Question 1

The deficit of which of these is most closely associated with Southeast Asian ovalocytosis?

Accepted Answer

A) Spectrin 
B) Ankyrin 
C) Molecular band 3 
D) G6PD 
A) Spectrin 
B) Ankyrin 
C) Molecular band 3 
D) G6PD C

Question 2

Cholelithiasis is a frequent complication of patients with hereditary spherocytosis because:

Accepted Answer

A) Spherocytes are an abnormal red blood cell morphology 
B) The gallbladder does not function well in this condition 
C) Continued hemolysis in this condition causes gallstones to form 
D) The filtration function of the spleen is overworked 
A) Spherocytes are an abnormal red blood cell morphology 
B) The gallbladder does not function well in this condition 
C) Continued hemolysis in this condition causes gallstones to form 
D) The filtration function of the spleen is overworked C

Question 3

A defect in stomatin is the main cause of hereditary spherocytosis.

Accepted Answer

A) True 
 B)False  False

Question 4

Bite cells are formed from:

Accepted Answer

A) The spleen "pitting" out Heinz bodies 
B) Third-degree burns 
C) Spectrin deficiency 
D) G6PD deficiency 
A) The spleen "pitting" out Heinz bodies 
B) Third-degree burns 
C) Spectrin deficiency 
D) G6PD deficiency

Question 5

One of the least severe clinical manifestations of G6PD deficiency is:

Accepted Answer

A) Acute hemolytic anemia 
B) Favism 
C) Neonatal jaundice 
D) Congenital non-spherocytic hemolytic anemia 
A) Acute hemolytic anemia 
B) Favism 
C) Neonatal jaundice 
D) Congenital non-spherocytic hemolytic anemia

Question 6

An osmotic fragility test is performed on a patient's sample.Initial hemolysis occurs at 0.75% NaCl and complete hemolysis occurs at 0.50% NaCl.These results are indicative of which of the following disorders?

Accepted Answer

A) Sickle cell anemia 
B) Hgb C disease 
C) Thalassemia major 
D) Hereditary spherocytosis 
A) Sickle cell anemia 
B) Hgb C disease 
C) Thalassemia major 
D) Hereditary spherocytosis

Question 7

Spherocytes differ from normal cells in all of the following ways except having:

Accepted Answer

A) Decreased surface-to-volume ratio 
B) Decreased central pallor 
C) Decreased resistance to hypotonic saline 
D) Increased deformability 
A) Decreased surface-to-volume ratio 
B) Decreased central pallor 
C) Decreased resistance to hypotonic saline 
D) Increased deformability

Question 8

Spherocytes may enter the circulation via a variety of mechanisms.To distinguish the CBC of a patient with hereditary spherocytosis from the CBC of a patient with autoimmune hemolytic anemia, one could use the:

Accepted Answer

A) MCHC 
B) Hematocrit 
C) MCH 
D) MCV 
A) MCHC 
B) Hematocrit 
C) MCH 
D) MCV

Question 9

Spherocytes do not function well in the splenic environment because the:

Accepted Answer

A) Osmotic environment of the spherocyte is impaired 
B) Immunologic function of the spleen is impaired 
C) Reservoir function is impaired 
D) Filtration function of the spleen is compromised 
A) Osmotic environment of the spherocyte is impaired 
B) Immunologic function of the spleen is impaired 
C) Reservoir function is impaired 
D) Filtration function of the spleen is compromised

Question 10

In hereditary spherocytosis, the reticulocyte count will typically be:

Accepted Answer

A) Less than 0.5% 
B) 0.5% to 1.5% 
C) 3% to 10% 
D) Greater than 10% 
A) Less than 0.5% 
B) 0.5% to 1.5% 
C) 3% to 10% 
D) Greater than 10%

Question 11

Which of the following red blood cell membrane defects results in an increased sensitivity to complement lysis?

