Question 1

The sis oncogene of the simian sarcoma virus was derived from what normal cellular gene?

Accepted Answer

A) the Ras gene 
B) the gene for platelet-derived growth factor (PDGF) 
C) the gene for the insulin receptor 
D) the gene for the glucagon receptor 
E) the gene for epidermal growth factor 
A) the Ras gene 
B) the gene for platelet-derived growth factor (PDGF) 
C) the gene for the insulin receptor 
D) the gene for the glucagon receptor 
E) the gene for epidermal growth factor

Question 2

You culture cells and selectively block MYC gene expression.What is the effect on the cells?

Accepted Answer

A) Cell progression through the cycle continues unabated. 
B) Cell progression through G1 is blocked. 
C) The cells arrest in the middle of mitosis. 
D) The cells arrest in the middle of meiosis. 
E) The cells arrest in the middle of S phase. 
A) Cell progression through the cycle continues unabated. 
B) Cell progression through G1 is blocked. 
C) The cells arrest in the middle of mitosis. 
D) The cells arrest in the middle of meiosis. 
E) The cells arrest in the middle of S phase.

Question 3

Which screening test just being developed will be able to warn us of the types of cancer to which we may be most susceptible by looking for the presence of specific genes associated with various types of cancer?

Accepted Answer

A) genomics 
B) Pap smear 
C) colonoscopy 
D) proteomics 
E) astronomics 
A) genomics 
B) Pap smear 
C) colonoscopy 
D) proteomics 
E) astronomics

Question 4

Cancer results from the uncontrolled proliferation of a single wayward cell and is therefore considered to be _________.

Accepted Answer

A) polyclonal 
B) biclonal 
C) monoclonal 
D) variant 
E) obstreperous 
A) polyclonal 
B) biclonal 
C) monoclonal 
D) variant 
E) obstreperous

Question 5

Which of the following enzymes is known to be expressed at a high level in the cancer cells of patients suffering from acute myeloid leukemia and at low levels in the cancer cells of patients suffering from acute lymphoblastic leukemia?

Accepted Answer

A) cholesterase 
B) catalase 
C) adenylyl cyclase 
D) phosphodiesterase 
E) protein kinase A 
A) cholesterase 
B) catalase 
C) adenylyl cyclase 
D) phosphodiesterase 
E) protein kinase A

Question 6

What was the initial explanation for the sensitivity of cancer cells to radiation therapy and chemotherapy as compared to normal cells?

Accepted Answer

A) Cancer cells are sensitive to radiation and chemotherapy because they divide more rapidly. 
B) Cancer cells are less resistant to drugs or radiation because once they sustain genetic damage,they either progress through the cell cycle while repair is incomplete and they may undergo apoptosis. 
C) Cancer cells are sensitive to radiation and chemotherapy because they divide more slowly. 
D) Cancer cells are less resistant to drugs or radiation because once they sustain genetic damage,they either arrest the cell cycle until repair is complete or undergo apoptosis. 
E) Cancer cells are sensitive to radiation and chemotherapy because they will not undergo apoptosis. 
A) Cancer cells are sensitive to radiation and chemotherapy because they divide more rapidly. 
B) Cancer cells are less resistant to drugs or radiation because once they sustain genetic damage,they either progress through the cell cycle while repair is incomplete and they may undergo apoptosis. 
C) Cancer cells are sensitive to radiation and chemotherapy because they divide more slowly. 
D) Cancer cells are less resistant to drugs or radiation because once they sustain genetic damage,they either arrest the cell cycle until repair is complete or undergo apoptosis. 
E) Cancer cells are sensitive to radiation and chemotherapy because they will not undergo apoptosis.

Question 7

The development of chronic myelogenous leukemia tumor-resistance to Gleevec appears to usually be caused by mutations in the ABL portion of the fusion gene.Therefore,what is thought to be the best drug regimen for treating CML?

Accepted Answer

A) a cocktail of several different inhibitors that target different parts of the Abl protein 
B) a cocktail of several different inhibitors that target the same parts of the Abl protein 
C) a cocktail of several different inhibitors that target common domains of different proteins 
D) a cocktail of several different inhibitors that target the different parts of different proteins 
E) an aperetif 
A) a cocktail of several different inhibitors that target different parts of the Abl protein 
B) a cocktail of several different inhibitors that target the same parts of the Abl protein 
C) a cocktail of several different inhibitors that target common domains of different proteins 
D) a cocktail of several different inhibitors that target the different parts of different proteins 
E) an aperetif

Question 8

Hypoxic conditions ___________.

