Question 1

Reticulocytopenia is a feature of MDS.Which one of the following is the mechanism behind this process?

Accepted Answer

A) Heavy tumor burden 
B) Marrow aplasia 
C) Ineffective erythropoiesis 
D) Toxic effects 
A) Heavy tumor burden 
B) Marrow aplasia 
C) Ineffective erythropoiesis 
D) Toxic effects B

Question 2

All of the following are features of the myelodysplastic syndromes except:

Accepted Answer

A) Anemia 
B) Organomegaly 
C) Dysplasia 
D) Hypercellular marrow 
A) Anemia 
B) Organomegaly 
C) Dysplasia 
D) Hypercellular marrow B

Question 3

Which of the following chromosome disorders in MDS has a poor predictive influence?

Accepted Answer

A) Chromosome 7 disorder 
B) Trisomy 12 
C) Trisomy 13 
D) 17q deletion 
A) Chromosome 7 disorder 
B) Trisomy 12 
C) Trisomy 13 
D) 17q deletion A

Question 4

One of the key white cell features in MDS is:

Accepted Answer

A) Hypersegmented neutrophils 
B) Auer rods 
C) Döhle bodies 
D) Pseudo-Pelger-Huët 
A) Hypersegmented neutrophils 
B) Auer rods 
C) Döhle bodies 
D) Pseudo-Pelger-Huët

Question 5

The most common hematological malignancy in the adult population is:

Accepted Answer

A) Acute leukemia 
B) Multiple myeloma 
C) Myelodysplastic syndrome 
D) Chronic leukemias 
A) Acute leukemia 
B) Multiple myeloma 
C) Myelodysplastic syndrome 
D) Chronic leukemias

Question 6

The blast count in most individuals with MDS is less than:

Accepted Answer

A) 10% 
B) 40% 
C) 5% 
D) 20% 
A) 10% 
B) 40% 
C) 5% 
D) 20%

Question 7

A major concern for the management of patients with MDSs is iron overload.

Accepted Answer

A) True 
 B)False

Question 8

Deleted 5q MDS is primarily seen in male patients.

Accepted Answer

A) True 
 B)False

Question 9

Typically, patients with MDS will exhibit partial or complete absence of:

Accepted Answer

A) Chromosomes 5 and 7 
B) Chromosomes 8 and 12 
C) The Y chromosome 
D) Dysplasia 
A) Chromosomes 5 and 7 
B) Chromosomes 8 and 12 
C) The Y chromosome 
D) Dysplasia

Question 10

The morphological classification of anemia in the myelodysplastic syndromes is:

Accepted Answer

A) Normocytic, normochromic 
B) Microcytic, hypochromic 
C) Macrocytic, normochromic 
D) Microcytic, normochromic 
A) Normocytic, normochromic 
B) Microcytic, hypochromic 
C) Macrocytic, normochromic 
D) Microcytic, normochromic

Question 11

A large percentage of the MDSs end in an acute leukemia.

Accepted Answer

A) True 
 B)False

Question 12

All of the following are associated with the development of the MDSs except:

Accepted Answer

A) Alkylating therapy 
B) Benzene exposure 
C) Alcoholism 
D) Radiation 
A) Alkylating therapy 
B) Benzene exposure 
C) Alcoholism 
D) Radiation

Question 13

The most effective means of treating iron overload in the myelodysplastic syndromes is:

Accepted Answer

A) Therapeutic phlebotomy 
B) Limiting iron-containing foods 
C) Iron chelation therapy 
D) Fasting 
A) Therapeutic phlebotomy 
B) Limiting iron-containing foods 
C) Iron chelation therapy 
D) Fasting

Question 14

The bone marrow and peripheral smear of a patient with an MDS will show dysplastic changes in _____ over time.

Accepted Answer

A) white blood cells 
B) red blood cells 
C) platelets 
D) All of the above 
A) white blood cells 
B) red blood cells 
C) platelets 
D) All of the above

Question 15

All of the following are dysplastic changes of platelets frequently seen in MDS except:

Accepted Answer

A) Abnormal granulation 
B) Micromega karyocytes 
C) Giant platelets 
D) Platelet satellitism 
A) Abnormal granulation 
B) Micromega karyocytes 
C) Giant platelets 
D) Platelet satellitism

Question 16

Which of the following bone marrow blast percentages will be consistent with the FAB classification of refractory anemia with excess of blasts (RAEB)?

