Exam 12: Myeloproliferative Neoplasms

A patient has the following CBC results: WBC count: 35 $\times$ 10⁹/L Differential: 60 segmented neutrophils 12 lymphocytes 8 metamyelocytes 10 band neutrophils 7 monocytes 3 eosinophils Platelets: Normal RBC morphology: Normocytic, normochromic LAP score: 5 These results are consistent with:

A term describing a peripheral blood finding of leukocytosis with a shift to the left accompanied by occasional nucleated red cells and platelet abnormalities is:

________ has the worst prognosis of all the myeloproliferative disorders.

Chronic myelogenous leukemia will present with less than _____ blasts in the peripheral blood.

What is the pathophysiology of the myeloproliferative disorders?

Patients with essential thrombocytosis do not experience fibrosis of their bone marrow.

The translocation of genetic material t9:22 is associated with:

Plethora is a condition associated with:

The red cell morphology associated with PMF is:

What effect does the Ph chromosome have on the prognosis of patients with chronic myelocytic leukemia?

A high-risk factor for the diagnosis of essential thrombocythemia is:

The accelerated phase of chronic myeloid leukemia is marked by:

The JAK2 chromosomal mutation is associated with:

The highest concentration of eosinophils seen in peripheral smear is seen in which of the following?

Essential thrombocytosis can affect all three cell lines, but the main cell line affected is the:

_______ indicates the transformation of a chronic process to an acute process.

Pancytosis is a prominent feature of which of the following disorders?

Myocardial infarctions, transient ischemic attacks, and deep vein thrombosis are likely to be complications of:

A "dry tap" is a characteristic of myeloid fibrosis with myeloid metaplasia due to increased infiltration of:

Myeloproliferative neoplasms are disorders of the young.