Question 1

Which of the following causes irreversible inactivation of platelets?

Accepted Answer

A) Heparin 
B) Coumadin 
C) Aspirin 
D) Vitamin K 
A) Heparin 
B) Coumadin 
C) Aspirin 
D) Vitamin K C

Question 2

All of the following can affect the platelet count except:

Accepted Answer

A) Improper mixing of specimen 
B) Not using a tourniquet 
C) Presence of EDTA-antibodies 
D) Not using anticoagulated tubes 
A) Improper mixing of specimen 
B) Not using a tourniquet 
C) Presence of EDTA-antibodies 
D) Not using anticoagulated tubes B

Question 3

The autoantibody generated in ITP is directed against:

Accepted Answer

A) vWF 
B) Collagen 
C) GP IIb/IIIa, GP Ib/IX 
D) Fibrinopeptides A and B 
A) vWF 
B) Collagen 
C) GP IIb/IIIa, GP Ib/IX 
D) Fibrinopeptides A and B C

Question 4

The presence of thrombocytopenia and giant platelets on the peripheral smear of a patient is characteristic of:

Accepted Answer

A) Classic von Willebrand's disease 
B) Hemophilia A 
C) Glanzmann's thrombasthenia 
D) Bernard-Soulier syndrome 
A) Classic von Willebrand's disease 
B) Hemophilia A 
C) Glanzmann's thrombasthenia 
D) Bernard-Soulier syndrome

Question 5

Immune drug-induced thrombocytopenia is a result of all of the following drugs except:

Accepted Answer

A) NSAIDs 
B) Heparin 
C) Amoxicillin 
D) Aspirin 
A) NSAIDs 
B) Heparin 
C) Amoxicillin 
D) Aspirin

Question 6

All of the following are associated with platelet disorders except:

Accepted Answer

A) Thrombocytopenia 
B) Deep muscle hemorrhages 
C) Epistaxis and menorrhagia 
D) Abnormal platelet morphology 
A) Thrombocytopenia 
B) Deep muscle hemorrhages 
C) Epistaxis and menorrhagia 
D) Abnormal platelet morphology

Question 7

Thrombocytosis is defined as a platelet count that is:

Accepted Answer

A) Greater than 450 × 109/L 
B) Less than 450 × w109/L 
C) Greater than 600 × 109/L 
D) Less than 300 × 109/L 
A) Greater than 450 × 109/L 
B) Less than 450 × w109/L 
C) Greater than 600 × 109/L 
D) Less than 300 × 109/L

Question 8

A 2-year-old boy develops the following symptoms: petechiae, purpura, and nosebleeds.The platelet count is 18,000.The most likely explanation is:

Accepted Answer

A) Drug-induced thrombocytopenia 
B) Secondary thrombocytopenia 
C) Idiopathic thrombocytopenic purpura 
D) Thrombotic thrombocytopenic purpura 
A) Drug-induced thrombocytopenia 
B) Secondary thrombocytopenia 
C) Idiopathic thrombocytopenic purpura 
D) Thrombotic thrombocytopenic purpura

Question 9

Platelets from patients with which two disorders will not aggregate with ristocetin?

Accepted Answer

A) Glanzmann's syndrome and von Willebrand's 
B) Glanzmann's syndrome and Chediak-Higashi 
C) HUS and Bernard-Soulier syndrome 
D) von Willebrand's disease and Bernard-Soulier 
A) Glanzmann's syndrome and von Willebrand's 
B) Glanzmann's syndrome and Chediak-Higashi 
C) HUS and Bernard-Soulier syndrome 
D) von Willebrand's disease and Bernard-Soulier

Question 10

In hemolytic uremic syndrome (HUS), which of the following statements is the most accurate?

Accepted Answer

A) The organ most affected is the spleen. 
B) The toxin responsible for this syndrome is produced by 
C) Impaired neurological function is one of the primary symptoms. 
D) Platelets are permanently impaired. 
A) The organ most affected is the spleen. 
B) The toxin responsible for this syndrome is produced by 
C) Impaired neurological function is one of the primary symptoms. 
D) Platelets are permanently impaired.

