Question 1

Retinoblastoma is inherited as a ____________.

Accepted Answer

A) dominant genetic trait 
B) recessive genetic trait 
C) sex-linked recessive treat 
D) sex-linked dominant trait 
E) codominant trait 
A) dominant genetic trait 
B) recessive genetic trait 
C) sex-linked recessive treat 
D) sex-linked dominant trait 
E) codominant trait

Question 2

Because they act to _______ tumorigenesis,the miR-15a and miR-16 miRNAs can be thought of as _________.

Accepted Answer

A) enhance,tumor suppressors 
B) inhibit,oncogenes 
C) enhance,oncogenes 
D) inhibit,tumor suppressors 
E) delete,parts of the mismatch repair mechanism 
A) enhance,tumor suppressors 
B) inhibit,oncogenes 
C) enhance,oncogenes 
D) inhibit,tumor suppressors 
E) delete,parts of the mismatch repair mechanism

Question 3

Whether a cell lives or dies after a particular event depends to a large degree on ________ between ________ and _________ signals.

Accepted Answer

A) the differences,mitotic,cytokinetic 
B) the balance,mitotic,cytokinetic 
C) the balance,proapoptotic,antiapoptotic 
D) the differences,on,off 
E) the similarities,proapoptotic,antiapoptotic 
A) the differences,mitotic,cytokinetic 
B) the balance,mitotic,cytokinetic 
C) the balance,proapoptotic,antiapoptotic 
D) the differences,on,off 
E) the similarities,proapoptotic,antiapoptotic

Question 4

What does telomerase do?

Accepted Answer

A) It maintains centromeres at chromosome ends (telomeres),thus allowing cells to continue to divide. 
B) It degrades centromeres at the telomeres of chromosomes,thus allowing cells to continue to divide. 
C) It maintains telomeres at the ends of chromosomes,thus allowing cells to continue to divide. 
D) It degrades telomeres at the ends of chromosomes,thus allowing cells to continue to divide. 
E) It maintains telomeres at the ends of chromosomes,thus preventing cells from continuing to divide. 
A) It maintains centromeres at chromosome ends (telomeres),thus allowing cells to continue to divide. 
B) It degrades centromeres at the telomeres of chromosomes,thus allowing cells to continue to divide. 
C) It maintains telomeres at the ends of chromosomes,thus allowing cells to continue to divide. 
D) It degrades telomeres at the ends of chromosomes,thus allowing cells to continue to divide. 
E) It maintains telomeres at the ends of chromosomes,thus preventing cells from continuing to divide.

Question 5

Against what form of cancer is Mylotarg most effective?

Accepted Answer

A) acute myeloid leukemia 
B) breast cancer 
C) non-Hodgkins B-cell lymphoma 
D) Hodgkins disease 
E) pancreatic cancer 
A) acute myeloid leukemia 
B) breast cancer 
C) non-Hodgkins B-cell lymphoma 
D) Hodgkins disease 
E) pancreatic cancer

Question 6

Mutant forms of which of the following genes have been associated with melanomas and colorectal cancers,respectively?

Accepted Answer

A) APC and BRAF 
B) BRAF and CCMD 
C) BRAF and APC 
D) CCMD and APC 
E) ZUNI and BRAF 
A) APC and BRAF 
B) BRAF and CCMD 
C) BRAF and APC 
D) CCMD and APC 
E) ZUNI and BRAF

Question 7

What is unusual about the inheritance of retinoblastoma,given that it appears to be inherited as a dominant trait?

Accepted Answer

A) All children who inherited one copy of the RB deletion developed retinoblastoma. 
B) Not all children who inherited the RB deletion developed retinoblastoma. 
C) No children who inherited the RB deletion developed retinoblastoma. 
D) Only boys appear to develop retinoblastoma. 
E) Only girls appear to develop retinoblastoma. 
A) All children who inherited one copy of the RB deletion developed retinoblastoma. 
B) Not all children who inherited the RB deletion developed retinoblastoma. 
C) No children who inherited the RB deletion developed retinoblastoma. 
D) Only boys appear to develop retinoblastoma. 
E) Only girls appear to develop retinoblastoma.

Question 8

You study two cell lines.In one,the MDM2 protein is overexpressed;in the other the p53 protein is absent.What difference would you expect in the behavior of these two cell lines?

