Question 1

A patient presents with generalized lymphadenopathy and a WBC of 100 $\times$ 109/L.This hematologic picture would most likely be seen in:

Accepted Answer

A) Chronic lymphocytic leukemia 
B) Acute lymphocytic leukemia 
C) Burkitt's lymphoma 
D) Hairy cell leukemia 
A) Chronic lymphocytic leukemia 
B) Acute lymphocytic leukemia 
C) Burkitt's lymphoma 
D) Hairy cell leukemia A

Question 2

The leukemia with a predominance of WBC cells positive for CD41 is:

Accepted Answer

A) AMML 
B) AML 
C) AMonoL 
D) AMegL 
A) AMML 
B) AML 
C) AMonoL 
D) AMegL D

Question 3

Greater than ______ of bone marrow cells must be identified as lymphoblasts to meet the WHO definition of ALL.

Accepted Answer

A) 10% 
B) 20% 
C) 25% 
D) 30% 
A) 10% 
B) 20% 
C) 25% 
D) 30% B

Question 4

Migration to extramedullary sites is a feature of which of the following leukemias?

Accepted Answer

A) Acute progranulocytic leukemia 
B) Acute myelocytic leukemia 
C) Acute monocytic leukemia 
D) Acute lymphocytic leukemia 
A) Acute progranulocytic leukemia 
B) Acute myelocytic leukemia 
C) Acute monocytic leukemia 
D) Acute lymphocytic leukemia

Question 5

Which of the following is characteristic of Auer rods?

Accepted Answer

A) Composed of fused primary granules 
B) Predominantly seen in ALL 
C) Predominantly seen in HCL 
D) Composed of specific granules 
A) Composed of fused primary granules 
B) Predominantly seen in ALL 
C) Predominantly seen in HCL 
D) Composed of specific granules

Question 6

The monoclonal marker that is often positive in T-ALL is:

Accepted Answer

A) CD1 
B) CD7 
C) CD10 
D) CD41 
A) CD1 
B) CD7 
C) CD10 
D) CD41

Question 7

The translocation t(15:17)(q22;q12) is associated with which of the following leukemias?

Accepted Answer

A) Acute promyelocytic leukemia 
B) Acute myelomonocytic leukemia 
C) Acute lymphocytic leukemia 
D) Acute myelocytic leukemia 
A) Acute promyelocytic leukemia 
B) Acute myelomonocytic leukemia 
C) Acute lymphocytic leukemia 
D) Acute myelocytic leukemia

Question 8

A patient with AML is likely to have a cytochemical stain panel that is positive for:

Accepted Answer

A) Sodium fluoride with tartrate resistance 
B) MPO, SBB, specific esterase 
C) MP0, SBB, nonspecific esterase 
D) SBB and TdT 
A) Sodium fluoride with tartrate resistance 
B) MPO, SBB, specific esterase 
C) MP0, SBB, nonspecific esterase 
D) SBB and TdT

Question 9

Which CD marker best represents the earliest progenitor cells?

Accepted Answer

A) CD11 
B) CD19 
C) CD34 
D) CD57 
A) CD11 
B) CD19 
C) CD34 
D) CD57

Question 10

The basic pathophysiology mechanism responsible for producing signs and symptoms in leukemia includes all of the following except:

Accepted Answer

A) Replacement of normal marrow precursors by leukemic cells 
B) Decrease in functional leukocytes causing infection 
C) Hemorrhage secondary to thrombocytopenia 
D) Decreased erythropoietin production 
A) Replacement of normal marrow precursors by leukemic cells 
B) Decrease in functional leukocytes causing infection 
C) Hemorrhage secondary to thrombocytopenia 
D) Decreased erythropoietin production

Question 11

When performing flow cytometry, the technologist interpreted the flow pattern as exhibiting a high degree of CD14- and CD4-positive cells.The peripheral smear showed large multilobulated blast cells.This pattern is most representative of:

Accepted Answer

A) ALL 
B) AMonoL 
C) AMML 
D) AML 
A) ALL 
B) AMonoL 
C) AMML 
D) AML

Question 12

According to current WHO classification criteria, acute leukemia is characterized by which of the following?

Accepted Answer

A) Hypercellular bone marrow with greater than 20% blasts 
B) Hypercellular bone marrow with less than 20% blasts 
C) Hypocellular bone marrow with greater than 20% blasts 
D) Hypocellular bone marrow with less than 20% blasts 
A) Hypercellular bone marrow with greater than 20% blasts 
B) Hypercellular bone marrow with less than 20% blasts 
C) Hypocellular bone marrow with greater than 20% blasts 
D) Hypocellular bone marrow with less than 20% blasts

Question 13

Pure erythroid leukemia is defined as:

Accepted Answer

A) Erythroid precursors greater than 30%, myeloblasts less than 20% 
B) Erythroid precursors greater than 50%, myeloblasts less than 40% 
C) Erythroid precursors less than 50% 
D) Erythroid precursors greater than 80% 
A) Erythroid precursors greater than 30%, myeloblasts less than 20% 
B) Erythroid precursors greater than 50%, myeloblasts less than 40% 
C) Erythroid precursors less than 50% 
D) Erythroid precursors greater than 80%