Question 11

In thrombotic thrombocytopenic purpura, which of the following statements is the most accurate?

Accepted Answer

A) It is associated with 
B) It is associated with fever, renal failure, and neurological complications. 
C) The organ most affected is the kidney. 
D) More males are affected than females 
A) It is associated with 
B) It is associated with fever, renal failure, and neurological complications. 
C) The organ most affected is the kidney. 
D) More males are affected than females

Question 12

Which the following test results is normal in a patient with classic von Willebrand's disease?

Accepted Answer

A) Bleeding time 
B) Activated partial thromboplastin time 
C) Platelet count 
D) Factor VIII and vWF levels 
A) Bleeding time 
B) Activated partial thromboplastin time 
C) Platelet count 
D) Factor VIII and vWF levels

Question 13

Aspirin therapy irreversibly inhibits the synthesis of:

Accepted Answer

A) ATP 
B) GP 1 
C) Prostaglandins 
D) GP IIb and IIIa 
A) ATP 
B) GP 1 
C) Prostaglandins 
D) GP IIb and IIIa

Question 14

A decreased platelet count is most often anticipated when a patient demonstrates:

Accepted Answer

A) Rectal bleeding 
B) Epistaxis 
C) Genitourinary bleeding 
D) Severe hemorrhage 
A) Rectal bleeding 
B) Epistaxis 
C) Genitourinary bleeding 
D) Severe hemorrhage

Question 15

A platelet aggregation defect in which there is a deficiency of GP IIb/IIIa is known as:

Accepted Answer

A) vWD 
B) Glanzmann's thrombasthenia 
C) Bernard-Soulier syndrome 
D) TTP 
A) vWD 
B) Glanzmann's thrombasthenia 
C) Bernard-Soulier syndrome 
D) TTP

Question 16

Decreased platelets in combination with bloody diarrhea, vomiting, and abdominal pain is seen in which of the following?

Accepted Answer

A) HUS 
B) ITP 
C) Glanzmann's thrombasthenia 
D) TTP 
A) HUS 
B) ITP 
C) Glanzmann's thrombasthenia 
D) TTP

Question 17

Increased platelets are seen in which of the following disorders?

Accepted Answer

A) ITP 
B) TTP 
C) ET 
D) vWD 
A) ITP 
B) TTP 
C) ET 
D) vWD

Question 18

Which of the following are platelet adhesion disorders?

Accepted Answer

A) von Willebrand's disease and Glanzmann's thrombasthenia 
B) von Willebrand's disease and Bernard-Soulier syndrome 
C) Glanzmann's thrombasthenia and Bernard-Soulier syndrome 
D) Glanzmann's thrombasthenia and congenital fibrinogenemia 
A) von Willebrand's disease and Glanzmann's thrombasthenia 
B) von Willebrand's disease and Bernard-Soulier syndrome 
C) Glanzmann's thrombasthenia and Bernard-Soulier syndrome 
D) Glanzmann's thrombasthenia and congenital fibrinogenemia

Question 19

Platelet aggregation cannot occur if _______ is absent.

Accepted Answer

A) vWF 
B) GP IIb/IIIa 
C) antibodies 
D) GP Ib/IX 
A) vWF 
B) GP IIb/IIIa 
C) antibodies 
D) GP Ib/IX

Which of the following causes irreversible inactivation of platelets?

All of the following can affect the platelet count except:

The autoantibody generated in ITP is directed against:

The presence of thrombocytopenia and giant platelets on the peripheral smear of a patient is characteristic of:

Immune drug-induced thrombocytopenia is a result of all of the following drugs except:

All of the following are associated with platelet disorders except:

Thrombocytosis is defined as a platelet count that is:

A 2-year-old boy develops the following symptoms: petechiae, purpura, and nosebleeds.The platelet count is 18,000.The most likely explanation is:

Platelets from patients with which two disorders will not aggregate with ristocetin?

