Question 1

A primary inhibitor of the fibrinolytic system is:

Accepted Answer

A) Alpha 2 antiplasmin 
B) Alpha 2 macroglobulin 
C) Antithrombin 
D) Protein C 
A) Alpha 2 antiplasmin 
B) Alpha 2 macroglobulin 
C) Antithrombin 
D) Protein C A

Question 2

Normal levels of fibrin degradation products are removed by the reticuloendothelial system and usually measure:

Accepted Answer

A) Less than 20 µg/mL 
B) Less than 40 µg/mL 
C) Less than 75 µg/mL 
D) Less than 100 µg/mL 
A) Less than 20 µg/mL 
B) Less than 40 µg/mL 
C) Less than 75 µg/mL 
D) Less than 100 µg/mL B

Question 3

Plasmin causes the inactivation of factors:

Accepted Answer

A) V, VII, X, XI 
B) V, VIII, XI, XII 
C) VII, VIII, XI, XII 
D) X, XI, XII, XIII 
A) V, VII, X, XI 
B) V, VIII, XI, XII 
C) VII, VIII, XI, XII 
D) X, XI, XII, XIII B

Question 4

The lowest levels of fibrinogen are seen in which inherited disorder of fibrinogen?

Accepted Answer

A) Hyperfibrinogenemia 
B) Hypofibrinogenemia 
C) Dysfibrinogenemia 
D) Afibrinogenemia 
A) Hyperfibrinogenemia 
B) Hypofibrinogenemia 
C) Dysfibrinogenemia 
D) Afibrinogenemia

Question 5

All of the following are functions of thrombin except:

Accepted Answer

A) Initiating the platelet release reaction 
B) Simulating platelets to product PGI2 
C) Activating factors V and VIII 
D) Activating thromboplastin 
A) Initiating the platelet release reaction 
B) Simulating platelets to product PGI2 
C) Activating factors V and VIII 
D) Activating thromboplastin

Question 6

An excess of which of the following is indicative of the breakdown of fibrin products within the circulating blood?

Accepted Answer

A) D-dimers 
B) Alpha-2-antiplasmin 
C) Protein C 
D) Plasmin 
A) D-dimers 
B) Alpha-2-antiplasmin 
C) Protein C 
D) Plasmin

Question 7

D-dimer analysis may have what kind of result in DIC?

Accepted Answer

A) Normal 
B) Low 
C) Elevated 
D) D-dimer is not an appropriate test for DIC. 
A) Normal 
B) Low 
C) Elevated 
D) D-dimer is not an appropriate test for DIC.

Question 8

The reference range for fibrinogen is:

Accepted Answer

A) 20 to 40 mg/dL 
B) 100 to 120 mg/dL 
C) 150 to 450 mg/dL 
D) 200 to 400 mg/dL 
A) 20 to 40 mg/dL 
B) 100 to 120 mg/dL 
C) 150 to 450 mg/dL 
D) 200 to 400 mg/dL

Question 9

The key component to clot dissolution is:

Accepted Answer

A) Plasminogen 
B) Plasmin 
C) Thrombin 
D) Fibrin 
A) Plasminogen 
B) Plasmin 
C) Thrombin 
D) Fibrin

Question 10

The best component to use for patients with afibrinogenemia is:

Accepted Answer

A) Whole blood 
B) Fresh frozen plasma 
C) Tissue plasminogen activator 
D) Factor XIII 
A) Whole blood 
B) Fresh frozen plasma 
C) Tissue plasminogen activator 
D) Factor XIII

Question 11

Primary fibrinolysis is a disorder closely related to DIC.All of the coagulation profile assays are the same as that for DIC with the exception of the:

Accepted Answer

A) D-dimer level, which is increased 
B) Fibrinogen level, which is decreased 
C) Platelet count, which is normal 
D) PT/INR, which is increased 
A) D-dimer level, which is increased 
B) Fibrinogen level, which is decreased 
C) Platelet count, which is normal 
D) PT/INR, which is increased

Question 12

The D-dimer test measures:

Accepted Answer

A) Fibrinogen deposition 
B) Fibrinogen degradation 
C) Fibrin degradation 
D) Fibrin deposition 
A) Fibrinogen deposition 
B) Fibrinogen degradation 
C) Fibrin degradation 
D) Fibrin deposition

Question 13

The process of fibrin degradation is called __________ and is controlled by the enzyme _________.

Accepted Answer

A) fibrination; plasmin 
B) fibrinolysis; plasmin 
C) fibrination; protease 
D) fibrinolysis; protease 
A) fibrination; plasmin 
B) fibrinolysis; plasmin 
C) fibrination; protease 
D) fibrinolysis; protease

Question 14

A patient with DIC will have the all following coagulation test results except:

Accepted Answer

A) An increased PT/INR 
B) An increased aPTT 
C) An increased fibrinogen 
D) An increased D-dimer 
A) An increased PT/INR 
B) An increased aPTT 
C) An increased fibrinogen 
D) An increased D-dimer

Question 15

Patients with the heterozygous form of afibrinogenemia will have plasma levels of fibrinogen in the range of:

Accepted Answer

A) 0 to 20 mg/dL 
B) 20 to 100 mg/dL 
C) 50 to 150 mg/dL 
D) 100 to 200 mg/dL 
A) 0 to 20 mg/dL 
B) 20 to 100 mg/dL 
C) 50 to 150 mg/dL 
D) 100 to 200 mg/dL

Question 16

A patient with DIC will have all the following coagulation test results except:

Accepted Answer

A) An increased PT/INR 
B) An increased aPTT 
C) An increased fibrinogen 
D) An increased D-dimer 
A) An increased PT/INR 
B) An increased aPTT 
C) An increased fibrinogen 
D) An increased D-dimer

Question 17

Which of these are byproducts of fibrinolysis?