Accepted Answer

A) cause cancer cells to activate a transcription factor called Hif 
B) can cause cancer cells to induce the formation of new blood vessels 
C) can promote the migratory properties of cancer cells 
D) can cause the spread of a tumor 
E) All of these are correct. 
A) cause cancer cells to activate a transcription factor called Hif 
B) can cause cancer cells to induce the formation of new blood vessels 
C) can promote the migratory properties of cancer cells 
D) can cause the spread of a tumor 
E) All of these are correct.

Question 9

The cancer vaccine Provenge has been designed to teach a person's immune cells to attack what cancer?

Accepted Answer

A) chronic lymphocytic leukemia 
B) Kaposi's sarcoma 
C) colorectal cancer 
D) bladder cancer 
E) prostate cancer 
A) chronic lymphocytic leukemia 
B) Kaposi's sarcoma 
C) colorectal cancer 
D) bladder cancer 
E) prostate cancer

Question 10

The BCL-2 oncogene is the oncogene most closely linked to _________;it encodes a membrane-bound ____________.

Accepted Answer

A) apoptosis,protein that normally acts to activate apoptosis 
B) apoptosis,protein that normally acts to inhibit apoptosis 
C) uncontrolled proliferation,protein that normally acts to inhibit apoptosis 
D) uncontrolled proliferation,protein that normally acts to activate apoptosis 
E) apoptosis,protein that binds to the insulin receptor tyrosine kinase 
A) apoptosis,protein that normally acts to activate apoptosis 
B) apoptosis,protein that normally acts to inhibit apoptosis 
C) uncontrolled proliferation,protein that normally acts to inhibit apoptosis 
D) uncontrolled proliferation,protein that normally acts to activate apoptosis 
E) apoptosis,protein that binds to the insulin receptor tyrosine kinase

Question 11

When telomerase appears in a cell,it is not because the coding sequences of the gene have been changed.Instead,the protein produced is essentially normal,but it is being produced at an abnormal time.A gene that is normally repressed has been activated for some reason.Such an alteration in cell behavior is referred to as a(n)_________ change.

Accepted Answer

A) androgenous 
B) mutational 
C) epigenetic 
D) structural 
E) ancillary 
A) androgenous 
B) mutational 
C) epigenetic 
D) structural 
E) ancillary

Question 12

What is the oncogene that is most often mutated in human tumors and what does it encode?

Accepted Answer

A) the RAS gene,a GTP-binding protein that serves as an on-off switch for a key cell signaling pathway that controls cell proliferation 
B) the RAS gene,a DNA polymerase that replicates DNA for dividing cells 
C) the MYC gene,an RNA polymerase that transcribes mRNA encoding proteins needed for cell division 
D) the RB gene,a GTP-binding protein that serves as an on-off switch for a key cell signaling pathway that controls cell proliferation 
E) the MYC gene,a protein kinase that enhances cell differentiation 
A) the RAS gene,a GTP-binding protein that serves as an on-off switch for a key cell signaling pathway that controls cell proliferation 
B) the RAS gene,a DNA polymerase that replicates DNA for dividing cells 
C) the MYC gene,an RNA polymerase that transcribes mRNA encoding proteins needed for cell division 
D) the RB gene,a GTP-binding protein that serves as an on-off switch for a key cell signaling pathway that controls cell proliferation 
E) the MYC gene,a protein kinase that enhances cell differentiation

Question 13

Which of the following is presently being used as a screening procedure for cancer?

Accepted Answer

A) mammography for detecting breast cancer 
B) Pap smears for detecting cervical cancer 
C) PSA determinations for detecting prostate cancer 
D) colonoscopy for detecting colorectal cancer 
E) All of these are correct. 
A) mammography for detecting breast cancer 
B) Pap smears for detecting cervical cancer 
C) PSA determinations for detecting prostate cancer 
D) colonoscopy for detecting colorectal cancer 
E) All of these are correct.

Question 14

Raf is a ________ protein kinase that resides at the head of the _______.

Accepted Answer

A) tyrosine,MAP kinase cascade 
B) serine/threonine,MAP kinase cascade 
C) tyrosine,glucagon cascade 
D) serine/threonine.glucagon cascade 
E) serine/threonine,apoptosis cascade 
A) tyrosine,MAP kinase cascade 
B) serine/threonine,MAP kinase cascade 
C) tyrosine,glucagon cascade 
D) serine/threonine.glucagon cascade 
E) serine/threonine,apoptosis cascade

The sis oncogene of the simian sarcoma virus was derived from what normal cellular gene?