In hemolytic uremic syndrome (HUS), which of the following statements is the most accurate?

In thrombotic thrombocytopenic purpura, which of the following statements is the most accurate?

Which the following test results is normal in a patient with classic von Willebrand's disease?

Aspirin therapy irreversibly inhibits the synthesis of:

A decreased platelet count is most often anticipated when a patient demonstrates:

A platelet aggregation defect in which there is a deficiency of GP IIb/IIIa is known as:

Decreased platelets in combination with bloody diarrhea, vomiting, and abdominal pain is seen in which of the following?

Increased platelets are seen in which of the following disorders?

Which of the following are platelet adhesion disorders?

Platelet aggregation cannot occur if _______ is absent.

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Blood Cell Production and Function and Relevant Red Cell Morphology

Hemoglobin Function and Principles of Hemolysis

The Microcytic Anemias

The Macrocytic Anemias

Normochromic Anemias: Biochemical and Membrane Disorders and Miscellaneous Red Cell Disorders

The Normochromic Anemias Due to Hemoglobinopathies

Leukopoiesis and Leukopoietic Function

Abnormalities of White Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Myeloproliferative Neoplasms

Lymphoproliferative Disorders and Related Plasma Cell Disorders

The Myelodysplastic Syndromes

Overview of Hemostasis and Platelet Physiology

Defects of Plasma Clotting Factors

Fibrinogen, Thrombin, and the Fibrinolytic System

Introduction to Thrombosis and Anticoagulant Therapy

Hematology Automation and Flow Cell Cytometry

Filters

Exam 16: Quantitative and Qualitative Platelet Disorders

Which of the following causes irreversible inactivation of platelets?

All of the following can affect the platelet count except:

The autoantibody generated in ITP is directed against:

The presence of thrombocytopenia and giant platelets on the peripheral smear of a patient is characteristic of:

Immune drug-induced thrombocytopenia is a result of all of the following drugs except:

All of the following are associated with platelet disorders except:

Thrombocytosis is defined as a platelet count that is:

A 2-year-old boy develops the following symptoms: petechiae, purpura, and nosebleeds.The platelet count is 18,000.The most likely explanation is:

Platelets from patients with which two disorders will not aggregate with ristocetin?

In hemolytic uremic syndrome (HUS), which of the following statements is the most accurate?

In thrombotic thrombocytopenic purpura, which of the following statements is the most accurate?

Which the following test results is normal in a patient with classic von Willebrand's disease?

Aspirin therapy irreversibly inhibits the synthesis of:

A decreased platelet count is most often anticipated when a patient demonstrates:

A platelet aggregation defect in which there is a deficiency of GP IIb/IIIa is known as:

Decreased platelets in combination with bloody diarrhea, vomiting, and abdominal pain is seen in which of the following?

Increased platelets are seen in which of the following disorders?

Which of the following are platelet adhesion disorders?

Platelet aggregation cannot occur if _______ is absent.

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Blood Cell Production and Function and Relevant Red Cell Morphology

Hemoglobin Function and Principles of Hemolysis

The Microcytic Anemias

The Macrocytic Anemias

Normochromic Anemias: Biochemical and Membrane Disorders and Miscellaneous Red Cell Disorders

The Normochromic Anemias Due to Hemoglobinopathies

Leukopoiesis and Leukopoietic Function

Abnormalities of White Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Myeloproliferative Neoplasms

Lymphoproliferative Disorders and Related Plasma Cell Disorders

The Myelodysplastic Syndromes

Overview of Hemostasis and Platelet Physiology

Defects of Plasma Clotting Factors

Fibrinogen, Thrombin, and the Fibrinolytic System

Introduction to Thrombosis and Anticoagulant Therapy

Hematology Automation and Flow Cell Cytometry

Filters