-year-old girl shows a grape-like polypoid mass protruding from the vagina. Histologic examination reveals that the mass has a myxoid stroma that contains small oval-shaped cells. Some of these cells have pink cytoplasm and resemble tennis rackets. These cells reacted positively upon immunohistochemical staining with the antibodies to desmin. Which of the following is the most likely diagnosis?

A 50-year-old woman sees her physician because she has noticed a bloody discharge from the left nipple. Upon physical examination, there are no palpable masses in the breast. Which of the following is the most likely cause of this discharge?