Question 1

In patients with sickle cell trait and no complicating disease:

Accepted Answer

A) NRBCs and polychromasia are usually seen on the peripheral smear 
B) Sickle cells are prevalent in the peripheral blood 
C) There may be occasional hematuria 
D) There is a severe decrease in Hgb, Hct, and RBC count 
A) NRBCs and polychromasia are usually seen on the peripheral smear 
B) Sickle cells are prevalent in the peripheral blood 
C) There may be occasional hematuria 
D) There is a severe decrease in Hgb, Hct, and RBC count C

Question 2

A 26-year-old day laborer with a long history of anemia has a several months' history of dyspnea, fever, and pulmonary pain.Additionally, he complains of tightness in the chest and upper abdominal region.His hematology values are as follows: WBC 15.9 $\times$ 109/L
RBC 2.9 $\times$ 1012/L
Hgb 9.5 g/dL
Hct 30%
MCV 103 fL
MCH 31 pg
MCHC 32%
NRBC 15/100 WBC
Platelets 275 $\times$ 109/L
Reticulocytes 16.8%
The hemoglobin electrophoresis results are as follows:
Hgb A =3%
Hgb A2 = 2%
Hgb S = 85%
Hgb F = 10%
The most likely diagnosis is:

Accepted Answer

A) Sickle cell trait 
B) Sickle cell disease 
C) Beta thalassemia minor 
D) Sickle thalassemia 
A) Sickle cell trait 
B) Sickle cell disease 
C) Beta thalassemia minor 
D) Sickle thalassemia B

Question 3

A patient with sickle cell anemia may develop cardiopulmonary disease due to:

Accepted Answer

A) Untreated leg ulcers 
B) High blood viscosity 
C) Increased Hgb F levels 
D) Hemolytic crisis 
A) Untreated leg ulcers 
B) High blood viscosity 
C) Increased Hgb F levels 
D) Hemolytic crisis B

Question 4

A male with sickle cell trait and a female sickle cell trait have what likelihood of having a child with sickle cell anemia?

Accepted Answer

A) 10% 
B) 25% 
C) 50% 
D) 100% 
A) 10% 
B) 25% 
C) 50% 
D) 100%

Question 5

Patients with sickle cell anemia generally have a hemoglobin value between:

Accepted Answer

A) 2 and 4 g/dL 
B) 6 and 8 g/dL 
C) 8 and 10 g/dL 
D) 10 and 12 g/dL 
A) 2 and 4 g/dL 
B) 6 and 8 g/dL 
C) 8 and 10 g/dL 
D) 10 and 12 g/dL

Question 6

The clinical picture of a patient with Hgb S-beta-thalassemia is similar to that seen in which other hemoglobinopathy?

Accepted Answer

A) Sickle cell anemia 
B) Sickle cell trait 
C) Hgb C disease 
D) Hgb E disease 
A) Sickle cell anemia 
B) Sickle cell trait 
C) Hgb C disease 
D) Hgb E disease

Question 7

The lungs are particularly susceptible in individuals with sickle cell disease and may be susceptible to:

Accepted Answer

A) COPD 
B) Pulmonary hypertension 
C) Aplastic crisis 
D) Cardiac crisis 
A) COPD 
B) Pulmonary hypertension 
C) Aplastic crisis 
D) Cardiac crisis

Question 8

Sickle cell disease is best differentiated from sickle cell trait by:

Accepted Answer

A) Wright smear examination 
B) Determination of fetal hemoglobin 
C) Genetic testing 
D) Hemoglobin electrophoresis 
A) Wright smear examination 
B) Determination of fetal hemoglobin 
C) Genetic testing 
D) Hemoglobin electrophoresis

Question 9

The principle behind hemoglobin electrophoresis is best represented by which of the following statements?

Accepted Answer

A) Normal hemoglobin does not precipitate in high-molarity buffered phosphate solutions. 
B) Hemoglobins migrate to different locations depending on time, pH, and media used. 
C) In a pH range of 3 to 10, hemoglobins achieve their isoelectric point. 
D) Hematology analyzers count nucleated red blood cells as white blood cells. 
A) Normal hemoglobin does not precipitate in high-molarity buffered phosphate solutions. 
B) Hemoglobins migrate to different locations depending on time, pH, and media used. 
C) In a pH range of 3 to 10, hemoglobins achieve their isoelectric point. 
D) Hematology analyzers count nucleated red blood cells as white blood cells.