Accepted Answer

A) In cells containing overexpressed MDM2,p53 levels will be low;in cells lacking the TP53 gene,p53 levels are also low;thus there is no difference in behavior. 
B) In cells containing overexpressed MDM2,p53 levels will be high;in cells lacking the TP53 gene,p53 levels are low;thus there is a drastic difference in behavior. 
C) In cells containing overexpressed MDM2,p53 levels will be high;in cells lacking the TP53 gene,p53 levels are high;thus there is no difference. 
D) In cells containing overexpressed MDM2,p53 levels will be low;in cells lacking the TP53 gene,p53 levels are high;thus there is no drastic difference. 
E) None of these are correct. 
A) In cells containing overexpressed MDM2,p53 levels will be low;in cells lacking the TP53 gene,p53 levels are also low;thus there is no difference in behavior. 
B) In cells containing overexpressed MDM2,p53 levels will be high;in cells lacking the TP53 gene,p53 levels are low;thus there is a drastic difference in behavior. 
C) In cells containing overexpressed MDM2,p53 levels will be high;in cells lacking the TP53 gene,p53 levels are high;thus there is no difference. 
D) In cells containing overexpressed MDM2,p53 levels will be low;in cells lacking the TP53 gene,p53 levels are high;thus there is no drastic difference. 
E) None of these are correct.

Question 9

What virus seems to be related to the development of Burkitt's lymphoma in African patients,while it is associated only with minor infections,like mononucleosis,in the Western world?

Accepted Answer

A) avian erythroblastosis virus 
B) simian sarcoma virus 
C) rhinovirus 
D) Epstein-Barr virus 
E) parvovirus 
A) avian erythroblastosis virus 
B) simian sarcoma virus 
C) rhinovirus 
D) Epstein-Barr virus 
E) parvovirus

Question 10

If Raf is mutated so that it is "on" constitutively,what is the effect on the cell?

Accepted Answer

A) The cells stop dividing. 
B) The cells differentiate. 
C) The cells dedifferentiate. 
D) The cells lose growth control. 
E) The cells increase in volume permanently. 
A) The cells stop dividing. 
B) The cells differentiate. 
C) The cells dedifferentiate. 
D) The cells lose growth control. 
E) The cells increase in volume permanently.

Question 11

If any of the proteins involved in mismatch repair are damaged,the mutation rate and cancer risk will rise;this is called the ___________.

Accepted Answer

A) stability phenotype 
B) mutator phenotype 
C) mutator genotype 
D) alteration phenotype 
E) alteration genotype 
A) stability phenotype 
B) mutator phenotype 
C) mutator genotype 
D) alteration phenotype 
E) alteration genotype

Question 12

Under what circumstances are tumor cells likely to undergo apoptosis when they have sustained damage to DNA?

Accepted Answer

A) if they have a functioning RP gene. 
B) if they have a functioning TP53 gene 
C) if they have a non-functioning RP gene. 
D) if they have a non-functioning TP53gene 
E) if they have a non-functioning BAX gene 
A) if they have a functioning RP gene. 
B) if they have a functioning TP53 gene 
C) if they have a non-functioning RP gene. 
D) if they have a non-functioning TP53gene 
E) if they have a non-functioning BAX gene

Question 13

What is the difference between a benign tumor and a malignant tumor?

Accepted Answer

Both benign and malignant tumo

Question 14

Another word for malignant transformation is ________.

Accepted Answer

A) oncorariness 
B) ontogenesis 
C) cancerogenesis 
D) tumorigenesis 
E) oncogenation 
A) oncorariness 
B) ontogenesis 
C) cancerogenesis 
D) tumorigenesis 
E) oncogenation

Question 15

Which molecule do Bexxar and Zevalin antibodies attack?

Accepted Answer

A) collagen 
B) CD20 
C) myeloid protein 
D) actin 
E) EGF receptor 
A) collagen 
B) CD20 
C) myeloid protein 
D) actin 
E) EGF receptor

Question 16

After his initial discoveries and for the rest of his life,Coley tried to develop a ______ extract that when injected under the skin would stimulate a patient's immune system to destroy their malignancy.His approach called ________ worked against some uncommon__________.