Accepted Answer

A) Cold agglutinin syndrome 
B) Paroxysmal nocturnal hemoglobinemia 
C) Diamond Blackfan anemia 
D) Hereditary spherocytosis 
A) Cold agglutinin syndrome 
B) Paroxysmal nocturnal hemoglobinemia 
C) Diamond Blackfan anemia 
D) Hereditary spherocytosis

Question 12

Which of the following is most closely associated with G6PD deficiency?

Accepted Answer

A) Continuous intravascular hemolysis occurs. 
B) G6PD deficiency is a sex-linked inherited disease. 
C) Splenectomy is commonly done to control symptoms. 
D) The majority of the erythrocytes in these individuals are microcytic. 
A) Continuous intravascular hemolysis occurs. 
B) G6PD deficiency is a sex-linked inherited disease. 
C) Splenectomy is commonly done to control symptoms. 
D) The majority of the erythrocytes in these individuals are microcytic.

Question 13

An anemia that manifests as decreased marrow cellularity, pancytopenia, and a reticulocytopenia is appropriately termed:

Accepted Answer

A) Megaloblastic anemia 
B) Aplastic anemia 
C) Sideroblastic anemia 
D) Iron deficiency anemia 
A) Megaloblastic anemia 
B) Aplastic anemia 
C) Sideroblastic anemia 
D) Iron deficiency anemia

Question 14

The RBC inclusions that are composed of denatured hemoglobin are called:

Accepted Answer

A) Pappenheimer bodies 
B) Howell-Jolly bodies 
C) Heinz bodies 
D) Siderotic granules 
A) Pappenheimer bodies 
B) Howell-Jolly bodies 
C) Heinz bodies 
D) Siderotic granules

Question 15

An eccentric "puddling" of a red blood cell's hemoglobin contents is most closely associated with:

Accepted Answer

A) Stomatocytosis 
B) Xerocytosis 
C) G6PD deficiency 
D) Pyruvate kinase deficiency 
A) Stomatocytosis 
B) Xerocytosis 
C) G6PD deficiency 
D) Pyruvate kinase deficiency

Question 16

The inability of the red blood cell to generate ATP for membrane function is most closely associated with:

Accepted Answer

A) Pyruvate kinase deficiency 
B) G6PD deficiency 
C) Fanconi's anemia 
D) Congenital hemolytic anemia 
A) Pyruvate kinase deficiency 
B) G6PD deficiency 
C) Fanconi's anemia 
D) Congenital hemolytic anemia

Question 17

Red blood cells that are rigid, provide resistance to malaria, and are spoon shaped are termed:

Accepted Answer

A) Burr cells from kidney disease 
B) Spherocytes from hereditary spherocytes 
C) Ovalocytes from Southeast Asian ovalocytosis 
D) Sickle cells from sickle cell disease 
A) Burr cells from kidney disease 
B) Spherocytes from hereditary spherocytes 
C) Ovalocytes from Southeast Asian ovalocytosis 
D) Sickle cells from sickle cell disease

Question 18

Individuals with Fanconi's anemia characteristically will have:

Accepted Answer

A) Intravascular hemolysis 
B) Increased Hgb F 
C) Ringed sideroblastics 
D) Thrombocytosis 
A) Intravascular hemolysis 
B) Increased Hgb F 
C) Ringed sideroblastics 
D) Thrombocytosis

The deficit of which of these is most closely associated with Southeast Asian ovalocytosis?

Cholelithiasis is a frequent complication of patients with hereditary spherocytosis because:

A defect in stomatin is the main cause of hereditary spherocytosis.

Bite cells are formed from:

One of the least severe clinical manifestations of G6PD deficiency is:

An osmotic fragility test is performed on a patient's sample.Initial hemolysis occurs at 0.75% NaCl and complete hemolysis occurs at 0.50% NaCl.These results are indicative of which of the following disorders?