Question 10

In hemoglobin C disease, the majority of the red blood cells appear as:

Accepted Answer

A) Target cells 
B) Spherocytes 
C) Elliptocytes 
D) "Bars of gold" 
A) Target cells 
B) Spherocytes 
C) Elliptocytes 
D) "Bars of gold"

Question 11

In sickle cell anemia, _____is substituted for glutamine.

Accepted Answer

A) valine 
B) lysine 
C) adenine 
D) leucine 
A) valine 
B) lysine 
C) adenine 
D) leucine

Question 12

Alkaline electrophoresis will not separate hemoglobin C from:

Accepted Answer

A) Hemoglobin A2 
B) Hemoglobin F 
C) Hemoglobin S 
D) Hemoglobin A 
A) Hemoglobin A2 
B) Hemoglobin F 
C) Hemoglobin S 
D) Hemoglobin A

Question 13

Which of the following "poikilocytes" are classically associated with hemoglobinopathies and liver disease?

Accepted Answer

A) Spherocytes 
B) Sickle cells 
C) Acanthocytes 
D) Target cells 
A) Spherocytes 
B) Sickle cells 
C) Acanthocytes 
D) Target cells

Question 14

Painful swelling of hands and feet caused by sickle cells in the microcirculation of infants is termed:

Accepted Answer

A) Dactylitis 
B) Necrosis 
C) Apoptosis 
D) Fibrosis 
A) Dactylitis 
B) Necrosis 
C) Apoptosis 
D) Fibrosis

Question 15

When the bone marrow temporarily ceases to produce cells in a sickle cell patient, a(n) _________ crisis has occurred.

Accepted Answer

A) aplastic 
B) hemolytic 
C) vaso-occlusive 
D) cardiac 
A) aplastic 
B) hemolytic 
C) vaso-occlusive 
D) cardiac

Question 16

In hemoglobin C disease, ____ is substituted for glutamic acid.

Accepted Answer

A) valine 
B) adenine 
C) lysine 
D) leucine 
A) valine 
B) adenine 
C) lysine 
D) leucine

Question 17

____ is the second most common hemoglobin variant worldwide.

Accepted Answer

A) Hemoglobin S 
B) Hemoglobin E 
C) Hemoglobin C 
D) Hemoglobin D 
A) Hemoglobin S 
B) Hemoglobin E 
C) Hemoglobin C 
D) Hemoglobin D

Question 18

Mr.Bennett was admitted with a hematocrit of 28%.He has a history of chronic anemia, moderate splenomegaly, and recent retinal hemorrhages.His peripheral smear reveals target cells, and some show structures jutting from the red blood cell membrane.The most probable diagnosis is:

Accepted Answer

A) Hgb S-S 
B) Hgb A-C 
C) Hgb S-C 
D) Hgb A-A 
A) Hgb S-S 
B) Hgb A-C 
C) Hgb S-C 
D) Hgb A-A

Question 19

Which of the following hemoglobins contain an alpha chain variant?

Accepted Answer

A) Hemoglobin C 
B) Hemoglobin G 
C) Hemoglobin S 
D) Hemoglobin A2 
A) Hemoglobin C 
B) Hemoglobin G 
C) Hemoglobin S 
D) Hemoglobin A2

Question 20

Autosplenectomy is characteristic of:

Accepted Answer

A) Sickle cell trait 
B) Hgb C disease 
C) Thalassemia 
D) Sickle cell anemia 
A) Sickle cell trait 
B) Hgb C disease 
C) Thalassemia 
D) Sickle cell anemia

In patients with sickle cell trait and no complicating disease:

A patient with sickle cell anemia may develop cardiopulmonary disease due to:

A male with sickle cell trait and a female sickle cell trait have what likelihood of having a child with sickle cell anemia?

Patients with sickle cell anemia generally have a hemoglobin value between:

The clinical picture of a patient with Hgb S-beta-thalassemia is similar to that seen in which other hemoglobinopathy?

The lungs are particularly susceptible in individuals with sickle cell disease and may be susceptible to:

Sickle cell disease is best differentiated from sickle cell trait by:

The principle behind hemoglobin electrophoresis is best represented by which of the following statements?