Accepted Answer

A) 5% to 20% 
B) 20% to 30% 
C) Greater than 30% 
D) Less than 5% 
A) 5% to 20% 
B) 20% to 30% 
C) Greater than 30% 
D) Less than 5%

Question 17

Refractory anemia is an anemia that:

Accepted Answer

A) Has more than 5% blasts in the peripheral blood 
B) Is resistant to treatment 
C) Will usually demonstrate a hypoplastic bone marrow 
D) Demonstrates a 17q deletion routinely 
A) Has more than 5% blasts in the peripheral blood 
B) Is resistant to treatment 
C) Will usually demonstrate a hypoplastic bone marrow 
D) Demonstrates a 17q deletion routinely

Reticulocytopenia is a feature of MDS.Which one of the following is the mechanism behind this process?

All of the following are features of the myelodysplastic syndromes except:

Which of the following chromosome disorders in MDS has a poor predictive influence?

One of the key white cell features in MDS is:

The most common hematological malignancy in the adult population is:

The blast count in most individuals with MDS is less than:

A major concern for the management of patients with MDSs is iron overload.

Deleted 5q MDS is primarily seen in male patients.

Typically, patients with MDS will exhibit partial or complete absence of:

The morphological classification of anemia in the myelodysplastic syndromes is:

A large percentage of the MDSs end in an acute leukemia.

All of the following are associated with the development of the MDSs except:

The most effective means of treating iron overload in the myelodysplastic syndromes is:

The bone marrow and peripheral smear of a patient with an MDS will show dysplastic changes in _____ over time.

All of the following are dysplastic changes of platelets frequently seen in MDS except:

Which of the following bone marrow blast percentages will be consistent with the FAB classification of refractory anemia with excess of blasts (RAEB)?

Refractory anemia is an anemia that:

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Blood Cell Production and Function and Relevant Red Cell Morphology

Hemoglobin Function and Principles of Hemolysis

The Microcytic Anemias

The Macrocytic Anemias

Normochromic Anemias: Biochemical and Membrane Disorders and Miscellaneous Red Cell Disorders

The Normochromic Anemias Due to Hemoglobinopathies

Leukopoiesis and Leukopoietic Function

Abnormalities of White Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Myeloproliferative Neoplasms

Lymphoproliferative Disorders and Related Plasma Cell Disorders

Overview of Hemostasis and Platelet Physiology

Quantitative and Qualitative Platelet Disorders

Defects of Plasma Clotting Factors

Fibrinogen, Thrombin, and the Fibrinolytic System

Introduction to Thrombosis and Anticoagulant Therapy

Hematology Automation and Flow Cell Cytometry

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Exam 14: The Myelodysplastic Syndromes

Reticulocytopenia is a feature of MDS.Which one of the following is the mechanism behind this process?

All of the following are features of the myelodysplastic syndromes except:

Which of the following chromosome disorders in MDS has a poor predictive influence?

One of the key white cell features in MDS is:

The most common hematological malignancy in the adult population is:

The blast count in most individuals with MDS is less than:

A major concern for the management of patients with MDSs is iron overload.

Deleted 5q MDS is primarily seen in male patients.

Typically, patients with MDS will exhibit partial or complete absence of:

The morphological classification of anemia in the myelodysplastic syndromes is:

A large percentage of the MDSs end in an acute leukemia.

All of the following are associated with the development of the MDSs except:

The most effective means of treating iron overload in the myelodysplastic syndromes is:

The bone marrow and peripheral smear of a patient with an MDS will show dysplastic changes in _____ over time.

All of the following are dysplastic changes of platelets frequently seen in MDS except:

Which of the following bone marrow blast percentages will be consistent with the FAB classification of refractory anemia with excess of blasts (RAEB)?

Refractory anemia is an anemia that:

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Blood Cell Production and Function and Relevant Red Cell Morphology

Hemoglobin Function and Principles of Hemolysis

The Microcytic Anemias

The Macrocytic Anemias

Normochromic Anemias: Biochemical and Membrane Disorders and Miscellaneous Red Cell Disorders

The Normochromic Anemias Due to Hemoglobinopathies

Leukopoiesis and Leukopoietic Function

Abnormalities of White Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Myeloproliferative Neoplasms

Lymphoproliferative Disorders and Related Plasma Cell Disorders

Overview of Hemostasis and Platelet Physiology

Quantitative and Qualitative Platelet Disorders

Defects of Plasma Clotting Factors

Fibrinogen, Thrombin, and the Fibrinolytic System

Introduction to Thrombosis and Anticoagulant Therapy

Hematology Automation and Flow Cell Cytometry

Filters