Accepted Answer

A) Fibrin degradation products and D-dimers 
B) Fibrinopeptides A and B 
C) Streptokinase and urokinase 
D) Alpha 2 antiplasmins 
A) Fibrin degradation products and D-dimers 
B) Fibrinopeptides A and B 
C) Streptokinase and urokinase 
D) Alpha 2 antiplasmins

Question 18

Which of the following hematology disorders will likely trigger an episode of DIC?

Accepted Answer

A) Sickle cell disease 
B) Iron-deficiency anemia 
C) Idiopathic thrombocythemia 
D) Acute promyelocytic leukemia 
A) Sickle cell disease 
B) Iron-deficiency anemia 
C) Idiopathic thrombocythemia 
D) Acute promyelocytic leukemia

Question 19

The substrate upon which the coagulation cascade is centered is:

Accepted Answer

A) Thrombin 
B) Vitamin K 
C) Fibrinogen 
D) Fibrin 
A) Thrombin 
B) Vitamin K 
C) Fibrinogen 
D) Fibrin

Question 20

Obstetrical complications such as retained placenta or abruptio placenta are leading causes of:

Accepted Answer

A) Thrombosis 
B) DIC 
C) ITP 
D) TTP 
A) Thrombosis 
B) DIC 
C) ITP 
D) TTP

A primary inhibitor of the fibrinolytic system is:

Normal levels of fibrin degradation products are removed by the reticuloendothelial system and usually measure:

Plasmin causes the inactivation of factors:

The lowest levels of fibrinogen are seen in which inherited disorder of fibrinogen?

All of the following are functions of thrombin except:

An excess of which of the following is indicative of the breakdown of fibrin products within the circulating blood?

D-dimer analysis may have what kind of result in DIC?

The reference range for fibrinogen is:

The key component to clot dissolution is:

The best component to use for patients with afibrinogenemia is:

Primary fibrinolysis is a disorder closely related to DIC.All of the coagulation profile assays are the same as that for DIC with the exception of the:

The D-dimer test measures:

The process of fibrin degradation is called __ and is controlled by the enzyme _.

A patient with DIC will have the all following coagulation test results except:

Patients with the heterozygous form of afibrinogenemia will have plasma levels of fibrinogen in the range of:

A patient with DIC will have all the following coagulation test results except:

Which of these are byproducts of fibrinolysis?

Which of the following hematology disorders will likely trigger an episode of DIC?

The substrate upon which the coagulation cascade is centered is:

Obstetrical complications such as retained placenta or abruptio placenta are leading causes of:

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Blood Cell Production and Function and Relevant Red Cell Morphology

Hemoglobin Function and Principles of Hemolysis

The Microcytic Anemias

The Macrocytic Anemias

Normochromic Anemias: Biochemical and Membrane Disorders and Miscellaneous Red Cell Disorders

The Normochromic Anemias Due to Hemoglobinopathies

Leukopoiesis and Leukopoietic Function

Abnormalities of White Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Myeloproliferative Neoplasms

Lymphoproliferative Disorders and Related Plasma Cell Disorders

The Myelodysplastic Syndromes

Overview of Hemostasis and Platelet Physiology

Quantitative and Qualitative Platelet Disorders

Defects of Plasma Clotting Factors

Introduction to Thrombosis and Anticoagulant Therapy

Hematology Automation and Flow Cell Cytometry

Filters

Exam 18: Fibrinogen, Thrombin, and the Fibrinolytic System

A primary inhibitor of the fibrinolytic system is:

Normal levels of fibrin degradation products are removed by the reticuloendothelial system and usually measure:

Plasmin causes the inactivation of factors:

The lowest levels of fibrinogen are seen in which inherited disorder of fibrinogen?

All of the following are functions of thrombin except:

An excess of which of the following is indicative of the breakdown of fibrin products within the circulating blood?

D-dimer analysis may have what kind of result in DIC?

The reference range for fibrinogen is:

The key component to clot dissolution is:

The best component to use for patients with afibrinogenemia is:

Primary fibrinolysis is a disorder closely related to DIC.All of the coagulation profile assays are the same as that for DIC with the exception of the:

The D-dimer test measures:

The process of fibrin degradation is called __________ and is controlled by the enzyme _________.

A patient with DIC will have the all following coagulation test results except:

Patients with the heterozygous form of afibrinogenemia will have plasma levels of fibrinogen in the range of:

A patient with DIC will have all the following coagulation test results except:

Which of these are byproducts of fibrinolysis?

Which of the following hematology disorders will likely trigger an episode of DIC?

The substrate upon which the coagulation cascade is centered is:

Obstetrical complications such as retained placenta or abruptio placenta are leading causes of:

Introduction to Hematology and Basic Laboratory Practice

From Hematopoiesis to the Complete Blood Count

Blood Cell Production and Function and Relevant Red Cell Morphology

Hemoglobin Function and Principles of Hemolysis

The Microcytic Anemias

The Macrocytic Anemias

Normochromic Anemias: Biochemical and Membrane Disorders and Miscellaneous Red Cell Disorders

The Normochromic Anemias Due to Hemoglobinopathies

Leukopoiesis and Leukopoietic Function

Abnormalities of White Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Acute Leukemias

Myeloproliferative Neoplasms

Lymphoproliferative Disorders and Related Plasma Cell Disorders

The Myelodysplastic Syndromes

Overview of Hemostasis and Platelet Physiology

Quantitative and Qualitative Platelet Disorders

Defects of Plasma Clotting Factors

Introduction to Thrombosis and Anticoagulant Therapy

Hematology Automation and Flow Cell Cytometry

Filters

The process of fibrin degradation is called __ and is controlled by the enzyme _.