You culture cells and selectively block MYC gene expression.What is the effect on the cells?

Which screening test just being developed will be able to warn us of the types of cancer to which we may be most susceptible by looking for the presence of specific genes associated with various types of cancer?

Cancer results from the uncontrolled proliferation of a single wayward cell and is therefore considered to be _________.

Which of the following enzymes is known to be expressed at a high level in the cancer cells of patients suffering from acute myeloid leukemia and at low levels in the cancer cells of patients suffering from acute lymphoblastic leukemia?

What was the initial explanation for the sensitivity of cancer cells to radiation therapy and chemotherapy as compared to normal cells?

The development of chronic myelogenous leukemia tumor-resistance to Gleevec appears to usually be caused by mutations in the ABL portion of the fusion gene.Therefore,what is thought to be the best drug regimen for treating CML?

Hypoxic conditions ___________.

The cancer vaccine Provenge has been designed to teach a person's immune cells to attack what cancer?

The BCL-2 oncogene is the oncogene most closely linked to _;it encodes a membrane-bound ____.

What is the oncogene that is most often mutated in human tumors and what does it encode?

Which of the following is presently being used as a screening procedure for cancer?

Raf is a __ protein kinase that resides at the head of the _.

Introduction to the Study of Cell and Molecular Biology

The Chemical Basis of Life

Bioenergetics, Enzymes, and Metabolism

The Structure and Function of the Plasma Membrane

Aerobic Respiration and the Mitochondrion

Photosynthesis and the Chloroplast

Interactions Between Cells and Their Environment

Cytoplasmic Membrane Systems: Structure, Function, and Membrane Trafficking

The Cytoskeleton and Cell Motility

The Nature of the Gene and the Genome

Gene Expression: From Transcription to Translation

Control of Gene Expression

Dna Replication and Repair

Cellular Reproduction

Cell Signaling and Signal Transduction: Communication Between Cells

The Immune Response

Techniques in Cell and Molecular Biology

Filters

Exam 16: Cancer

The sis oncogene of the simian sarcoma virus was derived from what normal cellular gene?

You culture cells and selectively block MYC gene expression.What is the effect on the cells?

Which screening test just being developed will be able to warn us of the types of cancer to which we may be most susceptible by looking for the presence of specific genes associated with various types of cancer?

Cancer results from the uncontrolled proliferation of a single wayward cell and is therefore considered to be _________.

Which of the following enzymes is known to be expressed at a high level in the cancer cells of patients suffering from acute myeloid leukemia and at low levels in the cancer cells of patients suffering from acute lymphoblastic leukemia?

What was the initial explanation for the sensitivity of cancer cells to radiation therapy and chemotherapy as compared to normal cells?

The development of chronic myelogenous leukemia tumor-resistance to Gleevec appears to usually be caused by mutations in the ABL portion of the fusion gene.Therefore,what is thought to be the best drug regimen for treating CML?

Hypoxic conditions ___________.

The cancer vaccine Provenge has been designed to teach a person's immune cells to attack what cancer?

The BCL-2 oncogene is the oncogene most closely linked to _________;it encodes a membrane-bound ____________.

What is the oncogene that is most often mutated in human tumors and what does it encode?

Which of the following is presently being used as a screening procedure for cancer?

Raf is a ________ protein kinase that resides at the head of the _______.

Introduction to the Study of Cell and Molecular Biology

The Chemical Basis of Life

Bioenergetics, Enzymes, and Metabolism

The Structure and Function of the Plasma Membrane

Aerobic Respiration and the Mitochondrion

Photosynthesis and the Chloroplast

Interactions Between Cells and Their Environment

Cytoplasmic Membrane Systems: Structure, Function, and Membrane Trafficking

The Cytoskeleton and Cell Motility

The Nature of the Gene and the Genome

Gene Expression: From Transcription to Translation

Control of Gene Expression

Dna Replication and Repair

Cellular Reproduction

Cell Signaling and Signal Transduction: Communication Between Cells

The Immune Response

Techniques in Cell and Molecular Biology

Filters

The BCL-2 oncogene is the oncogene most closely linked to _;it encodes a membrane-bound ____.

Raf is a __ protein kinase that resides at the head of the _.