Spherocytes differ from normal cells in all of the following ways except having:

Spherocytes may enter the circulation via a variety of mechanisms.To distinguish the CBC of a patient with hereditary spherocytosis from the CBC of a patient with autoimmune hemolytic anemia, one could use the:

Spherocytes do not function well in the splenic environment because the:

In hereditary spherocytosis, the reticulocyte count will typically be:

Which of the following red blood cell membrane defects results in an increased sensitivity to complement lysis?

Which of the following is most closely associated with G6PD deficiency?

An anemia that manifests as decreased marrow cellularity, pancytopenia, and a reticulocytopenia is appropriately termed:

The RBC inclusions that are composed of denatured hemoglobin are called:

An eccentric "puddling" of a red blood cell's hemoglobin contents is most closely associated with:

The inability of the red blood cell to generate ATP for membrane function is most closely associated with:

Red blood cells that are rigid, provide resistance to malaria, and are spoon shaped are termed:

Individuals with Fanconi's anemia characteristically will have:

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Blood Cell Production and Function and Relevant Red Cell Morphology

Hemoglobin Function and Principles of Hemolysis

The Microcytic Anemias

The Macrocytic Anemias

The Normochromic Anemias Due to Hemoglobinopathies

Leukopoiesis and Leukopoietic Function

Abnormalities of White Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Myeloproliferative Neoplasms

Lymphoproliferative Disorders and Related Plasma Cell Disorders

The Myelodysplastic Syndromes

Overview of Hemostasis and Platelet Physiology

Quantitative and Qualitative Platelet Disorders

Defects of Plasma Clotting Factors

Fibrinogen, Thrombin, and the Fibrinolytic System

Introduction to Thrombosis and Anticoagulant Therapy

Hematology Automation and Flow Cell Cytometry

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Exam 7: Normochromic Anemias: Biochemical and Membrane Disorders and Miscellaneous Red Cell Disorders

The deficit of which of these is most closely associated with Southeast Asian ovalocytosis?

Cholelithiasis is a frequent complication of patients with hereditary spherocytosis because:

A defect in stomatin is the main cause of hereditary spherocytosis.

Bite cells are formed from:

One of the least severe clinical manifestations of G6PD deficiency is:

An osmotic fragility test is performed on a patient's sample.Initial hemolysis occurs at 0.75% NaCl and complete hemolysis occurs at 0.50% NaCl.These results are indicative of which of the following disorders?

Spherocytes differ from normal cells in all of the following ways except having:

Spherocytes may enter the circulation via a variety of mechanisms.To distinguish the CBC of a patient with hereditary spherocytosis from the CBC of a patient with autoimmune hemolytic anemia, one could use the:

Spherocytes do not function well in the splenic environment because the:

In hereditary spherocytosis, the reticulocyte count will typically be:

Which of the following red blood cell membrane defects results in an increased sensitivity to complement lysis?

Which of the following is most closely associated with G6PD deficiency?

An anemia that manifests as decreased marrow cellularity, pancytopenia, and a reticulocytopenia is appropriately termed:

The RBC inclusions that are composed of denatured hemoglobin are called:

An eccentric "puddling" of a red blood cell's hemoglobin contents is most closely associated with:

The inability of the red blood cell to generate ATP for membrane function is most closely associated with:

Red blood cells that are rigid, provide resistance to malaria, and are spoon shaped are termed:

Individuals with Fanconi's anemia characteristically will have:

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Blood Cell Production and Function and Relevant Red Cell Morphology

Hemoglobin Function and Principles of Hemolysis

The Microcytic Anemias

The Macrocytic Anemias

The Normochromic Anemias Due to Hemoglobinopathies

Leukopoiesis and Leukopoietic Function

Abnormalities of White Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Myeloproliferative Neoplasms

Lymphoproliferative Disorders and Related Plasma Cell Disorders

The Myelodysplastic Syndromes

Overview of Hemostasis and Platelet Physiology

Quantitative and Qualitative Platelet Disorders

Defects of Plasma Clotting Factors

Fibrinogen, Thrombin, and the Fibrinolytic System

Introduction to Thrombosis and Anticoagulant Therapy

Hematology Automation and Flow Cell Cytometry

Filters