In hemoglobin C disease, the majority of the red blood cells appear as:

In sickle cell anemia, _____is substituted for glutamine.

Alkaline electrophoresis will not separate hemoglobin C from:

Which of the following "poikilocytes" are classically associated with hemoglobinopathies and liver disease?

Painful swelling of hands and feet caused by sickle cells in the microcirculation of infants is termed:

When the bone marrow temporarily ceases to produce cells in a sickle cell patient, a(n) _________ crisis has occurred.

In hemoglobin C disease, ____ is substituted for glutamic acid.

____ is the second most common hemoglobin variant worldwide.

Mr.Bennett was admitted with a hematocrit of 28%.He has a history of chronic anemia, moderate splenomegaly, and recent retinal hemorrhages.His peripheral smear reveals target cells, and some show structures jutting from the red blood cell membrane.The most probable diagnosis is:

Which of the following hemoglobins contain an alpha chain variant?

Autosplenectomy is characteristic of:

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Blood Cell Production and Function and Relevant Red Cell Morphology

Hemoglobin Function and Principles of Hemolysis

The Microcytic Anemias

The Macrocytic Anemias

Normochromic Anemias: Biochemical and Membrane Disorders and Miscellaneous Red Cell Disorders

Leukopoiesis and Leukopoietic Function

Abnormalities of White Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Myeloproliferative Neoplasms

Lymphoproliferative Disorders and Related Plasma Cell Disorders

The Myelodysplastic Syndromes

Overview of Hemostasis and Platelet Physiology

Quantitative and Qualitative Platelet Disorders

Defects of Plasma Clotting Factors

Fibrinogen, Thrombin, and the Fibrinolytic System

Introduction to Thrombosis and Anticoagulant Therapy

Hematology Automation and Flow Cell Cytometry

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Exam 8: The Normochromic Anemias Due to Hemoglobinopathies

In patients with sickle cell trait and no complicating disease:

A patient with sickle cell anemia may develop cardiopulmonary disease due to:

A male with sickle cell trait and a female sickle cell trait have what likelihood of having a child with sickle cell anemia?

Patients with sickle cell anemia generally have a hemoglobin value between:

The clinical picture of a patient with Hgb S-beta-thalassemia is similar to that seen in which other hemoglobinopathy?

The lungs are particularly susceptible in individuals with sickle cell disease and may be susceptible to:

Sickle cell disease is best differentiated from sickle cell trait by:

The principle behind hemoglobin electrophoresis is best represented by which of the following statements?

In hemoglobin C disease, the majority of the red blood cells appear as:

In sickle cell anemia, _____is substituted for glutamine.

Alkaline electrophoresis will not separate hemoglobin C from:

Which of the following "poikilocytes" are classically associated with hemoglobinopathies and liver disease?

Painful swelling of hands and feet caused by sickle cells in the microcirculation of infants is termed:

When the bone marrow temporarily ceases to produce cells in a sickle cell patient, a(n) _________ crisis has occurred.

In hemoglobin C disease, ____ is substituted for glutamic acid.

____ is the second most common hemoglobin variant worldwide.

Mr.Bennett was admitted with a hematocrit of 28%.He has a history of chronic anemia, moderate splenomegaly, and recent retinal hemorrhages.His peripheral smear reveals target cells, and some show structures jutting from the red blood cell membrane.The most probable diagnosis is:

Which of the following hemoglobins contain an alpha chain variant?

Autosplenectomy is characteristic of:

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Blood Cell Production and Function and Relevant Red Cell Morphology

Hemoglobin Function and Principles of Hemolysis

The Microcytic Anemias

The Macrocytic Anemias

Normochromic Anemias: Biochemical and Membrane Disorders and Miscellaneous Red Cell Disorders

Leukopoiesis and Leukopoietic Function

Abnormalities of White Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Myeloproliferative Neoplasms

Lymphoproliferative Disorders and Related Plasma Cell Disorders

The Myelodysplastic Syndromes

Overview of Hemostasis and Platelet Physiology

Quantitative and Qualitative Platelet Disorders

Defects of Plasma Clotting Factors

Fibrinogen, Thrombin, and the Fibrinolytic System

Introduction to Thrombosis and Anticoagulant Therapy

Hematology Automation and Flow Cell Cytometry

Filters