Accepted Answer

A) bacterial,Coley's toxin,soft-tissue carcinomas 
B) bacterial,Coley's solution,soft-tissue sarcomas 
C) viral,Coley's toxin,soft-tissue sarcomas 
D) bacterial,Coley's toxin,soft-tissue sarcomas 
E) human cytoplasmic,Coley's cure,soft-tissue hepatomas 
A) bacterial,Coley's toxin,soft-tissue carcinomas 
B) bacterial,Coley's solution,soft-tissue sarcomas 
C) viral,Coley's toxin,soft-tissue sarcomas 
D) bacterial,Coley's toxin,soft-tissue sarcomas 
E) human cytoplasmic,Coley's cure,soft-tissue hepatomas

Question 17

What is the name for tiny regulatory RNAs that negatively regulate the expression of target mRNAs?

Accepted Answer

A) tRNAs 
B) microRNAs 
C) mtRNAs 
D) macroRNAs 
E) rRNAs 
A) tRNAs 
B) microRNAs 
C) mtRNAs 
D) macroRNAs 
E) rRNAs

Question 18

__________ is new blood vessel formation.

Accepted Answer

A) Vesselogeny 
B) Angiogenesis 
C) Formational vessels 
D) Angiotension 
E) Venogenesis 
A) Vesselogeny 
B) Angiogenesis 
C) Formational vessels 
D) Angiotension 
E) Venogenesis

Question 19

Which statement below is a correct statement about the abilities of normal cells and cancer cells to grow and divide when cultured under conditions favorable for cell proliferation?

Accepted Answer

A) Malignant cells grow and divide at a somewhat faster rate than normal cells. 
B) Normal cells grow and divide at a faster rate than malignant cells. 
C) Malignant and normal cells grow and divide at similar rates. 
D) Neither type of cell grows well in culture. 
E) Normal cells do not grow at all,while malignant cells grow very rapidly. 
A) Malignant cells grow and divide at a somewhat faster rate than normal cells. 
B) Normal cells grow and divide at a faster rate than malignant cells. 
C) Malignant and normal cells grow and divide at similar rates. 
D) Neither type of cell grows well in culture. 
E) Normal cells do not grow at all,while malignant cells grow very rapidly.

Question 20

You are studying two rodent cell lines,one malignant and one normal.You carry out an experiment in which you fuse malignant and normal cells.What happens?

Accepted Answer

A) All of the hybrid (fused)cells behave like malignant cancer cells. 
B) Some of the hybrid cells lose malignant traits. 
C) Some of the hybrid cells gained more extreme malignant traits. 
D) Most of the hybrids died shortly after fusion. 
E) The hybrids began to fuse together spontaneously making giant multinucleate cells. 
A) All of the hybrid (fused)cells behave like malignant cancer cells. 
B) Some of the hybrid cells lose malignant traits. 
C) Some of the hybrid cells gained more extreme malignant traits. 
D) Most of the hybrids died shortly after fusion. 
E) The hybrids began to fuse together spontaneously making giant multinucleate cells.

Retinoblastoma is inherited as a ____________.

Because they act to _ tumorigenesis,the miR-15a and miR-16 miRNAs can be thought of as ___.

Whether a cell lives or dies after a particular event depends to a large degree on between and _ signals.

What does telomerase do?

Against what form of cancer is Mylotarg most effective?

Mutant forms of which of the following genes have been associated with melanomas and colorectal cancers,respectively?

What is unusual about the inheritance of retinoblastoma,given that it appears to be inherited as a dominant trait?

You study two cell lines.In one,the MDM2 protein is overexpressed;in the other the p53 protein is absent.What difference would you expect in the behavior of these two cell lines?

What virus seems to be related to the development of Burkitt's lymphoma in African patients,while it is associated only with minor infections,like mononucleosis,in the Western world?

If Raf is mutated so that it is "on" constitutively,what is the effect on the cell?

If any of the proteins involved in mismatch repair are damaged,the mutation rate and cancer risk will rise;this is called the ___________.

Under what circumstances are tumor cells likely to undergo apoptosis when they have sustained damage to DNA?

What is the difference between a benign tumor and a malignant tumor?

Another word for malignant transformation is ________.

Which molecule do Bexxar and Zevalin antibodies attack?

After his initial discoveries and for the rest of his life,Coley tried to develop a extract that when injected under the skin would stimulate a patient's immune system to destroy their malignancy.His approach called worked against some uncommon____.

What is the name for tiny regulatory RNAs that negatively regulate the expression of target mRNAs?

__________ is new blood vessel formation.

Which statement below is a correct statement about the abilities of normal cells and cancer cells to grow and divide when cultured under conditions favorable for cell proliferation?

You are studying two rodent cell lines,one malignant and one normal.You carry out an experiment in which you fuse malignant and normal cells.What happens?

Introduction to the Study of Cell and Molecular Biology

The Chemical Basis of Life

Bioenergetics, Enzymes, and Metabolism

The Structure and Function of the Plasma Membrane

Aerobic Respiration and the Mitochondrion

Photosynthesis and the Chloroplast

Interactions Between Cells and Their Environment

Cytoplasmic Membrane Systems: Structure, Function, and Membrane Trafficking

The Cytoskeleton and Cell Motility

The Nature of the Gene and the Genome

Gene Expression: From Transcription to Translation

Control of Gene Expression

Dna Replication and Repair

Cellular Reproduction

Cell Signaling and Signal Transduction: Communication Between Cells

The Immune Response

Techniques in Cell and Molecular Biology

Filters

Exam 16: Cancer

Retinoblastoma is inherited as a ____________.

Because they act to _______ tumorigenesis,the miR-15a and miR-16 miRNAs can be thought of as _________.

Whether a cell lives or dies after a particular event depends to a large degree on ________ between ________ and _________ signals.

What does telomerase do?

Against what form of cancer is Mylotarg most effective?

Mutant forms of which of the following genes have been associated with melanomas and colorectal cancers,respectively?

What is unusual about the inheritance of retinoblastoma,given that it appears to be inherited as a dominant trait?

You study two cell lines.In one,the MDM2 protein is overexpressed;in the other the p53 protein is absent.What difference would you expect in the behavior of these two cell lines?

What virus seems to be related to the development of Burkitt's lymphoma in African patients,while it is associated only with minor infections,like mononucleosis,in the Western world?

If Raf is mutated so that it is "on" constitutively,what is the effect on the cell?

If any of the proteins involved in mismatch repair are damaged,the mutation rate and cancer risk will rise;this is called the ___________.

Under what circumstances are tumor cells likely to undergo apoptosis when they have sustained damage to DNA?

What is the difference between a benign tumor and a malignant tumor?

Another word for malignant transformation is ________.

Which molecule do Bexxar and Zevalin antibodies attack?

After his initial discoveries and for the rest of his life,Coley tried to develop a ______ extract that when injected under the skin would stimulate a patient's immune system to destroy their malignancy.His approach called ________ worked against some uncommon__________.

What is the name for tiny regulatory RNAs that negatively regulate the expression of target mRNAs?

__________ is new blood vessel formation.

Which statement below is a correct statement about the abilities of normal cells and cancer cells to grow and divide when cultured under conditions favorable for cell proliferation?

You are studying two rodent cell lines,one malignant and one normal.You carry out an experiment in which you fuse malignant and normal cells.What happens?

Introduction to the Study of Cell and Molecular Biology

The Chemical Basis of Life

Bioenergetics, Enzymes, and Metabolism

The Structure and Function of the Plasma Membrane

Aerobic Respiration and the Mitochondrion

Photosynthesis and the Chloroplast

Interactions Between Cells and Their Environment

Cytoplasmic Membrane Systems: Structure, Function, and Membrane Trafficking

The Cytoskeleton and Cell Motility

The Nature of the Gene and the Genome

Gene Expression: From Transcription to Translation

Control of Gene Expression

Dna Replication and Repair

Cellular Reproduction

Cell Signaling and Signal Transduction: Communication Between Cells

The Immune Response

Techniques in Cell and Molecular Biology

Filters

Because they act to _ tumorigenesis,the miR-15a and miR-16 miRNAs can be thought of as ___.

Whether a cell lives or dies after a particular event depends to a large degree on between and _ signals.

After his initial discoveries and for the rest of his life,Coley tried to develop a extract that when injected under the skin would stimulate a patient's immune system to destroy their malignancy.His approach called worked against some uncommon____.