Question 14

Acute leukemic processes are marked by:

Accepted Answer

A) Slow onset, slow progression, anemia 
B) Rapid onset anemia, thrombocytopenia 
C) Splenomegaly 
D) Less than 30% in the BM 
A) Slow onset, slow progression, anemia 
B) Rapid onset anemia, thrombocytopenia 
C) Splenomegaly 
D) Less than 30% in the BM

Question 15

Pediatric patients with ALL have an overall complete remission rate of:

Accepted Answer

A) 50% 
B) 65% 
C) 75% 
D) 85% 
A) 50% 
B) 65% 
C) 75% 
D) 85%

Question 16

_____ is predominantly a disease of children.

Accepted Answer

A) AML 
B) CML 
C) ALL 
D) CLL 
A) AML 
B) CML 
C) ALL 
D) CLL

A patient presents with generalized lymphadenopathy and a WBC of 100 $\times$ 10⁹/L.This hematologic picture would most likely be seen in:

The leukemia with a predominance of WBC cells positive for CD41 is:

Greater than ______ of bone marrow cells must be identified as lymphoblasts to meet the WHO definition of ALL.

Migration to extramedullary sites is a feature of which of the following leukemias?

Which of the following is characteristic of Auer rods?

The monoclonal marker that is often positive in T-ALL is:

The translocation t(15:17)(q22;q12) is associated with which of the following leukemias?

A patient with AML is likely to have a cytochemical stain panel that is positive for:

Which CD marker best represents the earliest progenitor cells?

The basic pathophysiology mechanism responsible for producing signs and symptoms in leukemia includes all of the following except:

When performing flow cytometry, the technologist interpreted the flow pattern as exhibiting a high degree of CD14- and CD4-positive cells.The peripheral smear showed large multilobulated blast cells.This pattern is most representative of:

According to current WHO classification criteria, acute leukemia is characterized by which of the following?

Pure erythroid leukemia is defined as:

Acute leukemic processes are marked by:

Pediatric patients with ALL have an overall complete remission rate of:

_____ is predominantly a disease of children.

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Blood Cell Production and Function and Relevant Red Cell Morphology

Hemoglobin Function and Principles of Hemolysis

The Microcytic Anemias

The Macrocytic Anemias

Normochromic Anemias: Biochemical and Membrane Disorders and Miscellaneous Red Cell Disorders

The Normochromic Anemias Due to Hemoglobinopathies

Leukopoiesis and Leukopoietic Function

Abnormalities of White Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Myeloproliferative Neoplasms

Lymphoproliferative Disorders and Related Plasma Cell Disorders

The Myelodysplastic Syndromes

Overview of Hemostasis and Platelet Physiology

Quantitative and Qualitative Platelet Disorders

Defects of Plasma Clotting Factors

Fibrinogen, Thrombin, and the Fibrinolytic System

Introduction to Thrombosis and Anticoagulant Therapy

Hematology Automation and Flow Cell Cytometry

Filters

Exam 11: Acute Leukemias

A patient presents with generalized lymphadenopathy and a WBC of 100 ×\times× 109/L.This hematologic picture would most likely be seen in:

The leukemia with a predominance of WBC cells positive for CD41 is:

Greater than ______ of bone marrow cells must be identified as lymphoblasts to meet the WHO definition of ALL.

Migration to extramedullary sites is a feature of which of the following leukemias?

Which of the following is characteristic of Auer rods?

The monoclonal marker that is often positive in T-ALL is:

The translocation t(15:17)(q22;q12) is associated with which of the following leukemias?

A patient with AML is likely to have a cytochemical stain panel that is positive for:

Which CD marker best represents the earliest progenitor cells?

The basic pathophysiology mechanism responsible for producing signs and symptoms in leukemia includes all of the following except:

When performing flow cytometry, the technologist interpreted the flow pattern as exhibiting a high degree of CD14- and CD4-positive cells.The peripheral smear showed large multilobulated blast cells.This pattern is most representative of:

According to current WHO classification criteria, acute leukemia is characterized by which of the following?

Pure erythroid leukemia is defined as:

Acute leukemic processes are marked by:

Pediatric patients with ALL have an overall complete remission rate of:

_____ is predominantly a disease of children.

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Blood Cell Production and Function and Relevant Red Cell Morphology

Hemoglobin Function and Principles of Hemolysis

The Microcytic Anemias

The Macrocytic Anemias

Normochromic Anemias: Biochemical and Membrane Disorders and Miscellaneous Red Cell Disorders

The Normochromic Anemias Due to Hemoglobinopathies

Leukopoiesis and Leukopoietic Function

Abnormalities of White Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Myeloproliferative Neoplasms

Lymphoproliferative Disorders and Related Plasma Cell Disorders

The Myelodysplastic Syndromes

Overview of Hemostasis and Platelet Physiology

Quantitative and Qualitative Platelet Disorders

Defects of Plasma Clotting Factors

Fibrinogen, Thrombin, and the Fibrinolytic System

Introduction to Thrombosis and Anticoagulant Therapy

Hematology Automation and Flow Cell Cytometry

Filters

A patient presents with generalized lymphadenopathy and a WBC of 100 $\times$ 10⁹/L.This hematologic picture would most likely be seen in: